IF 3.9 3区医学

Pathology Pub Date : 2026-10-01 Epub Date: 2026-06-03 DOI: 10.1016/j.pathol.2026.05.001

Francesca Azzato, Leandra Elieh, Rianne Brizuela, Eileen Hor, Kerry Raios, Eloise Williams, Chuan Kok Lim, Maryza Graham

{"title":"Performance assessment of five Legionella urinary antigen tests for Legionella pneumophila and Legionellalongbeachae.","authors":"Francesca Azzato, Leandra Elieh, Rianne Brizuela, Eileen Hor, Kerry Raios, Eloise Williams, Chuan Kok Lim, Maryza Graham","doi":"10.1016/j.pathol.2026.05.001","DOIUrl":"10.1016/j.pathol.2026.05.001","url":null,"abstract":"Legionnaires' disease (LD) is a severe pneumonia caused by Legionella species., with Legionella pneumophila serogroup 1 (SG1) responsible for 70-80% of cases in Europe and the United States. In parts of Asia and the Western Pacific, Legionella longbeachae is also a common cause. Most urinary antigen tests (UATs) target only L. pneumophila SG1, limiting detection of other species. We evaluated the performance of five UATs: BinaxNOW immunochromatographic test (ICT), Sofia FIA, STANDARD F FIA, ImmuView and LIAISON, against the Binax enzyme immunoassay, with culture and polymerase chain reaction (PCR) used where available to confirm the infecting Legionella species. A total of 81 urine samples were tested across all assays, except STANDARD F (n=80). BinaxNOW ICT had the highest sensitivity for L. pneumophila SG1 with 100% specificity. ImmuView showed 100% sensitivity and specificity for L. longbeachae and 92.6% sensitivity for L. pneumophila SG1. In regions where L. longbeachae represents a substantial proportion of Legionella infections, the ImmuView assay offers an effective primary screening approach since it can simultaneously detect both L. pneumophila SG1 and L. longbeachae in a single test, thereby minimising reliance on slower diagnostic methods such as culture or PCR.","PeriodicalId":19915,"journal":{"name":"Pathology","volume":" ","pages":"718-722"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148497884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dedifferentiated chondrosarcoma showing a granular cell tumour-like component. 显示颗粒细胞肿瘤样成分的去分化软骨肉瘤。

IF 3.9 3区医学

Pathology Pub Date : 2026-10-01 Epub Date: 2026-06-20 DOI: 10.1016/j.pathol.2026.05.004

Shoki Yamada, Michiyuki Hakozaki, Yoichi Kaneuchi, Akihiko Yoshida, Yuko Hashimoto

引用次数: 0

IRF2BP2::CDX1-rearranged myoepithelial-like tumour of soft tissue. IRF2BP2:: cdx1 -重排软组织肌上皮样肿瘤。

IF 3.9 3区医学

Pathology Pub Date : 2026-10-01 Epub Date: 2026-05-28 DOI: 10.1016/j.pathol.2026.03.019

Julien Dagher, Maurice Guzman, Pranav Dorwal, Alison Potter, Noni Chan

引用次数: 0

Activating somatic EPOR mutation in primary erythrocytosis. 原发性红细胞增多症中激活体细胞EPOR突变。

IF 3.9 3区医学

Pathology Pub Date : 2026-10-01 Epub Date: 2026-06-09 DOI: 10.1016/j.pathol.2026.04.005

Francis Baumgartner, Ali Khalil, Jessica M Salmon, Piers Blombery, Ing Soo Tiong

引用次数: 0

Alveolar adenoma with dual hotspot mutations (PDGFRB p.N666K and PIK3CA p.H1047R): a rare case report with diagnostic implications. 双热点突变肺泡腺瘤（PDGFRB p.N666K和PIK3CA p.H1047R）：一个罕见的病例报告，具有诊断意义。

IF 3.9 3区医学

Pathology Pub Date : 2026-10-01 Epub Date: 2026-06-19 DOI: 10.1016/j.pathol.2026.05.005

Mei Kong, Qiqi Gao, Hui Tang

引用次数: 0

Considerations regarding the use of parathyroid hormone for defining vitamin D functional reference limits. 关于使用甲状旁腺激素确定维生素D功能参考限量的考虑。

IF 3.9 3区医学

Pathology Pub Date : 2026-10-01 Epub Date: 2026-07-03 DOI: 10.1016/j.pathol.2026.05.012

Wei Chen, Kexin Ye, Jun Ma

引用次数: 0

Stillbirth in Australia and New Zealand: the importance of perinatal autopsy and placental examination in the quest for answers. 澳大利亚和新西兰的死产：围产期尸检和胎盘检查在寻求答案中的重要性。

IF 3.9 3区医学

Pathology Pub Date : 2026-10-01 Epub Date: 2026-07-11 DOI: 10.1016/j.pathol.2026.06.007

Nick Manton, Jane E Dahlstrom

引用次数: 0

Diagnostic associations of hypergammaglobulinaemia in a paediatric hospital: a retrospective study. 儿科医院高γ球蛋白血症的诊断关联：一项回顾性研究。

IF 3.9 3区医学

Pathology Pub Date : 2026-10-01 Epub Date: 2026-06-30 DOI: 10.1016/j.pathol.2026.05.008

Tess O'Gorman, Timothy Ford, Andrew McLean-Tooke

引用次数: 0

BRCA1-mutant thymoma and the role of PARP inhibitors: a case report. brca1突变胸腺瘤和PARP抑制剂的作用：1例报告。

IF 3.9 3区医学

Pathology Pub Date : 2026-10-01 Epub Date: 2026-07-09 DOI: 10.1016/j.pathol.2026.06.006

Joey Yan Leng Tan, Jeanette Yuen, Joanne Ngeow, Wen Yee Chay, Francis Hong Xin Yap

引用次数: 0

Applicability of the WHO grading for reticulin and collagen fibrosis in a routine diagnostic laboratory. WHO分级对网状蛋白和胶原纤维化在常规诊断实验室的适用性。

IF 3.9 3区医学

Pathology Pub Date : 2026-10-01 Epub Date: 2026-07-03 DOI: 10.1016/j.pathol.2026.06.005

Zoe Loh, Christopher Hogan, Wai Khoon Ho

{"title":"Applicability of the WHO grading for reticulin and collagen fibrosis in a routine diagnostic laboratory.","authors":"Zoe Loh, Christopher Hogan, Wai Khoon Ho","doi":"10.1016/j.pathol.2026.06.005","DOIUrl":"10.1016/j.pathol.2026.06.005","url":null,"abstract":"Accurate grading of bone marrow fibrosis is essential for the diagnosis and prognostication of myeloproliferative neoplasms (MPNs). The 2017 World Health Organization (WHO) Classification recommends a trichrome stain be performed to evaluate collagen fibrosis when reticulin fibrosis grade is >1, but the inter-observer concordance in assessing collagen fibrosis in a routine diagnostic laboratory and the utility of this stain are unclear. This study assesses the inter-observer agreement in the grading of reticulin fibrosis and collagen fibrosis, and the concordance between reticulin and collagen fibrosis. Two pathologists assessed 174 consecutive bone marrow trephine biopsies with a diagnosis of an MPN at a tertiary referral centre. Reticulin fibrosis by silver impregnation and collagen fibrosis by Masson's trichrome stain were independently graded by the pathologists while blinded to clinical information. Discordant scores were reviewed to establish a final grade by consensus. Substantial inter-observer concordance was obtained for both reticulin [83%; Cohen's kappa 0.756, 95% confidence interval (CI) 0.69-0.84] and collagen fibrosis grading (81%; kappa 0.730, 95% CI 0.64-0.82). Using the final consensus scores, reticulin and collagen fibrosis grades were concordant in 60% of cases. Collagen fibrosis grade was higher than reticulin fibrosis score in 11% of cases. Inter-observer concordance in assessing the degree of collagen fibrosis using the trichrome stain is substantial. Reticulin (silver) staining alone may underestimate the degree of fibrosis. The prognostic significance where the degree of collagen fibrosis is greater than that of reticulin is uncertain and should be investigated in future studies.","PeriodicalId":19915,"journal":{"name":"Pathology","volume":" ","pages":"707-711"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148679563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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