Pain physician最新文献

{"title":"A Systematic Review of Self-Reported Pain Rating Scales for Children and Adolescents.","authors":"Joshua Calvano, Reza Ehsanian, Jordan A Buttner, Adi Balk, Deborah Lai, Matt McGillivray, Todd Jaffe, Shuhan He","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Pain assessment in pediatric populations via self-report tools pose unique challenges given the patients' cognitive abilities and developmental status; however, the accurate measurement of pediatric pain is crucial in improving patient outcomes.</p><p><strong>Objectives: </strong>This review evaluates recent medical literature to better understand potential correlations and concordance exhibited by self-reported pain intensity assessment tools for children and adolescents in addition to assessing the viability and utility of electronic delivery modalities.</p><p><strong>Study design: </strong>Systematic review without meta-analysis.</p><p><strong>Methods: </strong>An online database search was conducted utilizing PubMed/MEDLINE, EMBASE, and Google Scholar. Screened studies were limited to documents published between June 2004 and January 2022. All included studies were published in English, focused on pediatric self-report scales, and included comparisons of at least 2 different scales or various delivery modalities of the same scale. Risk of bias was assessed per the Cochrane Systematic Review Handbook.</p><p><strong>Results: </strong>A total of 19 articles were selected for inclusion in this review. The findings indicate that pain scales incorporating visual aids, such as faces and colors, exhibit strong correlations with other pain assessment scales. However, discriminating between pediatric pain scales is still more nuanced, as evidenced by the contrasting paired correlation results shown between 2 similar face-based scales, underscoring the potential differences in the perception of fine details included within the visuals.</p><p><strong>Limitations: </strong>Limitations of this review include its focus on specific pain intensity metrics in children aged 3 to 18 without consideration of cognitive age or inclusion of articles about both acute and chronic pain. Study section and publication bias may have impacted the general findings, as is true of any systematic review.</p><p><strong>Conclusions: </strong>Self-report pain scales that include visual aids such as colors and facial features may allow for the better assessment of pediatric pain than do pain scales without visual aids; however, additional research is required to fully elucidate the effects of such elements. This systematic review suggests that a universal, emoji-based electronic pain scale may enhance reporting accuracy and allow personalization for pediatric patients from various backgrounds.</p>","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 3","pages":"183-196"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Radiation Exposure Between Trident and Conventional Cannula in Genicular RF Procedures Under Fluoroscopy for Gonarthrosis.","authors":"Ahmet Yilmaz","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Genicular nerve radiofrequency ablation (GNRFA), including conventional, cooled, and pulsed techniques, has been used in the treatment of symptomatic knee osteoarthritis (OA).</p><p><strong>Objectives: </strong>This study aimed to compare conventional and trident GNRFA application methods, to evaluate the characteristics of fluoroscopy use and to evaluate the differences in terms of x-ray exposure.</p><p><strong>Study design: </strong>Observational study and original research.</p><p><strong>Setting: </strong>This work was conducted at Adana City Hospital, Adana, Turkey.</p><p><strong>Methods: </strong>A 3-pronged radiofrequency ablation (RFA) cannula was pushed under C-arm fluoroscopic guidance to known sites of the superomedial genicular nerve, superolateral genicular nerve, inferomedial genicular nerve, nerve to vastus medialis, nerve to vastus lateralis and nerve to vastus intermedius shortly after suitable placement, sterile preparation, and subcutaneous anaesthesia. All patients were exposed to ablation at RF 90°C for 60 seconds.</p><p><strong>Results: </strong>The study included 41 patients, 28 (68.3%) women and 13 (31.7%) men, with a mean age of 68.2 ± 7.0 years. Conventional and Trident™ GNRFA was performed in 22 and 19 patients, respectively. The median radioactivity exposure in the conventional GNRFA group was 0.14 (0.11/0.17) mGy, while the median radioactivity exposure in the Trident™ group was 0.11 (0.06/0.17) (P < 0.001). WOMAC scores between the baseline and first- and third-month post-treatment in the Trident™ group were significantly higher than in the conventional group (P = 0.018 and P = 0.006, respectively). In both treatment groups, the improvement in VAS and WOMAC scores was significant at one month and continued similarly at 3 months.</p><p><strong>Limitation: </strong>The study's limitations include a small sample size and a lack of blinding due to the study design, which may have introduced bias.</p><p><strong>Conclusion: </strong>GNRFA using a lateral approach and a Trident™ cannula offers significant advantages, including better improvement in WOMAC scores, shorter procedure times, fewer fluoroscopy shots, and reduced radiation exposure.</p>","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 3","pages":"E233-E242"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Platelet-Rich Plasma versus Genicular Nerve Radiofrequency Ablation in Knee Osteoarthritis: An Open-Label, Prospective, Randomized, Clinical Trial.","authors":"Shahzad Anwar, Swarnima Vardhan, Abhinav Aggarwal, Sulayman Waquar, Madhurima Vardhan, Gull A Rukh Shoukat, Sudhir A Diwan, Annu Navani","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Osteoarthritis is the most prevalent joint disorder, marked by significant pain, reduced functionality, and diminished quality of life. The prevalence of chronic knee osteoarthritis is increasing as the population ages. Minimally invasive therapeutic interventions, including platelet-rich plasma and radiofrequency ablation of genicular nerves, have demonstrated substantial efficacy in alleviating pain in these patients.</p><p><strong>Objective: </strong>The objective of this study was to compare the efficacy of intraarticular platelet-rich plasma (PRP) injection and genicular nerve radiofrequency ablation (GNRFA) in alleviating pain associated with knee osteoarthritis.</p><p><strong>Study design: </strong>An open-label, prospective, randomized clinical trial.</p><p><strong>Setting: </strong>A university hospital.</p><p><strong>Methods: </strong>This prospective, randomized, open-label clinical trial was conducted on 200 patients with Grade II-III knee osteoarthritis. Of these, 100 patients were assigned to the PRP group, receiving a single intraarticular PRP injection, while the remaining patients in the GNRFA group underwent radiofrequency ablation of the superomedial, superolateral, and inferomedial genicular nerves following a successful diagnostic block. Outcomes were assessed using the Visual Analog Scale (VAS) and the Oswestry Disability Index (ODI) at the baseline and subsequently at 2 weeks, 3 months, 6 months, one year, and 2 years post-intervention.</p><p><strong>Results: </strong>VAS scores were significantly lower in the PRP group than in the GNRFA group at 12 and 24 months, with P-values < 0.001. The PRP group also exhibited statistically significant reductions in ODI scores at all pre-specified time points. No adverse effects were reported in either treatment group.</p><p><strong>Limitations: </strong>The study did not include a control group, and the assessment of efficacy was primarily based on clinical scores without evaluating structural changes through MRI. Additionally, physical and analgesic therapies were not considered in the data collection.</p><p><strong>Conclusion: </strong>For patients with chronic knee osteoarthritis, intraarticular platelet-rich plasma therapy may offer superior sustained pain relief and a lower disability index compared to conventional radiofrequency ablation of the genicular nerves.</p>","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 3","pages":"207-215"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy and Safety of Applying the Combination of Pulsed Radiofrequency and Platelet-Rich Plasma to the Gasserian Ganglion for the Treatment of Idiopathic Trigeminal Neuralgia: A Protocol for a Multi-Center, Prospective, Open-Label, Propensity Score Match Cohort Study.","authors":"Tong Ren, Lingjie Xia, Yongjun Zheng, Yixuan Yang, Nan Ji, Fang Luo","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Trigeminal neuralgia (TN) is one of the severest and most common forms of neuropathic pain, and the current standard treatments for TN still have some disadvantages and limitations. Pulsed radiofrequency (PRF) has great potential as a micro-destructive method in treating refractory TN, but the long-term outcomes of PRF have been reported to be unsatisfactory. Autologous platelet-rich plasma (PRP) can reduce inflammation and promote nerve repair and has been proven effective in a previously published case report. So far, there have been no reports on combining PRF with PRP for the treatment of TN.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;We plan to conduct an open-label cohort study to compare the efficacy of PRF to that of PRF with PRP when each is applied to the Gasserian ganglion for the treatment of TN.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study design: &lt;/strong&gt;A study protocol for a multicentric, prospective, observational, propensity score matching (PSM), parallel, cohort, non-randomized, and assessor-blinded trial.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Setting: &lt;/strong&gt;Department of Pain Management, Beijing Tiantan Hospital, Capital Medical University in Beijing, China; Department of Pain Management, Henan Provincial People's Hospital, Henan, China; Department of Pain Management, Huadong Hospital, Fudan University, Shanghai.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 270 patients with idiopathic TN will be assigned equally to one of 2 groups, based on their willingness. Both groups will receive 2 Hz of PRF, with the PRP group also receiving 2 mL of leukocyte-poor platelet-rich plasma (LP-PRP) mixture, which will be injected slowly into the Gasserian ganglion and the mandibular nerve. It is estimated that 81 patients who receive the combination of PRF and PRP will be matched with 81 PRF-alone controls after a propensity score match (PSM) to ensure balanced comparisons between the 2 groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The primary outcome will be the response rate of the treatment after 12 months, which is the percentage of patients with a modified Barrow Neurological Institute (BNI) pain intensity score between I and III. The secondary outcome will include the following: BNI score, Numeric Rating Scale score, dose of carbamazepine, patient satisfaction score, score on the World Health Organization Quality of Life Questionnaire (WHOQOL-BREF), and adverse reactions. These data will be recorded over a one-year follow-up period.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Limitations: &lt;/strong&gt;The open-label study design may influence the measurement of outcomes and introduce bias, such as performance or ascertainment bias.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;To our knowledge, this trial will be the first multi-centric, prospective, observational study that has a relatively large sample size and compares the efficacy and safety of applied PRF to that of combined PRF and PRP for patients who have not responded to pharmacologic treatments for idiopathic TN. If the combination PRF-and-PRP treat","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 3","pages":"E263-E270"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Care Utilization for Chronic Low Back Pain Among Medicaid Patients Versus Privately Insured Patients - A Retrospective Study.","authors":"Robin Raju, Jesse Reynolds, Jiani Zhu, Sergio Uriel Mosquera Limas, Whinkie Leung","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Poor socioeconomic status and low access to care among patients have been identified as potential reasons for increased in disability associated with chronic low back pain.</p><p><strong>Objectives: </strong>This study aims to explore health care utilization by patients who have chronic low back pain and come from poor socioeconomic backgrounds by comparing Medicaid patients to privately insured patients.</p><p><strong>Study design: </strong>Retrospective study.</p><p><strong>Setting: </strong>A single-center academic hospital health system.</p><p><strong>Methods: </strong>This study reviewed the charts of all patients who had primary diagnoses of low back pain, were between the ages of 22 and 60 years old, and had been seen by 4 physiatrists from 2019 to 2023. Several health care utilization data were collected.</p><p><strong>Results: </strong>Of the 424 patients, 206 (49%) patients had Medicaid insurance, and 218 (51%) patients had private insurance. Individuals in the Medicaid group attended more physical therapy sessions (mean: 7.1, median: 2) than did those with private insurance (mean: 5.2, median: 0, P < 0.001). With respect to \"no-show\" appointments, the Medicaid group (mean: 8.6, median: 4) had a significantly higher number of missed appointments than did the private group (mean: 3.0, median: 1, P < 0.001). Further regression analyses showed that patients in the Medicaid group with high Charlson Comorbidity Index scores had statistically significant high no-show counts (P < 0.0001). The median number of behavioral health sessions was significantly higher in the Medicaid group (mean: 6.8, median: 4) than in the private group (mean: 5.6, median: 3, P = 0.030). The number of Physical Medicine & Rehabilitation sessions, magnetic resonance images, spine injections, and spine surgeries performed during the study period were similar for both groups.</p><p><strong>Limitations: </strong>The retrospective nature of the study and small sample size limit the ability to establish causation among observed variables. The health care utilization of privately insured patients as compared to Medicaid patients could have been underreported in this study, since the former could have gone to outside private practices for the management of low back pain.</p><p><strong>Conclusions: </strong>This study showed that Medicaid patients utilized health care to a similar if not greater extent than did privately insured patients. In addition, there was also a high \"no-show\" count in the Medicaid group.</p>","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 3","pages":"E271-E280"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Predicting Responses to Interventional Pain Management Techniques for Chronic Low Back Pain: A Single-Center Observational Study (PReTi-Back Study).","authors":"Natasha C Pocovi, Stephen A Sharp, Mark J Hancock","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 2","pages":"E230"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Tattoos on Spinal or Epidural Anesthesia: A Narrative Review.","authors":"Haixia Yang, Yali Ji","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The popularity of tattoos has increased significantly, particularly among younger demographics. However, the implications of tattoos on medical procedures, such as spinal or epidural anesthesia, are not well established. There is a need to understand the potential risks and complications associated with administering anesthesia through tattooed skin.</p><p><strong>Objectives: </strong>This narrative review aims to explore the principles of tattooing, the composition of tattoo pigments, the immune response to tattoos, the complications arising from tattoos, and the impact of tattoos on spinal or epidural anesthesia.</p><p><strong>Study design: </strong>A comprehensive literature review was conducted to gather information on the interaction between tattoos and anesthesia. The review included studies that examined the effects of tattoos on anesthesia outcomes and patient safety.</p><p><strong>Setting: </strong>The review spans both clinical and research environments, focusing on the interactions of tattooed skin and anesthesia administration, particularly in regions where tattoos are prevalent.</p><p><strong>Methods: </strong>Relevant databases were searched for studies discussing the relationship between tattoos and anesthesia. The analysis included examination of tattoo pigments, immune responses, and the potential for complications during the administration of anesthesia through tattooed skin.</p><p><strong>Results: </strong>The review found that tattoos could lead to various complications, including infections, allergic reactions, and skin lesions. The presence of tattoos does not preclude the use of spinal or epidural anesthesia but may necessitate modifications in anesthetic technique. The pigments used in tattoos, especially organic compounds, can potentially cause neurotoxic reactions if introduced into the spinal canal. Additionally, tattoos may interfere with the body's immune response, leading to localized inflammation and potential nerve injury.</p><p><strong>Limitations: </strong>The review is limited by the scarcity of studies specifically addressing the interactions between tattoos and anesthesia. The variability in tattoo pigments and individual patient responses further complicates the establishment of standardized guidelines.</p><p><strong>Conclusions: </strong>While tattoos present potential risks when considering spinal or epidural anesthesia, they do not absolutely contraindicate these procedures. Anesthesia providers should be aware of the possible complications and adapt their practices accordingly. These adjustments may include selecting alternative puncture sites, using caution with MRI and high-frequency electrosurgery, and obtaining detailed information about the tattoo's pigment composition. Further research is needed to establish clear guidelines and to better understand the long-term implications of tattoos on anesthesia safety and efficacy.</p>","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 2","pages":"E129-E135"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Experience with Open-Loop Spinal Cord Stimulation Devices Across Manufacturers and Waveforms: Results of a Double-Blind Survey.","authors":"Scott G Pritzlaff, Mehul Desai, Sean Li, Melissa Z Murphy, Vwaire Orhurhu, David A Provenzano, Henry E Vucetic, Kate Robertson, Louis Archila, Lisa M Johanek, Abi Franke, Ashish Gulve","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Spinal cord stimulation (SCS) is an established, efficacious therapy for chronic neuropathic pain. SCS therapy has the unique challenge of variability in the amount of applied stimulation that reaches the cord as it moves within the spinal canal during the patient's activities of daily living (ADLs). This variability is experienced by the patient as transient instances of overly strong (i.e., overstimulation) or overly weak (i.e., understimulation) therapy when the person changes their posture. While patients report a high degree of satisfaction with the pain reduction and quality-of-life improvement from this therapy, they make manual adjustments to the programmed settings, including turning the amplitude up, down or off, to avoid these events.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study was undertaken to understand patients' experiences with the current generation of open-loop (OL) SCS devices and what innovations would be meaningful to those patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study design: &lt;/strong&gt;The study was a prospective, double-blind survey of a representative sample of SCS patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Setting: &lt;/strong&gt;The study was executed by a third-party vendor as a 20-minute electronic survey.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Patients were recruited from the database of another market research vendor and screened via email or phone. Eligibility was determined based on screening questions, including location of implant, manufacturer, time since implant, and location of pain. Consent was obtained prior to participation, and patients were compensated for their time. The questions were tested prior to being administered to the patients in a separate cohort for ease of understanding and adequacy of choices.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;One hundred patients representative of the SCS population provided responses to this survey; the patients were implanted with devices manufactured by Medtronic (33%), Nevro (28%), Boston Scientific (24%), and Abbott (15%). Over 80% of patients were being treated for low-back pain with or without leg pain. Regardless of whether the patient was programmed to receive sub- or supra-perception therapy, 58% reported experiencing overstimulation, and 46% reported understimulation as they engaged in ADLs. Most of the patients (85%) reported avoiding one or more ADLs, and 70% reported increasing or decreasing the level of therapy proactively to avoid those side effects, resulting in a significant burden of device management. Over 80% of patients expressed being satisfied or very satisfied with the pain relief provided by the devices and technology.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Limitations: &lt;/strong&gt;This study has the inherent limitations of a direct-to-patient survey design, including subjective interpretation of the questions without a complete understanding of the relative merits of different waveforms or devices (e.g., MRI conditionality).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Patients report a high degree of ","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 2","pages":"E205-E214"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Memoriam: Dr. Jorge Antonia (\"Tony\") Aldrete 1937-2025.","authors":"Kenneth D Candido, Ricardo Plancarte Sanchez","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 2","pages":"E219-E225"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Pain in Neurofibromatosis 1, Neurofibromatosis 2, and Schwannomatosis: A Review on Epidemiology, Pathophysiology, Symptomatology and Treatment.","authors":"Barlas Benkli, Peter D Vu, Alaa Abd-Elsayed, John M Slopis, Yimin Geng, Matthew Chung","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Neurofibromatosis (NF) is a group of neurogenetic disorders (including neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis) known for their tendency to induce the development of numerous nerve sheath tumors. Pain is a common symptom associated with NF, and the incidence of this pain can vary significantly, severely affecting the quality of life for many patients.</p><p><strong>Objective: </strong>This narrative review aims to compile recent epidemiological data on NF1, NF2 and schwannomatosis, covering prevalence, incidence, and distribution across populations. It explores the disease's pathophysiology, highlighting the molecular mechanisms behind its development, and examines the diverse clinical manifestations and their impacts on patients. Additionally, the review evaluates current treatment approaches, synthesizing recent advancements to provide a comprehensive understanding. This review aims to offer researchers and health care professionals an updated perspective on managing NF effectively.</p><p><strong>Study design: </strong>A narrative review of peer-reviewed literature for NF, the management of its associated pain, and quality of life for patients who have the condition.</p><p><strong>Methods: </strong>The MEDLINE and Embase databases were reviewed to identify peer-reviewed research that discussed factors relevant to NF-related pain and its management.</p><p><strong>Limitations: </strong>This narrative review is not systematic and focuses primarily on existing literature without presenting new data.</p><p><strong>Conclusions: </strong>While advances have been made in understanding pain associated with NF, particularly for NF1, NF2, and schwannomatosis, significant gaps in treatment and understanding remain. Future research should prioritize targeted therapies and improved pain management strategies to enhance the quality of life for NF patients.</p>","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 2","pages":"105-115"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}