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Multiple myeloma masquerades as T-cell lymphoma by nodal presentation with anaplastic morphology and expression of CD3 and CD45 多发性骨髓瘤伪装成 T 细胞淋巴瘤，结节表现为无细胞形态，并表达 CD3 和 CD45
IF 3.6 3区 医学
Pathology Pub Date : 2024-07-02 DOI: 10.1016/j.pathol.2024.04.011
{"title":"Multiple myeloma masquerades as T-cell lymphoma by nodal presentation with anaplastic morphology and expression of CD3 and CD45","authors":"","doi":"10.1016/j.pathol.2024.04.011","DOIUrl":"10.1016/j.pathol.2024.04.011","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141715197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical validation of an abbreviated karyotype analysis protocol for fertility evaluation 用于生育力评估的简略核型分析方案的临床验证
IF 3.6 3区 医学
Pathology Pub Date : 2024-07-02 DOI: 10.1016/j.pathol.2024.04.010
{"title":"Clinical validation of an abbreviated karyotype analysis protocol for fertility evaluation","authors":"","doi":"10.1016/j.pathol.2024.04.010","DOIUrl":"10.1016/j.pathol.2024.04.010","url":null,"abstract":"<div><p>Conventional G-banded karyotype is an essential tool for detecting chromosomal variants in patients undergoing fertility evaluation. In Australia, 15 cells are traditionally analysed or counted, to enhance detection of mosaic chromosomal variants. However, this protocol is not backed by clinical evidence. This study aims to assess the test performance of an abbreviated 5-cell karyotype analysis protocol in adult patients undergoing fertility evaluation.</p><p>A retrospective review of 53,293 blood karyotype tests, performed between 2019 and 2023, was conducted on a patient cohort primarily referred by reproductive endocrinology specialists. There were 513 variants reported in this cohort. Low level mosaic variants, where the variant was observed in less than 40% of cells, were reported in 13 cases, or one in 4,100 patients. Due to reduced sensitivity for low level mosaic variants, a 5-cell protocol is estimated to have a test sensitivity of 97.3% and a negative predictive value of 99.97%. A decision-making flowchart is proposed and we show that additional chromosome analysis and/or counts would be triggered in fewer than one in 10 cases using a 5-cell protocol, whilst remaining appropriate for detecting clinically significant mosaicism.</p><p>A 5-cell karyotype analysis protocol therefore maintains analytical and clinical validity in adult patients undergoing fertility-related blood karyotyping. Future research is recommended to validate these findings across laboratories and to explore their application to other clinical contexts.</p></div>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141722249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immature platelet fraction levels predict the development of prolonged thrombocytopenia after haematopoietic stem cell transplantation 未成熟血小板分数水平可预测造血干细胞移植后出现长期血小板减少症的情况
IF 3.6 3区 医学
Pathology Pub Date : 2024-07-01 DOI: 10.1016/j.pathol.2024.04.014
Jun Cao, Jun Qiu, Jieyu Jin, Sheng Zhang, Jiahui Qu, Mingyue Wang, Longwei Qiao, Yuting Liang
{"title":"Immature platelet fraction levels predict the development of prolonged thrombocytopenia after haematopoietic stem cell transplantation","authors":"Jun Cao, Jun Qiu, Jieyu Jin, Sheng Zhang, Jiahui Qu, Mingyue Wang, Longwei Qiao, Yuting Liang","doi":"10.1016/j.pathol.2024.04.014","DOIUrl":"https://doi.org/10.1016/j.pathol.2024.04.014","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141713574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lung adenocarcinoma metastatic to the ovary: a retrospective clinicopathological analysis of 17 cases and literature review 转移到卵巢的肺腺癌：17 个病例的回顾性临床病理分析和文献综述
IF 3.6 3区 医学
Pathology Pub Date : 2024-07-01 DOI: 10.1016/j.pathol.2024.05.006
Wei Liu, Yan-mei Cui, Xiao-jiang Wang, Xian-dong Lin, Li-bin Zhang, Jing-cheng Liu, Qing-hu Lyu, Wei Chen, Dan Hu
{"title":"Lung adenocarcinoma metastatic to the ovary: a retrospective clinicopathological analysis of 17 cases and literature review","authors":"Wei Liu, Yan-mei Cui, Xiao-jiang Wang, Xian-dong Lin, Li-bin Zhang, Jing-cheng Liu, Qing-hu Lyu, Wei Chen, Dan Hu","doi":"10.1016/j.pathol.2024.05.006","DOIUrl":"https://doi.org/10.1016/j.pathol.2024.05.006","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141846975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laboratory validation and clinical utility of next-generation sequencing-based IGH/TCR clonality testing for the monitoring of measurable residual disease in acute lymphoblastic leukaemia: real-world experience at Austin Pathology 基于新一代测序的IGH/TCR克隆性检测在监测急性淋巴细胞白血病可测量残留病方面的实验室验证和临床实用性：奥斯汀病理中心的实际经验
IF 3.6 3区 医学
Pathology Pub Date : 2024-07-01 DOI: 10.1016/j.pathol.2024.04.012
Stephen B. Ma, Wendi Lin, Janine Campbell, Kerrie Clerici, Deborah White, David Yeung, Malgorzata Gorniak, Shaun Fleming, Chun Y. Fong, Rishu Agarwal
{"title":"Laboratory validation and clinical utility of next-generation sequencing-based IGH/TCR clonality testing for the monitoring of measurable residual disease in acute lymphoblastic leukaemia: real-world experience at Austin Pathology","authors":"Stephen B. Ma, Wendi Lin, Janine Campbell, Kerrie Clerici, Deborah White, David Yeung, Malgorzata Gorniak, Shaun Fleming, Chun Y. Fong, Rishu Agarwal","doi":"10.1016/j.pathol.2024.04.012","DOIUrl":"https://doi.org/10.1016/j.pathol.2024.04.012","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141707359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-grade histiocytic sarcoma with aggressive clinical behaviour: an unusual case with novel genetic mutations identified by whole genome sequencing 具有侵袭性临床表现的低级别组织细胞肉瘤：一个通过全基因组测序发现新型基因突变的不寻常病例
IF 3.6 3区 医学
Pathology Pub Date : 2024-07-01 DOI: 10.1016/j.pathol.2024.05.008
Ling-Jung Chiu, Wan-Ting Huang, Ming-Chung Wang, L. J. Medeiros, Kung-Chao Chang
{"title":"Low-grade histiocytic sarcoma with aggressive clinical behaviour: an unusual case with novel genetic mutations identified by whole genome sequencing","authors":"Ling-Jung Chiu, Wan-Ting Huang, Ming-Chung Wang, L. J. Medeiros, Kung-Chao Chang","doi":"10.1016/j.pathol.2024.05.008","DOIUrl":"https://doi.org/10.1016/j.pathol.2024.05.008","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141840917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leptospirosis ventriculoperitoneal shunt infection 钩端螺旋体脑室腹腔分流术感染
IF 3.6 3区 医学
Pathology Pub Date : 2024-07-01 DOI: 10.1016/j.pathol.2024.05.007
Manoshi Perera, Imal Hemachandra, A. Howard-Jones, W. Fong, V. Sintchenko, H. Varadhan, Syeda Naqvi
{"title":"Leptospirosis ventriculoperitoneal shunt infection","authors":"Manoshi Perera, Imal Hemachandra, A. Howard-Jones, W. Fong, V. Sintchenko, H. Varadhan, Syeda Naqvi","doi":"10.1016/j.pathol.2024.05.007","DOIUrl":"https://doi.org/10.1016/j.pathol.2024.05.007","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141844735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synchronous collision metastasis of melanoma and squamous cell carcinoma in a parotid lymph node: a very rare occurrence and literature review 腮腺淋巴结中黑色素瘤和鳞状细胞癌的同步碰撞转移：罕见病例和文献综述
IF 3.6 3区 医学
Pathology Pub Date : 2024-07-01 DOI: 10.1016/j.pathol.2024.05.004
Michelle Wu, Nigel G. Maher, R. Scolyer, Alexander M. Menzies, Thomas E. Pennington
{"title":"Synchronous collision metastasis of melanoma and squamous cell carcinoma in a parotid lymph node: a very rare occurrence and literature review","authors":"Michelle Wu, Nigel G. Maher, R. Scolyer, Alexander M. Menzies, Thomas E. Pennington","doi":"10.1016/j.pathol.2024.05.004","DOIUrl":"https://doi.org/10.1016/j.pathol.2024.05.004","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141698949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Demographic, clinical and molecular epidemiology of extended-spectrum beta-lactamase-producing Escherichia coli bloodstream infections in Central Australia 澳大利亚中部产广谱β-内酰胺酶大肠埃希菌血流感染的人口、临床和分子流行病学研究
IF 3.6 3区 医学
Pathology Pub Date : 2024-07-01 DOI: 10.1016/j.pathol.2024.04.013
Freya J Langham, D. Tsai, Brian M. Forde, Shayne Camilleri, Patrick N. A. Harris, Jason A. Roberts, Fabian Chiong
{"title":"Demographic, clinical and molecular epidemiology of extended-spectrum beta-lactamase-producing Escherichia coli bloodstream infections in Central Australia","authors":"Freya J Langham, D. Tsai, Brian M. Forde, Shayne Camilleri, Patrick N. A. Harris, Jason A. Roberts, Fabian Chiong","doi":"10.1016/j.pathol.2024.04.013","DOIUrl":"https://doi.org/10.1016/j.pathol.2024.04.013","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141706516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IgA deficiency in coeliac disease: verification of a cost-effective screening algorithm in a medical diagnostic laboratory 乳糜泻中的 IgA 缺乏症：在医疗诊断实验室中验证具有成本效益的筛查算法
IF 3.6 3区 医学
Pathology Pub Date : 2024-07-01 DOI: 10.1016/j.pathol.2024.05.010
Sarah Beck, John O’Donnell
{"title":"IgA deficiency in coeliac disease: verification of a cost-effective screening algorithm in a medical diagnostic laboratory","authors":"Sarah Beck, John O’Donnell","doi":"10.1016/j.pathol.2024.05.010","DOIUrl":"https://doi.org/10.1016/j.pathol.2024.05.010","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141850509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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