Periodontology 2000最新文献_第10页

Biological biomarkers of oral cancer 口腔癌的生物标志物

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2023-12-10 DOI: 10.1111/prd.12542

Allan Radaic, Pachiyappan Kamarajan, Alex Cho, Sandy Wang, Guo-Chin Hung, Fereshteh Najarzadegan, David T. Wong, Hung Ton-That, Cun-Yu Wang, Yvonne L. Kapila

{"title":"Biological biomarkers of oral cancer","authors":"Allan Radaic, Pachiyappan Kamarajan, Alex Cho, Sandy Wang, Guo-Chin Hung, Fereshteh Najarzadegan, David T. Wong, Hung Ton-That, Cun-Yu Wang, Yvonne L. Kapila","doi":"10.1111/prd.12542","DOIUrl":"https://doi.org/10.1111/prd.12542","url":null,"abstract":"The oral squamous cell carcinoma (OSCC) 5 year survival rate of 41% has marginally improved in the last few years, with less than a 1% improvement per year from 2005 to 2017, with higher survival rates when detected at early stages. Based on histopathological grading of oral dysplasia, it is estimated that severe dysplasia has a malignant transformation rate of 7%–50%. Despite these numbers, oral dysplasia grading does not reliably predict its clinical behavior. Thus, more accurate markers predicting oral dysplasia progression to cancer would enable better targeting of these lesions for closer follow-up, especially in the early stages of the disease. In this context, molecular biomarkers derived from genetics, proteins, and metabolites play key roles in clinical oncology. These molecular signatures can help predict the likelihood of OSCC development and/or progression and have the potential to detect the disease at an early stage and, support treatment decision-making and predict treatment responsiveness. Also, identifying reliable biomarkers for OSCC detection that can be obtained non-invasively would enhance management of OSCC. This review will discuss biomarkers for OSCC that have emerged from different biological areas, including genomics, transcriptomics, proteomics, metabolomics, immunomics, and microbiomics.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":null,"pages":null},"PeriodicalIF":18.6,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138571974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal. 牙周炎和动脉粥样硬化性心血管疾病:一个关键的评估。

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2023-11-23 DOI: 10.1111/prd.12528

Maria Clotilde Carra, Hélène Rangé, Giuseppina Caligiuri, Philippe Bouchard

引用次数: 0

The natural history of periodontal disease-Part 2: In populations with access to dental care: The Studies of Health in Pomerania (SHIP). 牙周病的自然史第2部分：可获得牙科护理的人群：波美拉尼亚健康研究（SHIP）。

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2023-10-25 DOI: 10.1111/prd.12535

Thomas Kocher, Peter Meisel, Reiner Biffar, Henry Völzke, Birte Holtfreter

{"title":"The natural history of periodontal disease-Part 2: In populations with access to dental care: The Studies of Health in Pomerania (SHIP).","authors":"Thomas Kocher, Peter Meisel, Reiner Biffar, Henry Völzke, Birte Holtfreter","doi":"10.1111/prd.12535","DOIUrl":"https://doi.org/10.1111/prd.12535","url":null,"abstract":"In this descriptive analysis of the 21-year follow-up data from the SHIP-START cohort and the 7-year follow-up data from the SHIP-TREND cohort, we report the progression of clinical attachment levels (CAL), age effects on CAL change, and a detailed description of CAL progression and remission. At baseline, 4307 and 4420 persons participated in SHIP-START and SHIP-TREND, respectively. At the final follow-up, 1181 and 2507 subjects were available for evaluation, respectively. In SHIP-START and SHIP-TREND participants, the mean CAL progressed by 0.04 and 0.02 mm/year, respectively. The older the participants were, the lower the average annual change in mean CAL (from 0.043 to 0.031 mm/year); annual tooth loss was 0.11-0.14 teeth/year. When participants were ranked according to their annual change in mean CAL, remission was more frequently observed in older subjects. To correctly understand the data, it is important to realize that selection bias due to dropouts during follow-up favored younger and more health-conscious persons. In addition, extraction of severely periodontally compromised teeth during follow-up biased the progression towards zero. Another explanation for these low CAL progression rates is that most sites had little or no change in CAL; this means that CAL progression was partly offset by CAL remission. Therefore, changes in mean CAL do not adequately describe the temporal course of periodontitis. Older age was not a risk factor for CAL progression in either cohort.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":null,"pages":null},"PeriodicalIF":18.6,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50162421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity. 牙周炎和代谢性疾病（糖尿病和肥胖症）：应对多种疾病。

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2023-10-16 DOI: 10.1111/prd.12536

Crystal Marruganti, Jean E Suvan, Francesco D'Aiuto

{"title":"Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity.","authors":"Crystal Marruganti, Jean E Suvan, Francesco D'Aiuto","doi":"10.1111/prd.12536","DOIUrl":"https://doi.org/10.1111/prd.12536","url":null,"abstract":"Noncommunicable diseases (NCDs) are multifactorial, long-term, chronic conditions that represent a burden to health-care systems worldwide as they can only be controlled rather than cured; hence, they require long-term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is also rapidly rising. \"Multimorbidity,\" defined as the presence of two or more long-term physical or mental disorders, is now considered a worldwide epidemic, affecting around 20% of the adult population. Periodontitis, diabetes, and obesity, all chronic inflammatory diseases, are an example of multimorbidity highly relevant to dental practitioners. Over the last three decades, the three-way relationship among the diseases has been vastly researched and accepted, with important contributions by European researchers. The interplay among periodontitis, diabetes, and obesity is sustained by shared biological mechanisms, such as systemic inflammation, insulin resistance, and metabolic dysfunction, as well as common lifestyle-related risk factors. As such, unhealthy lifestyles were found to generally increase systemic inflammation and insulin resistance and decrease immune function, hence, eventually increasing the risk of NCDs onset and the development of multimorbidity. This narrative review of the evidence supports the need for a paradigm shift from a \"single-disease\" to a \"multiple-disease\" framework, characterized by an integrated multidisciplinary approach, which should include lifestyle modification interventions to successfully tackle multimorbid periodontitis and metabolic diseases (diabetes and obesity). A multidisciplinary integrated care pathway in both dental and medical settings should be considered to further tackle the global health challenge of multimorbidity.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":null,"pages":null},"PeriodicalIF":18.6,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41237428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is alveolar ridge preservation an overtreatment? 牙槽嵴保留是过度治疗吗？

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2023-10-01 Epub Date: 2023-08-25 DOI: 10.1111/prd.12508

Nikos Mardas, Neil Macbeth, Nikolaos Donos, Ronald Ernst Jung, Anina Nives Zuercher

{"title":"Is alveolar ridge preservation an overtreatment?","authors":"Nikos Mardas, Neil Macbeth, Nikolaos Donos, Ronald Ernst Jung, Anina Nives Zuercher","doi":"10.1111/prd.12508","DOIUrl":"10.1111/prd.12508","url":null,"abstract":"The morphology and dimensions of the postextraction alveolar ridge are important for the surgical and restorative phases of implant treatment. Adequate new bone formation and preservation of alveolar ridge dimensions following extraction will facilitate installation of the implant in a restorative position, while preservation of soft tissue contour and volume is essential for an aesthetic and implant-supported restoration with healthy peri-implant tissues. Alveolar ridge preservation (ARP) refers to any procedure that aims to: (i) limit dimensional changes in the alveolar ridge after extraction facilitating implant placement without additional extensive bone and soft tissue augmentation procedures (ii) promote new bone formation in the healing alveolus, and (iii) promote soft tissue healing at the entrance of the alveolus and preserve the alveolar ridge contour. Although ARP is a clinically validated and safe approach, in certain clinical scenarios, the additional clinical benefit of ARP over unassisted socket healing has been debated and it appears that for some clinicians may represent an overtreatment. The aim of this critical review was to discuss the evidence pertaining to the four key objectives of ARP and to determine where ARP can lead to favorable outcomes when compared to unassisted socket healing.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":null,"pages":null},"PeriodicalIF":18.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10444483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D printing for bone regeneration: challenges and opportunities for achieving predictability. 骨骼再生的3D打印：实现可预测性的挑战和机遇。

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2023-10-01 Epub Date: 2023-10-12 DOI: 10.1111/prd.12525

Saso Ivanovski, Omar Breik, Danilo Carluccio, Jamil Alayan, Ruben Staples, Cedryck Vaquette

引用次数: 0

Efficacy of biomaterials for lateral bone augmentation performed with guided bone regeneration. A network meta-analysis. 生物材料在引导骨再生下进行侧骨增强的疗效。网络荟萃分析。

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2023-10-01 Epub Date: 2023-09-27 DOI: 10.1111/prd.12531

Elena Calciolari, Stefano Corbella, Nikolaos Gkranias, Marco Viganó, Anton Sculean, Nikolaos Donos

{"title":"Efficacy of biomaterials for lateral bone augmentation performed with guided bone regeneration. A network meta-analysis.","authors":"Elena Calciolari, Stefano Corbella, Nikolaos Gkranias, Marco Viganó, Anton Sculean, Nikolaos Donos","doi":"10.1111/prd.12531","DOIUrl":"10.1111/prd.12531","url":null,"abstract":"Bone regeneration is often required concomitant with implant placement to treat a bone fenestration, a dehiscence, and for contouring. This systematic review assessed the impact of different biomaterials employed for guided bone regeneration (GBR) simultaneous to implant placement on the stability of radiographic peri-implant bone levels at ≥12 months of follow-up (focused question 1), as well as on bone defect dimension (width/height) changes at re-assessment after ≥4 months (focused question 2). Only randomized controlled trials (RCTs) and controlled clinical trials (CCTs) that compared different biomaterials for GBR were considered. A Bayesian network meta-analysis (NMA) was performed using a random-effects model. A ranking probability between treatments was obtained, as well as an estimation of the surface under the cumulative ranking value (SUCRA). Overall, whenever the biological principle of GBR was followed, regeneration occurred in a predictable way, irrespective of the type of biomaterial used. A lower efficacy of GBR treatments was suggested for initially large defects, despite the trend did not reach statistical significance. Regardless of the biomaterial employed, a certain resorption of the augmented bone was observed overtime. While GBR was shown to be a safe and predictable treatment, several complications (including exposure, infection, and soft tissue dehiscence) were reported, which tend to be higher when using cross-linked collagen membranes.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":null,"pages":null},"PeriodicalIF":18.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indications and surgical technique for distraction osteogenesis of the alveolar bone for augmentation prior to insertion of dental implants. 牙槽骨牵张成骨的适应症和手术技术，用于在插入牙科植入物之前进行增强。

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2023-10-01 Epub Date: 2023-11-08 DOI: 10.1111/prd.12524

Hans-Joachim Nickenig, Joachim E Zöller, Matthias Kreppel

引用次数: 0

Bone regeneration in implant dentistry: Which are the factors affecting the clinical outcome? 种植牙的骨再生：影响临床效果的因素有哪些？

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2023-10-01 Epub Date: 2023-08-24 DOI: 10.1111/prd.12518

Nikolaos Donos, Aliye Akcali, Ninad Padhye, Anton Sculean, Elena Calciolari

{"title":"Bone regeneration in implant dentistry: Which are the factors affecting the clinical outcome?","authors":"Nikolaos Donos, Aliye Akcali, Ninad Padhye, Anton Sculean, Elena Calciolari","doi":"10.1111/prd.12518","DOIUrl":"10.1111/prd.12518","url":null,"abstract":"The key factors that are needed for bone regeneration to take place include cells (osteoprogenitor and immune-inflammatory cells), a scaffold (blood clot) that facilitates the deposition of the bone matrix, signaling molecules, blood supply, and mechanical stability. However, even when these principles are met, the overall amount of regenerated bone, its stability over time and the incidence of complications may significantly vary. This manuscript provides a critical review on the main local and systemic factors that may have an impact on bone regeneration, trying to focus, whenever possible, on bone regeneration simultaneous to implant placement to treat bone dehiscence/fenestration defects or for bone contouring. In the future, it is likely that bone tissue engineering will change our approach to bone regeneration in implant dentistry by replacing the current biomaterials with osteoinductive scaffolds combined with cells and mechanical/soluble factors and by employing immunomodulatory materials that can both modulate the immune response and control other bone regeneration processes such as osteogenesis, osteoclastogenesis, or inflammation. However, there are currently important knowledge gaps on the biology of osseous formation and on the factors that can influence it that require further investigation. It is recommended that future studies should combine traditional clinical and radiographic assessments with non-invasive imaging and with patient-reported outcome measures. We also envisage that the integration of multi-omics approaches will help uncover the mechanisms responsible for the variability in regenerative outcomes observed in clinical practice.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":null,"pages":null},"PeriodicalIF":18.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10435119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical efficacy of guided bone regeneration in peri-implantitis defects. A network meta-analysis. 引导骨再生治疗种植体周围炎缺损的临床疗效。网络荟萃分析

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2023-10-01 Epub Date: 2023-07-25 DOI: 10.1111/prd.12510

Ausra Ramanauskaite, Kathrin Becker, Emilio A Cafferata, Frank Schwarz

{"title":"Clinical efficacy of guided bone regeneration in peri-implantitis defects. A network meta-analysis.","authors":"Ausra Ramanauskaite, Kathrin Becker, Emilio A Cafferata, Frank Schwarz","doi":"10.1111/prd.12510","DOIUrl":"10.1111/prd.12510","url":null,"abstract":"Guided bone regeneration (GBR) at peri-implantitis-related bone defects involves the placement of bone-filler particles in the intrabony defects and the application of a barrier membrane. The efficacy of different GBR-supported reconstructive measures as well as their potential superiority compared to non-GBR-supported treatment strategies for bone defects at peri-implantitis sites, however, remains unclear. Therefore, this analysis was designed to evaluate the long-term (≥12 months) clinical efficacy of GBR-supported reconstructive surgical therapy for peri-implantitis-related bone defects. In terms of resolving inflammation, the implementation of GBR protocols applying xenogenic bone substitutes yielded a higher reduction of bleeding on probing and probing depth value compared to the GBR protocol applying autogenous bone. Furthermore, for the changes in bleeding on probing and probing depths, GBR approaches using xenogenic bone showed superiority over the non-GBR treatments. Xenogenic bone with or without a barrier membrane was associated with improved radiographic bone levels and less soft tissue recession compared to the use of a GBR protocol implementing autogenous bone. Nonetheless, when interpreting this findings, the limited number of available studies with low to serious risk of bias and the short follow-up periods limited to 12 months should be considered.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":null,"pages":null},"PeriodicalIF":18.6,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9876868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0