Pathology最新文献_第5页

Impact brain apnoea 影响大脑呼吸暂停

IF 3.6 3区医学

Pathology Pub Date : 2025-02-01 DOI: 10.1016/j.pathol.2024.12.068

Bernard l'Ons

引用次数: 0

Emerging treatments for Alzheimer's disease/lecanemab 阿尔茨海默病的新疗法/lecanemab

IF 3.6 3区医学

Pathology Pub Date : 2025-02-01 DOI: 10.1016/j.pathol.2024.12.036

Colin Masters

引用次数: 0

Case study and literature review: the role of selective venous sampling in the management of challenging primary hyperparathyroidism 个案研究及文献回顾：选择性静脉取样在原发性甲状旁腺功能亢进治疗中的作用

IF 3.6 3区医学

Pathology Pub Date : 2025-02-01 DOI: 10.1016/j.pathol.2024.12.031

Anila Hashmi

引用次数: 0

Genomic autopsy – path to definitive and candidate diagnoses: insights from 400+ genomic autopsies 基因组解剖-确定和候选诊断的路径：来自400多个基因组解剖的见解

IF 3.6 3区医学

Pathology Pub Date : 2025-02-01 DOI: 10.1016/j.pathol.2024.12.102

Thuong Ha , Genomic Autopsy Study Research Network, Christopher Barnett , Hamish Scott

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Diagnostic challenges in routine endometrial biopsy reporting 常规子宫内膜活检报告中的诊断挑战

IF 3.6 3区医学

Pathology Pub Date : 2025-02-01 DOI: 10.1016/j.pathol.2024.12.020

Adeline Tan

引用次数: 0

Emerging trends in sexual assault caseload 性侵犯案件数量的新趋势

IF 3.6 3区医学

Pathology Pub Date : 2025-02-01 DOI: 10.1016/j.pathol.2024.12.053

Janine Rowse , Liyasha Goonetilleke , Richard Bassed

引用次数: 0

Evaluation of a customised Sensititre YeastOne plate containing isavuconazole for antifungal susceptibility testing in Singapore 在新加坡对含有异黄酮唑的定制 Sensititre YeastOne 平板进行抗真菌药敏试验的评估。

IF 3.6 3区医学

Pathology Pub Date : 2025-02-01 DOI: 10.1016/j.pathol.2024.08.005

Wenjie Huang, Geraldine Xue Qin Goh, Mei Gie Tan, Jing Sen Chua, Samantha Hui Wen Tan, Yen Ee Tan

{"title":"Evaluation of a customised Sensititre YeastOne plate containing isavuconazole for antifungal susceptibility testing in Singapore","authors":"Wenjie Huang, Geraldine Xue Qin Goh, Mei Gie Tan, Jing Sen Chua, Samantha Hui Wen Tan, Yen Ee Tan","doi":"10.1016/j.pathol.2024.08.005","DOIUrl":"10.1016/j.pathol.2024.08.005","url":null,"abstract":"<div><div>This study evaluated the performance of a customised Sensititre YeastOne (SYO) plate including isavuconazole (YIT) against existing practice (comprising SYO YO10 plate and isavuconazole gradient strip) in order to streamline the workflow for antifungal susceptibility testing in a tertiary hospital in Singapore. A total of 101 (51 yeasts and 50 moulds) clinical isolates were included for analysis. Isolates included in the study were recovered from a variety of body sites and reflected the case mix encountered in daily practice. Antifungal susceptibility testing was performed using three methods: YO10, YIT and gradient diffusion strip (for isavuconazole only). Reproducibility, essential agreement (EA) and categorical agreement (CA) were calculated. When YO10 and YIT plates were compared, the reproducibility was 100% for eight common antifungals. The CA was >97% for all antifungals except for amphotericin B (89.4%), but this was attributed to seven isolates with minimum inhibitory concentrations bordering the wild-type (WT) cut-off. The EA obtained when testing isavuconazole using YIT versus gradient diffusion was 77.2% overall, 90.2% for yeasts and 64% for moulds. In conclusion, the YIT plate is suitable for antifungal susceptibility testing of yeasts in our laboratory. Its use for mould isolates needs to be monitored further.</div></div>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 1","pages":"Pages 100-104"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunoprecipitation assays for the detection of specific extractable nuclear antigen autoantibodies: a role in the modern immunology laboratory? 用于检测特异性可提取核抗原自身抗体的免疫沉淀测定：在现代免疫学实验室中的作用？

IF 3.6 3区医学

Pathology Pub Date : 2025-02-01 DOI: 10.1016/j.pathol.2024.08.008

Dimitra Beroukas , Peter J. Roberts-Thomson , Tom P. Gordon , Adrian Y.S. Lee

引用次数: 0

New challenges for HIV testing in the setting of long-acting cabotegravir pre-exposure prophylaxis 长效卡博替拉韦暴露前预防疗法对艾滋病毒检测的新挑战。

IF 3.6 3区医学

Pathology Pub Date : 2025-02-01 DOI: 10.1016/j.pathol.2024.08.011

Eloise Williams , Doris Chibo , Jodie D'Costa , Suellen Nicholson , Kathy Jackson , Chuan K. Lim , Deborah A. Williamson

引用次数: 0

Cribriform intraductal carcinoma of the prostate may be more aggressive than cribriform conventional/acinar prostatic adenocarcinoma 前列腺楔形导管内癌可能比楔形传统/尖锐前列腺腺癌更具侵袭性。

IF 3.6 3区医学

Pathology Pub Date : 2025-02-01 DOI: 10.1016/j.pathol.2024.08.012

Ying Wang , Yuki Teramoto , Hiroshi Miyamoto

{"title":"Cribriform intraductal carcinoma of the prostate may be more aggressive than cribriform conventional/acinar prostatic adenocarcinoma","authors":"Ying Wang , Yuki Teramoto , Hiroshi Miyamoto","doi":"10.1016/j.pathol.2024.08.012","DOIUrl":"10.1016/j.pathol.2024.08.012","url":null,"abstract":"<div><div>It remains to be determined if the prognostic value of cribriform morphology (Crib) associated with intraductal carcinoma of the prostate (IDC) is equivalent to that in conventional/acinar prostatic adenocarcinoma (CPA). We herein assessed radical prostatectomy findings and long-term oncologic outcomes in 732 men with Grade Group 2–4 CPA without any Gleason pattern 5. Our cases were divided into four cohorts according to the absence or presence of Crib within CPA and/or IDC: Cohort-1, no Crib (<em>n</em>=347; 47.4%); Cohort-2, Crib only in CPA (<em>n</em>=203; 27.7%); Cohort-3, Crib only in IDC (<em>n</em>=17; 2.3%); and Cohort-4, Crib in both CPA and IDC (<em>n</em>=165; 22.5%). Compared with that in CPA only (Cohort-2), Crib in both CPA and IDC (Cohort-4) was significantly associated with adverse histopathological features, including higher tumour grade/stage and larger tumour volume. Univariate analysis revealed significantly higher risks of postoperative recurrence in patients with Crib in IDC only [Cohort-3; hazard ratio (HR) 2.450, <em>p</em>=0.022] or both CPA and IDC (Cohort-4; HR 2.835, <em>p</em><0.001) than in those with Crib in CPA only (Cohort-2), whereas the prognosis was analogous between Cohort-3 and Cohort-4 (<em>p</em>=0.913). In a multivariable analysis [Crib in CPA only (Cohort-2) as a reference], Crib in IDC only (Cohort-3; HR 3.821, <em>p</em>=0.002) or both CPA and IDC (Cohort-4; HR 1.905, <em>p</em>=0.004) showed significantly worse recurrence-free survival. Compared with Crib in CPA only, its presence in both CPA and IDC was thus found to be independently associated with a poorer prognosis, suggesting a potentially greater clinical impact of Crib in IDC than in CPA.</div></div>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 1","pages":"Pages 3-9"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142731716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0