Franz-Tassilo Müller-Graff, David P Herrmann, Björn Spahn, Johannes Voelker, Anja Kurz, Tilmann Neun, Stephan Hackenberg, Kristen Rak
{"title":"Position Control of Flexible Electrodes With Regard to Intracochlear Structure Preservation and Hearing Outcomes: A Retrospective Study With Implementation of the Electrode Contact View.","authors":"Franz-Tassilo Müller-Graff, David P Herrmann, Björn Spahn, Johannes Voelker, Anja Kurz, Tilmann Neun, Stephan Hackenberg, Kristen Rak","doi":"10.1097/MAO.0000000000004528","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004528","url":null,"abstract":"<p><strong>Objective: </strong>To investigate complications related to electrode design, such as incomplete insertion, electrode tip fold-over (ETFO), and scalar deviation, and to evaluate hearing outcomes with a flexible 28-mm cochlear implant electrode.</p><p><strong>Study design: </strong>Retrospective.</p><p><strong>Setting: </strong>Tertiary referral center.</p><p><strong>Patients: </strong>Postoperative computed tomographic (CT) data analysis of 36 patients with regular cochlear anatomy was performed who received a flexible 28-mm-long electrode.</p><p><strong>Interventions: </strong>All patients received secondary reconstructions of flat-panel volume CT (fpVCTSECO; slice thickness: 99 μm), along with audiological testing. Radiologic analyses were performed using the otosurgical software OTOPLAN®, which included the following: (I) measurement of the cochlear parameters (A value and cochlear duct length [CDL]), (II) evaluation of insertion status and ETFO including angular insertion depth (AID), cochlear coverage, and apical electrode contact frequency; and (III) determination of the scala electrode position with the newly developed \"electrode contact view,\" analyzing individual electrode contact positioning within the cochlear duct. The audiological outcome with CI was tested with a monosyllabic word test at 65 dB SPL in quiet and correlated with several parameters.</p><p><strong>Main outcome measures: </strong>Complete insertion, ETFO, scalar deviation, postoperative hearing results.</p><p><strong>Results: </strong>Full electrode insertion was achieved in all patients with no observed cases of ETFO. The \"electrode contact view\" identified no cases of scalar deviation (34 electrodes inserted in the scala tympani and two electrodes deliberately inserted into the scala vestibuli via cochleostomy). The cochlear canal's cranial-caudal height averaged 2.3 mm at electrode contact 12 and 1.1 mm at electrode contact 1. Cochlear parameters averaged 9.3 mm for the A value and 36.9 mm for the CDL value. The AID of the most apical canal ranged from 459 to 705 degrees, with an average cochlear coverage of 81.2%. There was a significant negative correlation between cochlear size (A value and CDL) and AID. Audiological testing showed a 50% average improvement in monosyllables word scores with CI.</p><p><strong>Conclusion: </strong>This case series suggests that a 28-mm flexible electrode can achieve reliable full insertion with minimal risk of scalar deviation. Despite its high flexibility, ETFO was not observed. However, cochlea size influences AID, which may impact hearing results.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Audiological Progression and Treatment Outcomes in Superficial Siderosis: A 10-Year Retrospective Review of 46 Patients.","authors":"Ayako Nishio, Yoshiyuki Kawashima, Takamori Takeda, Taku Ito, Ayako Maruyama, Yoshimaru Mizoguchi, Natsuko Kurata, Ryo Iwase, Satoru Egawa, Takashi Hirai, Motonori Hashimoto, Takanori Yokota, Toshitaka Yoshii, Nobuo Sanjo, Takeshi Tsutsumi","doi":"10.1097/MAO.0000000000004535","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004535","url":null,"abstract":"<p><strong>Objective: </strong>To describe long-term hearing outcomes and evaluate the efficacy of interventions in patients with superficial siderosis (SS) of the central nervous system (CNS).</p><p><strong>Study design: </strong>Retrospective case review.</p><p><strong>Setting: </strong>Tertiary referral center.</p><p><strong>Patients: </strong>Forty-six patients diagnosed with SS.</p><p><strong>Interventions: </strong>Auditory examinations, including pure-tone audiometry, speech audiometry, and auditory brainstem response (ABR). Treatment modalities include surgical closure of the dural defect with postoperative iron chelator administration and cochlear implantation.</p><p><strong>Main outcome measures: </strong>Pure-tone average (PTA), maximum speech discrimination score, and interpeak latency between ABR waves I and V.</p><p><strong>Results: </strong>Sensorineural hearing loss (SNHL) was observed in 39 patients (84.8%), typically presenting in the fifth to sixth decades of life, and progressed gradually. Among the patients, SNHL was bilateral in 76.9%, with 56.7% showing asymmetry. The severity ranged from minimal to profound, with high-frequency loss being the most common (63.8%). Abnormal ABRs were observed in 82.6% of the ears. Long-term follow-up (median, 39 months) revealed hearing deterioration of ≥10 dB PTA in 25.9% of the ears. The long-term hearing prognosis can be predicted based on audiological changes within the first 12 months after the initial visit. Dural defect closure with iron chelator treatment seemed to prevent hearing deterioration in seven patients. Cochlear implantation showed limited effectiveness in three patients.</p><p><strong>Conclusions: </strong>SS-related hearing loss can mimic age-related hearing loss, potentially leading to misdiagnoses. Clinicians should consider SS in middle-aged to elderly patients with progressive SNHL of unknown etiology and conduct comprehensive examinations, including speech audiometry, ABR, and T2*-weighted MRI, to facilitate an early diagnosis and appropriate management.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrina MacDonald, René H Gifford, Allyson Sisler-Dinwiddie, Nichole Dwyer, Kareem Tawfik, Jourdan T Holder
{"title":"Intraoperative eSRTs: Feasibility of Measurement and Correlation With Postoperative eSRTs.","authors":"Andrina MacDonald, René H Gifford, Allyson Sisler-Dinwiddie, Nichole Dwyer, Kareem Tawfik, Jourdan T Holder","doi":"10.1097/MAO.0000000000004585","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004585","url":null,"abstract":"<p><strong>Objective: </strong>To assess the feasibility of intraoperative visual electrically evoked stapedial reflex threshold (eSRT) measurement using the Cochlear SmartNav 2 system, the correlation between intraoperative and postoperative eSRTs, and the correlation between eSRTs measured at 1 and 6 months post-activation.</p><p><strong>Study design: </strong>Prospective.</p><p><strong>Setting: </strong>Cochlear implant (CI) program at a tertiary medical center.</p><p><strong>Patients: </strong>Fourteen adult CI users.</p><p><strong>Main outcome measures: </strong>Intraoperative eSRTs and postoperative eSRTs.</p><p><strong>Results: </strong>Intraoperative eSRTs were successfully measurable on 11 of 14 participants and took approximately 3 minutes to measure. The mean intraoperative eSRT was 13.3 charge units higher than the mean 1-month post-activation eSRT (p < 0.0001). The mean difference between the intraoperative and 1-month post-activation eSRT was 17.5, 15.3, 11.1, 10.5, and 11.8 nC/phase for electrodes 1, 6, 11, 16, and 22, respectively. The combined intraoperative eSRT data for all patients and all electrodes had a standard deviation of 8.5 charge units, whereas the combined 1-month post-activation eSRT data had a standard deviation of 3.2 charge units demonstrating greater intraoperative variability. The mean difference between the 1-month and 6-month post-activation eSRT was 0.2 charge units (p > 0.999).</p><p><strong>Conclusions: </strong>Intraoperative eSRT measurement is feasible and time-efficient in adult CI patients. The mean difference between the intraoperative and 1-month post-activation eSRT is similar across the array. However, intraoperative eSRTs are more variable than post-activation eSRTs, and thus, further investigation is needed to reduce this variability and create a clinically useful correction factor. Finally, postoperative eSRTs are stable over time.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yassine Balhi, David Nauen, Deepa Galaiya, Amanda Lauer, Bryan K Ward
{"title":"Labyrinthine Sequestrum: Otopathologic Description of a Rare Condition in a Case From the Temporal Bone Histopathology Archives.","authors":"Yassine Balhi, David Nauen, Deepa Galaiya, Amanda Lauer, Bryan K Ward","doi":"10.1097/MAO.0000000000004566","DOIUrl":"10.1097/MAO.0000000000004566","url":null,"abstract":"","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sahiti Vemula, Dorothy W Pan, Adrian J Correa, Seiji B Shibata
{"title":"Facial Nerve Amyloidosis Leading to Unilateral Facial Paralysis and Sensorineural Hearing Loss.","authors":"Sahiti Vemula, Dorothy W Pan, Adrian J Correa, Seiji B Shibata","doi":"10.1097/MAO.0000000000004555","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004555","url":null,"abstract":"","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Surgical Outcomes of Endoscopic Transtympanic Myringoplasty Versus Over-Underlay Tympanoplasty Type I Versus Overlay Tympanoplasty Type I for Tympanic Membrane Perforations.","authors":"Pornsek Tananuchittikul, Nithita Sattaratpaijit","doi":"10.1097/MAO.0000000000004547","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004547","url":null,"abstract":"<p><strong>Objective: </strong>To compare the surgical outcomes of endoscopic transtympanic myringoplasty versus endoscopic over-underlay tympanoplasty versus endoscopic overlay tympanoplasty.</p><p><strong>Study design: </strong>Retrospective chart review.</p><p><strong>Setting: </strong>Tertiary referral university hospital.</p><p><strong>Patients: </strong>Adult subjects with first diagnosed dry tympanic membrane perforation for at least 3 months who underwent endoscopic tympanoplasty between September 2021 and January 2024.</p><p><strong>Intervention: </strong>Endoscopic transtympanic myringoplasty (ETM), endoscopic over-underlay tympanoplasty (EDT), and endoscopic overlay tympanoplasty (EVT).</p><p><strong>Main outcome measures: </strong>The primary outcome was graft success rate at 6 months after surgery. Secondary outcomes were audiologic data including preoperative and postoperative pure-tone air average, pure-tone bone average, and air-bone gap (ABG).</p><p><strong>Results: </strong>A total of 82 endoscopic tympanoplasty cases were included: 25 in ETM, 30 in EDT, and 27 in EVT. The overall graft success rate was 93.9%. The graft success rates were not different between the three groups: 92.0% in the ETM group versus 93.3% in the EDT group versus 96.3% in the EVT group (p = 0.860). Pure-tone air average improved significantly after surgery in all groups, and hearing gains for ETM, EDT and EVT were 7.9 ± 6.5, 11.3 ± 7.3, and 10.8 ± 6.2 dB, respectively, which were comparable (p = 0.141).</p><p><strong>Conclusions: </strong>Favorable graft success rates and audiologic outcomes were obtained in all groups. The ETM method is more suitable for medium-sized tympanic membrane (TM) perforations because it is easier to perform and minimally invasive. For large TM perforations, we suggest the EDT or the EVT method, depending on perforation size, location, and preoperative ABG.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gianfranco C Velasco, Jaclyn Leigh E Vidal, Chan Mi Lee, Min Chae Jeon, Jae Sang Han, Jae Hyun Seo, Shi Nae Park
{"title":"A Cure for Tinnitus After Tinnitus Retraining Therapy: Insights From a Large Case Series.","authors":"Gianfranco C Velasco, Jaclyn Leigh E Vidal, Chan Mi Lee, Min Chae Jeon, Jae Sang Han, Jae Hyun Seo, Shi Nae Park","doi":"10.1097/MAO.0000000000004583","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004583","url":null,"abstract":"<p><strong>Objectives: </strong>To identify the clinical features of sensorineural tinnitus patients who achieved complete symptom resolution or \"cure\" after tinnitus retraining therapy (TRT) and to determine significant factors that influence tinnitus resolution duration after TRT.</p><p><strong>Methods: </strong>A retrospective analysis of sensorineural tinnitus patients who underwent TRT and achieved a cure between January 2017 and January 2022 was performed. Cure of tinnitus was defined as patients experiencing symptoms for less than 5 minutes of awareness per day. Clinical information, including demographics, tinnitus duration, audiometric results, and therapeutic response, was examined.</p><p><strong>Results: </strong>A total of 1,027 patients who achieved a cure for tinnitus were included, with more females (65.4%, n = 672) than males (35.6%, n = 355). The median age was 57 years (range, 12-92), with most having unilateral tinnitus (73.3%, n = 753). More than half had tinnitus with hearing loss (53.3%, n = 549), and the majority was under Jastreboff's tinnitus category 2 (38.7%, n = 397). The median duration of tinnitus before consult was 12 months in range (range, 1-480), whereas the median duration before tinnitus resolution after TRT was 17 months (range, 1-96). In Jastreboff's tinnitus categories, category 4 had the longest resolution time (median, 18 months) and category 1 the shortest (median, 15 months), but the difference was not statistically significant. A moderate correlation was observed between age and tinnitus resolution duration (Spearman correlation coefficient = 0.391, p < 0.05) and between tinnitus duration before consult and tinnitus resolution duration (Spearman correlation coefficient = 0.355, p < 0.05).</p><p><strong>Conclusion: </strong>TRT seems to be a promising treatment option for patients with sensorineural tinnitus. The time to achieve this cure may range from a few months to years after TRT, indicating the heterogeneity of the mechanism and therapeutic response. The younger patients and the earlier management after the onset of tinnitus seem to be good prognostic factors for a shorter tinnitus cure time after TRT.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Serum Testosterone and Dehydroepiandrosterone Sulfate Levels and Hearing Loss in Older Males: The Hitachi Health Study II.","authors":"Aoi Ito, Shohei Yamamoto, Yosuke Inoue, Ami Fukunaga, Maki Konishi, Katsuyuki Ohara, Shuichiro Yamamoto, Tohru Nakagawa, Tetsuya Mizoue","doi":"10.1097/MAO.0000000000004577","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004577","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the association of serum testosterone and dehydroepiandrosterone sulfate levels with hearing loss in older males.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>A health care center.</p><p><strong>Patients: </strong>This study included 1,421 males aged 60 to 69 yrs who participated in the baseline survey of the Hitachi Health Study II.</p><p><strong>Exposures: </strong>Serum testosterone and DHEAS levels were measured using chemiluminescence and chemiluminescent enzyme immunoassays, respectively.</p><p><strong>Main outcome measures: </strong>Pure-tone audiometric testing was performed to identify hearing loss at 1 and 4 kHz.</p><p><strong>Results: </strong>Higher serum testosterone levels were associated with lower odds of hearing loss at 4 kHz. The OR (95% CI) of hearing loss was 0.71 (0.50, 0.999) for the highest compared with that for the lowest quartile of serum testosterone. A dose-response association was also found between serum testosterone levels and hearing loss at 4 kHz (P for linearity = 0.01). No association was found between serum testosterone levels and hearing loss at 1 kHz (OR for the highest vs lowest quartiles of serum testosterone = 1.06). Serum dehydroepiandrosterone sulfate levels were not associated with hearing loss: the ORs (95% CI) for the highest compared with that for the lowest quartile were 1.01 (0.64, 1.61) and 0.81 (0.58, 1.14) for 1 and 4 kHz, respectively.</p><p><strong>Conclusion: </strong>Our findings suggest that older males with higher serum testosterone levels were less likely to have high-frequency hearing loss.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Young-Soo Chang, Young Joon Seo, Chul Young Yoon, Kyoung Ho Park
{"title":"Association Between Cochlear Implants and Dementia in Severe-to-Profound Hearing Loss Patients: Results From the National Insurance Service Survey 2010-2020.","authors":"Young-Soo Chang, Young Joon Seo, Chul Young Yoon, Kyoung Ho Park","doi":"10.1097/MAO.0000000000004575","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004575","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate whether restoring hearing through a cochlear implant (CI) influences the risk of dementia development, using data obtained from the South Korea's National Health Information Database.</p><p><strong>Study design: </strong>A longitudinal follow-up study.</p><p><strong>Setting: </strong>Data from the Korean National Health Insurance Service.</p><p><strong>Patients and intervention: </strong>This study examines the association between CIs and dementia in patients with severe-to-profound hearing loss. Data were collected from January 2010 to December 2020. All eligible patients were confirmed to have no previous diagnosis of dementia at the time of their hearing loss diagnosis. A total of 356,850 patients 50 years and older were included, with 2,447 having had Cis implanted and 354,403 who had not.</p><p><strong>Main outcome measures: </strong>Patients who had CIs were compared with those who did not, focusing on the newly diagnosed dementia.</p><p><strong>Results: </strong>Among the CI recipients, 274 (11.2%) were newly diagnosed with dementia, compared with 61,939 (17.5%) among the nonrecipients. This difference was statistically significant (p < 0.001). For patients 70 years and older, a similar level of significance was observed. The interval between the diagnosis of the hearing loss and the subsequent development of dementia was significantly associated with the use of CIs (587.7 versus 1886.9 d, p < 0.001).</p><p><strong>Conclusions: </strong>The study elucidated the association between CIs and reduced dementia in patients with severe-to-profound hearing loss using nationwide data in South Korea. CIs are beneficial in preventing dementia, even in patients older than 70 years.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shengqing Nian, Chenyu Chen, Yuqing Chen, Xihang Chen, Chang Lin
{"title":"Diagnosis and Treatment of Middle Ear Cholesterol Granuloma Involving the Middle Cranial fossa.","authors":"Shengqing Nian, Chenyu Chen, Yuqing Chen, Xihang Chen, Chang Lin","doi":"10.1097/MAO.0000000000004551","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004551","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical features, surgical options, and prognosis of middle ear cholesterol granuloma involving the middle cranial fossa.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Setting: </strong>Tertiary referral center.</p><p><strong>Subjects and methods: </strong>Medical records of three patients with giant skull base cholesterol granuloma from 2006 to 2017 were retrospectively analyzed. The symptoms, signs, radiological features, treatment options, and prognosis were summarized.</p><p><strong>Results: </strong>All patients underwent radical mastoidectomy and resection of skull base lesions by means of a retroauricular approach. Postoperative pathological diagnosis showed cholesterol granuloma. All patients were followed for more than 1 year. The symptoms were relieved, and there was no recurrence. Postoperative imaging showed that the skull base lesions were cleared and the compressed brain tissue recovered.</p><p><strong>Conclusion: </strong>Patients with middle ear cholesterol granuloma involving the middle cranial fossa can be operated on by retroauricular approach. It can reduce the trauma of craniotomy and obtain good curative effect.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}