Periodontology 2000最新文献

{"title":"Analgesic effects of platelet‐rich fibrin (PRF): A systematic review","authors":"Nathan E. Estrin, Troy B. Tran, Paras Ahmad, Nima Farshidfar, Georgios E. Romanos, Anton Sculean, Richard J. Miron","doi":"10.1111/prd.70014","DOIUrl":"https://doi.org/10.1111/prd.70014","url":null,"abstract":"BackgroundPlatelet‐rich fibrin (PRF), a second‐generation autologous platelet concentrate, has gained significant interest for its anti‐inflammatory and regenerative characteristics. While its role in tissue healing is well‐recognized, the analgesic potential of PRF remains under‐investigated.AimThe primary objective of this systematic review was to critically evaluate any pain‐reported outcome of PRF across all medical and dental procedures in human studies. The secondary objective was to also evaluate outcomes regarding swelling reduction with PRF and other patient‐reported outcomes such as quality of life and analgesic consumption in all included studies.MethodsA systematic search of PubMed, Scopus, Web of Science, and Google Scholar databases was performed for comparative clinical studies assessing PRF's influence on postoperative pain. Eligible studies included human clinical trials comparing PRF with non‐PRF controls, with pain‐reported outcomes as the primary outcome. Data on swelling and other patient‐reported outcomes, including analgesic use and quality of life, was also evaluated as a secondary objective; however, studies that evaluated these outcomes alone were excluded. A total of 200 comparative clinical studies were included, covering a diverse range of procedures including third molar extractions, palatal wound healing, mucogingival procedures, periodontal/bone procedures, maxillary sinus lifts, endodontic procedures, orthodontic procedures, oral lesions, alveolar osteitis, oroantral communications, medically induced osteonecrosis of the jaw, temporomandibular joint disorders, orthopedic procedures, facial surgery and aesthetics, and other fields of medicine. However, heterogeneity in PRF preparation methods and outcome measures precluded a meta‐analysis.ResultsAlmost all studies reported reduced pain levels in the PRF group compared with non‐PRF controls, with additional benefits observed in terms of swelling reduction, decreased analgesic use, and improved patient‐reported outcomes. Importantly, it was observed that procedures that tend to generate the most patient‐reported pain, such as 3rd molar extractions and autogenous soft tissue grafting from the hard palate, generally reported much lower pain scores following PRF use (72%–85% of studies) and significantly reduced postoperative analgesic use (87.5% of studies).ConclusionsThe autologous nature of PRF, along with the sustained release of bioactive factors, likely plays a vital role in modulating inflammation and promoting tissue healing, hence enhancing patient comfort and recovery. As PRF continues to gain traction in clinical practice, integrating well‐designed comparative studies with standardized outcome measures will be necessary to completely understand its therapeutic potential and inform evidence‐based guidelines regarding its application.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":"25 1","pages":""},"PeriodicalIF":18.6,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of biologic factors on the surgical therapy of periodontal suprabony defects: A systematic review and network meta-analysis of randomized clinical trials.","authors":"Carrie Chew,Nikolaos Donos,Stefano Corbella,Isabella Manso,Greta Castellini,Elena Calciolari","doi":"10.1111/prd.70013","DOIUrl":"https://doi.org/10.1111/prd.70013","url":null,"abstract":"OBJECTIVESThis systematic review investigated the efficacy of biologic factors in the surgical treatment of periodontal suprabony defects.MATERIALS AND METHODSThree databases were searched to identify RCTs comparing open-flap debridement (OFD) combined with biologic factors only, or combined with bone substitute, and/or barriers to the same intervention without biologics or OFD in terms of probing pocket depth (PPD) reduction, clinical attachment level (CAL) gain, and number of pockets closed. Risk of bias was performed according to RoB 2. Pairwise meta-analyses and frequentist network meta-analyses by using random-effects models were performed. GRADE was employed to assess the certainty of evidence.RESULTSTen studies reporting on 253 subjects were included. Overall, adding biologics to OFD leads to a significant improvement in post-treatment PPD and CAL at 9-12 months, with enamel matrix derivative (EMD) having the highest probability of being the best biologic for changes in PPD (-1.91 mm, 95% CI: -3.02, -0.81) and CAL (-2.24 mm, 95% CI: -2.68, -1.79) at a low level of evidence.CONCLUSIONThe addition of biologics provides an adjunctive benefit in post-treatment PPD and CAL. However, data should be interpreted with caution due to the heterogeneity of studies, limited data available, risk of bias, and low/moderate evidence.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":"96 1","pages":""},"PeriodicalIF":18.6,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of liquid platelet-rich fibrin (liquid PRF) in temporomandibular joint disorders: A narrative review with clinical recommendations.","authors":"Nima Farshidfar,Mohammad Amin Amiri,Nathan E Estrin,Paras Ahmad,Yufeng Zhang,Anton Sculean,Richard J Miron","doi":"10.1111/prd.70012","DOIUrl":"https://doi.org/10.1111/prd.70012","url":null,"abstract":"AIMThis narrative review aimed to gather evidence from comparative and non-comparative clinical studies to assess: (1) whether the administration of liquid platelet-rich fibrin (liquid PRF) provides any clinical benefits for managing temporomandibular disorders (TMD), and if so, based on comparative clinical studies, (2) whether it offers more benefits than no treatment or other treatment modalities, either as a standalone therapy or as an adjunct.MATERIALS AND METHODSTo compile all relevant data, we performed a systematic search of PubMed, Scopus, and Web of Science, supplemented by a Google Scholar search for gray literature and a manual screening of reference lists from eligible studies and relevant reviews, up to April 22, 2025. A total of 23 clinical studies (19 comparative and 4 non-comparative) were ultimately included in this review.RESULTSAcross the included studies, the administration of liquid PRF has been shown to have beneficial effects in reducing pain and enhancing maximum mouth opening (MMO) in patients with TMD. In the majority of studies, the adjunctive use of liquid PRF following arthrocentesis demonstrated greater positive effects compared with arthrocentesis alone. When used adjunctively with arthrocentesis, liquid PRF also showed comparable or superior clinical outcomes in terms of pain reduction and MMO improvement compared with platelet-rich plasma (PRP) and hyaluronic acid (HA).CONCLUSIONSBased on these findings, the administration of liquid PRF following arthrocentesis appears to be a promising approach for the management of TMD. To support clinical application, this review also presented a step-by-step protocol to guide dental and medical practitioners in the effective use of liquid PRF in patients with TMD. However, further well-designed randomized clinical trials with standardized methodologies are required to strengthen the evidence base and confirm the therapeutic benefits of liquid PRF in the management of TMD due to the high variability among the included studies.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":"102 1","pages":""},"PeriodicalIF":18.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum cytokines in periodontal diseases.","authors":"Paras Ahmad, Jørgen Slots, Walter L Siqueira","doi":"10.1111/prd.12629","DOIUrl":"https://doi.org/10.1111/prd.12629","url":null,"abstract":"<p><p>Periodontal disease, including gingivitis and periodontitis, is a chronic inflammatory condition that leads to the destruction of the supporting structures of teeth. The disease is characterized by a complex immune response, where cytokines play a central role in regulating both inflammation and tissue breakdown. Cytokines are small signaling proteins that mediate communication between immune cells, driving the progression of periodontal diseases by activating immune cells, promoting osteoclast differentiation, and stimulating the production of matrix metalloproteinases. This leads to the degradation of periodontal ligament fibers, alveolar bone resorption, and eventual tooth loss. Cytokines contribute not only to localized tissue damage but also to systemic inflammation. Given that periodontal diseases are a chronic inflammatory diseases, their systemic implications are significant. Increasing evidence shows an association between periodontal diseases and other systemic conditions, suggesting that serum cytokine levels could provide valuable insights into both periodontal and systemic health. Understanding the role of serum cytokines in periodontal diseases is critical for identifying systemic inflammatory patterns and disease progression. Evaluating serum cytokine profiles may lead to the discovery of new diagnostic biomarkers and therapeutic targets. Cytokine-modulating therapies could potentially reduce the inflammatory burden in periodontal diseases and improve patient outcomes, especially in individuals with comorbid systemic conditions. This review highlights the current evidence on serum cytokines in periodontal diseases and emphasizes the need for further research to develop cytokine-targeted therapies for improved management of periodontal diseases.</p>","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic-mediated immune modulation in periodontitis.","authors":"Lina J Suárez, R M Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C Castro Dos Santos","doi":"10.1111/prd.70011","DOIUrl":"https://doi.org/10.1111/prd.70011","url":null,"abstract":"<p><p>Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial efficacy, emerging evidence suggests that certain antibiotics possess significant immune-modulatory properties independent of their bactericidal or bacteriostatic effects. This review explores the multifaceted immunomodulatory mechanisms by which various classes of antibiotics influence host immune cells and inflammatory pathways relevant to periodontal pathogenesis. Antibiotics were found to influence innate (e.g., pattern recognition receptors, neutrophils, macrophages, epithelial barriers, cytokine production) and acquired immunity (e.g., T and B cells). Additionally, they impact key osteoimmunology components, including interactions between immune and bone cells, the RANKL/osteoprotegerin pathway, and matrix metalloproteinase activity. Understanding the immunomodulatory actions of antibiotics enhances our understanding of their therapeutic potential in managing chronic inflammatory diseases, such as periodontitis. These properties may support inflammation resolution, immune regulation, and tissue repair, offering promising directions for future research and clinical application.</p>","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145054916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological definition of periodontal diseases: A historical review of host-response diagnostics and their implications for disease classification.","authors":"Nagihan Bostanci,Melissa M Grant,Moritz Kebschull","doi":"10.1111/prd.70005","DOIUrl":"https://doi.org/10.1111/prd.70005","url":null,"abstract":"BACKGROUNDUnderstanding periodontal diseases through a biological lens has been a central aim in periodontal research. Visionary pioneers in the field established the foundations of our knowledge, providing invaluable insights into disease mechanisms and progression.OBJECTIVEThis review highlights the evolving understanding of periodontal diseases, with particular focus on the transition from traditional diagnostic methods to molecular-based approaches.MATERIALS AND METHODSA narrative review was undertaken through a comprehensive literature search, synthesizing both historical perspectives and contemporary evidence.RESULTSOver recent decades, fundamental discoveries have significantly advanced our knowledge of periodontal pathogenesis. Despite this, current diagnostic protocols and classification systems remain largely reliant on clinical phenotypes such as pocket depth, attachment loss, and radiographic changes. These measures, while valuable, lack the precision to capture the underlying biological processes. To address this gap, a variety of biological samples (such as saliva, blood, gingival tissue and gingival crevicular fluid) have been explored as potential sources of diagnostic information. Investigations have identified diverse biomarkers, ranging from specific bacterial species and their products to host-derived enzymes, immune mediators, and tissue degradation products originating from the periodontal tissues. These findings colectively underscore the promise of molecular-based strategies to enhance disease detection and monitoring.CONCLUSIONThere is growing momentum toward the development of rapid, non-invasive, molecular diagnostic tools for periodontitis. Such approaches could not only enable earlier and more precise diagnosis within dentistry, but may also extend to applications in broader medical and non-dental settings.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":"41 1","pages":""},"PeriodicalIF":18.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ideal soft tissue graft in periodontal and peri‐implant applications: A scoping review","authors":"Madeline Yon, Elena Calciolari, Nikos Mardas, Anton Sculean, Nikolaos Donos","doi":"10.1111/prd.70010","DOIUrl":"https://doi.org/10.1111/prd.70010","url":null,"abstract":"Soft tissue grafts (STG) are used in a wide range of clinical situations including volume augmentation, keratinized tissue increase, and recession coverage around teeth and implants. Each STG, produced from different sources and processed with various techniques, possesses unique material properties and interaction with the host tissues, which ultimately impacts healing and clinical outcome. Certain STG material characteristics may be considered ideal depending on specific clinical requirements, such as mechanical strength, volume stability, and angiogenicity. Hybrid materials and graft engineering may further improve STG properties and provide new graft options. This scoping review evaluates the ideal characteristics of STG in periodontal and peri‐implant applications.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":"24 1","pages":""},"PeriodicalIF":18.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advancements in artificial intelligence-powered cancer prediction from oral microbiome.","authors":"Negin Soghli,Aminollah Khormali,Darius Mahboubi,Aimin Peng,Patricia A Miguez","doi":"10.1111/prd.70000","DOIUrl":"https://doi.org/10.1111/prd.70000","url":null,"abstract":"Oral cancer is a major global health burden, ranking sixth in prevalence, with oral squamous cell carcinoma (OSCC) being the most common type. Importantly, OSCC is often diagnosed at late stages, underscoring the need for innovative methods for early detection. The oral microbiome, an active microbial community within the oral cavity, holds promise as a biomarker for the prediction and progression of cancer. Emerging computational techniques in the artificial intelligence (AI) field have enabled the analysis of complex microbiome data sets to unravel the association between oral microbiome composition and oral cancer. This review provides a comprehensive overview of learning-based algorithms applied to oral microbiome data for cancer prediction. In particular, this work discusses how typical machine learning (ML) algorithms, such as logistic regression, random forests, and artificial neural networks, identify the unique microbial patterns associated with oral cancer and other malignancies. A search was conducted in Pubmed covering a 10-year period. The goal was to identify previous studies focused on the role of the oral microbiome in oral cancer prediction using AI-powered tools. The search strategy identified 3382 records in total, of which 44 studies met the inclusion criteria. While AI has shown a transformative power in understanding and revealing the oral microbiome's role in cancer studies, its application in clinical settings requires further efforts on standardization of protocols, curation of diverse cohorts, and validation through large-scale multi-centric and longitudinal studies. The integration of AI with oral microbiome analysis holds significant promise for improving early detection, risk stratification, and personalized treatment strategies for OSCC. By identifying unique microbial patterns associated with cancer, AI-driven models offer a noninvasive, cost-effective tool to predict disease progression and guide clinical decision-making. However, translating these advancements into routine clinical practice requires standardized protocols, diverse patient cohorts, and validation through large-scale, longitudinal studies. Once implemented, this approach could transform oral cancer management, enabling timely interventions and improving patient outcomes.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":"24 1","pages":""},"PeriodicalIF":18.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term clinical outcomes of periodontal regeneration of intrabony defects: A systematic review and meta-analysis.","authors":"Hom-Lay Wang,Parham Hazrati,Javier Calatrava,Muhammad S Saleh,Abdusalam E Alrmali","doi":"10.1111/prd.70002","DOIUrl":"https://doi.org/10.1111/prd.70002","url":null,"abstract":"This systematic review and meta-analysis aimed to evaluate the long-term clinical outcomes of regenerative procedures compared with access flap surgery for the treatment of intrabony defects, with a minimum follow-up period of 5 years. A systematic review protocol following PRISMA guidelines was conducted. Both electronic and manual searches were conducted to identify randomized clinical trials (RCTs) on regenerative treatment of deep intrabony defects (≥3 mm) with a follow-up of at least 5 years. Primary outcome variables were probing depth (PD) reduction, clinical attachment level (CAL) gain, recession depth (REC) and tooth loss. Meta-analyses and meta-regressions were performed using random-effects models. Seventeen RCTs published from 2004 to 2022, accounting for 501 defects, with follow-ups ranging from 5 to 20 years, were included. Thirteen studies with some concerns and four with high risks of bias were identified. Meta-analyses revealed that after ≥5 years of follow-up, guided tissue regeneration (GTR) on the intrabony defect resulted in significant CAL gain (3.27 mm; 95% CI: 2.90-3.65) and PD reduction (4.04 mm; 95% CI: 3.69-4.38) compared with baseline. After ≥5 years, regenerative procedures with biologics, bone grafts, or both showed significant improvements in CAL gain (3.21 mm; 95% CI: 2.72-3.70) and PD reduction (3.92 mm; 95% CI: 3.39-4.44). GTR on the intrabony defects obtained higher long-term CAL gain (1.52 mm; 95% CI: 0.06-3.10) and PD reduction (0.89 mm; 95% CI: 0.22-1.99) than OFD (open flap debridement); however, none of the outcomes reached statistical significance (p = 0.06; p = 0.115). Meta-regression identified significant associations between outcomes and factors, such as follow-up time, surgical technique, membrane type, and baseline measurements. The certainty of evidence was low for CAL and PD outcomes, but high for REC. Long-term studies indicate that regenerative procedures for the intrabony defects, particularly GTR, provide significant improvements in clinical parameters compared with baseline. However, the evidence does not conclusively demonstrate the superiority of regenerative approaches over OFD in the long term.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":"67 1","pages":""},"PeriodicalIF":18.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term stability of transcrestal sinus augmentation.","authors":"Sandra H Stuhr,Muhammad H A Saleh,Tiziano Testori,Hom-Lay Wang,Ann M Decker","doi":"10.1111/prd.70009","DOIUrl":"https://doi.org/10.1111/prd.70009","url":null,"abstract":"Transcrestal sinus augmentation has emerged as a minimally invasive alternative to lateral window techniques for vertical bone augmentation in the edentulous maxilla. Since its early introduction and modification over the last several decades, this technique has demonstrated predictable outcomes for implant placement in regions with limited bone height. This narrative review examines the current understanding and evolution of transcrestal sinus floor elevation (TSFE), focusing on factors related to long-term stability. We evaluate the procedure's foundational principles, including osteotome-mediated bone condensation and controlled fracture of the sinus floor, which contribute to enhanced primary implant stability. The review addresses critical aspects of treatment planning, surgical execution, and postoperative management while examining potential complications and their resolution. Special attention is given to emerging technologies and materials that may influence treatment outcomes. By synthesizing current evidence and clinical experience, this review aims to provide clinicians with a comprehensive framework for optimizing TSFE procedures and managing potential complications, ultimately working toward a standardized approach through a proposed clinical checklist. Finally, we provide a standardized checklist for TSFE outcome reporting in research studies to facilitate more consistent, reproducible, and comprehensive documentation of surgical procedures, complications, and long-term stability.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":"57 1","pages":""},"PeriodicalIF":18.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}