Pediatric Infectious Disease Journal最新文献

{"title":"Cytomegalovirus DNAemia After Pediatric Liver Transplantation: Clinical Characteristics, Risk Factors, and Outcomes.","authors":"Gül Arga, Zarife Kuloglu, Elif Somuncu, Ceyda Tuna Kirsaçlioğlu, Halil Özdemir, Arzu Meltem Demir, Hülya Akat, Kübra Arslan, Serpil Özdemir, İlkin Elif Günel Karaburun, Merve Havan, Meltem Koloğlu, Elvan Onur Kirimker, Tanil Kendirli, Aydan Kansu, Ergin Çiftçi","doi":"10.1097/INF.0000000000005424","DOIUrl":"https://doi.org/10.1097/INF.0000000000005424","url":null,"abstract":"<p><strong>Background: </strong>Cytomegalovirus (CMV) remains a frequent infectious complication after pediatric liver transplantation despite antiviral prophylaxis. However, the clinical significance of CMV DNAemia and predictors of treatment-requiring CMV DNAemia remain incompletely defined. We evaluated the epidemiology, timing, clinical characteristics and predictors of CMV DNAemia in pediatric liver transplant recipients managed with a hybrid prevention strategy.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of consecutive pediatric liver transplant recipients who underwent transplantation between 2014 and 2025 at a tertiary center. CMV DNAemia was identified through routine quantitative polymerase chain reaction surveillance during antiviral prophylaxis and the subsequent preemptive monitoring period. Treatment-requiring CMV DNAemia was defined as CMV DNAemia prompting antiviral therapy based on viral load kinetics, absolute viral load and accompanying clinical findings. Demographic, transplant-related, clinical and virological factors were analyzed.</p><p><strong>Results: </strong>Fifty-one recipients were included. CMV DNAemia developed in 35 recipients (68.6%), accounting for 77 episodes. Breakthrough CMV DNAemia occurred in 22 recipients (62.8%), whereas 13 developed CMV DNAemia only after prophylaxis discontinuation. Twenty-eight episodes occurred during prophylaxis, but only 7 (25.0%) required treatment. Overall, 15 recipients experienced 25 treatment-requiring episodes, representing 32.5% of all CMV DNAemia episodes; 72% occurred after prophylaxis discontinuation. No patient developed tissue-invasive CMV disease. Younger age at transplantation (OR: 0.979; 95% CI: 0.963-0.995; P = 0.013) and pretransplant intensive care unit requirement (OR: 7.75; 95% CI: 1.44-41.84; P = 0.017) independently predicted treatment-requiring CMV DNAemia. An age threshold of ≤26 months showed acceptable discrimination (area under the curve, 0.773) and was associated with lower CMV-free survival (P < 0.001).</p><p><strong>Conclusions: </strong>CMV DNAemia was common, but only one-third of episodes required antiviral treatment, and no tissue-invasive disease occurred. Younger recipients and those requiring pretransplant intensive care were at increased risk for clinically significant CMV infection. CMV DNAemia alone should not be considered a surrogate for clinically significant infection, supporting individualized, risk-adapted surveillance and prevention in pediatric liver transplant recipients.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149113444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive Haemophilus Influenzae Infection in Children: Clinical Characteristics, Serotypes and Outcome: A Multicenter Study in Oman.","authors":"Anood AlRawahi, Laila Al Yazidi, Azza Al Rashdi, Mohammed Al Reesi, Khalfan Al Abdali, Hadeel Al Amri, Nuha Altahir, Raya Al Habsi, Zahra Al Nadhairi, Hilal Al Sidari, Amina Al Jardani, Sara Al-Sumri, Noora Al Bulushi, Zakariya Al Mahrami, Moza Al Mamari, Badria AlWaili","doi":"10.1097/INF.0000000000005431","DOIUrl":"https://doi.org/10.1097/INF.0000000000005431","url":null,"abstract":"<p><strong>Background: </strong>Haemophilus influenzae remains an important cause of invasive bacterial infections in children despite widespread vaccination against H. influenzae type b (Hib). In recent years, changes in epidemiology and the emergence of non-Hib serotypes have been increasingly reported worldwide. This study aimed to describe the epidemiology, serotype distribution, clinical characteristics and outcomes of invasive H. influenzae infections among children in Oman.</p><p><strong>Methods: </strong>We conducted a multicenter retrospective study across 5 tertiary and secondary hospitals in Oman between January 2010 and June 2024. Children younger than 13 years with microbiologically confirmed invasive H. influenzae infection from sterile body sites (including cerebrospinal fluid, blood, pleural fluid, peritoneal fluid or synovial fluid) were included. Demographic, clinical, microbiological, vaccination and outcome data were extracted from electronic medical records. Incidence trends, serotype distribution and clinical outcomes were analyzed.</p><p><strong>Results: </strong>A total of 142 children with invasive H. influenzae infection were identified. The median age was 12 months, and infants under 1 year accounted for 45.1% of cases. Males represented 62.7% of patients. The most common clinical presentations were bacteremia (51.4%), meningitis (22.5%) and pneumonia (11.9%). The incidence increased significantly from 0.60 per 100,000 children in 2017 to 2.43 per 100,000 in 2023 (rate ratio 4.05, P = 0.016). Among typed isolates, serotype b was the most frequent (29.6%), followed by nontypeable strains (17.6%) and serotype a (16.9%). Neurological complications occurred in 53.1% of meningitis cases, and seizures at presentation were significantly associated with poor neurologic outcomes (P = 0.0066). Most children had received 3 doses of Hib-containing vaccine. Overall outcomes were favorable, with 89.4% recovering without sequelae.</p><p><strong>Conclusion: </strong>Invasive H. influenzae infection continues to affect children in Oman despite high vaccination coverage. The observed postpandemic increase and the presence of non-b serotypes highlight the need for ongoing surveillance, improved serotyping capacity and evaluation of vaccination strategies to mitigate future disease burden.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149113501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ceftaroline Diffusion Into Cerebrospinal Fluid of Children With Ventriculitis Due to Ventriculoperitoneal Shunt Infection.","authors":"Nahed Abdel-Haq, Jamal Ameli, Ronald L Thomas, Basim I Asmar","doi":"10.1097/INF.0000000000005432","DOIUrl":"https://doi.org/10.1097/INF.0000000000005432","url":null,"abstract":"<p><strong>Background: </strong>Data on ceftaroline cerebrospinal fluid (CSF) levels in children are limited. This study examined ceftaroline diffusion into CSF among children with ventriculoperitoneal shunt (VPS)-related ventriculitis and external ventricular drains.</p><p><strong>Methods: </strong>Patients received a single dose of 15 mg/kg of iv ceftaroline (maximum 600 mg) over 2 hours. Simultaneous plasma and CSF samples were obtained at 3 time points to measure ceftaroline concentration: end of infusion (0 hours), and 2 and 6 hours postinfusion. The areas under the curve (AUCs) for plasma and CSF were calculated using linear interpolation of concentrations at time intervals. The CSF diffusion ratio was measured as AUCCSF/AUCplasma. Clinical and laboratory data were reviewed.</p><p><strong>Results: </strong>Eight children (7 months-16 years; median, 9 years) were included. CSF cultures yielded staphylococcal species in 6 patients. Inflammation was defined by grossly abnormal CSF parameters and/or a C-reactive protein ≥30 mg/L. Among the 5 children meeting these criteria and with complete CSF sampling at 3 time points, the ceftaroline CSF diffusion ratio (0-6 hours) ranged from 1.96% to 35.39%, and the 0-2-hour diffusion ratio ranged from 1.47% to 21.11%. In contrast, the 2 patients with minimal inflammation and concentrations available at 2 time points demonstrated substantially lower 0-2-hour CSF diffusion ratios (0.68% and 0.61%).</p><p><strong>Conclusions: </strong>Ceftaroline CSF diffusion in children with VPS-related ventriculitis is variable and correlates with markers of meningeal inflammation. Prospective studies are needed to evaluate the use of ceftaroline in children with VPS infections.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149113479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Seroprevalence of Q Fever Antibodies to Coxiella burnetii in Children and Adolescents : A Systematic Review and Meta-analysis.","authors":"Suzy M Teutsch, Guy D Eslick, Carlos Nunez, Gulam Khandaker, Elizabeth J Elliott","doi":"10.1097/INF.0000000000005284","DOIUrl":"10.1097/INF.0000000000005284","url":null,"abstract":"<p><strong>Objective: </strong>To comprehensively determine global estimates of Q fever seroprevalence in children and adolescents by conducting a systematic review and meta-analysis.</p><p><strong>Data sources: </strong>Searches of published articles in MEDLINE, Embase and Scopus databases were conducted from inception until February 2025.</p><p><strong>Study selection: </strong>Cross-sectional studies reporting seroprevalence of Q fever/ Coxiella burnetii antibodies, using any established laboratory test, in any population of healthy children and adolescents <20 years old were included. The quality of eligible articles was assessed using a modified Newcastle-Ottawa Scale.</p><p><strong>Data extraction: </strong>Data from eligible articles were extracted using a standardized form, which included year of publication, year(s) the study was conducted, numbers of antibody-positive cases/specific population, age, country, geographic region, serology test used and antibody titer cutoff value.</p><p><strong>Data synthesis: </strong>DerSimonian and Laird random effects models were used to calculate pooled seroprevalence estimates and 95% confidence intervals in data from 41 eligible articles reporting 42 studies comprising 9841 children and adolescents. Q fever seroprevalence was observed in multiple countries across 7 geographic regions, and varied markedly between countries and regions, with the highest estimate observed by an individual country in Ethiopia (45%) and by region in the Middle East (14%). Seroprevalence estimates were higher in older children and adolescents ≥10 years (15%) compared with younger children <10 years of age (8%).</p><p><strong>Conclusion: </strong>Despite varying geographical prevalence, our findings demonstrate that widespread exposure to Q fever antigens occurs across multiple global regions in children and adolescents to potentially serious C. burnetii infection, indicating that diagnostic surveillance and preventive measures should be considered in both endemic and previously unreported areas.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":"e396-e405"},"PeriodicalIF":2.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infliximab in a Child With Relapsing Tuberculous Meningoencephalitis: A Case Report and Literature Review.","authors":"Chiara Barone, Martina Capitani, Beatrice Fresch, Chiara Veredice, Marco Piastra, Paolo Frassanito, Roberta Onesimo, Danilo Buonsenso","doi":"10.1097/INF.0000000000005253","DOIUrl":"10.1097/INF.0000000000005253","url":null,"abstract":"<p><p>A 5-year-old child with tuberculous meningoencephalitis developed severe drug-induced hepatitis after conventional antitubercular therapy. Consequently, standard treatment was discontinued, and second-line drugs were administered in combination with high-dose corticosteroids. However, the disease continued to progress significantly. The introduction of infliximab resulted in substantial clinical and radiologic improvement, highlighting its potential role in managing refractory cases of central nervous system tuberculosis.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":"894-898"},"PeriodicalIF":2.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in Seasonality of Kawasaki Disease After the COVID-19 Pandemic: A 10-Year Survey in Shiga, Japan (2015-2024).","authors":"Shinsuke Hoshino, Jun Matsubayashi, Yoshihide Shibata, Hiromichi Hamada, Ryusuke Ae","doi":"10.1097/INF.0000000000005228","DOIUrl":"10.1097/INF.0000000000005228","url":null,"abstract":"<p><strong>Background: </strong>During the coronavirus disease 2019 (COVID-19) pandemic, the seasonality of Kawasaki disease (KD) in Japan shifted from winter dominance to summer dominance. However, it remains unclear whether this pattern reverted after infection mitigation measures were lifted in 2023.</p><p><strong>Methods: </strong>We conducted a population-based retrospective survey among all hospitalized patients with KD in Shiga Prefecture, Japan, from 2015 to 2024. Monthly variations in the KD incidence from 2021 to 2024 were analyzed using the 2015-2019 period as reference. We also examined the seasonality of 10 common pediatric infectious diseases and seasonal influenza during the study period.</p><p><strong>Results: </strong>A total of 2077 patients with KD were identified. The KD incidence remained low during the implementation of public health measures against COVID-19 from 2020 to 2022. Subsequently, the incidence reached the maximum in 2023 (128.2 per 100,000 person-years), coinciding with the lifting of infection mitigation measures; the incidence remained high at 118.9 in 2024. The traditional winter peak in KD incidence disappeared after 2020. Instead, peak incidence was observed in the summer from 2021 to 2022 and in the spring from 2023 to 2024. The number of patients with respiratory syncytial virus infection, which had been highest during the fall and winter from 2015 to 2019, reached the highest levels during the spring and summer from 2021 onward.</p><p><strong>Conclusions: </strong>KD seasonality in Shiga Prefecture did not revert to the traditional winter-dominant pattern after COVID-19 infection mitigation measures were lifted. Continued surveillance is warranted to determine whether the winter-dominant pattern re-emerges.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":"872-878"},"PeriodicalIF":2.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Panton-Valentine Leukocidin Producing Staphylococcus aureus Causing Acute Hematogenous Osteomyelitis in the Pediatric Population : Implications on Clinical Course and Outcome.","authors":"Marí Thiart, Pieter Nel, Mae Newton-Foot, Ruvarashe Makova, Jacques du Toit, Marilize Burger, Nando Ferreira","doi":"10.1097/INF.0000000000005233","DOIUrl":"10.1097/INF.0000000000005233","url":null,"abstract":"<p><strong>Background: </strong>Panton-Valentine leukocidin (PVL) is a necrotizing cytotoxin that is produced by certain strains of Staphylococcus aureus , causing acute hematogenous osteomyelitis (AHOM). The PVL-positive strains are particularly virulent in the pediatric population, causing profound inflammatory responses. This study aimed to investigate whether the presence of PVL-producing S. aureus altered the clinical course of pediatric patients presenting with AHOM.</p><p><strong>Methods: </strong>This prospective descriptive study included all patients 16 years old or younger who presented to our institution with AHOM caused by S. aureus from September 2021 to September 2024. Patient demographics, clinical presentation and laboratory results, extent of the bone involvement, extraosseous involvement, and management were all recorded. Routinely collected samples were stored and tested in batches for PVL and specific clonal clusters.</p><p><strong>Results: </strong>Seventy-four patients were included in the study period. Seventy-two of 74 (97.3%) isolates tested positive for PVL. Twenty-three (31.10%) patients experienced a severe clinical course. Many patients required 3 or more surgical debridements. No association between PVL-positive S. aureus infection or specific spa -clonal clusters and experiencing a severe clinical course was observed.</p><p><strong>Conclusions: </strong>Despite almost a third of the study participants having a severe clinical course of disease, 97.3% of the patients tested positive for a PVL-producing S. aureus strain, suggesting that having a severe clinical course ismultifactorial. Given the high number of PVL-positive cases, we postulate that these bacteria cause AHOM with subperiosteal abscess formation requiring surgical drainage in our population.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":"846-852"},"PeriodicalIF":2.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remdesivir and Nitazoxanide for Chronic Norovirus Type 1 Infection in a Child Post-cardiac Transplantation.","authors":"Fabian J S van der Velden, Clive Graham, Glyn Jones, Khuen Foong Ng, Zdenka Reinhardt, Shirelle Burton-Fanning, Judith Breuer, Marieke Emonts","doi":"10.1097/INF.0000000000005246","DOIUrl":"10.1097/INF.0000000000005246","url":null,"abstract":"","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":"e430-e432"},"PeriodicalIF":2.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time, Space and Sociodemographic Factors Related to Neonatal Healthcare-associated Infection Rates in Brazil.","authors":"Ludmila Gerios, Lucas Martins Liporaci, Geraldine Madalosso, Denise Brandão de Assis, Cassiano Victoria, Maria Regina Bentlin, Carlos Magno Castelo Branco Fortaleza","doi":"10.1097/INF.0000000000005275","DOIUrl":"10.1097/INF.0000000000005275","url":null,"abstract":"<p><strong>Background: </strong>Healthcare-associated infections (HAI) are a limiting factor for survival of high-risk newborns, especially in low-and middle-income countries. This study aimed to associate time, space, hospital characteristics and sociodemographic factors with the rates of HAI in neonatal intensive care units in the State of São Paulo, Brazil.</p><p><strong>Methods: </strong>We conducted an ecologic study based on annual rates of central-line-associated bloodstream infections (CLABSI) and ventilator-associated pneumonia (VAP) in high-risk nurseries of hospitals included in a statewide surveillance system in Brazil, from 2009 to 2019. We used Poisson regression models to investigate time-space trends of those rates, as well as their association with socioeconomic indexes and hospital care complexity. We represented the space distribution of CLABSI and VAP with Kernel density maps.</p><p><strong>Results: </strong>A total of 294 hospitals reported neonatal data to São Paulo State Program for Infection Control, amounting to 2345 year-hospitals. The median rates of device-related infections were VAP 1.49 (0-3.91), confirmed CLABSI 6.82 (5.9-9.4) and clinical CLABSI 2.47 (0-6.29), with a significant decrease in all HAI rates over time. Hotspots were detected in metropolitan and coastal areas, especially for CLABSI rates.</p><p><strong>Conclusions: </strong>The establishment of a surveillance system, as well as quality improvement measures, can promote a reduction in neonatal HAI rates, even in low-resource scenarios. The impact of socioeconomic factors on infection rates can be associated with the availability of diagnostic resources.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":"e385-e391"},"PeriodicalIF":2.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long COVID-19 in Hospitalized and Ambulatory Children in Jamaica.","authors":"Samantha Ann-Patrice Mosha Miller, Mark Daniel Hicar, Crista-Lee Shahine Berry, Kathryn B Anderson, John F Lindo, Gene D Morse, Celia Dana Claire Christie","doi":"10.1097/INF.0000000000005259","DOIUrl":"10.1097/INF.0000000000005259","url":null,"abstract":"<p><p>This retrospective observational cohort study evaluated acute illness predictors of pediatric Long coronavirus disease 2019 in Jamaica. Poisson regression modeling associated acute univariate symptoms of vomiting, abdominal pain, ageusia, anosmia, fatigue, confusion, brain fog, and multisystem inflammatory syndrome in children and multivariable composite predictors of multisystem inflammatory syndrome in children, vomiting and ageusia. The 47.3% incidence supports the need for improvements in similar resource-constrained settings.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":"885-887"},"PeriodicalIF":2.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}