Pharmacology Biochemistry and Behavior最新文献

{"title":"Dopamine type II receptors in amygdala along with oxytocin in hypothalamus regulate social behavior in male mandarin voles","authors":"Xiaolei An ,&nbsp;Peng Yu ,&nbsp;Gang Chang","doi":"10.1016/j.pbb.2025.174002","DOIUrl":"10.1016/j.pbb.2025.174002","url":null,"abstract":"<div><div>The amygdala dopamine (DA) system and hypothalamic oxytocin (OT) play important roles in emotion regulation, and emotions are important in regulating social behavior. However, it is unclear whether DA in the amygdala is involved in the regulation of social behavior, and whether OT in the hypothalamus is also involved in this process. In this study, we examined the release of DA in the medial amygdala (MeA) during different social interactions and the effect of injecting the dopamine II receptor (D2R) agonist quinpirole and the D2R antagonist raclopride into the MeA on social behavior and OT in the paraventricular nucleus (PVN) and supraoptic nucleus (SON), as well as in the blood of male mandarin voles (<em>Microtus mandarinus</em>). The results showed that the DA in the MeA increased in the process of social behavior, and the DA in the face of strangers was higher than that in the face of familiars. In addition, the injection of D2R antagonists in the MeA reduced attacking and escaping behaviors but increased physical contact and investigating behaviors, increased the number of OT-IR neurons in the PVN and SON, and increased OT levels in the blood. While injection of D2R agonists in the MeA increased attacking and escaping behaviors but reduced physical contact and investigating behaviors, it also reduced OT-IR neurons in the SON. In conclusion, D2R in the medial amygdala and oxytocin in the hypothalamus regulate social behavior.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"250 ","pages":"Article 174002"},"PeriodicalIF":3.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermittent environmental enrichment induces behavioral despair, while intermittent social isolation impairs spatial learning in rats","authors":"Aybuke Akkaya ,&nbsp;Deren Aykan ,&nbsp;Sinem Gencturk,&nbsp;Gunes Unal","doi":"10.1016/j.pbb.2025.174001","DOIUrl":"10.1016/j.pbb.2025.174001","url":null,"abstract":"<div><div>Environmental enrichment and social isolation constitute two well-studied experimental manipulations that result in several behavioral, neural, and molecular changes in rodents. Enrichment is linked to enhanced cognitive performance, and mitigation of different nervous system injuries and disorders. In contrast, social isolation or impoverished environment often induce negative effects on cognitive and affective systems. Both manipulations are typically examined with a short-term or chronic exposure, which cannot capture the actual human experiences. In this study, we explored the behavioral and neural alterations led by intermittent environmental enrichment or social isolation in adult Wistar rats. Animals were assigned to an enriched condition (EC), isolation/impoverished condition (IC), or standard condition (SC). The differential housing protocol involved transferring the animals to their respective cages for two days at the end of each five-day standard housing period for 8 weeks. Enriched animals exhibited behavioral despair in the forced swim test without differential overall locomotor activity. In the Morris water maze, impoverished animals displayed a slower learning rate compared to the SC and EC groups. In line with this, the IC group had fewer parvalbumin (PV) immunopositive (+) cells in the CA1 and dentate gyrus. No differences were observed in PV+ cell levels in the amygdala, while the IC group had more c-Fos+ cells in the same region following acute restraint stress. These findings implicate that intermittent isolation or enrichment are sufficient to trigger distinct behavioral changes at the cognitive and affective domains, and pinpoint PV as a biomarker for environmentally induced alterations in hippocampal memory performance.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"250 ","pages":"Article 174001"},"PeriodicalIF":3.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Operant effort-based decision-making task reveals sex differences in motivational behavior but no long-term effects of adolescent intermittent ethanol in Sprague Dawley rats","authors":"Anny Gano,&nbsp;Andrew S. Vore,&nbsp;Daniella Geraci,&nbsp;Elena I. Varlinskaya,&nbsp;Terrence Deak","doi":"10.1016/j.pbb.2025.173998","DOIUrl":"10.1016/j.pbb.2025.173998","url":null,"abstract":"<div><div>Loss of motivated behavior, or apathy, is a key feature across multiple affective disorders, and is assessed via operant effort-based decision-making (EBDM). The mechanisms of amotivation have been connected to pro-inflammatory signaling which can directly impact dopamine signaling. Chronic alcohol exposure is associated with altered immune signaling and impaired goal-directed behavior, so the present studies assessed the impact of adolescent intermittent ethanol (AIE) on EBDM in adulthood across sex. Adolescent male and female (<em>N</em> = 32/<em>n</em> = 8 per group) Sprague-Dawley rats were exposed to ethanol (4 g/kg) intragastrically on a 3 days on/2 days off schedule during postnatal days ~30–50 or given vehicle, and allowed to age into adulthood (P80+). All rats were then trained on the operant EBDM concurrent FR5/chow task, after which we tested the impact of sex and AIE history on responding 1) during breakpoint challenge raising the FR requirement in a log₂ pattern, 2) 90 min after immune challenge (2 μg/kg IL-1β), 3) 18 h after 3.5 g/kg intraperitoneal ethanol challenge (hangover), and 4) immediately after a 30-min restraint stress challenge. Immune challenge disrupted motivated behavior without affecting appetite. No effects of AIE emerged and sex differences were evident throughout all challenges. Females responded less for pellets yet persisted responding until a higher breakpoint. This work indicates that AIE does not alter baseline or evoked EBDM as can be measured with this approach. Testing across aging and using other modalities should be performed to continue examining the effects of chronic alcohol on apathy.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"250 ","pages":"Article 173998"},"PeriodicalIF":3.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-treatment with cannabidiol and escitalopram in ineffective doses induces antidepressant effect in maternally separated male adolescent rats","authors":"Jonasz Dragon,&nbsp;Miłosz Gołyszny,&nbsp;Ewa Obuchowicz","doi":"10.1016/j.pbb.2025.174000","DOIUrl":"10.1016/j.pbb.2025.174000","url":null,"abstract":"<div><div>Due to low efficacy and delayed therapeutic effect of drugs currently used in the therapy of depression in adolescent population, a lot of effort has been put into finding new substances using alternative target points that could support treatment with traditional antidepressive drugs. Cannabidiol, compound derived from <em>Cannabis sativa</em> may have therapeutic potential in depressive disorders. This study aimed to investigate whether combined administration of escitalopram with cannabidiol in ineffective doses, will provide better or similar effects in behavioral tests compared to escitalopram in an effective dose in adolescent maternally separated rats. Maternal separation has been used as a form of early life adversity. The pups were separated from their dams for 360 min daily from postnatal day (PND) 2 until PND 15. Later, escitalopram (15 or 5 mg/kg) or vehicle were administered ip. in a subacute manner in mid-adolescent male rats. Cannabidiol (15 mg/kg) or vehicle were injected ip. in a single dose about 1 h prior to behavioral assessment. Three standard behavioral tests were performed: the elevated plus maze and the open field test on PND 42 and the forced swimming test on PND 43–44 on the subsequent groups of rats. The combined treatment with escitalopram and cannabidiol in ineffective doses did not induce anxiolytic-like effects but successfully relieved despair behavior in the forced swimming test showing similar efficacy as treatment with escitalopram in effective dose. This result might be the basis for future research and the development of new therapeutic strategies for treatment of adolescent depression.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"250 ","pages":"Article 174000"},"PeriodicalIF":3.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melanin-concentrating hormone: A promising target for antidepressant treatment","authors":"Lingchang Shi ,&nbsp;Ying He ,&nbsp;Yujun Lian ,&nbsp;Jie Luo ,&nbsp;Xuan Zhu ,&nbsp;Hongqing Zhao","doi":"10.1016/j.pbb.2025.173999","DOIUrl":"10.1016/j.pbb.2025.173999","url":null,"abstract":"<div><div>Depression represents a complex neuropsychiatric disorder with an escalating global health burden, characterized by heterogeneous pathophysiology and profound impairments in cognitive-emotional functioning. Current treatment methods have limited efficacy in some individuals and may induce undesirable side effects, necessitating the exploration of novel therapeutic targets and techniques. Emerging research has identified neuropeptide systems as pivotal regulators of mood-related circuits, with melanin-concentrating hormone (MCH) signaling emerging as a particularly promising candidate for antidepressant development. The potential involvement of MCH in the pathophysiology of depression was first proposed over two decades ago. Since then, accumulating evidence from recent studies has progressively illuminated its multifaceted roles in modulating depressive behaviors and underlying neurobiological mechanisms. This review systematically analyzes the mechanistic interplay between MCH signaling and depression pathophenotypes, including its relationship with the hypothalamic-pituitary-adrenal (HPA) axis, neurotransmitter systems, synaptic plasticity, and the regulation of sleep-wakefulness. Particular emphasis is placed on advancing the therapeutic rationale for MCH receptor 1 (MCHR1) antagonists, which demonstrate rapid-onset antidepressant efficacy in preclinical studies compared to traditional agents. Nonetheless, the antidepressant mechanism of the MCH system still requires further elucidation to confirm its therapeutic potential.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"250 ","pages":"Article 173999"},"PeriodicalIF":3.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Divergent effects of noradrenergic activation and orexin receptor 1 blockade on hippocampal structure, anxiety-like behavior, and social interaction following chronic stress","authors":"Masoumeh Sarfi,&nbsp;Mahmoud Elahdadi Salmani,&nbsp;Taghi Lashkarbolouki,&nbsp;Iran Goudarzi","doi":"10.1016/j.pbb.2025.173997","DOIUrl":"10.1016/j.pbb.2025.173997","url":null,"abstract":"<div><div>Chronic stress (Ch.S) has detrimental effects on the brain's structure and function, particularly in the hippocampus. The noradrenergic and orexinergic systems play crucial roles in the stress response and regulation of stress-related behaviors. This study aimed to investigate the interaction between noradrenergic activation and orexin receptor 1 inhibition on chronic stress-induced hippocampal alterations.</div><div>The study conducted experiments on male Wistar rats, subjected to Ch.S, OXr1 blocking, noradrenergic activation, or a combination of these treatments. Plasma corticosterone level was measured using a fluorometric method. Behavioral assessment of social maze, elevated plus maze (EPM) and novel object recognition (NOR) test were performed. Then, the expression of prepro-orexin, OXr1, and glucocorticoid receptor (GR) was analyzed using semiquantitative RT-PCR. Neuronal populations were quantified through Nissl staining.</div><div>The data revealed that all stress and yohimbine groups had elevated plasma corticosterone levels. Ch.S significantly altered behavior, impairing social interaction, disrupting object recognition memory and increasing anxiety-like responses in the EPM. OXr1 blocking reversed these stress-induced behavioral deficits, while yohimbine did not improve these behavioral outcomes. Chronic stress led to a significant increase in prepro-orexin, OXr1, and GR expression. While blocking OXr1 helped counteract these stress-induced changes, yohimbine failed to restore the expression levels. Ch.S reduced hippocampal neuronal populations, while OXr1 blocking partially reversed this effect, and yohimbine further recovered the reversal.</div><div>These findings indicate that blocking hippocampal OXr1 can mitigate the adverse effects of chronic stress on both hippocampal structure and anxiety-like behaviors, while noradrenergic signaling appears to have differential effects on behavioral and cellular measures.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"250 ","pages":"Article 173997"},"PeriodicalIF":3.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous cocaine and ethanol self-administration promotes a sex-dimorphic pattern in drug-seeking behaviour and alters plasma amino acid profile related to glutamate homeostasis in young adult rats","authors":"Lucía Garrido-Matilla,&nbsp;Alberto Marcos,&nbsp;Natalia Puig-Martínez,&nbsp;Emilio Ambrosio","doi":"10.1016/j.pbb.2025.173988","DOIUrl":"10.1016/j.pbb.2025.173988","url":null,"abstract":"<div><div>The concurrent use of cocaine and alcohol is highly prevalent in Western countries and carries a substantial risk of relapse in recovering process. Craving, characterized as a strong desire for consuming drugs, is a core feature of cocaine and ethanol use disorders and presents a significant challenge to maintaining abstinence and preventing relapse. The primary objective of this study was to explore the behavioural patterns associated with the incubation of drug-seeking for a cocaine-ethanol combination and, secondarily, to examine the plasma amino acid profile that might be associated with this combination. To achieve this, we employed an extended-access intravenous self-administration model over 10 sessions with both substances, followed by withdrawal periods of 2 and 30 days in young adult rats in both sexes. After the subsequent drug-seeking test, changes in plasma amino acid concentrations were examined. Cocaine and ethanol co-administration resulted in a lower consumption rate among rats compared to those consuming cocaine alone. However, both groups exhibited incubation of drug-seeking behaviour. Sex differences were observed in self-administration patterns and in the incubation of drug-seeking behaviour. Notably, after 30 days of withdrawal, alterations were detected in plasma levels of several amino acids, including glutamine, glycine, serine, threonine, and glutamate, which are associated with glutamate homeostasis. This study aims to contribute to our understanding of potential changes in the plasma amino acid profile in cocaine users who also consume ethanol, particularly during abstinence and craving incubation.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"251 ","pages":"Article 173988"},"PeriodicalIF":3.3,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coadministration of scopolamine and mGlu2 receptor negative allosteric modulator VU6001966 as a potential therapeutic approach for depression: Rat frontal cortex neurochemistry and behavior","authors":"Yana Babii ,&nbsp;Agnieszka Pałucha-Poniewiera ,&nbsp;Krystyna Gołembiowska ,&nbsp;Agnieszka Bysiek ,&nbsp;Izabela Szpręgiel ,&nbsp;Andrzej Pilc","doi":"10.1016/j.pbb.2025.173996","DOIUrl":"10.1016/j.pbb.2025.173996","url":null,"abstract":"<div><div>Clinical studies provide evidence that scopolamine, a nonselective antagonist of muscarinic cholinergic receptors, exerts rapid and prolonged antidepressant effects. However, its use as a psychiatric drug has been limited due to its significant adverse effects. A therapeutic option that could help reduce the adverse effects of scopolamine is its coadministration at lower doses with other substances with similar antidepressant properties. To address this issue, we have investigated the effect of a single acute coadministration of scopolamine and a negative allosteric modulator of the mGlu2 receptor VU6001966 on rat behavior using a forced swim test (FST) and locomotor activity test. The effect of given compounds on the extracellular levels of neurotransmitters in the rat frontal cortex (FCX) was examined using microdialysis in freely moving rats. Both scopolamine and VU6001966 induced dose-dependent antidepressant-like effects in the FST test without affecting locomotor activity. Furthermore, VU6001966 enhanced extracellular dopamine and serotonin levels while lowering glutamate, without affecting GABA level. Both scopolamine alone or in combination with VU6001966 increased dopamine, serotonin, and glutamate levels in the FCX, without affecting GABA levels. Our results suggest that coadministration of scopolamine with mGlu2 NAM might be a promising alternative to using scopolamine alone in depression therapy, potentially allowing for a lower therapeutically effective dose. The common mechanism underlying the observed behavioral effects of the tested drugs may be associated with the modulation of the serotoninergic, glutamatergic, and dopaminergic systems.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"250 ","pages":"Article 173996"},"PeriodicalIF":3.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astrocyte gap junction dysfunction activates JAK2-STAT3 pathway to mediate inflammation in depression","authors":"Xue-Ying Yang ,&nbsp;Hui-Qin Wang ,&nbsp;Meng-Zhang ,&nbsp;Ai-Ping Chen ,&nbsp;Xin-Mu Li ,&nbsp;Zan Xing ,&nbsp;Hong Jiang ,&nbsp;Xu Yan ,&nbsp;Shi-Feng Chu ,&nbsp;Zhen-Zhen Wang ,&nbsp;Nai-Hong Chen","doi":"10.1016/j.pbb.2025.173987","DOIUrl":"10.1016/j.pbb.2025.173987","url":null,"abstract":"<div><div>Connexin 43 (Cx43) is highly expressed in astrocytes and forms gap junctions that maintain intercellular communication. Dysfunctional gap junctions in astrocytes exacerbate depressive symptoms, which has been implicated in the pathogenesis of depression. Inflammatory responses occur in the brains of most people with depression. However, it is unclear whether dysfunctional astrocyte gap junctions mediate the onset of the inflammatory response in the brains of depressed patients. Transporter protein (TSPO), the most common neuroinflammatory marker and a novel target of antidepressants identified in recent years, is mainly expressed by glial cells in the brain and is abnormally upregulated during inflammatory activation. We found that in a mouse model of chronic unpredictable stress (CUS), astrocyte gap junctions in the prefrontal cortex are impaired and the JAK2-STAT3 signaling pathway is activated, leading to an increase in the inflammatory marker TSPO. Based on this finding, we further verified using Cx43 transgenic mice that conditional knockdown of Cx43 in prefrontal cortex astrocytes also activated the JAK2-STAT3 inflammatory signaling pathway, with concomitant elevated levels of the inflammatory marker TSPO, and the mice developed depressive-like behavior. In contrast, impaired corticosterone (CORT)-induced gap junction function and increased TSPO were ameliorated by the JAK2-STAT3 inhibitor protosappanin A (PTA). Thus, targeting astrocyte Cx43 attenuates the inflammatory response in depression and improves depressive symptoms. This provides a new perspective on the pathogenesis of depression and a new therapeutic target for antidepressant research.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"252 ","pages":"Article 173987"},"PeriodicalIF":3.3,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardization of decision-making skills but persistent impulsivity after chronic stimulant exposure in ADHD patients","authors":"Francisco José Lobato-Camacho,&nbsp;Juan Pedro Vargas,&nbsp;Juan Carlos López","doi":"10.1016/j.pbb.2025.173986","DOIUrl":"10.1016/j.pbb.2025.173986","url":null,"abstract":"<div><div>Attention deficit hyperactivity disorder (ADHD) is commonly associated with deficits in executive function. Even though attention, hyperactivity, and impulsivity are the more distinctive symptoms, impairment in other cognitive processes, for instance memory, could be due to the interferences from these symptoms. However, it remains unclear whether information processing errors made by individuals with ADHD arise primarily from impulsive responding or reflect a more fundamental difference in how they process information, potentially due to compensatory mechanisms developed throughout childhood. This study analyzes pattern separation (distinguishing similar stimuli), recognition memory, decision-making, and impulsivity in both ADHD-diagnosed and non-diagnosed youth population. We further examined possible treatment effects by dividing the ADHD group into three cohorts based on stimulant medication duration. We evaluate their response latency and responses utilizing the signal detection theory method. While ADHD participants exhibited poorer recognition memory compared to controls, this pattern did not show a statistically significant difference in pattern separation. Additionally, both processes improved with longer treatment duration within the ADHD group, leading to decreased error commission. Decision-making analyses revealed sex-specific response strategies within the ADHD group, but both groups showed similar adjustment to task difficulty. However, the ADHD group responses were notably faster, associated with a higher error rate. Additionally, response times varied depending on the stimulus type, suggesting potential differences in how the ADHD group processed information compared to the control group. These findings collectively point towards a possible difference in information management in ADHD, that is also characterized by faster, but less accurate, processing.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"249 ","pages":"Article 173986"},"PeriodicalIF":3.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}