Pharmacology Biochemistry and Behavior最新文献

{"title":"Neuroimmune pathways as targets to reduce alcohol consumption","authors":"Emily K. Grantham, Riccardo Barchiesi, Nihal A. Salem, R. Dayne Mayfield","doi":"10.1016/j.pbb.2022.173491","DOIUrl":"10.1016/j.pbb.2022.173491","url":null,"abstract":"","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"222 ","pages":"Article 173491"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906983/pdf/nihms-1870333.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9453603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychopharmacology across the Lifespan","authors":"Diana Dow-Edwards , Annelyn Torres-Reveron","doi":"10.1016/j.pbb.2022.173494","DOIUrl":"10.1016/j.pbb.2022.173494","url":null,"abstract":"","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"222 ","pages":"Article 173494"},"PeriodicalIF":3.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10639129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobehavioral effects of environmental enrichment and drug abuse vulnerability: An updated review","authors":"Samantha G. Malone ,&nbsp;Jakob D. Shaykin ,&nbsp;Dustin J. Stairs ,&nbsp;Michael T. Bardo","doi":"10.1016/j.pbb.2022.173471","DOIUrl":"10.1016/j.pbb.2022.173471","url":null,"abstract":"<div><p><span><span>Environmental enrichment consisting of social peers and novel objects is known to alter neurobiological functioning and have an influence on the behavioral effects of drugs of abuse in preclinical rodent models. An earlier review from our laboratory (Stairs and Bardo, 2009) provided an overview of enrichment-specific changes in addiction-like behaviors and </span>neurobiology. The current review updates the literature in this extensive field. Key findings from this updated review indicate that enrichment produces positive outcomes in drug abuse vulnerability beyond just </span>psychostimulants<span>. Additionally, recent studies indicate that enrichment activates key genes involved in cell proliferation<span><span><span> and protein synthesis in </span>nucleus accumbens<span> and enhances growth factors in hippocampus<span> and neurotransmitter </span></span></span>signaling pathways<span> in prefrontal cortex, amygdala, and hypothalamus. Remaining gaps in the literature and future directions for environmental enrichment and drug abuse research are identified.</span></span></span></p></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"221 ","pages":"Article 173471"},"PeriodicalIF":3.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9474874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of interaction of mGlu2 and 5-HT2A receptors in antipsychotic effects","authors":"Daisuke Ibi","doi":"10.1016/j.pbb.2022.173474","DOIUrl":"10.1016/j.pbb.2022.173474","url":null,"abstract":"<div><p><span>The serotonergic<span><span><span> and glutamatergic<span> neurotransmitter systems have been implicated in the </span></span>pathophysiology of </span>schizophrenia, and increasing evidence shows that they interact functionally. Of note, the G</span></span>_q/11-coupled serotonin 5-HT_2A (5-HT_2A) and the G_i/o<span>-coupled metabotropic glutamate type 2 (mGlu2) receptors have been demonstrated to assemble into a functional heteromeric complex that modulates the function of each individual receptor.</span></p><p>For conformation of the heteromeric complex, corresponding transmembrane-4 segment of 5-HT_2A and mGlu2 are required. The 5-HT_2A/mGlu2 heteromeric complex is necessary for the activation of G_q/11 proteins and for the subsequent increase in the levels of the intracellular messenger Ca²⁺<span>. Furthermore, signaling via the heteromeric complex is dysregulated in the post-mortem brains of patients with schizophrenia, and could be linked to altered cortical function. From a behavioral perspective, this complex contributes to the hallucinatory and antipsychotic<span> behaviors associated with 5-HT</span></span>_2A<span> and mGlu2/3 agonists, respectively. Synaptic and epigenetic mechanisms have also been found to be significantly associated with the mGlu2/5-HT</span>_2A heteromeric complex. This review summarizes the role of crosstalk between mGlu2 and 5-HT_2A in the mechanism of antipsychotic effects and introduces recent key advancements on this topic.</p></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"221 ","pages":"Article 173474"},"PeriodicalIF":3.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10671953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substance use disorders and social determinants of health from electronic medical records obtained during Kentucky's “triple wave”","authors":"Chris Delcher ,&nbsp;Daniel R. Harris ,&nbsp;Nicholas Anthony ,&nbsp;William W. Stoops ,&nbsp;Katherine Thompson ,&nbsp;Dana Quesinberry","doi":"10.1016/j.pbb.2022.173495","DOIUrl":"10.1016/j.pbb.2022.173495","url":null,"abstract":"<div><p><span><span>Social determinants of health (SDOH) play a critical role in the risk of harmful drug use. Examining SDOH as a means of differentiating populations with multiple co-occurring substance use disorders (SUDs) is particularly salient in the era of prevalent opioid and stimulant use known as the “Third Wave”. This study uses </span>electronic medical records (EMRs) from a safety net hospital system from 14,032 patients in Kentucky from 2017 to 2019 in order to 1) define three types of SUD cohorts with shared/unique risk factors, 2) identify patients with unstable housing using novel methods for EMRs and 3) link patients to their residential neighborhood to obtain quantitative perspective on social vulnerability. We identified patients in three cohorts with statistically significant unique risk factors that included race, biological sex, insurance type, smoking status, and urban/rural residential location. Adjusting for these variables, we found a statistically significant, increasing risk gradient for patients experiencing unstable housing by cohort type: opioid-only (</span><em>n</em> = 7385, reference), stimulant-only (<em>n</em> = 4794, odds ratio (aOR) 1.86 95 % confidence interval (CI): 1.66–2.09), and co-diagnosed (<em>n</em> = 1853, aOR = 2.75, 95 % CI: 2.39 to 3.16). At the neighborhood-level, we used 8 different measures of social vulnerability and found that, for the most part, increasing proportions of patients with stimulant use living in a census tract was associated with more social vulnerability. Our study identifies potentially modifiable factors that can be tailored by substance type and demonstrates robust use of EMRs to meet national goals of enhancing research on social determinants of health.</p></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"221 ","pages":"Article 173495"},"PeriodicalIF":3.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9332459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time course of plasticity-related alterations following the first exposure to amphetamine in juvenile rats","authors":"Andrey Sequeira-Cordero ,&nbsp;Juan C. Brenes","doi":"10.1016/j.pbb.2022.173489","DOIUrl":"10.1016/j.pbb.2022.173489","url":null,"abstract":"<div><p><span>In vulnerable consumers, the first drug exposure induces various neurobehavioral adaptations that may represent the starting point toward addiction. Elucidating the neuroplastic mechanisms underlying that first rewarding experience would contribute to understanding the transition from recreational to compulsive drug use. In a preclinical model with juvenile rats<span>, we analyzed the time-dependent fluctuations in the expression of neuroplasticity-related genes like the brain-derived neurotrophic factor (BDNF), its tropomyosin<span><span> receptor kinase B (TrkB), the cAMP response element-binding protein (CREB), the microRNA-132, the Rho GTPase-activating protein 32 (p250GAP), the corticotropin-releasing factor (CRF), and the neurotransmitters contents in the </span>nucleus accumbens (NAc) and the </span></span></span>dorsal striatum<span> (DS) 45, 90, and 180 min after an amphetamine (AMPH) injection. As expected, AMPH altered the concentration of norepinephrine<span>, dopamine, DOPAC, and serotonin in a region- and time-dependent manner. Regarding gene expression, AMPH at 45 min upregulated BDNF and primiR-132 expression in NAc and downregulated TrkB expression in DS. At 90 min, AMPH upregulated TrkB, CREB, p250GAP, and primiR-132 expression in NAc and BDNF, primiR-132, and CRF in DS. At 180 min, only BNDF in NAc continued to be upregulated by AMPH. Based on the levels of AMPH-induced hyperactivity, we classified the rats as low and high AMPH responders. High AMPH responders characterized by overexpressing BDNF, CREB, p250GAP, and CRF in NAc and by showing lower levels of dopamine and serotonin metabolites and turnovers in both regions. Our findings demonstrated that a single AMPH administration is enough to induce neuroplastic adaptations, especially in the NAc of prone rats.</span></span></p></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"221 ","pages":"Article 173489"},"PeriodicalIF":3.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10689406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energy drinks and alcohol in a binge drinking protocol in Wistar rats: Male and female behavioral and reproductive effects","authors":"Marina Tuerlinckx Costa-Valle ,&nbsp;Juliana Fank Gomes ,&nbsp;Caroline Rodrigues De Oliveira ,&nbsp;Andressa Scherer ,&nbsp;Sarah Carobini Werner de Souza Eller Franco De Oliveira ,&nbsp;Rafaella Câmara Rocha Menezes ,&nbsp;Mirna Bainy Leal ,&nbsp;Pedro Roosevelt Torres Romão ,&nbsp;Eliane Dallegrave","doi":"10.1016/j.pbb.2022.173487","DOIUrl":"10.1016/j.pbb.2022.173487","url":null,"abstract":"<div><p><span>The consumption of energy drinks is common among adolescents and young adults. The possible effects (mainly behavioral and reproductive) of ingestion<span> in this population remain unknown. For this reason, this study aimed to evaluate the behavioral and reproductive effects of energy drinks and their main constituents (caffeine and taurine), as well as their combinations with alcohol, via a binge drinking protocol in male and female Wistar rats during puberty. In this study, 100 male and 100 </span></span>female rats<span> were treated with a binge drinking protocol 3 days a week over 4 weeks from postnatal day (PND) 28 to PND 60, which included 10 mL/kg by oral gavage of distilled water, energy drink, caffeine (3.2 mg/kg), taurine (40 mg/kg), and their combinations with alcohol (2 g/kg). The animals were evaluated by behavioral tests from PND 56 to PND 60 (open field, plus maze and object recognition) and reproductive parameters (estrous cycle regularity, weight of sexual organs, oocyte quality, spermatid and sperm count, sperm morphology and testosterone level). Locomotor activity was increased in females in the groups combined with alcohol (except alcohol + caffeine) and in the caffeine group. Long-term memory was increased in males in the caffeine and taurine groups even when combined with alcohol. The combination of energy drinks and alcohol did not have significant effects on the reproductive parameters of either sex of rats during puberty. We concluded that energy drinks (and their main constituents) and alcohol combinations did not cause alterations in reproductive profiles, and locomotor activity and long-term memory were increased in females and males, respectively.</span></p></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"221 ","pages":"Article 173487"},"PeriodicalIF":3.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10317753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The α2C-adrenoceptor antagonist JP-1302 controls behavioral parameters, tyrosine hydroxylase activity and receptor expression in a rat model of ketamine-induced schizophrenia-like deficits","authors":"Nurdan Tekin ,&nbsp;Tuğba Eryiğit Karamahmutoğlu ,&nbsp;Aslı Aykaç ,&nbsp;Dilek Akakın ,&nbsp;Mehmet Zafer Gören","doi":"10.1016/j.pbb.2022.173490","DOIUrl":"10.1016/j.pbb.2022.173490","url":null,"abstract":"<div><p><span><span>Schizophrenia is a chronic disabling disease affecting 1 % of the population. Current </span>antipsychotics have limited efficacy in mitigating the severity of the symptoms of the disease. Therefore, searching for new therapeutic targets is essential. Previous studies have shown that α</span>_2C-adrenoceptor antagonists may have antipsychotic and pro-cognitive effects. Therefore, the current study evaluates the behavioral and neurochemical effects of JP-1302, a selective α_2C<span>-adrenoceptor antagonist, in a model of schizophrenia-like deficits induced by sub-chronic ketamine (KET) administration.</span></p><p><span><span>Here, we administered ketamine (25 mg/kg, i.p.) to male and female Wistar rats<span> for eight consecutive days. On the last two days of ketamine administration, rats were pretreated with either JP-1302 (1-3-10 μmol/kg, i.p.), chlorpromazine (0.1 mg/kg, i.p.), or saline, and the behavioral tests were performed. Behaviors related to positive (locomotor activity), negative (social interaction), and cognitive (novel object recognition) symptoms of schizophrenia were assessed. </span></span>Glutamate, glutamine, GABA levels, and α</span>_2C<span><span>-adrenoceptor expression were measured in the frontal cortex and the hippocampus. </span>Tyrosine hydroxylase immunocytochemical reactivity was also shown in the midbrain regions.</span></p><p><span><span>Sub-chronic ketamine administration increased locomotor activity and produced robust social interaction and object recognition deficits, and JP-1302 significantly ameliorated ketamine-induced </span>cognitive deficits. Ketamine induced a hyperdopaminergic activity in the striatum, which was reversed by the treatment with JP-1302. Also, the α</span>_2C-adrenoceptor expression was higher in the frontal cortex and hippocampus in the ketamine-treated rats.</p><p>Our findings confirm that α_2C-adrenoceptor antagonism may be a potential drug target for treating cognitive disorders related to schizophrenia.</p></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"221 ","pages":"Article 173490"},"PeriodicalIF":3.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10323454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of the endocannabinoid system and the therapeutic action of cannabinoids in autism spectrum disorder: A literature review","authors":"Rick Wilhiam de Camargo,&nbsp;Linério Ribeiro de Novais Júnior,&nbsp;Larissa Mendes da Silva,&nbsp;Vicente Meneguzzo,&nbsp;Guilherme Cabreira Daros,&nbsp;Marina Goulart da Silva,&nbsp;Rafael Mariano de Bitencourt","doi":"10.1016/j.pbb.2022.173492","DOIUrl":"10.1016/j.pbb.2022.173492","url":null,"abstract":"<div><p><span><span><span>Autism spectrum disorder (ASD) is a </span>neurodevelopmental disorder, onset in early childhood and associated with cognitive, social, behavioral, and sensory impairments. The </span>pathophysiology<span> is still unclear, and it is believed that genetic<span> and environmental factors are fully capable of influencing ASD, especially cell signaling<span> and microglial functions. Furthermore, the endocannabinoid system (ECS) participates in the modulation of various brain processes and is also involved in the pathophysiological mechanisms of this condition. Due to the health and quality of life impacts of autism for the patient and his/her family and the lack of effective medications, the literature has elucidated the possibility that </span></span></span></span><em>Cannabis</em><span><span><span><span> phytocannabinoids act favorably on ASD symptoms, probably through the modulation of neurotransmitters, in addition to endogenous ligands derived from </span>arachidonic acid, metabolizing </span>enzymes and even transporters of the membrane. These findings support the notion that there are links between key features of ASD and ECS due to the favorable actions of </span>cannabidiol<span> (CBD) and other cannabinoids<span> on symptoms related to behavioral and cognitive disorders, as well as deficits in communication and social interaction, hyperactivity, anxiety and sleep disorders. Thus, phytocannabinoids emerge as therapeutic alternatives for ASD.</span></span></span></p></div>","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"221 ","pages":"Article 173492"},"PeriodicalIF":3.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10323457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical opinions for new fiber photometry users to obtain rigorous recordings and avoid pitfalls","authors":"Jennifer Mejaes ,&nbsp;Dhruvi Desai ,&nbsp;Cody A. Siciliano ,&nbsp;David J. Barker","doi":"10.1016/j.pbb.2022.173488","DOIUrl":"10.1016/j.pbb.2022.173488","url":null,"abstract":"","PeriodicalId":19893,"journal":{"name":"Pharmacology Biochemistry and Behavior","volume":"221 ","pages":"Article 173488"},"PeriodicalIF":3.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10680653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}