Pathology最新文献

{"title":"Intraductal carcinoma of the prostate is a marker of invasive disease","authors":"Brett Delahunt , Hemamali Samaratunga , Lars Egevad","doi":"10.1016/j.pathol.2025.06.002","DOIUrl":"10.1016/j.pathol.2025.06.002","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 6","pages":"Pages 808-809"},"PeriodicalIF":3.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does precursor-type intraductal carcinoma of the prostate exist? An academic debate of limited clinical significance","authors":"Murali Varma , Theodorus H. van der Kwast","doi":"10.1016/j.pathol.2025.06.003","DOIUrl":"10.1016/j.pathol.2025.06.003","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 6","pages":"Pages 809-810"},"PeriodicalIF":3.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraenteric gastrointestinal neuroectodermal tumour masquerading as mucosal melanoma of the bronchus","authors":"Louise A. Jackett , Catherine Mitchell , Julie Chu","doi":"10.1016/j.pathol.2025.05.003","DOIUrl":"10.1016/j.pathol.2025.05.003","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 6","pages":"Pages 795-797"},"PeriodicalIF":3.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of renal diseases caused by monoclonal immunoglobulin: experience from an Australian tertiary referral centre over a 10-year period.","authors":"Seethalakshmi Viswanathan, Angela Bayly, David A Brown, Levina Neill, Michael Piza, Brian Nankivell","doi":"10.1016/j.pathol.2025.06.001","DOIUrl":"https://doi.org/10.1016/j.pathol.2025.06.001","url":null,"abstract":"<p><p>Monoclonal immunoglobulin (MIg)-associated renal diseases are caused by nephrotoxic MIg originating from underlying plasma cell or lymphoid clone. The present study is an analysis of patient demographics, pathological characteristics, haematological and renal biomarkers of 83 biopsy-proven cases of diseases mediated by MIg, accrued from 6196 renal biopsies in a single Australian tertiary referral centre, over a decade. Older patients were more commonly affected with 89.2% of patients over the age of 50 years, with a male predominance. The spectrum consisted of direct MIg deposition diseases with organised and non-organised deposits, immunoglobulin light-chain amyloidosis +/- light chain cast nephropathy (AL amyloidosis +/- LCCN; 60.2%), cryoglobulinaemic glomerulonephritis types I and II (6%), monoclonal immunoglobulin deposition disease +/- light-chain cast nephropathy (MIDD +/- LCCN; 14.4%), proliferative glomerulonephritis with monoclonal immunoglobulin deposition disease (PGNMID; 13.3%), light-chain proximal tubulopathy (LCPT; 1.2%), light-chain cast nephropathy (LCCN; 2.4%), and indirect complement-mediated lesions including monoclonal thrombotic microangiopathy (TMA; 1.2%) and C3 glomerulopathy (1.2%). PGNMID was the only type of lesion seen with post-transplant graft recurrences (3.6%). Tissue clonality was reliably established by immunofluorescence (IF) on frozen tissue, with paraffin IF and immunohistochemistry as useful salvage procedures. An underlying plasma cell clone was identified in 80.3% cases and a lymphoid clone in 19.7% cases. An overt haematological malignancy was seen in 39.8% of cases. A confirmed diagnosis of monoclonal gammopathy of renal significance (MGRS) was made in 70.5% of cases and renal biopsy preceded haematological investigations in 65.8% of cases, emphasising the significant role of the pathologist in the accurate diagnosis and classification of these lesions. MIg-mediated renal diseases can be accurately diagnosed and classified on renal biopsies. The presence of LCCN was associated with adverse renal outcome and overall survival. Future studies with a larger sample size are necessary to determine individual parameters that affect renal and overall survival.</p>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood melanoma ex-blue naevus leading to the identification of a BAP1 tumour predisposition syndrome","authors":"Mohamad El Jiar ,&nbsp;Sophie Huybrechts ,&nbsp;Daniel Pissaloux ,&nbsp;Franck Tirode ,&nbsp;Celso Pouget ,&nbsp;François Sales ,&nbsp;Nadège Wallet-Faber ,&nbsp;Arnaud de la Fouchardiere","doi":"10.1016/j.pathol.2025.05.004","DOIUrl":"10.1016/j.pathol.2025.05.004","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 6","pages":"Pages 797-799"},"PeriodicalIF":3.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epstein-Barr virus-associated intrahepatic cholangiocarcinoma: a diverse morphological spectrum that correlates with patient prognosis.","authors":"Wei Liu, Yan-Mei Cui, Zheng-Jin Liu, Xiao-Jiang Wang, Li-Bin Zhang, Mei-Fang Zhang, Wen-Xiu Miu, Xi-Yao Yan, Hui-Lin Zhang, Shu-Qi Yang, Wen Li, Jun-Cheng Ye, Jing-Cheng Liu, Tong-Mei He, Yi Shi, Dan Hu","doi":"10.1016/j.pathol.2025.04.011","DOIUrl":"https://doi.org/10.1016/j.pathol.2025.04.011","url":null,"abstract":"<p><p>Epstein-Barr virus (EBV)-associated intrahepatic cholangiocarcinoma (EBVaICC) is a rare condition with limited comprehensive descriptions of its clinicopathological features. This study investigated the wide morphological spectrum of EBVaICC to improve diagnostic accuracy and explored the associations between morphological characteristics and prognosis. Nineteen cases of EBVaICC were retrospectively analysed, and 102 cases reported in the literature were reviewed. Four patients were male, and 15 were female. The median age of the patients was 56 years (range 37-78 years). The median size of the tumours was 4.5 cm (range 1.3-14.0 cm), and 13 patients (68.4%) presented with a single tumour, while six (31.6%) exhibited multiple hepatic lesions. Tumours were assessed for various histological features and assigned to the following morphological groups: duct (31.6%, 6/19), lymphoepithelioma-like (15.8%, 3/19), anaplastic (26.3%, 5/19), and mixed subtypes (26.3%, 5/19). The duct subtype exhibited a variety of tubular formations with low-grade nuclear atypia and few mitoses [<5/10 high-power fields (HPFs)], mimicking well-differentiated cholangiocarcinoma within a background of dense lymphoplasmacytic infiltration. The lymphoepithelioma-like subtype featured vesicular nuclei with indistinct cell boundaries, cohesive arrangements, and characteristic lymphoepithelial lesions. The anaplastic subtype was characterised by a nest-like or solid growth pattern with high-grade nuclear atypia with abundant mitoses (≥10/10 HPF), ​yet lacked abundant lymphoplasmacytic infiltration. Immunohistochemically, the neoplastic cells stained positive for biliary markers (CK7 and CK19) and were 100% positive for EBV-encoded RNA. Six anaplastic cases (including one case of mixed subtype) were categorised into group A, and the other 13 cases were classified as group B. The follow-up assessment revealed significantly lower 2-year progression-free survival (0% vs 81.5%) and overall survival (0% vs 100%) rates in patients in group A than in group B (p<0.05). EBVaICC presents a diverse morphological spectrum and correlates with the patient prognosis. Recognising these morphological variations, especially the anaplastic subtype, is essential for accurate diagnosis, prognostic assessment, and personalised management.</p>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Papillary intralymphatic angioendothelioma with a novel YAP1::MAML2 fusion","authors":"Lan Shen ,&nbsp;Xiufen Xue ,&nbsp;Ting Jiang ,&nbsp;Xiaojuan Pei","doi":"10.1016/j.pathol.2025.04.013","DOIUrl":"10.1016/j.pathol.2025.04.013","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 6","pages":"Pages 799-802"},"PeriodicalIF":3.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Papillary renal neoplasm with reverse polarity along with papillary adenoma in a non-functioning kidney: a rare report","authors":"Sushmita Vangapandu ,&nbsp;Hari Siddardha Malla ,&nbsp;Manoj Kumar Das ,&nbsp;Taraprasad Tripathy ,&nbsp;Pavithra Ayyanar","doi":"10.1016/j.pathol.2025.04.012","DOIUrl":"10.1016/j.pathol.2025.04.012","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 6","pages":"Pages 805-808"},"PeriodicalIF":3.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GAB1::ABL1 fusion-associated spindle cell neoplasm: expanding our knowledge of kinase-rearranged spindle cell tumours","authors":"Pranav Dorwal ,&nbsp;Alexandra Currie ,&nbsp;James Bennett ,&nbsp;Benjamin Wallwork ,&nbsp;Liyan Song ,&nbsp;Christopher Joy ,&nbsp;Michael Walsh","doi":"10.1016/j.pathol.2025.05.002","DOIUrl":"10.1016/j.pathol.2025.05.002","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 6","pages":"Pages 802-805"},"PeriodicalIF":3.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated histomolecular approach to discriminate primary cutaneous follicle centre and marginal zone lymphoma of the scalp.","authors":"Marie Donzel, Alexis Trecourt, Stéphane Dalle, Olivier Harou, Marie Perier-Muzet, Florent Grange, Brigitte Balme, Florian Pesce, Alexandra Traverse-Glehen, Claire Mauduit","doi":"10.1016/j.pathol.2025.04.009","DOIUrl":"https://doi.org/10.1016/j.pathol.2025.04.009","url":null,"abstract":"<p><p>Overlapping features between follicular lymphomas (FLs) and marginal zone lymphomas (MZLs) have been described, especially in their paediatric forms. Although adult primary cutaneous follicle centre lymphoma (PCFL) and primary cutaneous marginal zone lymphoma (PCMZL) of the scalp appear to display overlapping histological and molecular features, these entities have never been studied. The aim of this study was to describe the clinical, histological, and mutational profiles of PCFL and PCMZL of the scalp and to highlight possible overlapping features. From 2011 to 2023, 38 patients with PCFL or PCMZL of the scalp from two centres were retrospectively included. In each case, a histological review, immunohistochemistry with additional immunostaining for myeloid cell nuclear differentiation antigen, BCL2 fluorescence in situ hybridisation, and targeted next-generation sequencing were performed. Among the 23 PCFL (60%) and 15 PCMZL (40%) cases included, 10 had a difficult initial diagnosis based on histological data alone. The most frequent pathogenic variants in PCFL cases were TNFRSF14 (15%), BCL2 (11%), SOCS1 (11%), and CREBBP (6%). The most frequent pathogenic variants in PCMZL cases were TNFAIP3 (24%), KMT2D (14%), CARD11 (10%), and ITPKB (10%). The integrated histomolecular approach helped reclassify five PCMZL cases into PCFL and showed plasmacytic differentiation in 12% of PCFL cases. This study highlights the histological and molecular overlaps between PCFL and PCMZL of the scalp and underscores the interest of an integrated histomolecular diagnosis to discriminate between these entities.</p>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}