IF 3 3区医学

Pathology Pub Date : 2026-03-23 DOI: 10.1016/j.pathol.2025.11.018

Timothy Ming Him Yeung, Tsz Ki Ling, Chun Fung So, Felix Chi Kin Wong, Ching-Wan Lam

引用次数: 0

Comparable histomorphology aided by massively parallel sequencing in diagnosing unusual presentation of metastatic phyllodes tumour. 相当组织形态学辅助大规模平行测序在诊断转移性叶状瘤的不寻常表现。

IF 3 3区医学

Pathology Pub Date : 2026-03-21 DOI: 10.1016/j.pathol.2026.02.006

Hannah Matthews, Daniel Wong, Huan Tom Sim, Dilini Gunawardena

引用次数: 0

MPL W515R hereditary thrombocytosis associated with a benign long-term clinical course. MPL W515R遗传性血小板增多症与良性长期临床病程相关。

IF 3 3区医学

Pathology Pub Date : 2026-03-21 DOI: 10.1016/j.pathol.2025.12.010

Erin O'Reilly, Samuel Grigg, Paul Monagle, Piers Blombery

引用次数: 0

A case of Candida-associated duodenal ulceration in an immunocompetent patient. 一例念珠菌相关的十二指肠溃疡的免疫功能正常的病人。

IF 3 3区医学

Pathology Pub Date : 2026-03-20 DOI: 10.1016/j.pathol.2026.01.365

Anita S Iyer

引用次数: 0

Immune receptor translocation-associated protein 1 and myeloid nuclear differentiation antigen are useful markers for the differential diagnosis of marginal zone lymphoma. 免疫受体易位相关蛋白1和髓核分化抗原是边缘带淋巴瘤鉴别诊断的有用标志物。

IF 3 3区医学

Pathology Pub Date : 2026-03-19 DOI: 10.1016/j.pathol.2025.11.016

Wen-Wen Zhang, Long-Feng Ke, Chen-Yu Wu, Shu-Yi Lu, Yun-Li Xie, Huan-Huan Zhu, Wei-Feng Zhu, Gang Chen, Yan-Ping Chen

{"title":"Immune receptor translocation-associated protein 1 and myeloid nuclear differentiation antigen are useful markers for the differential diagnosis of marginal zone lymphoma.","authors":"Wen-Wen Zhang, Long-Feng Ke, Chen-Yu Wu, Shu-Yi Lu, Yun-Li Xie, Huan-Huan Zhu, Wei-Feng Zhu, Gang Chen, Yan-Ping Chen","doi":"10.1016/j.pathol.2025.11.016","DOIUrl":"https://doi.org/10.1016/j.pathol.2025.11.016","url":null,"abstract":"This study aimed to assess the potential diagnostic utility of immune receptor translocation-associated protein 1 (IRTA1) and myeloid nuclear differentiation antigen (MNDA) expression in marginal zone lymphoma (MZL). We evaluated whole-tissue sections from 686 specimens; specifically, reactive lymphoid hyperplasia (n=60), MZL (n=284), follicular lymphoma (n=156), mantle cell lymphoma (n=64), chronic lymphocytic leukaemia/small lymphocytic lymphoma (n=51), lymphoplasmacytic lymphoma (n=17), and diffuse large B-cell lymphoma (DLBCL; n=54). Immunohistochemical staining for IRTA1, MNDA, and other markers (CD10, BCL-6, CD5, CD23, cyclin D1, SOX-11, and LEF-1) was performed using an automated system. IRTA1 was expressed in 62.3% (177/284) of MZL vs 8.7% (25/288) of other small B-cell lymphoma and 14.81% (8/54) of DLBCL specimens (p<0.001 and p<0.001, respectively). MNDA was expressed in 60.9% (173/284) of MZL vs 24.7% (71/288) of other small B-cell lymphoma and 25.93% (14/54) DLBCL specimens (p<0.001 and p<0.001, respectively). Expression of IRTA1 had a higher specificity than MNDA for MZL. Expression of either IRTA1+ or MNDA+ was detected in 78.9% (224/284) of MZL specimens, whereas coexpression was less common (44.4%, 126/284). Within MZL subtypes, IRTA1 and MNDA were expressed at lower frequencies in nodal MZL (55.7% and 55.7%, respectively) than in mucosa-associated lymphoid tissue lymphoma (64.1% and 62.7%, respectively). Expression of IRTA1 alone, or either IRTA1+ or MNDA+, was less frequent among MZL with plasma cell differentiation than among MZL with classical cell morphology (p=0.063 and 0.071, respectively), albeit not significantly. IRTA1 and MNDA are sensitive and specific markers for the differential diagnosis of MZL, and they may be helpful in distinguishing MZL from histologic mimics.","PeriodicalId":19915,"journal":{"name":"Pathology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary benign notochordal cell tumour: a case report of a rare finding. 肺良性脊索细胞瘤：罕见发现1例报告。

IF 3 3区医学

Pathology Pub Date : 2026-03-19 DOI: 10.1016/j.pathol.2025.11.019

Emma Moloney, Emily Granger, Vanathi Sivasubramaniam

引用次数: 0

The value of external quality assurance programs in identifying shifts in high-sensitivity troponin assays: a case for careful selection of low-level target concentrations. 外部质量保证程序在识别高灵敏度肌钙蛋白测定变化中的价值：一个谨慎选择低水平靶浓度的案例。

IF 3 3区医学

Pathology Pub Date : 2026-03-19 DOI: 10.1016/j.pathol.2025.11.017

Christina M Trambas, Yvonne S Reidy, Tony Badrick

引用次数: 0

Histopathological features of rapidly progressive interstitial lung disease associated with anti-MDA5 dermatomyositis: a case series and literature review. 与抗mda5皮肌炎相关的快速进展性间质性肺病的组织病理学特征：病例系列和文献综述

IF 3 3区医学

Pathology Pub Date : 2026-03-18 DOI: 10.1016/j.pathol.2026.02.005

Hala Alnuaim, Ying-Han R Hsu

{"title":"Histopathological features of rapidly progressive interstitial lung disease associated with anti-MDA5 dermatomyositis: a case series and literature review.","authors":"Hala Alnuaim, Ying-Han R Hsu","doi":"10.1016/j.pathol.2026.02.005","DOIUrl":"https://doi.org/10.1016/j.pathol.2026.02.005","url":null,"abstract":"Dermatomyositis (DM) is a rare autoimmune inflammatory myopathy disorder that affects skeletal muscles, skin, and other organs including the lungs. DM is associated with anti-melanoma differentiation-associated gene 5 (MDA5) antibody is frequently complicated by rapidly progressive interstitial lung disease (RPILD), leading to poor prognosis. Reports describing histopathological features in detail were limited in the literature. We retrospectively identified and reviewed the morphological features in the explanted lung specimens of six patients with RPILD associated with DM between 2016 and 2023. The mean age of our cohort was 47.5 years with a female predominance (67%). All cases showed diffuse alveolar damage (DAD) of varying phases and extent with some resembling a fibrotic non-specific interstitial pneumonia pattern in the background. In addition, we performed a literature review of RPILD associated with anti-MDA5 antibody-positive DM with depictions of histopathological features. Our findings suggest that acute lung injury characterised by varying phases of DAD are the hallmark of fulminant and/or treatment-refractory RPILD associated with DM, and we highlight issues in identifying this process on small biopsies.","PeriodicalId":19915,"journal":{"name":"Pathology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical relevance of discordant urine and serum electrophoresis immunofixation cases. 尿、血清电泳免疫固定不一致病例的临床意义。

IF 3 3区医学

Pathology Pub Date : 2026-03-17 DOI: 10.1016/j.pathol.2026.02.004

Fakhria Kakar, Ming Wei Lin, Adrian Y S Lee

{"title":"Clinical relevance of discordant urine and serum electrophoresis immunofixation cases.","authors":"Fakhria Kakar, Ming Wei Lin, Adrian Y S Lee","doi":"10.1016/j.pathol.2026.02.004","DOIUrl":"https://doi.org/10.1016/j.pathol.2026.02.004","url":null,"abstract":"Protein electrophoresis (PEP) is a key laboratory technique for identifying and quantifying proteins in body fluids, commonly used for detection of paraproteins in plasma cell disorders like multiple myeloma (MM), amyloidosis, and related conditions. The utility of urine PEP and urine immunofixation electrophoresis (uIFE) has been criticised in recent years due to its poorer sensitivity and precision than the corresponding serum assays. This study, conducted in an Australian cohort, aimed to assess the utility of uIFE when serum immunofixation electrophoresis (sIFE) results are negative and determine the predictors for such cases. We conducted a single-laboratory retrospective cross-sectional study over 18 months (2023-2024) involving 1065 individual patient encounters who had a uIFE test performed. Samples were run on the Sebia HYDRASYS system and were read independently by three experienced readers. We identified 51 discordant cases (5% of cases) where uIFE detected monoclonal proteins absent in paired sIFE. Common diagnoses in these 51 patients included MM (n=1, 22%) and amyloidosis (n=9, 18%). A random selection of 51 age- and gender-matched uIFE patients with positive sIFE results were compared to the discordant cases. Renal function or serum-free light chain status did not influence the presence of discordant results. Discordant uIFE/sIFE results may be seen in clinically relevant syndromes. Our findings highlight the importance of uIFE in detecting low-level monoclonal proteins, particularly in conditions where serum assays fall short, such as in minimal residual disease or light chain amyloidosis.","PeriodicalId":19915,"journal":{"name":"Pathology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STAT6 mutational status and expression in primary mediastinal large B-cell lymphoma. STAT6在原发性纵隔大b细胞淋巴瘤中的突变状态及表达。

IF 3 3区医学

Pathology Pub Date : 2026-03-17 DOI: 10.1016/j.pathol.2025.11.014

Siba El Hussein, Giby V George, Diana G Adlowitz, Lily B Benedict, Fatima Zahra Jelloul, L Jeffrey Medeiros, W Richard Burack, Dennis P O'Malley

引用次数: 0

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