Distinct genetic alterations in CD10-negative MUM1-positive follicular lymphoma.

IF 3.6 3区医学 Q1 PATHOLOGY

Pathology Pub Date : 2025-04-17 DOI:10.1016/j.pathol.2025.01.012

Yan Yang, Wei Wang, Liang Zhang, Xu Lu, Huihui Li, Yixiong Liu, Zhouyi Xu, Danhui Zhao, Jia Chai, Longfei Shao, Linni Fan, Mingyang Li, Yanru Yang, Chuanshu Gao, Haibo Wu, Zhe Wang

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引用次数: 0

Abstract

Conventional follicular lymphoma (FL) is positive for CD10 and negative for multiple myeloma oncogene 1 (MUM1). However, a subset of FL shows CD10-MUM1+ features, and the genetic alterations of this unique FL subtype are poorly understood. Thus, we conducted whole-exome sequencing in 20 cases of CD10-MUM1+ FL and analysed the genetic and clinicopathological features of these patients. The results suggested that CD10-MUM1+ FL patients were predominantly elderly women, lacked BCL2 rearrangement (17/17, 100%) and showed a higher grade (17/20, 85% grade 3) than patients with conventional FL. The most frequently mutated genes in these tumours were CD79B, GOLGA6L2, IGLL5, KMT2D, NFKBIE, ROBO1, BTG2, DTX1, LRP3 and PTPN6. In contrast to conventional FL, CD10-MUM1+ FL exhibited an elevated mutation frequency of CD79B and NFKBIE and decreased mutation frequencies of CREBBP, BCL2, KMT2D and TNFRSF14. No significant difference was found in the overall survival between CD10-MUM1+ FL and conventional FL patients. In summary, this study demonstrated that CD10-MUM1+ FL has unique clinical, pathological and genetic features.

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cd10阴性mum1阳性滤泡性淋巴瘤的明显遗传改变。

常规滤泡性淋巴瘤（FL） CD10阳性，多发性骨髓瘤癌基因1 （MUM1）阴性。然而，FL的一个子集显示CD10-MUM1+特征，并且这种独特的FL亚型的遗传改变知之甚少。因此，我们对20例CD10-MUM1+ FL进行了全外显子组测序，并分析了这些患者的遗传和临床病理特征。结果表明，CD10-MUM1+ FL患者以老年女性为主，缺乏BCL2重排（17/17,100%），分级（17/20,85%，3级）高于常规FL患者。这些肿瘤中最常见的突变基因为CD79B、GOLGA6L2、IGLL5、KMT2D、NFKBIE、ROBO1、BTG2、DTX1、LRP3和PTPN6。与常规FL相比，CD10-MUM1+ FL表现出CD79B和NFKBIE的突变频率升高，CREBBP、BCL2、KMT2D和TNFRSF14的突变频率降低。CD10-MUM1+ FL与常规FL患者的总生存率无显著差异。综上所述，本研究表明CD10-MUM1+ FL具有独特的临床、病理和遗传特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology 医学-病理学

CiteScore

6.50

自引率

2.20%

发文量

459

审稿时长

54 days

期刊介绍： Published by Elsevier from 2016 Pathology is the official journal of the Royal College of Pathologists of Australasia (RCPA). It is committed to publishing peer-reviewed, original articles related to the science of pathology in its broadest sense, including anatomical pathology, chemical pathology and biochemistry, cytopathology, experimental pathology, forensic pathology and morbid anatomy, genetics, haematology, immunology and immunopathology, microbiology and molecular pathology.