Pathology最新文献_第10页

Macrophage aggregates: a potential pitfall yet a clue of an inflammatory pattern in ulcerative cytomegalovirus colitis 巨噬细胞聚集：溃疡性巨细胞病毒性结肠炎炎症模式的潜在隐患和线索

IF 3.6 3区医学

Pathology Pub Date : 2024-04-08 DOI: 10.1016/j.pathol.2024.02.005

Badr AbdullGaffar

引用次数: 0

Trends in SARS-CoV-2 cycle threshold (Ct) values from nucleic acid testing predict the trajectory of COVID-19 waves 核酸检测中的 SARS-CoV-2 周期阈值 (Ct) 值趋势预测了 COVID-19 波的轨迹

IF 3.6 3区医学

Pathology Pub Date : 2024-04-06 DOI: 10.1016/j.pathol.2024.02.004

Vishal Ahuja , Thomas Bowe , Gayle Warnock , Catherine Pitman , Dominic E. Dwyer

{"title":"Trends in SARS-CoV-2 cycle threshold (Ct) values from nucleic acid testing predict the trajectory of COVID-19 waves","authors":"Vishal Ahuja , Thomas Bowe , Gayle Warnock , Catherine Pitman , Dominic E. Dwyer","doi":"10.1016/j.pathol.2024.02.004","DOIUrl":"10.1016/j.pathol.2024.02.004","url":null,"abstract":"<div><p>Forecasting COVID-19 waves helps with public health planning and resource allocation. Cycle threshold (Ct) values obtained from positive SARS-CoV-2 nucleic acid amplification test (NAAT) results offer limited value for individual patient management, but real-time analysis of temporal trends of aggregated Ct values may provide helpful information to predict the trajectories of COVID-19 waves in the community. Ct value trends on 59,609 SARS-CoV-2 NAAT-positive results from 574,403 tests using a single testing assay system, between September 2021 and January 2023, were examined to monitor the trend of the proportion of positive NAAT with lower Ct values (≤28) in relation to changing COVID-19 case numbers over time. We applied regression with autoregressive integrated moving average errors modelling approach to study the relation between Ct values and case counts. We also developed an insight product to monitor the temporal trends with Ct values obtained from SARS-CoV-2 NAAT-positive results. In this study, the proportion of lower Ct values preceded by a range of 7–32 days the rising population COVID-19 testing rate reflecting onset of a COVID-19 wave. Monitoring population Ct values may assist in predicting increased disease activity.</p></div>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"56 5","pages":"Pages 710-716"},"PeriodicalIF":3.6,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140609780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Germline potential should not be overlooked for cancer variants identified in tumour-only somatic mutation testing 不应忽视仅在肿瘤体细胞突变检测中发现的癌症变异的种系潜能

IF 4.5 3区医学

Pathology Pub Date : 2024-03-29 DOI: 10.1016/j.pathol.2024.03.001

Mohammad Al-Shinnag , Pak Leng Cheong , Annabel Goodwin , Ronald Trent , Bing Yu

{"title":"Germline potential should not be overlooked for cancer variants identified in tumour-only somatic mutation testing","authors":"Mohammad Al-Shinnag , Pak Leng Cheong , Annabel Goodwin , Ronald Trent , Bing Yu","doi":"10.1016/j.pathol.2024.03.001","DOIUrl":"10.1016/j.pathol.2024.03.001","url":null,"abstract":"<div><p>DNA sequencing of tumour tissue has become the standard care for many solid cancers because of the option to detect somatic variants that have significant therapeutic, diagnostic and prognostic implications. Variants found within the tumour may be either somatic or germline in origin. Somatic cancer gene panels are developed to detect acquired (somatic) variants that are relevant for therapeutic or molecular characterisation of the tumour, expanding gene panels now include genes which may also inform patient management such as cancer predisposition syndromes (CPS) genes. Identifying germline cancer predisposition variants can alter cancer management, the risk of developing new primary cancers and risk for cancer in at-risk family members. This paper discusses the clinical, technical and ethical challenges related to identifying and reporting potential germline pathogenic variants that are detected on tumour sequencing. It also highlights the existence of the eviQ national guidelines for CPS with advice on germline confirmation of somatic findings to pathology laboratories in Australia.</p></div>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"56 4","pages":"Pages 468-472"},"PeriodicalIF":4.5,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140407261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uterine myxoid leiomyosarcoma: identification of a novel PLAG1 fusion partner 子宫肌样白肌瘤：新型 PLAG1 融合伴侣的鉴定

IF 3.6 3区医学

Pathology Pub Date : 2024-03-27 DOI: 10.1016/j.pathol.2024.01.009

Wen-Qi Li, Hai-Xia Wu, Han-Bo Li, Yan Shen

引用次数: 0

Dermatopathic lymphadenopathy after COVID-19 vaccination 接种COVID-19疫苗后的皮肤病性淋巴结病

IF 3.6 3区医学

Pathology Pub Date : 2024-03-26 DOI: 10.1016/j.pathol.2024.01.005

Jie-Yang Jhuang , Yen-Chieh Chen , Yung-Fang Chia , Shih-Sung Chuang

引用次数: 0

Cryoglobulinaemia sine cryoglobulin: a heat insoluble cryoglobulin 低温球蛋白血症：一种热不溶性低温球蛋白

IF 3.6 3区医学

Pathology Pub Date : 2024-03-26 DOI: 10.1016/j.pathol.2024.01.007

Hamish Anderson , Catherine Rollo , John O'Donnell

引用次数: 0

Two Chinese cases of cutaneous squamous cell carcinoma in patients with Lynch syndrome 两例林奇综合征患者皮肤鳞状细胞癌的中国病例

IF 3.6 3区医学

Pathology Pub Date : 2024-03-26 DOI: 10.1016/j.pathol.2024.01.006

Yi-Cong Nie , Zuo-Hua Yin , Fang Hua , Li Yan , Ying-Jie Xue , Yu-Ting Ma , Zhi-Gang Yao

引用次数: 0

Epithelioid haemangioma after bone surgery: an event not previously described 骨外科手术后出现上皮样血管瘤：前所未见的事件

IF 3.6 3区医学

Pathology Pub Date : 2024-03-26 DOI: 10.1016/j.pathol.2024.01.008

Francisco Miguel Izquierdo , Paula Casas , Enrique de Álava , María Cleofé Romagosa , Tulio Silva , Luis Rafael Ramos

引用次数: 0

Association of gut microbiome with immune microenvironment in surgically treated colorectal cancer patients 手术治疗结直肠癌患者肠道微生物组与免疫微环境的关系

IF 4.5 3区医学

Pathology Pub Date : 2024-03-26 DOI: 10.1016/j.pathol.2024.01.010

Nayoung Han , Hee Jin Chang , Hyun Yang Yeo , Byung Chang Kim , Bun Kim , Sung Chan Park , Jeongseon Kim , Ji Won Park , Jae Hwan Oh

{"title":"Association of gut microbiome with immune microenvironment in surgically treated colorectal cancer patients","authors":"Nayoung Han , Hee Jin Chang , Hyun Yang Yeo , Byung Chang Kim , Bun Kim , Sung Chan Park , Jeongseon Kim , Ji Won Park , Jae Hwan Oh","doi":"10.1016/j.pathol.2024.01.010","DOIUrl":"10.1016/j.pathol.2024.01.010","url":null,"abstract":"<div><p>This study explored the relationship between faecal microbiota distribution and local or systemic immune response in patients with colorectal cancer (CRC).</p><p>The study population included 114 surgically treated CRC patients. Faeces were analysed using 16S rRNA gene sequencing. The immune score in tumour microenvironment was evaluated using CD3 and CD8 immunohistochemistry. Genetic alterations, microsatellite instability status and five systemic inflammatory markers were also analysed.</p><p>Thirty of 114 (26.3%) CRC patients were categorised as the ‘immune type’ with a high density of T-cells. The immune type CRC cases showed lower angiolymphatic invasion and longer overall survival. Of the 123 selected bacterial species, <em>Bacteroides fragilis</em> and <em>Collinsella aerofaciens</em> were prevalent in immune CRC cases, whereas <em>Odoribacter splanchnicus</em> and <em>Phascolarctobacterium succinatutens</em> were prevalent in non-immune CRC patients. <em>Bacteroides fragilis</em> was associated with shorter disease free survival in univariable and multivariable survival analyses. Regarding systemic immunity, a high prevalence of <em>C. aerofaciens</em> was associated with a high modified Glasgow prognostic score.</p><p>This study revealed a potential relationship among the gut microbiome, immune microenvironment, and disease progression in patients with CRC. Our findings suggest that abundant <em>B. fragilis</em> in patients with CRC is associated with a ‘cold immune’ tumour microenvironment.</p></div>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"56 4","pages":"Pages 528-539"},"PeriodicalIF":4.5,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140408142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reporting bone marrow biopsies for myelodysplastic neoplasms and acute myeloid leukaemia incorporating WHO 5th edition and ICC 2022 classification systems: ALLG/RCPA joint committee consensus recommendations 骨髓增生异常肿瘤和急性髓性白血病的骨髓活检报告纳入世界卫生组织第五版和国际协调委员会 2022 年分类系统：ALLG/RCPA联合委员会共识建议

IF 4.5 3区医学

Pathology Pub Date : 2024-03-19 DOI: 10.1016/j.pathol.2024.02.002

Ashley P. Ng , Rebecca Adams , Ing Soo Tiong , Louise Seymour , Dipti Talaulikar , Emma Palfreyman , Anoop Enjeti , Courtney Tate

{"title":"Reporting bone marrow biopsies for myelodysplastic neoplasms and acute myeloid leukaemia incorporating WHO 5th edition and ICC 2022 classification systems: ALLG/RCPA joint committee consensus recommendations","authors":"Ashley P. Ng , Rebecca Adams , Ing Soo Tiong , Louise Seymour , Dipti Talaulikar , Emma Palfreyman , Anoop Enjeti , Courtney Tate","doi":"10.1016/j.pathol.2024.02.002","DOIUrl":"10.1016/j.pathol.2024.02.002","url":null,"abstract":"<div><p>The classification of myeloid neoplasms continues to evolve along with advances in molecular diagnosis, risk stratification and treatment of disease. An approach for disease classification has been grounded in international consensus that has facilitated understanding, identification and management of molecularly heterogeneous entities, as well as enabled consistent patient stratification into clinical trials and clinical registries over time. The new World Health Organization (WHO) and International Consensus Classification (ICC) Clinical Advisory Committee releasing separate classification systems for myeloid neoplasms in 2022 precipitated some concern amongst haematopathology colleagues both locally and internationally. While both classifications emphasise molecular disease classification over the historical use of morphology, flow cytometry and cytogenetic based diagnostic methods, notable differences exist in how morphological, molecular and cytogenetic criteria are applied for defining myelodysplastic neoplasms (MDS) and acute myeloid leukaemias (AML). Here we review the conceptual advances, diagnostic nuances, and molecular platforms required for the diagnosis of MDS and AML using the new WHO and ICC 2022 classifications. We provide consensus recommendations for reporting bone marrow biopsies. Additionally, we address the logistical challenges encountered implementing these changes into routine laboratory practice in alignment with the National Pathology Accreditation Advisory Council reporting requirements for Australia and New Zealand.</p></div>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"56 4","pages":"Pages 459-467"},"PeriodicalIF":4.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140268074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0