Pharmacology Biochemistry and Behavior最新文献

{"title":"Baseline-dependent enhancement of working memory by memantine in male rats: Involvement of NMDA receptor subunits and CaMKII signaling","authors":"Shuo-Fu Chen ,&nbsp;Wan-Ju Cheng ,&nbsp;Chih-Chang Chao ,&nbsp;Chun-Hsien Kuo ,&nbsp;Ruey-Ming Liao","doi":"10.1016/j.pbb.2024.173904","DOIUrl":"10.1016/j.pbb.2024.173904","url":null,"abstract":"<div><div><em>N</em>-methyl-<span>d</span>-aspartate (NMDA) receptors, activated by glutamate, play a crucial role in learning and memory. Memantine (MEM), a non-competitive NMDA receptor antagonist, is currently prescribed for the treatment of Alzheimer's disease or dementia, which meanwhile simultaneously promotes a need to clarify its potential pro-cognitive effects that exist in normal healthy individuals. However, the neurobehavioral mechanisms underlying the cognitive improvement by MEM in normal individuals remain to be elucidated. This study aimed to assess the effects of MEM on working memory, measured by a discrete paired-trial delay alternation task in a T-maze in normal male rats. The impacts of MEM were hypothesized to vary depending on different baseline levels of working memory performance. Neurochemical examination of the levels of calcium/calmodulin-dependent kinase 2 (CaMKII) and NMDA receptor subunits within five targeted brain regions was conducted after behavioral tests. The results showed that acute administration of MEM enhanced working memory performance, with 2.5, 5.0, and 10 mg/kg doses increasing task accuracy compared to the vehicle, particularly in low performers. Neurochemically, the protein expression of CaMKII in the amygdala and that of the glutamate (Glu) N2A subunit in the dorsal striatum were greater in the low-performance group than in the high-performance group. Additionally, the protein expression of the GluN2A subunit in the dorsal striatum was negatively associated with task performance at baseline. The expression of GluN1 and GluN2B in the nucleus accumbens was negatively associated with task performance in the retest three weeks after drug treatment. These findings underscore the baseline-dependent improvement of working memory resulting from MEM administration, with observed drug effects associated with alterations in the levels of NMDA receptor subunits in striatal subareas and CaMKII in the amygdala.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173904"},"PeriodicalIF":3.3,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANXIOLYTICS: Introduction to a special issue celebrating 50 years of Pharmacology, Biochemistry and Behavior","authors":"Jeffrey M. Witkin ,&nbsp;James E. Barrett","doi":"10.1016/j.pbb.2024.173905","DOIUrl":"10.1016/j.pbb.2024.173905","url":null,"abstract":"","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173905"},"PeriodicalIF":3.3,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal running training reversed postnatal anxiety and depressive-like behavior and cognitive impairment in mice following prenatal subchronic variable stress","authors":"Lin Zhou ,&nbsp;Zuotian Wu ,&nbsp;Yixin Li ,&nbsp;Ling Xiao ,&nbsp;Huiling Wang ,&nbsp;Gaohua Wang","doi":"10.1016/j.pbb.2024.173898","DOIUrl":"10.1016/j.pbb.2024.173898","url":null,"abstract":"<div><h3>Background</h3><div>Pregnancy is a very complex and highly stressful time in women. Despite the high prevalence of postpartum depression, more than 50 % of mothers are undiagnosed or untreated, showing an urgent need to explore an effective preventive strategy. Regular physical activity has been suggested to be associated with an increased quality of life in pregnant and postpartum women. The purpose of this study was to determine whether perinatal running training can affect maternal care stress-related anxiety, depressive-like behavior, and cognitive changes in postpartum dams and to explore the possible underlying mechanism.</div></div><div><h3>Methods</h3><div>40 female C57BL/6J mice were divided into four groups: prenatal control (NC) and running training (EX) group (NC+EX), prenatal control and nonrunning training (RE) group (NC+RE), prenatal subchronic variable stress (SCVS) and running training group (SCVS+EX) and prenatal SCVS and non-running training group (SCVS+RE). Mice in prenatal stress groups were subjected to SCVS after pregnancy confirmed. Mice in running training groups subjected to running training throughout pregnancy and lactation. Then after the delivery, maternal behavior, cognitive changes, anxiety and depressive-like behaviors were tested. Then we measured the serum prolactin (PRL), hypothalamic–pituitary adrenal (HPA) axis activity, and adult hippocampus neurogenesis (AHN) in dams.</div></div><div><h3>Results</h3><div>Compared to NC+RE, prenatal SCVS caused cognitive impairments, the decrease in maternal behavior, and anxiety and depressive-like behavior in SCVS+RE dams, accompanying increase in HPA axis activity and decreased the PRL levels and AHN in postpartum period. Then compared to SCVS+RE, perinatal running training mitigates cognitive impairments, increased maternal behavior, and alleviates anxiety and depressive-like behavior in SCVS+EX dams, accompanying the decreased HPA axis activity, and the increased PRL levels and AHN in postpartum period.</div></div><div><h3>Conclusion</h3><div>Overall, this study suggests that perinatal running training might improve maternal care and reverse prenatal stress-related cognitive impairment and anxiety and depressive-like behavior in postpartum dams.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173898"},"PeriodicalIF":3.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular signature underlying (R)-ketamine rapid antidepressant response on anhedonic-like behavior induced by sustained exposure to stress","authors":"Ellen Scotton ,&nbsp;Paola Rampelotto Ziani ,&nbsp;Renata Luiza Boff Wilges ,&nbsp;Pedro Henrique da Rosa Correa ,&nbsp;Lucas Azambuja Giordano ,&nbsp;Jéferson Ferraz Goularte ,&nbsp;Tainá Schons ,&nbsp;Felipe Borges Almeida ,&nbsp;Dirson João Stein ,&nbsp;Josimar Macedo de Castro ,&nbsp;Marco Antônio de Bastiani ,&nbsp;Eduardo Giovanni de Oliveira Soares ,&nbsp;Douglas Bernardo Paixão ,&nbsp;Caren Daniele Galeano da Silva ,&nbsp;Paulo Henrique Schneider ,&nbsp;Rafael Colombo ,&nbsp;Adriane R. Rosa","doi":"10.1016/j.pbb.2024.173882","DOIUrl":"10.1016/j.pbb.2024.173882","url":null,"abstract":"<div><div>Anhedonia induced by sustained stress exposure is a hallmark symptom of major depressive disorder (MDD) and in rodents, it can be accessed through the sucrose preference test (SPT). (<em>R</em>)-ketamine is a fast-acting antidepressant with less detrimental side effects and abuse liability compared to racemic ketamine. The present study combined high-throughput proteomics and network analysis to identify molecular mechanisms involved in chronic variable stress (CVS)-induced anhedonia and promising targets underlying (<em>R</em>)-ketamine rapid antidepressant response. Male Wistar rats were subjected to CVS for five weeks. Based on the SPT, animals were clustered into resilient or anhedonic-like (ANH) groups. ANH rats received a single dose of saline or (<em>R</em>)-ketamine (20 mg/kg, i.p.), which was proceeded by treatment response evaluation. After prefrontal cortex collection, proteomic analysis was performed to uncover the differentially expressed proteins (DEPs) related to both anhedonic-like behavior and pharmacological response. The behavioral assessment showed that the ANH animals had a significant decrease in SPT, and that (<em>R</em>)-ketamine responders showed a reversal of anhedonic-like behavior. On a molecular level, anhedonia-like behavior was associated with the downregulation of Neuronal Pentraxin Receptor (Nptxr) and Galectin−1 (Gal-1). These data reinforce a disruption in the inflammatory response, neurotransmitter receptor activity, and glutamatergic synapses in chronic stress-induced anhedonia. (<em>R</em>)-ketamine response-associated DEPs included novel potential targets involved in the modulation of oxidative stress, energetic metabolism, synaptogenesis, dendritic arborization, neuroinflammation, gene expression, and telomere length, converging to biological themes extensively documented in MDD physiopathology. Our data provide valuable insights into the molecular mechanisms underlying the response to (<em>R</em>)-ketamine and highlight these pathways as potential therapeutic targets for anhedonia. By addressing proteins involved in oxidative stress, energy metabolism, synaptogenesis, dendritic arborization, neuroinflammation, gene expression, and telomere length, we can target multiple key factors involved in the pathophysiology of MDD. Modulating these proteins could open avenues for novel therapeutic strategies and deepen our understanding of anhedonia, offering hope for improved outcomes in individuals facing this challenging condition. However, additional studies will be essential to validate these findings and further explore their therapeutic implications.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173882"},"PeriodicalIF":3.3,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal ingestion of cannabidiol (CBD) in mice leads to sex-dependent changes in memory, anxiety, and metabolism in the adult offspring, and causes a decrease in survival to weaning age.","authors":"Martina Krakora Compagno, Claudia Rose Silver, Alexis Cox-Holmes, Kari B Basso, Caroline Bishop, Amber Michal Bernstein, Aidan Carley, Joshua Cazorla, Jenna Claydon, Ashleigh Crane, Chloe Crespi, Emma Curley, Tyla Dolezel, Ezabelle Franck, Katie Heiden, Carley Marie Huffstetler, Ashley M Loeven, Camilla Ann May, Nicholas Maykut, Alejandro Narvarez, Franklin A Pacheco, Olivia Turner, Debra Ann Fadool","doi":"10.1016/j.pbb.2024.173902","DOIUrl":"10.1016/j.pbb.2024.173902","url":null,"abstract":"<p><strong>Rationale: </strong>The consequences of perinatal cannabidiol (CBD) exposure are severely understudied, but are important, given its widespread use and believed safety as a natural supplement.</p><p><strong>Objective: </strong>The objective of this study was to test the health, metabolic, and behavioral consequences of perinatal CBD exposure on dams and their offspring raised to adult.</p><p><strong>Methods: </strong>Primiparous female C57BL/6J mice were orally administered 100 mg/kg CBD in strawberry jam to expose offspring during gestation, lactation, or both using a cross-fostering design. Adult offspring were metabolically profiled using indirect calorimetry and intraperitoneal glucose tolerance testing. Adults were behaviorally phenotyped, video recorded, and mouse position tracked using DeepLabCut.</p><p><strong>Results: </strong>CBD was detected in maternal plasma using LC-MS 10-min post consumption (34.2 ± 1.7 ng/μl) and peaked within 30 min (371.0 ± 34.0 ng/μl). Fetal exposure to CBD significantly decreased survival of the pups, and decreased male postnatal development, but did not alter litter size, maternal body weight or pup birth weight. We observed many sex-dependent effects of perinatal CBD exposure. Exposure to CBD during gestation and lactation increased meal size, caloric intake, and respiratory exchange ratio for adult male offspring, while exposure during lactation decreased fasting glucose, but had no effect on clearance. Adult female offspring exposed to CBD during lactation showed increased drink size. Perinatal CBD exposure increased obsessive compulsive- and decreased anxiety-like behaviors (marble burying, light-dark box, elevated-plus maze) in female mice, decreased long-term object memory in male mice, and had no effect on attention tasks for either sex.</p><p><strong>Conclusions: </strong>We conclude that orally-administered CBD during pregnancy affects behavior and metabolism in a sex-dependent manner, and mice are differentially sensitive to exposure during gestation vs. lactation, or both. Because long-term changes are observed following perinatal exposure to the drug, and exposure significantly decreases survival to weaning, more research during development is warranted.</p>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":" ","pages":"173902"},"PeriodicalIF":3.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute stress induces different changes on the expression of CB1 receptors in the hippocampus of two lines of male rats differing in their response to stressors","authors":"Maria Pina Serra ,&nbsp;Marianna Boi ,&nbsp;Ylenia Lai ,&nbsp;Marcello Trucas ,&nbsp;Alberto Fernández-Teruel ,&nbsp;Maria Giuseppa Corda ,&nbsp;Osvaldo Giorgi ,&nbsp;Marina Quartu","doi":"10.1016/j.pbb.2024.173901","DOIUrl":"10.1016/j.pbb.2024.173901","url":null,"abstract":"<div><div>The stress-induced alterations in cognitive processes and psychiatric disorders can be accelerated when acute stressors challenge the hippocampal functions. To address this issue, we used Western Blot (WB) and immunohistochemistry assays to investigate the impact of acute forced swimming (FS) on the expression of the CB1 cannabinoid receptors (CB1R) in the hippocampus (HC) of the male outbred Roman High- (RHA) and Low-Avoidance (RLA) rat lines, one of the most validated genetic models for the study of behavior related to fear/anxiety and stress-induced depression.</div><div>The distinct responses to FS confirmed the different behavioral strategies displayed by the two phenotypes when exposed to stressors, with RLA and RHA rats displaying reactive vs. proactive coping, respectively. In control rats, the WB analysis showed lower hippocampal CB1R relative levels in RLA rats than in their RHA counterparts. After FS, RLA rats showed increased CB1R levels in the dorsal HC (dHC) vs. no change in the ventral HC (vHC), while RHA rats displayed no change in the dHC vs. a decrease in the vHC. In the tissue sections from dHC, FS elicited an increment over the control level of CB1R-like immunoreactivity (LI) in the CA1 and CA3 sectors of the Ammon's horn of RLA rats, while in RHA rats the density of CB1R-LI increased only in the CA1 sector. In tissue sections from the vHC, FS caused an increase over the control values of CB1R-LI only in the CA1 sector of RLA rats and a decrement of the CB1R-LI in the CA1 sector and dentate gyrus of control RHA rats.</div><div>This study shows for the first time that, in baseline conditions, the CB1Rs are present in the dHC and the vHC of the Roman rat lines with a different distribution along the septo-temporal extension of the HC and that the FS induces rapid and distinct changes in the hippocampal expression of CB1R of RLA vs. RLA rats, in keeping with the view that endocannabinoid signaling may contribute to the molecular mechanisms that regulate the different responses of the dHC vs. the vHC to aversive situations in male Roman rats. Our results also provide evidence supporting the involvement of CB1R in the molecular underpinnings of the susceptibility of RLA rats and the resistance of RHA rats to stress-induced depression-like behavior.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173901"},"PeriodicalIF":3.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting retrieval of methamphetamine reward memory in the context of REM sleep deprivation: Age-dependent role of GABAB receptors","authors":"Mehdi Khodamoradi ,&nbsp;Christian P. Müller ,&nbsp;Hamed Ghazvini ,&nbsp;Abolhassan Ghaderi ,&nbsp;Nasrin Abdoli ,&nbsp;Shahab Aldin Zarei","doi":"10.1016/j.pbb.2024.173900","DOIUrl":"10.1016/j.pbb.2024.173900","url":null,"abstract":"<div><div>GABA_B receptors play a modulatory role in the mechanisms underlying drug addiction, sleep problems, and aging; however, there are few studies addressing their relationships to each other. Therefore, this study aimed to examine whether blockade of these receptors affects methamphetamine (METH) reward memory in adult and adolescent rapid-eye movement sleep-deprived (RSD) rats. Adolescent and adult male Wistar rats were subjected to RSD for seven days. They were then conditioned to receive methamphetamine (METH; 2 mg/kg, ip) during an eight-day conditioning period. METH reward memory was then reactivated during a retrieval trial and the GABA_B receptor agonist baclofen (2.5 or 5 mg/kg, ip) was injected prior to the retrieval trial. Afterward, animals were retested for the expression of conditioned place preference (CPP) and hippocampal expression of GABA_B receptors. Baclofen dose-dependently decreased the retrieval of METH reward memory in control and RSD adult and adolescent rats, but its effects were stronger at the higher dose. Moreover, we found stronger effects of baclofen in adolescent animals than in adult ones. In addition, baclofen at its higher dose decreased GABA_B overexpression in the hippocampus of adolescent rats, but not in adult rats. These findings shed new light on the mechanisms underlying the role of GABA_B receptors in the retrieval of METH reward memory and highlight the importance of considering age and sleep problems in understanding addiction. Further research could potentially lead to the development of therapeutics for individuals struggling with METH addiction.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173900"},"PeriodicalIF":3.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonsedating anxiolytics","authors":"Rok Cerne ,&nbsp;Jodi L. Smith ,&nbsp;Aleksandra Chrzanowska ,&nbsp;Arnold Lippa","doi":"10.1016/j.pbb.2024.173895","DOIUrl":"10.1016/j.pbb.2024.173895","url":null,"abstract":"<div><div>Anxiety disorders are the most prevalent psychiatric pathology with substantial cost to society, but the existing treatments are often inadequate. This has rekindled the interest in the GABA_A-receptor (GABA_AR) positive allosteric modulator (PAM) compounds, which have a long history in treatment of anxiety beginning with diazepam, chlordiazepoxide, and alprazolam. While the GABA_AR PAMs possess remarkable anxiolytic efficacy, they have fallen out of favor due to a host of adverse effects including sedation, motor impairment, addictive potential and tolerance development. A substantial effort was thus devoted to the design of GABA_AR PAMs as anxiolytics with reduced sedative liabilities. Several non-benzodiazepine (BZD) GABA_APAMs progressed to clinical trials (bretazenil, abecarnil, alpidem, and ocinaplon) with alpidem obtaining regulatory approval as anxiolytic, but later withdrawn from market due to hepatotoxicity. Advances in molecular biology gave birth to a host of subtype selective GABA_AR-PAMs which suffered from signs of sedation and motor impairment and only three compounds progressed to proof-of-concept studies (TPA-023, AZD7325 and PF-06372865). TPA-023 was terminated due to toxicity in preclinical species while AZD7325 and PF-06372865 did not achieve efficacy endpoints in patients. We highlight a new compound, KRM-II-81, that is an imidazodiazepine selective for GABA_AR containing α2/3 and β3 proteins. In preclinical studies KRM-II-81 produced anxiolytic-like effects but with minimal sedation, respiratory depression, and abuse liability. Thus, KRM-II-81 is a newly discovered, non- BZD anxiolytic compound, which targets a selective population of GABA_AR for improved therapeutic gain and reduced side effects.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173895"},"PeriodicalIF":3.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroplasticity-related effects of vitamin D relevant to its neuroprotective effects: A narrative review","authors":"Bruna R. Kouba,&nbsp;Ana Lúcia S. Rodrigues","doi":"10.1016/j.pbb.2024.173899","DOIUrl":"10.1016/j.pbb.2024.173899","url":null,"abstract":"<div><div>The pathophysiology of a wide range of central nervous system (CNS) disorders, such as neurodegenerative and psychiatric diseases, has been associated with impairment of neurogenic and synaptogenic processes. Therefore, pharmacological and/or nutritional strategies based on the stimulation and/or restoration of these processes may have beneficial effects against diseases in which these processes are impaired. In this context, vitamin D has emerged as a promising neuroprotective compound. Due to its pleiotropic properties, it can interact with multiple molecular targets and thereby affect different cell types, including neurons and glial cells. This neurosteroid contributes to CNS homeostasis by non-genomic and genomic mechanisms through its interaction with vitamin D receptors (VDRs). Among several properties of this vitamin, its role in neuronal proliferation and differentiation as well as in synaptic plasticity has received attention. Considering this background, this narrative review aims to highlight the neuroplasticity-related mechanisms of vitamin D that may be associated with its neuroprotective effects.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173899"},"PeriodicalIF":3.3,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term administration of paroxetine increases cortical EEG beta and gamma band activities in healthy awake rats","authors":"Gökçer Eskikurt ,&nbsp;Bilge Özerman Edis ,&nbsp;Ali Umut Dalanay ,&nbsp;Ilknur Özen ,&nbsp;Asiye Nurten ,&nbsp;Ihsan Kara ,&nbsp;Sacit Karamürsel","doi":"10.1016/j.pbb.2024.173896","DOIUrl":"10.1016/j.pbb.2024.173896","url":null,"abstract":"<div><div>Understanding the electrophysiological properties of antidepressant medications is important to resolve the response heterogeneity of these drugs in clinical practice. Administration of paroxetine, a selective serotonin reuptake inhibitor, has been shown to increase serotonin levels that affect cortical activities in healthy subjects. However, the extent to which cortical oscillations can be altered by ongoing administration of paroxetine is not known. Here, we develop EEG biomarkers showing long-term effects of paroxetine. EEG changes were analyzed using Neuroscan in healthy wakeful rats administered paroxetine (4 mg/kg/day) for six weeks. Subsequent EEG recordings taken at 3 and 6 weeks after treatment showed differences in cortical oscillations obtained from both hemispheres and frontal-central-parietal regions. Chronic paroxetine administration resulted in an increase in gamma band activity. Comparison of EEG frequency bands of paroxetine and saline groups showed an enhancement in higher frequency activities at third weeks after the treatment. Higher activity of alpha oscillations in the temporal cortex was persistent at sixth week of the administration. Overall, our results suggest that chronic paroxetine administration affects cortical oscillations across an expansive network.</div></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"245 ","pages":"Article 173896"},"PeriodicalIF":3.3,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}