Pathology最新文献

{"title":"Mycoplasma pneumoniae: evolving diagnostic methods for a known pathogen","authors":"Samuel Baumgart ,&nbsp;Darcy Gray ,&nbsp;Juliette Holland ,&nbsp;Rebecca Rockett ,&nbsp;Vitali Sintchenko ,&nbsp;Jen Kok","doi":"10.1016/j.pathol.2025.03.002","DOIUrl":"10.1016/j.pathol.2025.03.002","url":null,"abstract":"<div><div><em>Mycoplasma pneumoniae</em> causes community-acquired pneumonia and extrapulmonary manifestations. It is an important cause of atypical pneumonia in children and can be associated with cyclical epidemics. This manuscript reviews the performance of current <em>M. pneumoniae</em> diagnostic methods, including culture-based, serological and nucleic acid amplification testing. The added value of molecular typing and genome sequencing in controlling <em>M. pneumoniae</em> epidemics is also considered, especially in characterising the evolving epidemiology and detecting genes and mutations associated with antimicrobial resistance, studies of which are lacking in Australia at present.</div></div>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 4","pages":"Pages 415-424"},"PeriodicalIF":3.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why we need molecular testing guidelines for lung cancer in Australia","authors":"Vivek Rathi","doi":"10.1016/j.pathol.2025.03.001","DOIUrl":"10.1016/j.pathol.2025.03.001","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 4","pages":"Pages 401-402"},"PeriodicalIF":3.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saving pathologists and the planet: reducing environmental footprint, expenditure and toxicity for our laboratories","authors":"Simone L. Van Es","doi":"10.1016/j.pathol.2025.02.002","DOIUrl":"10.1016/j.pathol.2025.02.002","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 4","pages":"Pages 399-400"},"PeriodicalIF":3.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encapsulating the diagnostics of cryptococcal infections: what to do when there is minimal capsule","authors":"Ravin Hettiarachchi ,&nbsp;Michael Han ,&nbsp;Mark Krockenberger ,&nbsp;Louella Davey ,&nbsp;Pamela Konecny ,&nbsp;Robert Stevens ,&nbsp;Chris Weatherall","doi":"10.1016/j.pathol.2024.12.646","DOIUrl":"10.1016/j.pathol.2024.12.646","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 4","pages":"Pages 532-535"},"PeriodicalIF":3.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotypic diversity and antimicrobial resistance phenotype of carbapenem-resistant and carbapenem-susceptible Acinetobacter species isolates.","authors":"Ka Lip Chew, Ker Xin Tan, Nur Aisyah Binte Abu Bakar, Raymond Lin, Jeanette W P Teo","doi":"10.1016/j.pathol.2024.12.647","DOIUrl":"https://doi.org/10.1016/j.pathol.2024.12.647","url":null,"abstract":"<p><p>Members of the Acinetobacter baumannii complex are common nosocomial pathogens with propensity for developing carbapenem resistance. Much emphasis is placed on carbapenem-resistant Acinetobacter baumannii (CRAB), although carbapenem-susceptible Acinetobacter baumannii (CSAB) isolates also cause serious infections. Genomic and phenotypic differences between these isolates are analysed in this study. Whole-genome sequencing was performed on a collection of 90 non-duplicate isolates of Acinetobacter spp. isolates. Phenotypic susceptibility results performed routinely were also collected and correlated against presence of antimicrobial resistance (AMR) genes. The included isolates were predominantly A. baumannii (n=77), followed by Acinetobacter nosocomialis (n=8), Acinetobacter pittii (n=2), Acinetobacter ursingii (n=1), Acinetobacter soli (n=1), and Acinetobacter colistiniresistens (n=1). After excluding duplicate isolates, most of the 77 A. baumannii isolates were identified as carbapenem-resistant sequence type (ST) 2 strains (n=43), which were associated with the presence of oxacillinase (OXA)-23 carbapenemases. Comparatively, CSAB were more diverse, comprising various STs. Overall susceptibilities to non-β-lactam antibiotics indicate ​highest susceptibility rates to co-trimoxazole, followed by gentamicin and quinolones. Isolates that were resistant to co-trimoxazole possessed sul1 and/or sul2 genes and isolates resistant to gentamicin had armA and/or ant(2″)-Ia genes. CRAB and CSAB were also distinctly different in terms of resistance to non-β-lactam antibiotics with >90% susceptibility to quinolones, co-trimoxazole, and gentamicin in CSAB isolates, compared to 4.2%, 56.3%, and 33.3% in CRAB. Further stratification was performed based on capsular polysaccharide [K locus (KL)] types. The resistance rates amongst the three most common KL types in carbapenem-resistant ST2 isolates showed considerable variation. For gentamicin, 92.9% (13/14) of KL10, 61.5% (8/13) of KL210, and 45.5% (5/11) of KL2 isolates were resistant. For co-trimoxazole, 0.0% (0/14) of KL10, 92.3% (12/13) of KL210, and 36.4% (4/11) of KL2 isolates were resistant. Overall, the most common types were KL10 (n=15), KL210 (n=14), KL2 (n=11), KL24 (n=6), and KL106 (n=5). The most common types seen in blood isolates were KL210 and KL24 (n=4 each). In summary, CRAB in our institution is dominated by ST2 isolates. There was also strong correlation between the AMR genes present with phenotypic resistance in our collection of isolates. KL type provides further stratification of isolates in terms of invasiveness and AMR.</p>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microvascular density using the Chalkley method: a potential alternative to the World Health Organization nuclear grading in pleural mesothelioma prognostication","authors":"Revania Pillay ,&nbsp;Ashleigh J. Hocking ,&nbsp;Sarita Prabhakaran ,&nbsp;Sonja Klebe","doi":"10.1016/j.pathol.2024.12.643","DOIUrl":"10.1016/j.pathol.2024.12.643","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 4","pages":"Pages 505-506"},"PeriodicalIF":3.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel mutation in acaeruloplasminaemia: a rare case of neurodegeneration mimicking normal pressure hydrocephalus","authors":"Man-Kwan Yip ,&nbsp;Hoi Kevin Chin ,&nbsp;Man Au Yeung ,&nbsp;Wing-Tat Poon","doi":"10.1016/j.pathol.2024.12.644","DOIUrl":"10.1016/j.pathol.2024.12.644","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 4","pages":"Pages 521-524"},"PeriodicalIF":3.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A modified cut-off index for the Elecsys Anti-SARS-CoV-2 nucleocapsid electrochemiluminescence immunoassay","authors":"Caitlin Hooker ,&nbsp;Brittany Lavender ,&nbsp;Chris Frampton ,&nbsp;Sian Horan ,&nbsp;James Ussher ,&nbsp;Maia Brewerton","doi":"10.1016/j.pathol.2024.12.642","DOIUrl":"10.1016/j.pathol.2024.12.642","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 4","pages":"Pages 535-537"},"PeriodicalIF":3.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep nabothian cysts: an underappreciated phenomenon and mimic of cervical gastric-type adenocarcinoma","authors":"Stephanie N.J. Chapple ,&nbsp;Rachel Maywald ,&nbsp;Niveditha Rajadevan ,&nbsp;Karen L. Talia ,&nbsp;W. Glenn McCluggage","doi":"10.1016/j.pathol.2024.12.645","DOIUrl":"10.1016/j.pathol.2024.12.645","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 4","pages":"Pages 514-517"},"PeriodicalIF":3.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A complex case of mixed-phenotype acute leukaemia B/T/myeloid","authors":"Nourhan Ibrahim,&nbsp;Zubaidah Al-Jumaili,&nbsp;Phuoc T. Christie-Nguyen,&nbsp;Sibel Ak,&nbsp;Brenda Mai","doi":"10.1016/j.pathol.2024.12.641","DOIUrl":"10.1016/j.pathol.2024.12.641","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 4","pages":"Pages 524-527"},"PeriodicalIF":3.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}