Periodontology 2000最新文献_第2页

Autologous platelet concentrates after third molar extraction: A systematic review. 第三磨牙拔除术后的自体血小板浓缩物：系统综述。

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2024-09-24 DOI: 10.1111/prd.12600

S A M Siawasch,J Yu,A B Castro,A Temmerman,W Teughels,M Quirynen

{"title":"Autologous platelet concentrates after third molar extraction: A systematic review.","authors":"S A M Siawasch,J Yu,A B Castro,A Temmerman,W Teughels,M Quirynen","doi":"10.1111/prd.12600","DOIUrl":"https://doi.org/10.1111/prd.12600","url":null,"abstract":"Surgical removal of impacted mandibular third molars is often followed by postoperative sequelae like pain, swelling, trismus, etc. This systematic review explored the benefits of applying different autologous platelet concentrates (APCs) in the extraction socket of third molars. For this systematic review, PubMed, EMBASE, Web of Science, and Scopus have been utilized, initially yielding 544 papers. The search was narrowed to randomized controlled trials (RCTs, n = 59) published before 2024, all comparing the outcome of applying APCs in the extraction socket of surgically removed impacted mandibular third molars with unassisted healing (blood clot). Most RCTs primarily assessed the impact of APCs on postoperative sequelae. Some RCTs looked at soft- and hard-tissue healing. Eleven studies used PRP, three PRGF, and 45 L-PRF. A detailed analysis revealed a large heterogeneity between studies rendering a meta-analysis impossible. Moreover, the risk of bias was considered high. In the majority of RCTs, the application of an APC resulted in statistically significant reductions of postoperative sequelae (lower pain intensity, lower consumption of analgesics, less postoperative edema, and a lower incidence of trismus and alveolar osteitis), as well as a faster soft tissue healing, and qualitatively and quantitatively better bone healing. A minority of studies reported significant differences in periodontal parameters distally from the second molar.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":null,"pages":null},"PeriodicalIF":18.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142321176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

L‐PRF in extra‐oral wound care L-PRF 在口腔外伤口护理中的应用

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2024-09-21 DOI: 10.1111/prd.12605

Nelson Pinto, Jize Yu, Sushil Koirala, Carlos Fernando Mourão, Catherine Andrade, Enrico Rescigno, Yelka Zamora, Diego Pinto, Marc Quirynen

{"title":"L‐PRF in extra‐oral wound care","authors":"Nelson Pinto, Jize Yu, Sushil Koirala, Carlos Fernando Mourão, Catherine Andrade, Enrico Rescigno, Yelka Zamora, Diego Pinto, Marc Quirynen","doi":"10.1111/prd.12605","DOIUrl":"https://doi.org/10.1111/prd.12605","url":null,"abstract":"Leukocyte‐ and platelet‐rich fibrin (L‐PRF), a by‐product of centrifuged autologous whole blood, contains high concentrations of platelets, leukocytes, and fibrin (the latter spontaneously creating a strong 3‐D network (a membrane)). L‐PRF membranes possess several characteristics essential in wound healing, including a barrier function, an antibacterial and analgesic activity, and the release of growth factors enhancing tissue regeneration and neo‐vasculogenesis. This review investigated the role of L‐PRF in treating non‐responding chronic wounds such as diabetic foot, venous leg ulcers, pressure ulcers, complex wounds, leprosy ulcers (Hansen's Disease), and other demanding wounds. Chronic wounds affect millions worldwide, negatively impacting their quality of life, productivity, and life expectancy while incurring high treatment costs for themselves and private and public health systems. L‐PRF has demonstrated clear adjunctive advantages in treating chronic skin wounds, shortening the time to complete wound closure, and improving patient‐reported outcome measures (including reducing pain and minimizing the need for analgesics). Also, in other demanding wounds, L‐PRF facilitates healing. To help clinicians, this article also proposes recommendations for the use of L‐PRF in the treatment of extra‐oral wounds.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":null,"pages":null},"PeriodicalIF":18.6,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142276042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological associations between periodontitis and cancer. 牙周炎与癌症之间的流行病学关联。

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2024-09-20 DOI: 10.1111/prd.12599

Jon Higham,Frank A Scannapieco

引用次数: 0

Severe periodontitis and congenital cytomegalovirus: Cleft lip and cleft palate 严重牙周炎和先天性巨细胞病毒：唇裂和腭裂

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2024-09-12 DOI: 10.1111/prd.12606

Jørgen Slots, Vanessa Slots

引用次数: 0

Introduction and overview on autogenous Platelet concentrates 自体血小板浓缩物简介和概述

IF 18.6 1区医学

Periodontology 2000 Pub Date : 2024-09-11 DOI: 10.1111/prd.12607

Marc Quirynen, Anton Sculean, J. Blanco, Hom‐Lay Wang, Nikos Donos

{"title":"Introduction and overview on autogenous Platelet concentrates","authors":"Marc Quirynen, Anton Sculean, J. Blanco, Hom‐Lay Wang, Nikos Donos","doi":"10.1111/prd.12607","DOIUrl":"https://doi.org/10.1111/prd.12607","url":null,"abstract":"This special issue on autologous platelet concentrates (APCs) provides clinicians with an overview on the current understanding of the use of these biomaterials for soft and hard‐tissue regeneration. The included papers summarize scientific evidence and the clinical findings, presented in simple tables that outline potential benefits including Patient Reported Outcome Measures (PROMs). This approach enables clinicians to assess clinical relevance and researchers to identify significant gaps in the literature. The first part provides a comprehensive summary of the basic science surrounding APC, with particular focus on their preparation methods. Clear recommendations are outlined, which are crucial for obtaining high‐quality APCs, alongside an exploration of how APCs may influence both soft and hard tissue healing processes. Part 2 delves into the clinical evidence for the potential benefits of APCs across a range of applications: alveolar ridge preservation, sinus floor elevation, periodontal plastic surgery, guided tissue regeneration, guided bone regeneration, the healing of Medication‐Related Osteonecrosis of the Jaw (MRONJ), and endodontic surgery. In the part 3, the discussion turns to the effects of APCs on the healing of extra‐oral wounds, including diabetic foot ulcers, venous leg ulcers, pressure injuries, burns, and more. For those clinicians persuaded by the evidence, the fourth section offers a detailed, step‐by‐step flowchart for each treatment modality, providing a clear guide for clinical application.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":null,"pages":null},"PeriodicalIF":18.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep and periodontal health. 睡眠与牙周健康

IF 17.5 1区医学

Periodontology 2000 Pub Date : 2024-09-04 DOI: 10.1111/prd.12611

Maria Clotilde Carra, Pauline Balagny, Philippe Bouchard

引用次数: 0

Microbiota-immune-brain interactions: A new vision in the understanding of periodontal health and disease. 微生物群-免疫-大脑相互作用：了解牙周健康和疾病的新视角。

IF 17.5 1区医学

Periodontology 2000 Pub Date : 2024-09-04 DOI: 10.1111/prd.12610

Torbjørn Jarle Breivik, Per Gjermo, Yngvar Gundersen, Per Kristian Opstad, Robert Murison, Anders Hugoson, Stephan von Hörsten, Inge Fristad

{"title":"Microbiota-immune-brain interactions: A new vision in the understanding of periodontal health and disease.","authors":"Torbjørn Jarle Breivik, Per Gjermo, Yngvar Gundersen, Per Kristian Opstad, Robert Murison, Anders Hugoson, Stephan von Hörsten, Inge Fristad","doi":"10.1111/prd.12610","DOIUrl":"https://doi.org/10.1111/prd.12610","url":null,"abstract":"This review highlights the significance of interactions between the microbiota, immune system, nervous and hormonal systems, and the brain on periodontal health and disease. Microorganisms in the microbiota, immune cells, and neurons communicate via homeostatic nervous and hormonal systems, regulating vital body functions. By modulating pro-inflammatory and anti-inflammatory adaptive immune responses, these systems control the composition and number of microorganisms in the microbiota. The strength of these brain-controlled responses is genetically determined but is sensitive to early childhood stressors, which can permanently alter their responsiveness via epigenetic mechanisms, and to adult stressors, causing temporary changes. Clinical evidence and research with humans and animal models indicate that factors linked to severe periodontitis enhance the responsiveness of these homeostatic systems, leading to persistent hyperactivation. This weakens the immune defense against invasive symbiotic microorganisms (pathobionts) while strengthening the defense against non-invasive symbionts at the gingival margin. The result is an increased gingival tissue load of pathobionts, including Gram-negative bacteria, followed by an excessive innate immune response, which prevents infection but simultaneously destroys gingival and periodontal tissues. Thus, the balance between pro-inflammatory and anti-inflammatory adaptive immunity is crucial in controlling the microbiota, and the responsiveness of brain-controlled homeostatic systems determines periodontal health.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":null,"pages":null},"PeriodicalIF":17.5,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A narrative review on the use of autologous platelet concentrates during alveolar bone augmentation: Horizontal (simultaneous/staged) & vertical (simultaneous/staged). 自体血小板浓缩物在牙槽骨增量术中的应用综述：水平（同时/分阶段）和垂直（同时/分阶段）。

IF 17.5 1区医学

Periodontology 2000 Pub Date : 2024-08-28 DOI: 10.1111/prd.12604

J Blanco, J Caramês, M Quirynen

{"title":"A narrative review on the use of autologous platelet concentrates during alveolar bone augmentation: Horizontal (simultaneous/staged) & vertical (simultaneous/staged).","authors":"J Blanco, J Caramês, M Quirynen","doi":"10.1111/prd.12604","DOIUrl":"https://doi.org/10.1111/prd.12604","url":null,"abstract":"This review aimed to answer the general question of whether autologous platelet concentrates (APCs, an autologous blood-derivative) can improve the outcome of alveolar bone augmentation. Three clinical scenarios were assessed: horizontal/vertical bone augmentation in combination with implant placement (simultaneous approach), horizontal bone augmentation in a staged approach, and vertical bone augmentation in a staged approach. An electronic literature search strategy was conducted for each review from the outset to July 1st, 2023. The titles and abstracts (when available) of all identified studies were screened and imported into a database. If articles appeared to meet the inclusion criteria or their title and abstract had insufficient data, the full text was obtained to make the final decision. All studies that met the inclusion criteria underwent data extraction. Moreover, the references of the identified papers were screened for additional studies. After title and abstract screening and selection criteria application, 14 clinical studies were included for the qualitative analysis: seven for horizontal/vertical bone augmentation in a simultaneous approach, five for horizontal bone augmentation in a staged approach, and two for vertical bone augmentation in a staged approach. There is scarce literature regarding the added value of APCs in bone augmentation, and most studies had small sample sizes, a lack of standardized protocols, and different outcome variables, which makes comparisons between studies difficult. Out of the 14 studies, four were well-designed randomized clinical trials, where we could find better results for the APCs groups. Most studies, particularly comparative and well-designed studies, demonstrated beneficial and promising results of using APCs in alveolar bone augmentation. However, before high-level evidence-based conclusions can be drawn, more randomized clinical trials must compare the benefits of adding APCs to the gold-standard approach.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":null,"pages":null},"PeriodicalIF":17.5,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142093663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resolution of chronic inflammation and cancer. 解决慢性炎症和癌症问题

IF 17.5 1区医学

Periodontology 2000 Pub Date : 2024-08-23 DOI: 10.1111/prd.12603

Gulcin Tezcan, Nil Yakar, Hatice Hasturk, Thomas E Van Dyke, Alpdogan Kantarci

引用次数: 0

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement. 回顾口腔成纤维细胞与间充质干细胞相比，在正畸牙齿移动期间或之后修复牙周缺损的益处和临床效果。

IF 17.5 1区医学

Periodontology 2000 Pub Date : 2024-08-20 DOI: 10.1111/prd.12602

Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen

{"title":"Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement.","authors":"Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen","doi":"10.1111/prd.12602","DOIUrl":"https://doi.org/10.1111/prd.12602","url":null,"abstract":"Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's esthetic awareness rises. However, adults may already have periodontal tissue abnormalities, rendering orthodontic treatment inefficient because a healthy periodontium is essential for success. Numerous risk factors have been linked to periodontal lesions, with orthodontic tooth movement possibly playing a minimal influence. Although such tissue damages are mostly of esthetic rather than functional concern for patients, restoration frequently requires invasive procedures. Autologous cells for the treatment of periodontal complications have grown in popularity as a less intrusive alternative. The present review analyzed the literature on the use of mesenchymal stem cells and oral tissue-derived fibroblasts for the healing of periodontal defects that may be related to orthodontic tooth movement. Furthermore, the advantages and challenges of the two cell types have been examined. Although the number of clinical studies is currently limited, our study demonstrates that oral fibroblasts have the potential to be the next emergent frontrunners for tissue engineering in the periodontium.","PeriodicalId":19736,"journal":{"name":"Periodontology 2000","volume":null,"pages":null},"PeriodicalIF":17.5,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0