Pathology最新文献_第3页

Sclerosing epithelioid fibrosarcoma with initial presentation as pulmonary masses: clinicopathological characteristics and diagnostic challenges. 最初表现为肺肿块的硬化性上皮样纤维肉瘤：临床病理特征和诊断挑战。

IF 3.9 3区医学

Pathology Pub Date : 2026-08-24 DOI: 10.1016/j.pathol.2026.07.004

You-Li Wu, Xiao-Qing Chen, Jia-Jun Su, Jie Wu, Jia-Le Ji, Jing-Jie Sun, Xiao-Chu Yan, Xiu-Wu Bian, Mian-Fu Cao, Guang-Jie Duan

{"title":"Sclerosing epithelioid fibrosarcoma with initial presentation as pulmonary masses: clinicopathological characteristics and diagnostic challenges.","authors":"You-Li Wu, Xiao-Qing Chen, Jia-Jun Su, Jie Wu, Jia-Le Ji, Jing-Jie Sun, Xiao-Chu Yan, Xiu-Wu Bian, Mian-Fu Cao, Guang-Jie Duan","doi":"10.1016/j.pathol.2026.07.004","DOIUrl":"https://doi.org/10.1016/j.pathol.2026.07.004","url":null,"abstract":"<p><p>Sclerosing epithelioid fibrosarcoma (SEF) initially presenting as pulmonary masses is exceptionally rare, and pathological diagnosis based on lung biopsy specimens is challenging. To enhance the understanding of its clinicopathological characteristics and improve diagnostic accuracy, we performed a comprehensive analysis of four such cases, including clinical, radiological, histological, immunohistochemical, and molecular characteristics. The mean age was 43 years, comprising three females and one male. Radiologically, the lesions appeared as solitary or multiple pulmonary masses. Morphologically, in addition to the classic appearance of monomorphic epithelioid cells in cords, nests, or sheets within a sclerotic stroma, the tumours also displayed alveolar-like architecture, pseudoalveolar pattern, adenofibroma-like morphology, and spread through air spaces (STAS). Significant pleomorphism and necrosis were observed in some cases, and the stroma could be collagen-poor or lymphocyte-rich. Morphological mimicry was evident: the tumours resembled adenofibroma when entrapping respiratory epithelium, lymphoma in lymphocyte-rich areas, neuroendocrine tumours in biopsies containing compressed atypical cells, and normal alveoli when arranged in an alveolar-like architecture. Immunohistochemically, all cases were positive for MUC4. Molecular analysis revealed EWSR1 rearrangement by fluorescence in situ hybridisation (FISH) in two cases. Notably, one case showed a deletion of chromosome 22 and no EWSR1 rearrangement by FISH, but harboured an EWSR1::CREB3L2 fusion by next-generation sequencing (NGS). Furthermore, a separate case exhibited FUS rearrangement independent of EWSR1 involvement. This study demonstrates the diverse morphological characteristics of SEF initially presenting as pulmonary masses and highlights key diagnostic challenges, which may contribute to improved diagnostic accuracy for such lesions.</p>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein Kinase C-fused blue naevi with gene rearrangements involving PRKCD, PRKCQ, and PRKCG: expanding the genetic spectrum of an uncommon entity. 蛋白激酶c融合蓝痣与基因重排涉及PRKCD， PRKCQ和PRKCG：扩大一个不常见实体的遗传谱。

IF 3.9 3区医学

Pathology Pub Date : 2026-08-22 DOI: 10.1016/j.pathol.2026.07.003

Angelique F J Versteegen, May P Chan, Diane Frankel, Daniel Pissaloux, Maren Buntinx, Pieter A Valkema, Arnaud de la Fouchardière

引用次数: 0

Sweet syndrome, macrocytic anaemia, and elevated IgE in VEXAS syndrome: a series of three cases from Taiwan. 甜证、大细胞性贫血与VEXAS综合征的IgE升高：附台湾3例。

IF 3.9 3区医学

Pathology Pub Date : 2026-08-20 DOI: 10.1016/j.pathol.2026.06.013

Tzu-Chen Yeh, Shu-Hsien Wang, Li-Chang Chang, Tsai-Yun Chen, Wei-Ting Liu, L Jeffrey Medeiros, Kung-Chao Chang

引用次数: 0

Corrigendum to "Epstein-Barr virus-associated B-cell lymphoproliferative disorders and lymphomas: a review" [Pathology 52 (1):40-52]. Epstein-Barr病毒相关的b细胞淋巴增生性疾病和淋巴瘤：综述[病理学52(1):40-52]。

IF 3.9 3区医学

Pathology Pub Date : 2026-08-18 DOI: 10.1016/j.pathol.2026.08.001

Mario L Marques-Piubelli, Yessenia I Salas, Carlos Pachas, Renato Becker-Hecker, Francisco Vega, Roberto N Miranda

引用次数: 0

Practical applications of computational pathology: bridging technology and clinical practice. 计算病理学的实际应用：桥接技术和临床实践。

IF 3.9 3区医学

Pathology Pub Date : 2026-08-18 DOI: 10.1016/j.pathol.2026.06.012

Matthew G Hanna, Hooman Rashidi, Liron Pantanowitz

{"title":"Practical applications of computational pathology: bridging technology and clinical practice.","authors":"Matthew G Hanna, Hooman Rashidi, Liron Pantanowitz","doi":"10.1016/j.pathol.2026.06.012","DOIUrl":"https://doi.org/10.1016/j.pathol.2026.06.012","url":null,"abstract":"<p><p>Computational pathology, driven by advances in artificial intelligence and digital imaging, is rapidly reshaping how pathology data are interpreted and utilised in clinical settings. By leveraging machine learning models and pathology text, tabular, molecular, and imaging data, these technologies offer practical solutions to support routine diagnostics, workflow optimisation, quality assurance, and personalised patient care. From automated screening and triage to diagnostic decision support and prognostic modelling, computational tools are increasingly being evaluated for integration into the pathologist's toolkit. Despite clear potential, real-world adoption remains uneven, and the evidence base is still limited by retrospective study designs, small or enriched cohorts, variable external validation, model generalisability across scanners and institutions, clinical integration, reimbursement, and regulatory authorisation. Addressing these issues requires access to diverse datasets, collaborative model development, analytical and clinical validation using real-world data, robust deployment infrastructure, post-deployment monitoring, and education for end-users. This review explores the current landscape of computational pathology with a focus on actionable clinical applications. It highlights successful use cases, critically appraises common barriers to adoption, and outlines key steps to translate technological advances into clinical value. By bridging the divide between innovation and implementation, computational pathology has the potential to become a vital component of modern diagnostic medicine.</p>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149113431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of gastric follicular dendritic cell sarcoma: a diagnostic conundrum. 一例罕见的胃滤泡树突状细胞肉瘤：一个诊断难题。

IF 3.9 3区医学

Pathology Pub Date : 2026-08-11 DOI: 10.1016/j.pathol.2026.06.011

Shatabdi Pal, Tanmay Dutta, Pritinanda Mishra, Tara Prasad Tripathy, P Sai Sradha Patro, Pavithra Ayyanar

引用次数: 0

Malignant gastrointestinal neuroectodermal tumour in the pancreas. 胰腺恶性胃肠道神经外胚层肿瘤。

IF 3.9 3区医学

Pathology Pub Date : 2026-08-08 DOI: 10.1016/j.pathol.2026.06.009

Min Yi, Jiang-Hua Huang, Qian-Wen Wu, Ne-Min Su, Ling-Feng Tan, Yu-Sen Qin

引用次数: 0

Primary pulmonary composite haemangioendothelioma harbouring a YAP1::FOXR1 fusion. 含有YAP1::FOXR1融合的原发性肺复合血管内皮瘤。

IF 3.9 3区医学

Pathology Pub Date : 2026-08-08 DOI: 10.1016/j.pathol.2026.06.010

Chia-Fa Hu, Hsuan-Ying Huang, Wan-Shan Li, Pei-Hang Lee

引用次数: 0

A contemporary review of the limitations of adjusted calcium in clinical practice 调整钙在临床实践中的局限性的当代回顾。

IF 3 3区医学

Pathology Pub Date : 2026-03-01 Epub Date: 2025-10-28 DOI: 10.1016/j.pathol.2025.08.010

Kay Weng Choy , Shayna Hickey , Tze Ping Loh

{"title":"A contemporary review of the limitations of adjusted calcium in clinical practice","authors":"Kay Weng Choy , Shayna Hickey , Tze Ping Loh","doi":"10.1016/j.pathol.2025.08.010","DOIUrl":"10.1016/j.pathol.2025.08.010","url":null,"abstract":"<div><div>Since the 1970s, albumin-adjusted calcium has been widely used to approximate ionised calcium concentrations, particularly in patients with abnormal serum albumin levels. This adjustment was introduced to mitigate misclassification of calcium status when direct measurement of ionised calcium (technically demanding and resource-intensive at that time) was unavailable. Despite its historical utility, emerging evidence has highlighted significant limitations. This review critically examines the validity and clinical utility of adjusted calcium, with a focus on specific populations such as the elderly, critically ill, and those with kidney disease, in whom albumin derangement is more common. Adjusted calcium assumes stable ionised calcium levels across varying albumin concentrations and overlooks key modifiers such as pH, phosphate, lactate, and between-assay variability. Multiple studies demonstrate that adjusted calcium does not outperform unadjusted total calcium and may misclassify calcium status, particularly in patients with hypoalbuminaemia and impaired kidney function. Further limitations include variability in albumin assays and the derivation of adjustment formulas from non-representative populations. Adjusted calcium offers limited diagnostic value and should not replace ionised calcium where accurate assessment is essential. A reflex testing strategy, using total calcium as a screening tool, followed by ionised calcium testing when indicated, may provide a more reliable and pragmatic approach. Laboratory professionals and clinicians should recognise the considerable analytical and clinical limitations of adjusted calcium and interpret results with caution.</div></div>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"58 2","pages":"Pages 148-155"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145637390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic, structural, and functional foundations of alkaline phosphatase measurement in clinical diagnostics 临床诊断中碱性磷酸酶测定的遗传、结构和功能基础。

IF 3 3区医学

Pathology Pub Date : 2026-03-01 Epub Date: 2025-12-15 DOI: 10.1016/j.pathol.2025.11.003

Kenneth Andrew Sikaris , Karen Rankin

{"title":"Genetic, structural, and functional foundations of alkaline phosphatase measurement in clinical diagnostics","authors":"Kenneth Andrew Sikaris , Karen Rankin","doi":"10.1016/j.pathol.2025.11.003","DOIUrl":"10.1016/j.pathol.2025.11.003","url":null,"abstract":"<div><div>Alkaline phosphatase (ALP) is a membrane-bound ectoenzyme with critical diagnostic relevance in clinical medicine, particularly for bone and liver diseases. This review examines the genetic, structural, and functional foundations of ALP, highlighting its distribution across tissues such as bone, liver, intestine, placenta, and neutrophils. The article details the evolution of the ALP gene family, including tissue-non-specific and tissue-specific isoenzymes, and discusses how genetic variation and post-translational modifications influence ALP activity, serum levels, and clinical interpretation. Isoenzyme analysis, including electrophoretic and immunoassay techniques, enables differentiation of tissue origins in cases of elevated ALP, improving diagnostic precision for conditions such as Paget's disease, renal osteodystrophy, and malignancy. The review also explores the impact of ABO blood group on ALP levels, the functional roles of ALP in skeletal mineralisation and inflammation, and the importance of understanding molecular diversity for accurate measurement. The stability, clearance, and carbohydrate composition of ALP isoforms are discussed as key determinants in clinical assays. Overall, a comprehensive understanding of ALP's genetic and biochemical diversity is essential for interpreting serum ALP measurements, distinguishing between bone and liver pathology, and informing clinical decision-making. This knowledge enhances the utility of ALP as a diagnostic biomarker and supports its role in monitoring metabolic bone disease and other disorders.</div></div>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"58 2","pages":"Pages 167-171"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0