Pharmacy World & Science最新文献

{"title":"THE RESEARCH OUTCOME OF INFLUENCE ON THE FUEL FILTER CONTAMINATION FOR THE BASIC ENGINE PERFORMANCE","authors":"Erdenesaikhan Oyunsurtal, Ulziibaatar Tserendorj","doi":"10.31435/rsglobal_ws/28022022/7769","DOIUrl":"https://doi.org/10.31435/rsglobal_ws/28022022/7769","url":null,"abstract":"We performed an experiment to determine the resistance impact on the engine performance resulted from the engine fuel system. Therefore we designed a tool for creating artificial resistance in the fuel pipe for determining resistance contamination in the fuel system. The artificial resistance between high pressure pump pipe and engine fuel filter was created in the field and laboratory then the diagnostic program EEM3 was used in the experiment. We tested the resistance by the pipe and decreased the pipe diameter of the fuel flow resistance from 8.5mm to 2.3 mm with 18 versions. As a result of the test, the basic indicators of the engine were changed when pipe diameter reached 6.5mm from 8.2 mm. The certain change on cyclic fuel supply occurred when the fuel flow increased and pipe diameter dropped. Moreover, the basic indicators of fuel consumption, torque and engine power were changed. It influences to the basic indicators due to the fuel filter contamination and regression of permeability proficiency then the engine will lose out the fuel.","PeriodicalId":19855,"journal":{"name":"Pharmacy World & Science","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81057455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPROVING THE PERFORMANCE PROPERTIES OF AUTOMOTIVE PARTS BY FORMING WEAR-RESISTANT COATINGS","authors":"Posviatenko E. K., Holovashchuk M. V.","doi":"10.31435/rsglobal_ws/28022022/7774","DOIUrl":"https://doi.org/10.31435/rsglobal_ws/28022022/7774","url":null,"abstract":"The work is devoted to solving the scientific and technical problem of ensuring the tribotechnical properties of car parts through the use of wearresistant coatings. The synthesis of the main types of wear of car parts and ways to improve their tribotechnical properties was carried out, which allowed to substantiate the feasibility of using wear-resistant coatings to restore and strengthen them.An urgent problem is the reasonable search and development of highly efficient, easy-to-use technologies for the restoration of parts to improve the performance of cars. Solving this problem requires the introduction into practice of strengthening and restoring car parts wear-resistant coatings. Summarizing the results of research on the main types of wear of car parts allowed us to conclude that they work in conditions where operating loads (pressure, temperature, environmental action, etc.) perceive mainly their surface layers, and therefore it is enough to restore not all parts but only worn surfaces by applying wear-resistant coatings.It has been proven that to improve the performance of car parts, it is important to choose the right simple and affordable ways to apply coatings that will increase their service life. It is substantiated that among the methods of applying wear-resistant coatings are the most common, cheapest and simplest methods of gas-thermal spraying, namely gas-flame spraying and electric arc spraying. Restoration and strengthening of car parts by applying wear-resistant coatings has solved the problem of providing their resource, which is not inferior to the resource of new parts.","PeriodicalId":19855,"journal":{"name":"Pharmacy World & Science","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81789910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SEARCH FOR AN EXTREMUM USING THE STEEPEST DESCENT METHOD UNDER THE CONDITIONS OF EXPERIMENTAL ERRORS","authors":"Nona Otkhozoria, Vano Otkhozoria, Shorena Khorava","doi":"10.31435/rsglobal_ws/28022022/7785","DOIUrl":"https://doi.org/10.31435/rsglobal_ws/28022022/7785","url":null,"abstract":"One of the spread first level methods of optimum search is learned by the steepest descent method in conditions when there are mistakes in the experiment. The steepest descent method is investigated and is successfully applied in situations, when, there are no mistakes of experiment. However, in real situations the used means of measurement always have determined errors owing to what the appropriate meanings of the response receives with mistakes. The model of the steepest descent algorithm in created, when the length of the step does not depend on the meaning of the purpose functioning. Stepping process realization algorithm and program provision in MathCAD, computer mathematic, system is designed. The realization outcome mistakes for different meaning are presented, the step movement of the optimum dot direction is shown according to function meaning and argument meaning as well. The amount needed for the tactics necessary to approach the minimum is established, the quake amplitude in the surrounding of different level experiment mistakes at the optimum search efficiency in different step conditions.","PeriodicalId":19855,"journal":{"name":"Pharmacy World & Science","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81367107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RECURRENT VULVOVAGINAL CANDIDIASIS: CURRENT ISSUES (A REVIEW)","authors":"Nataliia Ratushniak, Aurika Sukhanova","doi":"10.31435/rsglobal_ws/28022022/7780","DOIUrl":"https://doi.org/10.31435/rsglobal_ws/28022022/7780","url":null,"abstract":"Recurrent vulvovaginal candidiasis (RVVC) is a widespread problem for today. Symptoms of the disease significantly reduce women life quality. It is common reason for medical help. Clinical sings of vaginal candidiasis are nonspecific. The most common method of diagnosis - microscopy of vaginal discharge, does not always provide enough information. Among the causative agents of candidiasis, Candida albicans and Candida nonalbicans have different prevalence in different regions of the world.Resistance to antifungal drugs is increasing due to it widespread applying.Risk factors for RVVK are: antibiotic therapy, immunodeficiency conditions, diseases of the gastrointestinal tract, contraceptives, corticosteroids, hormonal disorders of women, allergic diseases. Recent studies indicate the multifactorial cause of candidiasis, especially the imbalanced composition of the vaginal microflora and genetic predisposition. Resistance to antifungal drugs is increasing, especially to Fluconazole, that is most often applied in clinical practice.The role of immunoregulatory mechanisms is reflected in the reduced activity of immunity in the vagina. Changes in Tol-like receptor (TLR) genes have been reported in women with RVVC. Also, interlexins can lead to a prolonged inflammatory process in the vagina. Currently, polymorphism of the mannose-binding lectin gene in women with RVVK relevant topic for research. That changes may be a reasone of recurrence.Determination of mannose-binding lectin for diagnostic and therapeutic purposes is promising research area. There is increasing scientific interest in the study of this pathology. In publication described diagnosis of RVVK, the species composition of the pathogen, risk factors, impact of hormones and genetic predisposition.","PeriodicalId":19855,"journal":{"name":"Pharmacy World & Science","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89082203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROSPECTS FOR THE USE OF ZEOLITE CONTAINING GEOMIN FORTE IN THE TREATMENT OF COVID-19 AND POST COVID-19 CONDITION","authors":"Marina Giorgobiani, Nana Gorgaslidze, Aliosha Bakuridze, Lasha Bakuridze, Nodar Sulashvili","doi":"10.31435/rsglobal_ws/28022022/7781","DOIUrl":"https://doi.org/10.31435/rsglobal_ws/28022022/7781","url":null,"abstract":"The aim of the research was to study and analyze peculiarities and prospects for the use of zeolite containing Geomin Forte in the treatment of covid-19 and post covid-19 condition. Antioxidants are substances that the human body constantly needs in order to maintain it in a normal state, which means maintaining the necessary balance between free oxidative radicals and antioxidant forces, the role of which is played by antioxidants.Vitamin E increases the body's nonspecific resistance, and by activating the synthesis of cytokines, tocopherol stimulates its own anti-inflammatory activity. The effect of vitamin E is to stimulate the reproduction of immune cells, systems that need to quickly multiply when they meet the source of a possible disease. In the body, this process is called mitogenesis.The pharmacodynamic effects of tocopherol are synergistic when combined with vitamins C and A. Retinol provides formation of immune (protective) cells, lining respiratory tract and gastrointestinal tract, serving as a natural barrier to infection. Medicine will enhance possibilities of adaptation of the organism to the changed environment, because, in many cases, it is very difficult to protect the population from the impact of the negative factor (including ionizing radiation, natural disasters, etc.) According the study results “Geomin Forte” can be used during intoxications (used as the best sorbent for food, infectious, occupational intoxications, chronic metals and chronic exposure to radiation). As well as when the functional state of the immune system is impaired and fatigue and as an adjunct for allergic diseases. The mineral zeolite (clinoptilolite), the 500 mg activated clinoptilolite \"Geomin Forte\" developed by us is characterized by antioxidant action. Unlike the conventional antioxidants, it stimulates the body's endogenous antioxidant system and is a direct-acting oxidoreductive agent. Its activated natural mineral zeolite (clinoptilolite) acts directly on the cell membrane as a surface-active donor of electrons.With its oxidizing effect, \"Geomin Forte\" is 200 times more than vitamins C and E. Used in combination with antioxidant therapy in the context of standard treatment for the following diseases: Diabetes mellitus, accelerated aging process; alzheimer's disease; parkinson's disease; endocrine pathologies; atherosclerosis and ischemic heart disease, hypertensive disease, stroke, rheumatism.","PeriodicalId":19855,"journal":{"name":"Pharmacy World & Science","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74085623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RELIABILITY OF VEHICLE VEHICLES AT THE STAGE OF PREPARATION","authors":"Dmytrychenko M. F., Богданов І. М","doi":"10.31435/rsglobal_ws/28022022/7773","DOIUrl":"https://doi.org/10.31435/rsglobal_ws/28022022/7773","url":null,"abstract":"The reduction of the duration of running-in is most strongly influenced by the speed-power and technological factors. It was experimentally established that at specific loads of 0.15 – 3 MPa and tribopair velocities of 6 – 40 m/min (0.1 - 0.66 m/sec) and methods of surface hardening and surface hardening, nitrocementation and ion-plasma thermocyclic nitriding, a combination of speed, power and technological factors can reduce the running-in process by 1.5 - 2 times.A mathematical model has been developed that combines the components of these factors for the running-in process in relation to the reduction of the latter.The stand for experimental research of the tribotechnical system, which consists of an automatic gearbox with a magnetic brake, a power supply, a control panel and a PC, has been upgraded. The firmware is written in the Python programming language.For further research in the chosen direction, the application of wear-resistant coatings with a thickness of 3 … 10 μm by PVD methods containing nitrides and carbides is promising.","PeriodicalId":19855,"journal":{"name":"Pharmacy World & Science","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85714016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FEATURES OF THE CLINIC AND DIAGNOSIS OF CROHN'S DISEASE IN CHILDREN AT THE PRESENT STAGE","authors":"Denisova M. F., Chernega N.V., Muzika N.N., Bukulova N.Y., Archakova T.N., Reminnaia N.T., Doroshenko O.A.","doi":"10.31435/rsglobal_ws/28022022/7779","DOIUrl":"https://doi.org/10.31435/rsglobal_ws/28022022/7779","url":null,"abstract":"Based on a retrospective analysis of case histories, the article presents modern data on the features of the clinical course of Crohn's disease in childhood, laboratory, endoscopic and morphological markers of the disease. The symptomatology of Crohn's disease is described in the onset and in the period of the developed clinical picture, depending on the localization of the inflammatory process.","PeriodicalId":19855,"journal":{"name":"Pharmacy World & Science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90335095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POLYPHENOL COMPOSITION OF THE FRUIT AND STEM OF ELDERFLOWER WILD-GROWING IN GEORGIA","authors":"Gabidzashvili Manana, Guleishvili Nino, Inga Bochoidze","doi":"10.31435/rsglobal_ws/28022022/7782","DOIUrl":"https://doi.org/10.31435/rsglobal_ws/28022022/7782","url":null,"abstract":"Extending the range of medicinal products produced from plant raw materials and great interest in herbal medicine are totally linked to the availability of plant raw materials, minor toxicity and side effects. The use of medicinal plant raw materials as a source of valuable biologically active substances in the pharmaceutical and food industries is relevant.The aim of the study was to quantify and evaluate antioxidant activity of biologically active compounds (total phenols, anthocyanins) in the fruit and stem of elderflower (Sambucis nigra) and fruits of Caucasian bilberry (Vaccinium artostaphyion) wild-growing in Georgia.As raw material under study, we used wild-growing elderflower fruit with the fruit-bearing stem and bilberry fruits collected in August 2020 in the mountainous region of Georgia (Racha-Lechkhumi) in the phase of full ripeness.It has been confirmed that the elderflower’s fruit stems, as well as the fruit of elderflower anise and bilberry are rich in: phenolic compounds (elderflower’s fruit -13.8 mg/g, stem - 9.2 mg/g; bilberry fruit - 24.9 mg/g); anthocyanins (elderflower’s fruit - 1.4 mg / g, stem - 3.68 mg/g; bilberry fruit - 18.03 mg /g); they are characterized by high antioxidant activity (elderflower’s fruit - 48.2%, stem - 40.5%; bilberry fruit - 60.3%). Based on the results obtained, the fruits of bilberry and elderflower can be considered to be a cheap alternative source of natural antioxidants for the pharmaceutical, cosmetic and food industries.","PeriodicalId":19855,"journal":{"name":"Pharmacy World & Science","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86747912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RESEARCH OF THE PULSE PARAMETERS OF A DEFORMATION WAVE AT SURFACE-PLASTIC STRENGTHENING","authors":"Kostyuk S. A., Kosiyuk M. M., Tkachuk V. P., Luzhanskiy V. I., Kostyuk М. A.","doi":"10.31435/rsglobal_ws/28022022/7768","DOIUrl":"https://doi.org/10.31435/rsglobal_ws/28022022/7768","url":null,"abstract":"The article considers the issue of increasing the efficiency of shock energy and recording equipment for the study of the parameters of the deformation wave pulse. The review of the last researches and publications is carried out and perspective directions at designing of the special measuring equipment are established. A method is proposed and an experimental-measuring complex for the study of the momentum parameters in the deformation zone under different initial conditions is developed. The study of the parameters, of the shock pulse and micro hardness, of the strengthened material in the deformation zone using different versions, of the impact systems. It is established that when using a shock system with a step-shaped striker, the shock wave is characterized by a complex shape of the pulse. To assess the reliability of the obtained results, a test problem was solved in the environment of the Abaqus software package. When designing new technological processes of strengthening, the results of experimental studies such as the impact system and the parameters and modes of the processing process are of particular importance. It is established that the best result is shown by shock systems, which allow forming a prolonged shock pulse.","PeriodicalId":19855,"journal":{"name":"Pharmacy World & Science","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88015606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE INCIDENCE OF OSTEOCHONDROSIS IN COMBINATION WITH MALOCCLUSION AMONG STUDENTS OF THE MEDICAL UNIVERSITY","authors":"Volynets L. N., Volynets V. N., Vovk V. V.","doi":"10.31435/rsglobal_ws/28022022/7778","DOIUrl":"https://doi.org/10.31435/rsglobal_ws/28022022/7778","url":null,"abstract":"Relevance. The prevalence of posture defects, according to various researchers, is from 0.6% to 78%. The disruptions in the posture biomechanics leads to excessive stress on the main joints of the human body including temporomandibular joint.Objective. The research aimed to study the prevalence of violations of the anatomical and functional system \"posture-occlusion\" and the structure of early signs of degenerative-dystrophic changes in the spine in medical students.Materials and methods. 130 students of medicals and dental faculties (including 42 men and 88 women) with posture disorders were examined in accordance with special questionnaires developed at the department.The assessment of the functional state of the spinal was carried out using motor tests by the method of Goryana G.A. and complaints of pain according to the 10-point numerical scale of pain \"NSP\". The malocclusion was assessed according to the method of Khvatov depending on the type of mandibular displacement. Statistical analyses with program IBM SPSS Statistic Base v.22. Results. It has been found that 78 students or 60% did not have restricted and widespread osteochondrosis and pain degree was lower than 5 points.A high prevalence (40%) of combined deformity of posture and displacement of the lower jaw in combination with pain syndrome was established. Along with restricted osteochondrosis 38 (73,08%), distal type of lower jaw displacement was more commonly seen amongst students with postural defects 35 (67,31%). These clinically manifested a pain level of more than 5 points. Signs and symptoms of a combined pathology posture-occlusion were more common among women (37 patients, or 71.15%) than men (15 patients, or 28.85%)","PeriodicalId":19855,"journal":{"name":"Pharmacy World & Science","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82854207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}