Periodontology 2000最新文献_第9页

Can vitamins improve periodontal wound healing/regeneration? 维生素能改善牙周伤口愈合/再生吗？

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2024-02-01 Epub Date: 2023-08-17 DOI: 10.1111/prd.12513

Karim M Fawzy El-Sayed, Raluca Cosgarea, Anton Sculean, Christof Doerfer

{"title":"Can vitamins improve periodontal wound healing/regeneration?","authors":"Karim M Fawzy El-Sayed, Raluca Cosgarea, Anton Sculean, Christof Doerfer","doi":"10.1111/prd.12513","DOIUrl":"10.1111/prd.12513","url":null,"abstract":"Periodontitis is a complex inflammatory disorder of the tooth supporting structures, associated with microbial dysbiosis, and linked to a number if systemic conditions. Untreated it can result in an irreversible damage to the periodontal structures and eventually teeth loss. Regeneration of the lost periodontium requires an orchestration of a number of biological events on cellular and molecular level. In this context, a set of vitamins have been advocated, relying their beneficial physiological effects, to endorse the biological regenerative events of the periodontium on cellular and molecular levels. The aim of the present article is to elaborate on the question whether or not vitamins improve wound healing/regeneration, summarizing the current evidence from in vitro, animal and clinical studies, thereby shedding light on the knowledge gap in this field and highlighting future research needs. Although the present review demonstrates the current heterogeneity in the available evidence and knowledge gaps, findings suggest that vitamins, especially A, B, E, and CoQ10, as well as vitamin combinations, could exert positive attributes on the periodontal outcomes in adjunct to surgical or nonsurgical periodontal therapy.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":" ","pages":"539-602"},"PeriodicalIF":18.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10375145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herpesvirus-Bacteria pathogenic interaction in juvenile (aggressive) periodontitis. A novel etiologic concept of the disease. 青少年(侵袭性)牙周炎的疱疹病毒-细菌致病性相互作用。一个新的病因学概念的疾病。

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2024-02-01 Epub Date: 2023-06-21 DOI: 10.1111/prd.12501

Jørgen Slots, Thomas E Rams

引用次数: 0

Nanocages and cell-membrane display technology as smart biomaterials. 作为智能生物材料的纳米笼和细胞膜显示技术。

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2024-02-01 Epub Date: 2023-08-24 DOI: 10.1111/prd.12514

Yulan Wang, Richard J Miron, Xiaoxin Zhang, Hao Zeng, Yufeng Zhang

引用次数: 0

Ion incorporation into bone grafting materials. 离子掺入骨移植材料。

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2024-02-01 Epub Date: 2023-10-12 DOI: 10.1111/prd.12533

Qin Zhao, Yueqi Ni, Hongjiang Wei, Yiling Duan, Jingqiu Chen, Qi Xiao, Jie Gao, Yiqian Yu, Yu Cui, Simin Ouyang, Richard J Miron, Yufeng Zhang, Chengtie Wu

{"title":"Ion incorporation into bone grafting materials.","authors":"Qin Zhao, Yueqi Ni, Hongjiang Wei, Yiling Duan, Jingqiu Chen, Qi Xiao, Jie Gao, Yiqian Yu, Yu Cui, Simin Ouyang, Richard J Miron, Yufeng Zhang, Chengtie Wu","doi":"10.1111/prd.12533","DOIUrl":"10.1111/prd.12533","url":null,"abstract":"The use of biomaterials in regenerative medicine has expanded to treat various disorders caused by trauma or disease in orthopedics and dentistry. However, the treatment of large and complex bone defects presents a challenge, leading to a pressing need for optimized biomaterials for bone repair. Recent advances in chemical sciences have enabled the incorporation of therapeutic ions into bone grafts to enhance their performance. These ions, such as strontium (for bone regeneration/osteoporosis), copper (for angiogenesis), boron (for bone growth), iron (for chemotaxis), cobalt (for B12 synthesis), lithium (for osteogenesis/cementogenesis), silver (for antibacterial resistance), and magnesium (for bone and cartilage regeneration), among others (e.g., zinc, sodium, and silica), have been studied extensively. This review aims to provide a comprehensive overview of current knowledge and recent developments in ion incorporation into biomaterials for bone and periodontal tissue repair. It also discusses recently developed biomaterials from a basic design and clinical application perspective. Additionally, the review highlights the importance of precise ion introduction into biomaterials to address existing limitations and challenges in combination therapies. Future prospects and opportunities for the development and optimization of biomaterials for bone tissue engineering are emphasized.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":" ","pages":"213-230"},"PeriodicalIF":18.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41208183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selecting biomaterials in the reconstructive therapy of peri-implantitis. 种植体周围炎重建治疗中生物材料的选择。

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2024-02-01 Epub Date: 2023-09-20 DOI: 10.1111/prd.12523

Alberto Monje, Ramón Pons, José Nart, Richard J Miron, Frank Schwarz, Anton Sculean

引用次数: 0

Emerging factors affecting peri-implant bone metabolism. 影响种植体周围骨代谢的新因素。

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2024-02-01 Epub Date: 2023-10-30 DOI: 10.1111/prd.12532

Angel Insua, Pablo Galindo-Moreno, Richard J Miron, Hom-Lay Wang, Alberto Monje

{"title":"Emerging factors affecting peri-implant bone metabolism.","authors":"Angel Insua, Pablo Galindo-Moreno, Richard J Miron, Hom-Lay Wang, Alberto Monje","doi":"10.1111/prd.12532","DOIUrl":"10.1111/prd.12532","url":null,"abstract":"Implant dentistry has evolved to the point that standard implant osseointegration is predictable. This is attributed in part to the advancements in material sciences that have led toward improvements in implant surface technology and characteristics. Nonetheless, there remain several cases where implant therapy fails (specifically at early time points), most commonly attributed to factors affecting bone metabolism. Among these patients, smokers are known to have impaired bone metabolism and thus be subject to higher risks of early implant failure and/or late complications related to the stability of the peri-implant bone and mucosal tissues. Notably, however, emerging data have unveiled other critical factors affecting osseointegration, namely, those related to the metabolism of bone tissues. The aim of this review is to shed light on the effects of implant-related factors, like implant surface or titanium particle release; surgical-related factors, like osseodensification or implanted biomaterials; various drugs, like selective serotonin reuptake inhibitors, proton pump inhibitors, anti-hypertensives, nonsteroidal anti-inflammatory medication, and statins, and host-related factors, like smoking, diet, and metabolic syndrome on bone metabolism, and aseptic peri-implant bone loss. Despite the infectious nature of peri-implant biological complications, these factors must be surveyed for the effective prevention and management of peri-implantitis.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":" ","pages":"27-78"},"PeriodicalIF":18.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71413401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 associated oral and oropharyngeal microbiome: Systematic review and meta-analysis. 与 COVID-19 相关的口腔和口咽微生物组：系统回顾和荟萃分析。

IF 17.5 1区医学

Periodontology 2000 Pub Date : 2024-02-01 Epub Date: 2023-06-05 DOI: 10.1111/prd.12489

Sukirth M Ganesan, Tabitha K Peter, Miyuraj H H Withanage, Frank Boksa, Erliang Zeng, April Martinez, Shareef M Dabdoub, Kunaal Dhingra, Yvonne Hernandez-Kapila

{"title":"COVID-19 associated oral and oropharyngeal microbiome: Systematic review and meta-analysis.","authors":"Sukirth M Ganesan, Tabitha K Peter, Miyuraj H H Withanage, Frank Boksa, Erliang Zeng, April Martinez, Shareef M Dabdoub, Kunaal Dhingra, Yvonne Hernandez-Kapila","doi":"10.1111/prd.12489","DOIUrl":"10.1111/prd.12489","url":null,"abstract":"Three years into the coronavirus disease 2019 (COVID-19) pandemic, there are still growing concerns with the emergence of different variants, unknown long- and short-term effects of the virus, and potential biological mechanisms underlying etiopathogenesis and increased risk for morbidity and mortality. The role of the microbiome in human physiology and the initiation and progression of several oral and systemic diseases have been actively studied in the past decade. With the proof of viral transmission, carriage, and a potential role in etiopathogenesis, saliva and the oral environment have been a focus of COVID-19 research beyond diagnostic purposes. The oral environment hosts diverse microbial communities and contributes to human oral and systemic health. Several investigations have identified disruptions in the oral microbiome in COVID-19 patients. However, all these studies are cross-sectional in nature and present heterogeneity in study design, techniques, and analysis. Therefore, in this undertaking, we (a) systematically reviewed the current literature associating COVID-19 with changes in the microbiome; (b) performed a re-analysis of publicly available data as a means to standardize the analysis, and (c) reported alterations in the microbial characteristics in COVID-19 patients compared to negative controls. Overall, we identified that COVID-19 is associated with oral microbial dysbiosis with significant reduction in diversity. However, alterations in specific bacterial members differed across the study. Re-analysis from our pipeline shed light on Neisseria as the potential key microbial member associated with COVID-19.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":" ","pages":"603-626"},"PeriodicalIF":17.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10026499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding exosomes: Part 1-Characterization, quantification and isolation techniques. 理解外泌体：第1部分——表征、定量和分离技术。

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2024-02-01 Epub Date: 2023-09-22 DOI: 10.1111/prd.12520

Richard J Miron, Yufeng Zhang

引用次数: 0

Control of tissue homeostasis by the extracellular matrix: Synthetic heparan sulfate as a promising therapeutic for periodontal health and bone regeneration. 细胞外基质对组织稳态的控制：合成硫酸天门冬酰胺是牙周健康和骨再生的理想疗法。

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2024-02-01 Epub Date: 2023-08-24 DOI: 10.1111/prd.12515

P A Miguez, E Bash, M L Musskopf, S A Tuin, A Rivera-Concepcion, I L C Chapple, J Liu

{"title":"Control of tissue homeostasis by the extracellular matrix: Synthetic heparan sulfate as a promising therapeutic for periodontal health and bone regeneration.","authors":"P A Miguez, E Bash, M L Musskopf, S A Tuin, A Rivera-Concepcion, I L C Chapple, J Liu","doi":"10.1111/prd.12515","DOIUrl":"10.1111/prd.12515","url":null,"abstract":"Proteoglycans are core proteins associated with carbohydrate/sugar moieties that are highly variable in disaccharide composition, which dictates their function. These carbohydrates are named glycosaminoglycans, and they can be attached to proteoglycans or found free in tissues or on cell surfaces. Glycosaminoglycans such as hyaluronan, chondroitin sulfate, dermatan sulfate, keratan sulfate, and heparin/heparan sulfate have multiple functions including involvement in inflammation, immunity and connective tissue structure, and integrity. Heparan sulfate is a highly sulfated polysaccharide that is abundant in the periodontium including alveolar bone. Recent evidence supports the contention that heparan sulfate is an important player in modulating interactions between damage associated molecular patterns and inflammatory receptors expressed by various cell types. The structure of heparan sulfate is reported to dictate its function, thus, the utilization of a homogenous and structurally defined heparan sulfate polysaccharide for modulation of cell function offers therapeutic potential. Recently, a chemoenzymatic approach was developed to allow production of many structurally defined heparan sulfate carbohydrates. These oligosaccharides have been studied in various pathological inflammatory conditions to better understand their function and their potential application in promoting tissue homeostasis. We have observed that specific size and sulfation patterns can modulate inflammation and promote tissue maintenance including an anabolic effect in alveolar bone. Thus, new evidence provides a strong impetus to explore heparan sulfate as a potential novel therapeutic agent to treat periodontitis, support alveolar bone maintenance, and promote bone formation.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":" ","pages":"510-531"},"PeriodicalIF":18.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10891305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10126461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Twenty-five years of recombinant human growth factors rhPDGF-BB and rhBMP-2 in oral hard and soft tissue regeneration. 重组人生长因子 rhPDGF-BB 和 rhBMP-2 在口腔软硬组织再生中的应用已有 25 年。

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2024-02-01 Epub Date: 2023-09-08 DOI: 10.1111/prd.12522

Maria Elisa Galarraga-Vinueza, Shayan Barootchi, Marc L Nevins, Myron Nevins, Richard J Miron, Lorenzo Tavelli

{"title":"Twenty-five years of recombinant human growth factors rhPDGF-BB and rhBMP-2 in oral hard and soft tissue regeneration.","authors":"Maria Elisa Galarraga-Vinueza, Shayan Barootchi, Marc L Nevins, Myron Nevins, Richard J Miron, Lorenzo Tavelli","doi":"10.1111/prd.12522","DOIUrl":"10.1111/prd.12522","url":null,"abstract":"Contemporary oral tissue engineering strategies involve recombinant human growth factor approaches to stimulate diverse cellular processes including cell differentiation, migration, recruitment, and proliferation at grafted areas. Recombinant human growth factor applications in oral hard and soft tissue regeneration have been progressively researched over the last 25 years. Growth factor-mediated surgical approaches aim to accelerate healing, tissue reconstruction, and patient recovery. Thus, regenerative approaches involving growth factors such as recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and recombinant human bone morphogenetic proteins (rhBMPs) have shown certain advantages over invasive traditional surgical approaches in severe hard and soft tissue defects. Several clinical studies assessed the outcomes of rhBMP-2 in diverse clinical applications for implant site development and bone augmentation. Current evidence regarding the clinical benefits of rhBMP-2 compared to conventional therapies is inconclusive. Nevertheless, it seems that rhBMP-2 can promote faster wound healing processes and enhance de novo bone formation, which may be particularly favorable in patients with compromised bone healing capacity or limited donor sites. rhPDGF-BB has been extensively applied for periodontal regenerative procedures and for the treatment of gingival recessions, showing consistent and positive outcomes. Nevertheless, current evidence regarding its benefits at implant and edentulous sites is limited. The present review explores and depicts the current applications, outcomes, and evidence-based clinical recommendations of rhPDGF-BB and rhBMPs for oral tissue regeneration.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":" ","pages":"483-509"},"PeriodicalIF":18.6,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10185656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0