Proanthocyanidin offers protection against diabetic nephropathy: elucidation of its mechanism of action using animal models.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-12-01 Epub Date: 2024-10-06 DOI:10.1080/13880209.2024.2409772

Dengpiao Xie, Huan Wang, Qing Ji, Jianting Wang

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引用次数: 0

Abstract

Context: Diabetic nephropathy (DN) is a major complication of diabetes mellitus and is the leading cause of kidney disease in patients undergoing renal replacement therapy. DN is associated with an increased risk of death in patients with diabetes. Conventional therapy for DN includes intensive control of blood glucose level and blood pressure and renin-angiotensin system blockade. However, this approach has limited treatment effects on DN. Therefore, identifying novel drugs to delay the progression of DN is urgently needed. Proanthocyanidin (PA) has been shown to exert potentially beneficial effects on DN. However, the protective mechanism and efficacy are yet to be elucidated.

Objective: This study evaluates the efficacy and potential mechanisms of PA in animal models of DN.

Methods: Preclinical studies were searched from Chinese National Knowledge Infrastructure, PubMed, Web of Science, Embase, and Google Scholar databases, with the search deadline of August 2023. Keywords ('diabetic nephropathies', 'nephropathies, diabetic', 'diabetic kidney diseases', 'proanthocyanidin', 'anthocyanidin polymers', 'procyanidins', 'animal*', 'rat', and 'mice') were used to search the databases. RevMan 5.3 was used for statistical analysis.

Results: A total of 22 studies involving 538 animals were included in this analysis. The pooled results indicated that PA therapy significantly improved kidney function and reduced proteinuria and blood glucose levels. The protective mechanism of PA was associated with anti-inflammatory, antioxidant, antifibrotic, and antiapoptotic effects; inhibition of endoplasmic reticulum stress; and alleviation of mitochondrial dysfunction and dyslipidemia.

Conclusion: These findings suggest that PA alleviates DN by mediating multiple targets and pathways.

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原花青素可预防糖尿病肾病：利用动物模型阐明其作用机制。

背景：糖尿病肾病（DN）是糖尿病的主要并发症，也是接受肾脏替代治疗的患者出现肾病的主要原因。糖尿病肾病会增加糖尿病患者的死亡风险。治疗 DN 的传统方法包括强化控制血糖水平和血压，以及阻断肾素-血管紧张素系统。然而，这种方法对 DN 的治疗效果有限。因此，迫切需要找到新型药物来延缓 DN 的进展。原花青素（PA）已被证明对 DN 具有潜在的益处。然而，其保护机制和功效仍有待阐明：本研究评估了 PA 在 DN 动物模型中的疗效和潜在机制：方法：从中国国家知识基础设施、PubMed、Web of Science、Embase 和 Google Scholar 数据库中检索临床前研究，检索截止日期为 2023 年 8 月。使用关键词（"糖尿病肾病"、"肾病、糖尿病"、"糖尿病肾病"、"原花青素"、"花青素聚合物"、"原花青素"、"动物*"、"大鼠 "和 "小鼠"）检索数据库。使用 RevMan 5.3 进行统计分析：本次分析共纳入了 22 项研究，涉及 538 只动物。汇总结果表明，PA疗法能显著改善肾功能，降低蛋白尿和血糖水平。PA 的保护机制与抗炎、抗氧化、抗纤维化和抗细胞凋亡作用、抑制内质网应激、缓解线粒体功能障碍和血脂异常有关：这些研究结果表明，PA 可通过介导多个靶点和途径缓解 DN。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567