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TIGIT expression on neoplastic cells is a poor prognostic factor for adult T-cell leukaemia/lymphoma 肿瘤细胞上的 TIGIT 表达是成人 T 细胞白血病/淋巴瘤的不良预后因素
IF 4.5 3区 医学
Pathology Pub Date : 2024-08-12 DOI: 10.1016/j.pathol.2024.06.003
Yuichi Yamada, Hiroaki Miyoshi, Mai Takeuchi, Kazutaka Nakashima, Kyohei Yamada, Takeharu Kato, Ken Tanaka, Kei Kohno, Yoshitaka Imaizumi, Yasushi Miyazaki, Koichi Ohshima
{"title":"TIGIT expression on neoplastic cells is a poor prognostic factor for adult T-cell leukaemia/lymphoma","authors":"Yuichi Yamada, Hiroaki Miyoshi, Mai Takeuchi, Kazutaka Nakashima, Kyohei Yamada, Takeharu Kato, Ken Tanaka, Kei Kohno, Yoshitaka Imaizumi, Yasushi Miyazaki, Koichi Ohshima","doi":"10.1016/j.pathol.2024.06.003","DOIUrl":"https://doi.org/10.1016/j.pathol.2024.06.003","url":null,"abstract":"Adult T-cell leukaemia/lymphoma (ATLL) is an aggressive peripheral T-cell neoplasm with a poor prognosis. T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains (TIGIT) is an immune checkpoint receptor expressed on T and natural killer cells. Although increased TIGIT expression in the tumour microenvironment is associated with poor prognosis in various neoplasms, its relevance in ATLL remains unknown. Herein, we investigated the clinicopathological impact of TIGIT expression on ATLL using immunohistochemistry. TIGIT expression was detected in 21 of 84 patients (25%). A partial association between the clinical features and immune checkpoint molecules and the expression of TIGIT was found including sIL-2R, CD86 and GITR. TIGIT-positive patients [median survival time (MST) 8.9 months, 95% confidence interval (CI) 7.7–15.6] had inferior overall survival compared with TIGIT-negative patients (MST 18.7 months, 95% CI 12.0–36.4) (=0.0124]. TIGIT expression maintained its prognostic value for overall survival in both univariate and multivariate analyses [hazard ratio (HR) 1.909; 95% CI 1.044–3.488; =0.0356]. Further studies are required to clarify the clinical and biological significance of TIGIT expression in patients with ATLL.","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142205258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benign prostatic hyperplasia and insignificant prostate cancer with very high levels of serum prostate specific antigen. 血清前列腺特异性抗原水平非常高的良性前列腺增生和不明显的前列腺癌。
IF 3.6 3区 医学
Pathology Pub Date : 2024-08-12 DOI: 10.1016/j.pathol.2024.05.013
Hemamali Samaratunga, Brett Delahunt, Mats Olsson, Markus Aly, Lars Egevad, John Yaxley
{"title":"Benign prostatic hyperplasia and insignificant prostate cancer with very high levels of serum prostate specific antigen.","authors":"Hemamali Samaratunga, Brett Delahunt, Mats Olsson, Markus Aly, Lars Egevad, John Yaxley","doi":"10.1016/j.pathol.2024.05.013","DOIUrl":"https://doi.org/10.1016/j.pathol.2024.05.013","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep learning-based diagnosis and survival prediction of patients with renal cell carcinoma from primary whole slide images 基于深度学习的原发性全切片图像肾细胞癌患者诊断与生存预测
IF 4.5 3区 医学
Pathology Pub Date : 2024-08-03 DOI: 10.1016/j.pathol.2024.05.012
Siteng Chen, Xiyue Wang, Jun Zhang, Liren Jiang, Feng Gao, Jinxi Xiang, Sen Yang, Wei Yang, Junhua Zheng, Xiao Han
{"title":"Deep learning-based diagnosis and survival prediction of patients with renal cell carcinoma from primary whole slide images","authors":"Siteng Chen, Xiyue Wang, Jun Zhang, Liren Jiang, Feng Gao, Jinxi Xiang, Sen Yang, Wei Yang, Junhua Zheng, Xiao Han","doi":"10.1016/j.pathol.2024.05.012","DOIUrl":"https://doi.org/10.1016/j.pathol.2024.05.012","url":null,"abstract":"It remains an urgent clinical demand to explore novel diagnostic and prognostic biomarkers for renal cell carcinoma (RCC). We proposed deep learning-based artificial intelligence strategies. The study included 1752 whole slide images from multiple centres.","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141943156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macaque liver substrate for evaluating dense fine speckled-like patterns on HEp2010 cells 用于评估 HEp2010 细胞上密集细小斑点状图案的猕猴肝脏基质
IF 4.5 3区 医学
Pathology Pub Date : 2024-08-03 DOI: 10.1016/j.pathol.2024.05.011
Anthea Anantharajah, Roger A. Silvestrini, David Campbell, Suzanne Culican, Adrian Y.S. Lee, Ming Wei Lin
{"title":"Macaque liver substrate for evaluating dense fine speckled-like patterns on HEp2010 cells","authors":"Anthea Anantharajah, Roger A. Silvestrini, David Campbell, Suzanne Culican, Adrian Y.S. Lee, Ming Wei Lin","doi":"10.1016/j.pathol.2024.05.011","DOIUrl":"https://doi.org/10.1016/j.pathol.2024.05.011","url":null,"abstract":"Antinuclear antibody (ANA) detection by indirect immunofluorescence (IIF) is instrumental in the evaluation of systemic autoimmune diseases (SAD). The dense fine speckled (DFS) ANA staining predominantly associates with anti-DFS70, an autoantibody that is thought to exclude the presence of SAD. However, the DFS pattern may mask the presence of other ANA patterns that may be clinically relevant. Our laboratory uses the HEp2010 substrate which contains both HEp2 and liver substates. The aim of this study was to determine whether negative liver nucleus immunofluorescence could exclude the presence of antibodies to extractable nuclear antigens (ENA) in sera with DFS-like patterns.","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141943155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imprecision of myositis line immunoassay attributable to batch variability 可归因于批次差异的肌炎系免疫测定不精确性
IF 4.5 3区 医学
Pathology Pub Date : 2024-07-29 DOI: 10.1016/j.pathol.2024.05.009
Matthew Krummenacher, Brittany Stevenson, Chris Bundell, Andrew McLean-Tooke
{"title":"Imprecision of myositis line immunoassay attributable to batch variability","authors":"Matthew Krummenacher, Brittany Stevenson, Chris Bundell, Andrew McLean-Tooke","doi":"10.1016/j.pathol.2024.05.009","DOIUrl":"https://doi.org/10.1016/j.pathol.2024.05.009","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":4.5,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141943236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From the midfacial destructive drama to the unfolding EBV story: a short history of EBV-positive NK-cell and T-cell lymphoproliferative diseases 从面部中段破坏性戏剧到不断发展的 EBV 故事：EBV 阳性 NK 细胞和 T 细胞淋巴组织增生性疾病简史
IF 3.6 3区 医学
Pathology Pub Date : 2024-07-25 DOI: 10.1016/j.pathol.2024.07.002
{"title":"From the midfacial destructive drama to the unfolding EBV story: a short history of EBV-positive NK-cell and T-cell lymphoproliferative diseases","authors":"","doi":"10.1016/j.pathol.2024.07.002","DOIUrl":"10.1016/j.pathol.2024.07.002","url":null,"abstract":"<div><p>Epstein–Barr virus (EBV) is a ubiquitous gammaherpesvirus that has been related to oncogenesis of lymphoid and epithelial malignancies. Although the mechanism of EBV infection of NK and T cells remains enigmatic, it plays a pathogenic role in various EBV<sup>+</sup> NK-cell and T-cell lymphoproliferative diseases (LPDs), through promotion of cell activation pathways, inhibition of cell apoptotic pathways, behaving as oncogenes, interacting with host oncogenes or acting epigenetically. The study of NK-cell LPDs, previously hampered by the lack of immunophenotypical and genotypical criteria of NK cells, has become feasible with the recently accepted criteria. EBV<sup>+</sup> NK- and T-cell LPDs are mostly of poor prognosis. This review delivers a short history from primeval to recent EBV<sup>+</sup> NK- and T-cell LPDs in non-immunocompromised subjects, coupled with increasing interest, and work on the biological and oncogenic roles of EBV.</p></div>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141846374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperammonaemia: review of the pathophysiology, aetiology and investigation 高氨血症：病理生理学、病因和调查综述
IF 3.6 3区 医学
Pathology Pub Date : 2024-07-25 DOI: 10.1016/j.pathol.2024.06.002
{"title":"Hyperammonaemia: review of the pathophysiology, aetiology and investigation","authors":"","doi":"10.1016/j.pathol.2024.06.002","DOIUrl":"10.1016/j.pathol.2024.06.002","url":null,"abstract":"<div><p>Acute hyperammonaemia is a medical emergency as it can progress to cerebral oedema, seizures, coma and death. Hepatic encephalopathy secondary to cirrhotic disease or portosystemic shunting are relatively well-known causes, but non-cirrhotic aetiologies of acute hyperammonaemia are less well-known, especially in the emergency department. However, an elevated ammonia is not required to make the diagnosis of hepatic encephalopathy. Although measurement of plasma ammonia is recommended for patients with acute, unexplained, altered mental status, as early identification allows early effective management which may prevent irreversible brain damage, there is currently reduced awareness among physicians of the non-cirrhotic aetiologies of acute hyperammonaemia. Furthermore, measurement of ammonia in patients with cirrhosis has been shown to have low sensitivity and specificity, and not to have altered management in the majority of cases; thus, measurement of ammonia is currently not recommended in guidelines for management of hepatic encephalopathy.</p><p>We sought to describe the pathophysiology of hyperammonaemia and review the non-cirrhotic causes. This was achieved by review of MEDLINE, PubMed and Web of Science databases to include published English literature within the last 20 years. We also present a framework for investigating the acute non-cirrhotic causes of hyperammonaemia to assist both chemical pathologists and clinicians managing these often challenging cases.</p></div>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adenomatoid tumour with perineural space involvement: the utility of next-generation sequencing in this diagnostic conundrum 神经周围受累的腺瘤样肿瘤：新一代测序在这一诊断难题中的应用
IF 3.6 3区 医学
Pathology Pub Date : 2024-07-14 DOI: 10.1016/j.pathol.2024.05.003
{"title":"Adenomatoid tumour with perineural space involvement: the utility of next-generation sequencing in this diagnostic conundrum","authors":"","doi":"10.1016/j.pathol.2024.05.003","DOIUrl":"10.1016/j.pathol.2024.05.003","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141715430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “Prognostic and predictive biomarkers in head and neck cancer: something old, something new, something borrowed, something blue and a sixpence in your shoe” [Pathology 56 (2) (2024) 170–185] 头颈癌的预后性和预测性生物标记物：旧的、新的、借来的、蓝色的和鞋里的六便士"[《病理学》56（2）（2024）170-185]勘误表
IF 3.6 3区 医学
Pathology Pub Date : 2024-07-09 DOI: 10.1016/j.pathol.2024.07.001
{"title":"Corrigendum to “Prognostic and predictive biomarkers in head and neck cancer: something old, something new, something borrowed, something blue and a sixpence in your shoe” [Pathology 56 (2) (2024) 170–185]","authors":"","doi":"10.1016/j.pathol.2024.07.001","DOIUrl":"10.1016/j.pathol.2024.07.001","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0031302524001739/pdfft?md5=4fa7f8d7b1bf03f094b2db3ccb66e226&pid=1-s2.0-S0031302524001739-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141703808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paul Craig Vincent, BSc(Med), MBBS, MD, FRACP, FRCPA, 1935–2024 保罗-克雷格-文森特，理学士（医学）、医学博士、医学博士、英国皇家医学会会员、英国皇家医学会会员，1935-2024 年
IF 3.6 3区 医学
Pathology Pub Date : 2024-07-04 DOI: 10.1016/j.pathol.2024.06.001
{"title":"Paul Craig Vincent, BSc(Med), MBBS, MD, FRACP, FRCPA, 1935–2024","authors":"","doi":"10.1016/j.pathol.2024.06.001","DOIUrl":"https://doi.org/10.1016/j.pathol.2024.06.001","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0031302524001636/pdfft?md5=54d75a765d0140826745385935cfe381&pid=1-s2.0-S0031302524001636-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141543395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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