Pediatric Infectious Disease Journal最新文献

{"title":"The Utility of Serologic TORCH Testing During Pregnancy for Maternal-related Versus Fetal-related Indications: A Retrospective Study.","authors":"Raneen Abu Shqara, Maya Kaufman, Shany Or, Daniel Glikman, Lior Lowenstein, Maya Frank Wolf","doi":"10.1097/INF.0000000000004591","DOIUrl":"10.1097/INF.0000000000004591","url":null,"abstract":"<p><strong>Background: </strong>Clear guidelines have not been established about the utility of TORCH serology testing in women for whom TORCH infection is suspected according to clinical and laboratory manifestations during pregnancy. We aimed to compare rates of TORCH infections [specifically cytomegalovirus (CMV), Toxoplasma and rubella] in women who underwent TORCH serology testing due to maternal- versus fetal-related indications.</p><p><strong>Methods: </strong>This 10-year single-center retrospective study included all the women beyond 24 weeks of gestation who underwent TORCH serology testing due to maternal- or fetal-related indications. Maternal-related indications included fever, gastroenteritis, elevated liver enzymes and thrombocytopenia. Fetal-related indications included intrauterine growth restriction, polyhydramnios and oligohydramnios.</p><p><strong>Results: </strong>During the study period, 304 women underwent TORCH serology testing due to maternal-related indications and 771 due to fetal-related indications. For the maternal-related compared with the fetal-related indication group, maternal and congenital TORCH infections were more prevalent ( P = 0.015), specifically CMV ( P = 0.036). Eight (2.6%) of the women with maternal-related indications had a primary TORCH infection; 4 of them (50%) had concomitant congenital infections. Six (0.8%) of the women with fetal-related indications had a primary infection; none had a related congenital infection. Among the women with maternal-related indications, higher rates of maternal TORCH infection were found among those with thrombocytopenia (7.1%) and elevated liver enzymes (3.0%). During the study period, maternal-indicated TORCH testing detected 10.8% of neonates born with a confirmed TORCH infection.</p><p><strong>Conclusions: </strong>The clinical yield of TORCH serology for nonspecific sonographic fetal features was low. Nonetheless, maternal-related indications should prompt testing for CMV and Toxoplasma infection.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":"257-262"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influenza-associated Intussusception: \"You Too, Intussusception\".","authors":"Mitsuaki Yoshino, Daisuke Matsubara, Yoshitaka Shinno, Tadahiro Mitani, Hironori Shimozawa, Kazuo Takahashi, Tomoyuki Ota, Yuji Gunji","doi":"10.1097/INF.0000000000004590","DOIUrl":"10.1097/INF.0000000000004590","url":null,"abstract":"","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":"e107-e109"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral Sensorineural Hearing Loss in Congenital Cytomegalovirus Retrospective Observational Study.","authors":"Layah Alkoby-Meshulam, Daisy Rosenthal-Shtern, Ori Snapiri, David Levy, Nimrod Sachs, Merav Sokolov, Efraim Bilavsky","doi":"10.1097/INF.0000000000004574","DOIUrl":"10.1097/INF.0000000000004574","url":null,"abstract":"<p><strong>Background: </strong>The leading nonhereditary cause of childhood sensorineural hearing loss has been attributed to congenital cytomegalovirus (cCMV). Sensorineural hearing loss can be unilateral (UHL) or bilateral (BHL), and may be progressive. Our objective was to describe the characteristics, clinical nature and follow-up of ears in cCMV-associated UHL.</p><p><strong>Methods: </strong>This 16-year retrospective study was performed at Schneider's Medical Center, Israel. Data were collected from all cCMV infants with UHL at birth who were treated with antiviral treatment initiated within the first 4 weeks of life and had a follow-up period of at least 1 year.</p><p><strong>Results: </strong>We enrolled 67 infants diagnosed with UHL at birth: 17 (25%) with mild hearing loss, 22 (33%) with moderate hearing loss and 28 (42%) with severe hearing loss. At the last follow-up visit, 7 (41%) ears in the mild hearing loss group improved to normal hearing, 8 (47%) ears exhibited no change and 2 (12%) ears deteriorated. In the moderate hearing loss group, 9 (41%) ears improved, 7 (32%) remained static and 6 (27%) deteriorated to the severe hearing loss group. One (4%) ear in the severe hearing loss group showed improvement. Of the 67 ears with normal hearing at birth, 4 (6%) ears deteriorated.</p><p><strong>Conclusions: </strong>This study assessed and elucidated the characteristics, clinical nature and long-term follow-up of both the affected and unaffected ears diagnosed with UHL due to cCMV. These data are crucial when medical and/or surgical interventions are considered.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":"234-238"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sense and Nonsense of Bacterial Decolonization in Neonatal Care.","authors":"Katharina Last, Cihan Papan, Julia Anna Bielicki","doi":"10.1097/INF.0000000000004701","DOIUrl":"10.1097/INF.0000000000004701","url":null,"abstract":"","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":"e99-e101"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Recent Increase in Invasive Bacterial Infections: A Report From the National COVID Cohort Collaborative.","authors":"Blake Martin, Peter E DeWitt, Seth Russell, Melissa Haendel, Nelson Sanchez-Pinto, David J Albers, Ravi R Jhaveri, Richard Moffitt, Tellen D Bennett","doi":"10.1097/INF.0000000000004575","DOIUrl":"10.1097/INF.0000000000004575","url":null,"abstract":"<p><strong>Background: </strong>When coronavirus disease 2019 (COVID-19) mitigation efforts waned, viral respiratory infections (VRIs) surged, potentially increasing the risk of postviral invasive bacterial infections (IBIs). We sought to evaluate the change in epidemiology and relationships between specific VRIs and IBIs [complicated pneumonia, complicated sinusitis and invasive group A streptococcus (iGAS)] over time using the National COVID Cohort Collaborative (N3C) dataset.</p><p><strong>Methods: </strong>We performed a secondary analysis of all prospectively collected pediatric (<19 years old) and adult encounters at 58 N3C institutions, stratified by era: pre-pandemic (January 1, 2018, to February 28, 2020) versus pandemic (March 1, 2020, to June 1, 2023). We compared the characteristics and outcomes of patients with prespecified VRIs and IBIs, including correlation between VRI cases and subsequent IBI cases.</p><p><strong>Results: </strong>We identified 965,777 pediatric and 9,336,737 adult hospitalizations. Compared with pre-pandemic, pandemic-era children demonstrated higher mean monthly cases of adenovirus (121 vs. 79.1), iGAS (5.8 vs. 3.3), complicated pneumonia (282 vs. 178) and complicated sinusitis (29.8 vs. 16.3), P < 0.005 for all. Among pandemic-era children, peak correlation between RSV cases and subsequent complicated sinusitis cases occurred with a 60-day lag (correlation coefficient 0.56, 95% confidence interval: 0.52-0.59, P < 0.001) while peak correlation between influenza and complicated sinusitis occurred with a 33-day lag (0.55, 0.51-0.58, P < 0.001). Correlation among other VRI-IBI pairs was modest during the pandemic and often lower than during the pre-pandemic era.</p><p><strong>Conclusions: </strong>Since COVID-19 emerged, mean monthly cases of iGAS, complicated pneumonia, and complicated sinusitis have been higher. Pandemic-era RSV and influenza cases were correlated with subsequent cases of complicated sinusitis in children. However, many other VRI-IBI correlations decreased during the pandemic.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":"44 3","pages":"217-227"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Characterization of Treponema pallidum pallidum in an Adolescent With Syphilitic Hepatitis.","authors":"Luciana Noemi Garcia, Samanta Moroni, Magdalena Meijomil, Nicolas Gonzalez, Fernanda Lascano, Franco Mangone, Belen Warszatska, Guillermo Moscatelli, María Angeles Pando, Jaime Marcelo Altcheh","doi":"10.1097/INF.0000000000004611","DOIUrl":"https://doi.org/10.1097/INF.0000000000004611","url":null,"abstract":"","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":"44 3","pages":"e111-e112"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiviral Treatment and Risk of Hearing Loss in Asymptomatic and Mild Symptomatic Infants With Congenital Cytomegalovirus.","authors":"Serena Villaverde, Roberto Pedrero-Tomé, Vassiliki Papaevangelou, Garyfallia Syridou, Sofia Karagiannidou, Hermione Lyall, Helen Payne, Marie Antoinette Frick, Pere Soler-Palacín, Fernando Baquero-Artigao, Paula Rodríguez-Molino, Claudia Fortuny-Guasch, Maria Rios-Barnés, Miguel Sánchez-Mateos, Jesús Saavedra-Lozano, Xavier Bringué, Elisenda Moliner, Laura Castells, Oihana Muga, Isabel Vives-Oños, Despoina Gkentzi, Giuseppina Lombardi, Alfredo Tagarro, Elena Colino, Jose A Couceiro, Pablo Rojo, Joaquín de Vergas, Daniel Blázquez-Gamero","doi":"10.1097/INF.0000000000004583","DOIUrl":"10.1097/INF.0000000000004583","url":null,"abstract":"<p><strong>Background: </strong>To assess hearing outcomes at 24 months of age in infants with mild congenital cytomegalovirus (cCMV) infection, depending on whether they have received antiviral treatment or not.</p><p><strong>Methods: </strong>A retrospective study within the European Registry of Children with cCMV was performed. Included children had cCMV diagnosed in utero/in the first 21 days of life, with normal physical examination, alanine aminotransferase <80 U/L and platelets >100,000 cs/mm 3 and absence of hearing loss (HL) at birth. Cranial ultrasound (cUS) and/or cranial magnetic resonance imaging was normal or with minor findings (isolated lenticulostriate vasculopathy and/or germinolysis/caudothalamic or subependymal cysts, and/or focal/multifocal white matter involvement). The main outcome was the presence of HL at 24 months of age.</p><p><strong>Results: </strong>One hundred ninety-six patients met inclusion criteria. A total of 34.7% received antiviral treatment with valganciclovir/ganciclovir. Children treated had lower gestational age, birth weight and head circumference, and maternal primary infection was less frequent. Among treated children, 21.3% presented minor findings in cUS versus 6.3% in nontreatment group ( P = 0.003). Nine patients (4.6%) developed HL at 24 months. Among children with HL, 20% presented minor findings in cUS versus 11.3% in non-HL group ( P = NS). HL rate was similar in treated and nontreated groups (4.6% vs. 6.3%; P = 0.6).</p><p><strong>Conclusions: </strong>One-third of the children were treated with antivirals and infants with minor neuroimaging findings at birth were more likely to receive antiviral. There were no differences in the prevalence of HL at 2 years of age between treated and not-treated children. Minor neuroimaging findings were not clearly associated with an increased risk of delayed onset HL.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":"239-245"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Reported Case of Brain Abscess in an Infant Caused by Staphylococcus argenteus.","authors":"Omar Imam, Patrick Tang, Eman Almaslamani, Mohammad Sawahreh, Mohammed Suleiman, Anju Sharma, Andres Perez Lopez","doi":"10.1097/INF.0000000000004600","DOIUrl":"10.1097/INF.0000000000004600","url":null,"abstract":"","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":"e107"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Drug Monitoring of High-dose Sulbactam in Pediatric Patients: Preliminary Data From a Prospective Observational Pharmacokinetic Study.","authors":"Kankamol Charoenwong, Noppadol Wacharachaisurapol, Warumphon Sukkummee, Jiratchaya Sophonphan, Pintip Suchartlikitwong, Tanittha Chatsuwan, Suvaporn Anugulruengkitt, Thanyawee Puthanakit","doi":"10.1097/INF.0000000000004582","DOIUrl":"10.1097/INF.0000000000004582","url":null,"abstract":"<p><strong>Background: </strong>Rates of carbapenem-resistant Acinetobacter baumannii are rising in Thailand. Although high-dose (HD) sulbactam is recommended for treating carbapenem-resistant A. baumannii infections, data on plasma sulbactam concentrations in children are limited. We aimed to evaluate plasma sulbactam concentrations and pharmacokinetic-pharmacodynamic (PK-PD) target achievement in pediatric patients.</p><p><strong>Methods: </strong>Prospective study data (January-November 2023) on children (1 month-18 years) who received sulbactam every 6-8 hours were analyzed. Mid-dosing ( Cmid , 50% f T) and trough ( Ctrough , 100% f T) concentrations were evaluated. PK-PD target achievement [50% f T > minimum inhibitory concentration (MIC), 100% f T > MIC] was evaluated using Clinical and Laboratory Standards Institute 2024 MIC cutoffs and MIC data of isolates of Acinetobacter calcoaceticus-baumannii complex from this study.</p><p><strong>Results: </strong>Thirty-five patients (median age 50 months) were categorized into standard-dose (SD) or HD groups. The geometric mean Cmid was higher in the HD (41.3 mg/L) versus SD (19.5 mg/L) groups ( P = 0.006). Among 101 isolates of Acinetobacter calcoaceticus-baumannii complex, the MIC50 and MIC90 (concentrations that inhibit 50% and 90% of isolates of the A. calcoaceticus-baumannii complex) were 16 and 128 mg/L, respectively. The HD group achieved Cmid >MIC50 in 87.5% of the patients compared with 63.6% in SD ( P = 0.17). Within the HD group, patients with augmented renal clearance (ARC) had lower Cmid (geometric mean 31.9 mg/L) compared with non-ARC (geometric mean 63.4 mg/L) ( P = 0.04).</p><p><strong>Conclusions: </strong>HD sulbactam resulted in higher Cmid and PK-PD achievement. ARC significantly compromised plasma sulbactam concentration. HD sulbactam may be preferable for treating critically ill pediatric patients and those with ARC, especially during the empirical period.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":"207-213"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Group A Streptococcal Disease in Sudden Unexpected Death in Youth in the Pre- and Post-COVID-19 Era.","authors":"Evelien B van Kempen, Annelotte M Pries, Emmeline P Buddingh, Patrycja J Puiman, Mirjam van Veen","doi":"10.1097/INF.0000000000004775","DOIUrl":"https://doi.org/10.1097/INF.0000000000004775","url":null,"abstract":"<p><strong>Background: </strong>An upsurge in pediatric invasive group A streptococcal infection (iGAS) has been observed in the Netherlands along with a suspected increase in iGAS-related sudden death. Sudden unexplained deaths in youth (SUDY) are investigated nationally through a standardized procedure [(Postmortem Evaluation of Sudden Unexplained Death in Youth (PESUDY)]. We investigate epidemiological differences between pediatric iGAS-related sudden deaths (iGAS-PESUDY) and surviving iGAS cases.</p><p><strong>Methods: </strong>This observational study used data from the COPP-iGAS study on pediatric iGAS infections in Dutch hospitals and the PESUDY database. Children aged 0-18 years were included between August 2016 and December 2022.</p><p><strong>Results: </strong>Twenty-one iGAS-PESUDY cases and 156 iGAS survivors were included. iGAS-PESUDY cases tended to be older compared to survivors. iGAS-PESUDY cases significantly increased in 2022 compared to the pre-COVID period. Pre- and/or coinciding infections were present in 66% of iGAS-PESUDY cases, predominantly varicella zoster (19%) and influenza (24%). In survivors, 13% had varicella zoster virus and 3% had influenza virus (P ≤ 0.001). C-reactive protein levels tended to be lower in iGAS-PESUDY cases (81 mg/L; interquartile range, 26.8-307.5) compared to survivors (266 mg/L; interquartile range, 218.0-302.0).</p><p><strong>Conclusion: </strong>iGAS is currently a prevalent cause of SUDY. The finding of moderately elevated C-reactive protein levels compared to high levels in survivors might suggest children dying suddenly of iGAS have a rapid and fulminant disease course. Children with a pre- and/or coinciding infection of varicella zoster or influenza virus may be at greater risk of succumbing to iGAS infections.</p>","PeriodicalId":19858,"journal":{"name":"Pediatric Infectious Disease Journal","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}