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Treatment with onion bulb extract both prevents and reverses allergic inflammation in a murine model of asthma 用洋葱球茎提取物治疗小鼠哮喘模型可预防和逆转过敏性炎症
IF 3.8 3区 医学
Pharmaceutical Biology Pub Date : 2024-04-08 DOI: 10.1080/13880209.2024.2335187
Ahmed Z. El-Hashim, Maitham A. Khajah, Khaled Y. Orabi, Sowmya Balakrishnan, Hanan G. Sary, Ahmad M. Barakat
{"title":"Treatment with onion bulb extract both prevents and reverses allergic inflammation in a murine model of asthma","authors":"Ahmed Z. El-Hashim, Maitham A. Khajah, Khaled Y. Orabi, Sowmya Balakrishnan, Hanan G. Sary, Ahmad M. Barakat","doi":"10.1080/13880209.2024.2335187","DOIUrl":"https://doi.org/10.1080/13880209.2024.2335187","url":null,"abstract":"Asthma presents a global health challenge. The main pharmacotherapy is synthetic chemicals and biological-based drugs that are costly, and have significant side effects. In contrast, use of natural...","PeriodicalId":19942,"journal":{"name":"Pharmaceutical Biology","volume":"240 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Babaodan overcomes cisplatin resistance in cholangiocarcinoma via inhibiting YAP1 巴巴丹通过抑制 YAP1 克服胆管癌的顺铂耐药性
IF 3.8 3区 医学
Pharmaceutical Biology Pub Date : 2024-04-04 DOI: 10.1080/13880209.2024.2331060
Jiong Li, Xiangjun Ma, Faying Xu, Yuanliang Yan, Weiqing Chen
{"title":"Babaodan overcomes cisplatin resistance in cholangiocarcinoma via inhibiting YAP1","authors":"Jiong Li, Xiangjun Ma, Faying Xu, Yuanliang Yan, Weiqing Chen","doi":"10.1080/13880209.2024.2331060","DOIUrl":"https://doi.org/10.1080/13880209.2024.2331060","url":null,"abstract":"Cholangiocarcinoma with highly heterogeneous, aggressive, and multidrug resistance has a poor prognosis. Although babaodan (BBD) combined with cisplatin improved non-small cell lung cancer efficacy...","PeriodicalId":19942,"journal":{"name":"Pharmaceutical Biology","volume":"58 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140563185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liuwei Dihuang pills attenuate ovariectomy-induced bone loss by alleviating bone marrow mesenchymal stem cell (BMSC) senescence via the Yes-associated protein (YAP)-autophagy axis 六味地黄丸通过YAP-自噬轴缓解骨髓间充质干细胞（BMSC）衰老，从而减轻卵巢切除术引起的骨质流失
IF 3.8 3区 医学
Pharmaceutical Biology Pub Date : 2023-12-19 DOI: 10.1080/13880209.2023.2291675
Bing Liang, Xiongbin Chen, Min Li, Lingling Zhang, Xia Yang, Liangqin Shi, Yanju Gong, Yuanyuan Gong, Huan Xu, Xiao Wu, Zhong Jin, Yanru Wang, Luwei Liu, Xiaohong Yi, Lushuang Xie, Hua Zhong, Chongyang Shen, Yong Wang, Lan Yang
{"title":"Liuwei Dihuang pills attenuate ovariectomy-induced bone loss by alleviating bone marrow mesenchymal stem cell (BMSC) senescence via the Yes-associated protein (YAP)-autophagy axis","authors":"Bing Liang, Xiongbin Chen, Min Li, Lingling Zhang, Xia Yang, Liangqin Shi, Yanju Gong, Yuanyuan Gong, Huan Xu, Xiao Wu, Zhong Jin, Yanru Wang, Luwei Liu, Xiaohong Yi, Lushuang Xie, Hua Zhong, Chongyang Shen, Yong Wang, Lan Yang","doi":"10.1080/13880209.2023.2291675","DOIUrl":"https://doi.org/10.1080/13880209.2023.2291675","url":null,"abstract":"Liuwei Dihuang pill (LWDH) has been used to treat postmenopausal osteoporosis (PMOP).To explore the effects and mechanisms of action of LWDH in PMOP.Forty-eight female Sprague-Dawley rats were divi...","PeriodicalId":19942,"journal":{"name":"Pharmaceutical Biology","volume":"33 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138741987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shenqi Fuzheng injection restores the sensitivity to gefitinib in non-small cell lung cancer by inhibiting the IL-22/STAT3/AKT pathway 参芪扶正注射液通过抑制 IL-22/STAT3/AKT 通路恢复非小细胞肺癌患者对吉非替尼的敏感性
IF 3.8 3区 医学
Pharmaceutical Biology Pub Date : 2023-12-15 DOI: 10.1080/13880209.2023.2292266
Jiali Wang, Xianhai He, Zhirong Jia, Aiwen Yan, Kang Xiao, Shuo Liu, Mengjun Hou, Yaling Long, Xuansheng Ding
{"title":"Shenqi Fuzheng injection restores the sensitivity to gefitinib in non-small cell lung cancer by inhibiting the IL-22/STAT3/AKT pathway","authors":"Jiali Wang, Xianhai He, Zhirong Jia, Aiwen Yan, Kang Xiao, Shuo Liu, Mengjun Hou, Yaling Long, Xuansheng Ding","doi":"10.1080/13880209.2023.2292266","DOIUrl":"https://doi.org/10.1080/13880209.2023.2292266","url":null,"abstract":"Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Gefitinib is a first-line treatment for NSCLC. However, its effectiveness is hindered by the development of drug resistanc...","PeriodicalId":19942,"journal":{"name":"Pharmaceutical Biology","volume":"31 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138741868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nicotinamide mononucleotide alleviates endotoxin-induced acute lung injury by modulating macrophage polarization via the SIRT1/NF-κB pathway 烟酰胺单核苷酸通过 SIRT1/NF-κB 途径调节巨噬细胞极化，从而减轻内毒素诱导的急性肺损伤
IF 3.8 3区 医学
Pharmaceutical Biology Pub Date : 2023-12-15 DOI: 10.1080/13880209.2023.2292256
Simeng He, Xianhong Jiang, Jing Yang, Ya Wu, Jia Shi, Xiaoyang Wu, Shihan Du, Yuan Zhang, Lirong Gong, Shuan Dong, Jianbo Yu
{"title":"Nicotinamide mononucleotide alleviates endotoxin-induced acute lung injury by modulating macrophage polarization via the SIRT1/NF-κB pathway","authors":"Simeng He, Xianhong Jiang, Jing Yang, Ya Wu, Jia Shi, Xiaoyang Wu, Shihan Du, Yuan Zhang, Lirong Gong, Shuan Dong, Jianbo Yu","doi":"10.1080/13880209.2023.2292256","DOIUrl":"https://doi.org/10.1080/13880209.2023.2292256","url":null,"abstract":"Sepsis-induced acute lung injury (ALI) is a severe condition with limited effective therapeutics; nicotinamide mononucleotide (NMN) has been reported to exert anti-inflammatory activities.This stud...","PeriodicalId":19942,"journal":{"name":"Pharmaceutical Biology","volume":"8 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138689936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bibliometric analysis of research trends and topic areas in traditional Chinese medicine therapy for lymphoma 中医药治疗淋巴瘤的研究趋势和主题领域的文献计量分析
IF 3.8 3区 医学
Pharmaceutical Biology Pub Date : 2023-12-13 DOI: 10.1080/13880209.2023.2288697
Gaofeng Zhang, Yanmei Qin, Shaobing Liu, Xi Chen, Wenwen Zhang
{"title":"Bibliometric analysis of research trends and topic areas in traditional Chinese medicine therapy for lymphoma","authors":"Gaofeng Zhang, Yanmei Qin, Shaobing Liu, Xi Chen, Wenwen Zhang","doi":"10.1080/13880209.2023.2288697","DOIUrl":"https://doi.org/10.1080/13880209.2023.2288697","url":null,"abstract":"Traditional Chinese Medicine (TCM) is effective as a cancer treatment modality. However, this is the first bibliometric analysis of TCM in lymphoma treatment.This study explores the current trends ...","PeriodicalId":19942,"journal":{"name":"Pharmaceutical Biology","volume":"15 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138630213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shenxiang Suhe pill improves cardiac function through modulating gut microbiota and serum metabolites in rats after acute myocardial infarction 神效苏合丸通过调节急性心肌梗死大鼠肠道微生物群和血清代谢物改善心功能
IF 3.8 3区 医学
Pharmaceutical Biology Pub Date : 2023-12-12 DOI: 10.1080/13880209.2023.2289577
Xinqin Zhong, Junyuan Yan, Xing Wei, Tian Xie, Zhaojian Zhang, Kaiyue Wang, Congying Sun, Wei Chen, Jiaming Zhu, Xin Zhao, Xiaoying Wang
{"title":"Shenxiang Suhe pill improves cardiac function through modulating gut microbiota and serum metabolites in rats after acute myocardial infarction","authors":"Xinqin Zhong, Junyuan Yan, Xing Wei, Tian Xie, Zhaojian Zhang, Kaiyue Wang, Congying Sun, Wei Chen, Jiaming Zhu, Xin Zhao, Xiaoying Wang","doi":"10.1080/13880209.2023.2289577","DOIUrl":"https://doi.org/10.1080/13880209.2023.2289577","url":null,"abstract":"Shenxiang Suhe pill (SXSH), a traditional Chinese medicine, is clinically effective against coronary heart disease, but the mechanism of cardiac-protective function is unclear.We investigated the c...","PeriodicalId":19942,"journal":{"name":"Pharmaceutical Biology","volume":"22 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138575518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Network pharmacology integrated with experimental verification reveals the antipyretic characteristics and mechanism of Zi Xue powder 结合实验验证的网络药理学揭示了紫雪散的解热特性和机制
IF 3.8 3区 医学
Pharmaceutical Biology Pub Date : 2023-12-09 DOI: 10.1080/13880209.2023.2287658
Hanyu Zhang, Shining Ge, Fengyin Diao, Wen Song, Ying Zhang, Pengwei Zhuang, Yanjun Zhang
{"title":"Network pharmacology integrated with experimental verification reveals the antipyretic characteristics and mechanism of Zi Xue powder","authors":"Hanyu Zhang, Shining Ge, Fengyin Diao, Wen Song, Ying Zhang, Pengwei Zhuang, Yanjun Zhang","doi":"10.1080/13880209.2023.2287658","DOIUrl":"https://doi.org/10.1080/13880209.2023.2287658","url":null,"abstract":"Zi Xue Powder (ZXP) is a traditional formula for the treatment of fever. However, the potential mechanism of action of ZXP remains unknown.This study elucidates the antipyretic characteristics of Z...","PeriodicalId":19942,"journal":{"name":"Pharmaceutical Biology","volume":"108 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138560747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Network pharmacology identification and in vivo validation of key pharmacological pathways of Qin Jiao for gout and arthritis 秦艽治疗痛风和关节炎关键药理通路的网络药理学鉴定和体内验证
IF 3.8 3区 医学
Pharmaceutical Biology Pub Date : 2023-12-09 DOI: 10.1080/13880209.2023.2288289
Xiaoxiong Yang, Yu Wang, Xueli Ding, Shanshan Ju, Xiaoye An, Bing Zhang, Zhijian Lin
{"title":"Network pharmacology identification and in vivo validation of key pharmacological pathways of Qin Jiao for gout and arthritis","authors":"Xiaoxiong Yang, Yu Wang, Xueli Ding, Shanshan Ju, Xiaoye An, Bing Zhang, Zhijian Lin","doi":"10.1080/13880209.2023.2288289","DOIUrl":"https://doi.org/10.1080/13880209.2023.2288289","url":null,"abstract":"Context: Gout is a chronic disease that imposes a huge financial and health burden on patients, which might diminish quality of life. Qin Jiao, a perennial herb found in northwestern China and Japa...","PeriodicalId":19942,"journal":{"name":"Pharmaceutical Biology","volume":"2 1","pages":""},"PeriodicalIF":3.8,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138561054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chaihu Shugan San promotes gastric motility in rats with functional dyspepsia by regulating Drp-1-mediated ICC mitophagy. 柴胡疏肝散通过调节Drp-1介导的ICC线粒体自噬促进功能性消化不良大鼠的胃运动。
IF 3.8 3区 医学
Pharmaceutical Biology Pub Date : 2023-12-01 DOI: 10.1080/13880209.2023.2166966
Li Li, Qingling Jia, Xiangxiang Wang, Yujiao Wang, Chenheng Wu, Jun Cong, Jianghong Ling
{"title":"Chaihu Shugan San promotes gastric motility in rats with functional dyspepsia by regulating Drp-1-mediated ICC mitophagy.","authors":"Li Li, Qingling Jia, Xiangxiang Wang, Yujiao Wang, Chenheng Wu, Jun Cong, Jianghong Ling","doi":"10.1080/13880209.2023.2166966","DOIUrl":"10.1080/13880209.2023.2166966","url":null,"abstract":"<p><strong>Context: </strong>Chaihu Shugan San (CHSGS) was effective in the treatment of functional dyspepsia (FD).</p><p><strong>Objective: </strong>To investigate the mechanism of CHSGS in FD through dynamin-related protein 1 (Drp-1)-mediated interstitial cells of cajal (ICC) mitophagy.</p><p><strong>Materials and methods: </strong>Forty Sprague-Dawley (SD) rats were randomly divided into control, model, mdivi-1, mdivi-1 + CHSGS and CHSGS groups. Tail-clamping stimulation was used to establish the FD model. Mdivi-1 + CHSGS and CHSGS groups were given CHSGS aqueous solution (4.8 g/kg) by gavage twice a day. Mdivi-1 (25 mg/kg) was injected intraperitoneally once every other week for 4 w. Mitochondrial damage was observed by corresponding kits and related protein expressions were assessed by Immunofluorescence and (or) Western Blot.</p><p><strong>Results: </strong>Compared with the mean value of the control group, superoxide dismutase (SOD) and citrate synthase (CS) in the model group were decreased by 11% and 35%; malondialdehyde (MDA) and reactive oxygen species (ROS) were increased by 1.2- and 2.8-times; ckit fluorescence and protein expressions were decreased by 85% and 51%, co-localization expression of LC3 and voltage dependent anion channel 1 (VDAC1), Drp-1 and translocase of the outer mitochondrial membrane 20 (Tom20) were increased by 10.1- and 5.4-times; protein expressions of Drp-1, Beclin-1, and LC3 were increased by 0.5-, 1.4-, and 2.5-times whereas p62 was decreased by 43%. After mdivi-1 and (or) CHSGS intervention, the above situation has been improved.</p><p><strong>Discussion and conclusion: </strong>CHSGS could improve mitochondrial damage and promote gastric motility in FD rats by regulating Drp-1-mediated ICC mitophagy.</p>","PeriodicalId":19942,"journal":{"name":"Pharmaceutical Biology","volume":"61 1","pages":"249-258"},"PeriodicalIF":3.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a8/c9/IPHB_61_2166966.PMC9858526.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10567305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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