{"title":"MYOPERICARDITIS DUE TO COXIELLA BURNETII IN A TEENAGE MALE.","authors":"Anh Vo, Daniele Gusland, Prachi Singh, Su Jin Joo","doi":"10.1097/INF.0000000000004651","DOIUrl":"https://doi.org/10.1097/INF.0000000000004651","url":null,"abstract":"<p><p>A 15-year-old male presented with acute chest pain and was diagnosed with myopericarditis due to acute Q fever, detected by cell-free DNA method. Despite taking a 2-week course of doxycycline, myopericarditis recurred after 6 months. In the absence of an alternative diagnosis, he began treatment for possible chronic Q fever with doxycycline and hydroxychloroquine and has not had further recurrence.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eric Jeziorski, Antoine Ouziel, Marie Cotillon, Constance Bridonneau, Etienne Bizot, Clément Basse, Aurélie Portefaix, François Dubos, Stéphane Béchet, Lea Domitien, Carine Jaillet, Sorin Abrudan, Rolf Kramer, Vincent Gajdos, Elise Launay, Romain Basmaci, Yves Gillet, Robert Cohen, Corinne Levy
{"title":"IMPACT OF NIRSEVIMAB ON RESPIRATORY SYNCYTIAL VIRUS BRONCHIOLITIS IN HOSPITALIZED INFANTS: A REAL-WORLD STUDY.","authors":"Eric Jeziorski, Antoine Ouziel, Marie Cotillon, Constance Bridonneau, Etienne Bizot, Clément Basse, Aurélie Portefaix, François Dubos, Stéphane Béchet, Lea Domitien, Carine Jaillet, Sorin Abrudan, Rolf Kramer, Vincent Gajdos, Elise Launay, Romain Basmaci, Yves Gillet, Robert Cohen, Corinne Levy","doi":"10.1097/INF.0000000000004630","DOIUrl":"https://doi.org/10.1097/INF.0000000000004630","url":null,"abstract":"<p><p>Regarding nirsevimab immunization status, among 1085 infants hospitalized for bronchiolitis, the odds of hospitalization for respiratory syncytial virus bronchiolitis were 4.7 times higher for nonimmunized children. Immunized infants were less likely to require oxygen supplementation (20.2% vs. 30.6%, P = 0.02) and had a 1-day shorter hospital stay. Respiratory syncytial virus bronchiolitis was less frequent and less severe in infants immunized with nirsevimab.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amanda Marie Egeskov-Cavling, Caroline Klint Johannesen, Fredrik Folke, Thea K Fischer
{"title":"Evaluating the Impact of Moderate and Severe Varicella Infections on Danish Children Under 18 Years Old: A Comprehensive Analysis From 2015 to 2023.","authors":"Amanda Marie Egeskov-Cavling, Caroline Klint Johannesen, Fredrik Folke, Thea K Fischer","doi":"10.1097/INF.0000000000004612","DOIUrl":"10.1097/INF.0000000000004612","url":null,"abstract":"<p><strong>Background: </strong>Varicella (chickenpox) caused by varicella-zoster virus (VZV) is a highly contagious pediatric disease. While it typically manifests as a mild disease, complications leading to hospitalization are not uncommon. Knowing the current disease burden, seasonality and risk groups is pivotal for evidence-based decisions on the introduction of a varicella vaccine.</p><p><strong>Methods: </strong>Using the Danish National Patient Register and medical helpline records from the Capital Region, we estimated the burden of VZV infections among children younger than 18 years in Denmark from 2015 to June 2023.</p><p><strong>Results: </strong>We identified 14,443 cases with annual incidence rates of 325/100,000 children for mild-to-moderate varicella cases (helpline calls), 35/100,000 for moderate-to-severe cases (outpatients) and 10/100,000 for severe cases (hospitalized). Mild cases were most prevalent in children aged 1-4 years, while moderate-to-severe cases were most prevalent among infants <1 year old. Among hospitalized cases, 23.2% had underlying diseases and 47.3% experienced complications. In April 2022, rapid surge in all types of VZV cases occurred, where admissions surpassed the prepandemic level.</p><p><strong>Conclusion: </strong>This study documents that varicella is highly prevalent among Danish young children. Mild-to-moderately severe cases strain healthcare, causing increased helpline calls and posing a persistent hospitalization risk, especially for infants and children with underlying conditions.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
George A Syrogiannopoulos, Philippe Bidet, Aspasia N Michoula, Athanasios D Goutzourelas, Theoni G Syrogiannopoulou, Michael B Anthracopoulos, Stéphane Bonacorsi, Ioanna N Grivea
{"title":"KINGELLA KINGAE SEQUENCE TYPE 25 MENINGITIS IN AN IMMUNOCOMPETENT TODDLER: CLINICAL AND MOLECULAR APPROACH.","authors":"George A Syrogiannopoulos, Philippe Bidet, Aspasia N Michoula, Athanasios D Goutzourelas, Theoni G Syrogiannopoulou, Michael B Anthracopoulos, Stéphane Bonacorsi, Ioanna N Grivea","doi":"10.1097/INF.0000000000004621","DOIUrl":"10.1097/INF.0000000000004621","url":null,"abstract":"<p><p>Kingella kingae is a cause of bacteremia, endocarditis, and the leading cause of osteoarticular infections between 6 and 48 months of life. We report on a rare case of K. kingae meningitis in the absence of endocarditis and immune deficiency in a 26-month-old boy emphasizing the distinct genomic determinants of the strain which may be of importance to the pathogenesis of the disease.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hélène Faury, Alix Flamant, Agnès Ferroni, Jérémie F Cohen
{"title":"Diagnostic Accuracy of a Rapid Antigen Detection Test for Group A Streptococcus in Children With Pleural Empyema.","authors":"Hélène Faury, Alix Flamant, Agnès Ferroni, Jérémie F Cohen","doi":"10.1097/INF.0000000000004610","DOIUrl":"https://doi.org/10.1097/INF.0000000000004610","url":null,"abstract":"","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melanie M Dubois, Jennifer Jao, Shan Sun, Justine Legbedze, Sara Schenkel, Nicholas Mmasa, Samuel W Kgole, Gosego Masasa, Anna-Ursula Happel, Saori C Iwase, Roxanna Haghighat, Sikhulile Moyo, Tanvi S Sharma, Paul T Edlefsen, Danica Shao, Heather Jaspan, Kathleen M Powis
{"title":"Infectious Morbidity and All-cause Mortality of Infants HIV-exposed Uninfected Compared to Infants HIV-unexposed Uninfected in Botswana.","authors":"Melanie M Dubois, Jennifer Jao, Shan Sun, Justine Legbedze, Sara Schenkel, Nicholas Mmasa, Samuel W Kgole, Gosego Masasa, Anna-Ursula Happel, Saori C Iwase, Roxanna Haghighat, Sikhulile Moyo, Tanvi S Sharma, Paul T Edlefsen, Danica Shao, Heather Jaspan, Kathleen M Powis","doi":"10.1097/INF.0000000000004603","DOIUrl":"https://doi.org/10.1097/INF.0000000000004603","url":null,"abstract":"<p><p>Some studies have reported increased infectious morbidity and all-cause mortality risk among infants HIV-exposed uninfected compared with infants HIV-unexposed uninfected. In a retrospective analysis of infants enrolled in the Botswana-based Tshilo Dikotla study, we found no difference in the prevalence of infectious hospitalizations or deaths from any cause in the first year of life by perinatal HIV exposure.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"NONTYPHOIDAL SALMONELLA OSTEOMYELITIS IN IMMUNOCOMPETENT CHILDREN: REPORT OF TWO CASES AND LITERATURE REVIEW.","authors":"Hyun A Lee, Hyun Joo Jung","doi":"10.1097/INF.0000000000004579","DOIUrl":"https://doi.org/10.1097/INF.0000000000004579","url":null,"abstract":"<p><p>Salmonella is a rare causative pathogen of osteomyelitis and is commonly detected in patients with sickle cell disease. We described 2 consecutive cases of nontyphoidal Salmonella osteomyelitis identified in immunocompetent children. It is evident that even children without apparent risk factors for immune dysfunctions can be affected, so maintaining clinical suspicion is crucial for early diagnosis and prompt treatment.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Defining a Therapeutic Target for Ganciclovir Therapy in Immunocompromised Children With Cytomegalovirus Infection: A Brief Report.","authors":"Maggie Gao, Heather Weerdenburg, Wenyu Yang, Xiao Zhu, Amanda Gwee","doi":"10.1097/INF.0000000000004602","DOIUrl":"https://doi.org/10.1097/INF.0000000000004602","url":null,"abstract":"<p><p>Ganciclovir and valganciclovir are first-line treatments for cytomegalovirus in immunocompromised children; however, the optimal therapeutic target remains unclear. This review identified 6 studies that showed clearance of cytomegalovirus viremia occurs with a median area under the concentration-time curve (AUC24) between 23 and 70 μg·h/mL, with no clear correlation with efficacy or toxicity.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}