Otology & Neurotology最新文献_第8页

Bacteriophage Therapy for Chronic Mastoiditis. 慢性乳突炎的噬菌体治疗。

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-01-22 DOI: 10.1097/MAO.0000000000004417

Julia Casazza, Donald Tan, Mark Newcomer, Hitomi Sakano, Brandon Isaacson, Jacob B Hunter

引用次数: 0

Surgical Transcanal Procedure for Injection of Cells and Substances into the Human Cochlear Modiolus. 细胞和物质注射入人耳蜗的经鼻外科手术。

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-20 DOI: 10.1097/MAO.0000000000004463

Per Cayé-Thomasen, Peter Erfurt, Peter Baumhoff, Andrej Kral, Charlotte Amalie Navntoft

{"title":"Surgical Transcanal Procedure for Injection of Cells and Substances into the Human Cochlear Modiolus.","authors":"Per Cayé-Thomasen, Peter Erfurt, Peter Baumhoff, Andrej Kral, Charlotte Amalie Navntoft","doi":"10.1097/MAO.0000000000004463","DOIUrl":"10.1097/MAO.0000000000004463","url":null,"abstract":"Introduction: Cochlear implants (CIs) enhance hearing by stimulating spiral ganglion neurons (SGNs) but are less effective in individuals with compromised SGN functionality. Advances in regenerative medicine suggest that local delivery of medical drugs or cell therapy could regenerate the auditory nerve. This study evaluates a minimally invasive technique for precise delivery of cell-sized beads, simulating cell therapy, into the cochlear modiolus of human temporal bones.Methods: Ten fresh-frozen human temporal bone specimens were used. Five bones served to establish the injection trajectory using a tungsten rod probe, and the remaining five for injecting microbeads into the modiolus. The surgical procedure involved accessing the middle ear via the external ear canal, performing a cochleostomy at the first cochlear turn, and drilling into the modiolus. Beads were injected into the modiolus using a Hamilton syringe connected to an injection pump, followed by micro-computed tomography imaging and histological assessment.Results: Accurate placement of the tungsten rod probe within the modiolus was achieved in four out of five bones. Microbead injections indicated 89 to 97% retention within the modiolus, with minimal leakage. The technique showed consistent trajectory with low variability.Conclusion: The study demonstrates the feasibility of a minimally invasive, precise injection method for delivering and retaining cell-sized beads into the cochlear modiolus. This technique enables future local delivery of medical drugs or cell therapy drugs aimed at hearing restoration, benefiting both current CI users and CI candidates. Further research is necessary to evaluate precision, reproducibility, and long-term outcomes of the procedure.","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"476-484"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11939087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remote Care: The Future of Cochlear Implants. 远程医疗：人工耳蜗的未来。

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-04 DOI: 10.1097/MAO.0000000000004432

Meredith A Holcomb, Jennifer Coto, Tina Stern, Christina M Sarangoulis, Ivette Cejas, Chrisanda M Sanchez

{"title":"Remote Care: The Future of Cochlear Implants.","authors":"Meredith A Holcomb, Jennifer Coto, Tina Stern, Christina M Sarangoulis, Ivette Cejas, Chrisanda M Sanchez","doi":"10.1097/MAO.0000000000004432","DOIUrl":"10.1097/MAO.0000000000004432","url":null,"abstract":"Objective: The aims of this study were to 1) evaluate whether remote cochlear implant (CI) programming has comparable outcomes to traditional in-person CI management, 1) determine the effects of remote programming on family burden and associated costs, and 1) demonstrate feasibility and satisfaction of remote programming by patients and families for both the adult and pediatric CI populations.Study design: Prospective study of one CI program.Patients and intervention: Adult and pediatric patients with at least one CI underwent CI programming via in-person and remote visits.Main outcome measures: CI programming parameters (impedances, neural response telemetry, upper and lower stimulation levels, datalogging), technology comfort self-report, visit burden and satisfaction, mental health and quality of life.Results: Fifteen pediatric participants (mean age: 4.17 yr; SD = 3.24) and 15 adult participants (mean age: 56.73 yr; SD = 21.11) were enrolled. In-person and remote programming sessions yielded comparable results for measuring CI programming parameters. Adult and parent participants were highly satisfied with remote programming and reported receiving excellent care. Listening effort was significantly less for the remote visit as compared to the in-person visit for adults. Burden of care to attend the in-person visit was greater for the pediatric population in terms of expenses incurred, unpaid time off work, and coordination of care for other children.Conclusions: Remote programming is a feasible and effective service delivery model for the adult and pediatric CI population. Inclusion of remote services into postoperative CI protocols should be considered as a means of reducing barriers to hearing healthcare.","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"372-380"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active Osseointegrated Steady-State Implant System: Surgical and Clinical Performance. 主动骨整合稳态种植体系统：手术和临床表现。

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-19 DOI: 10.1097/MAO.0000000000004453

Leornardo Ordoñez-Ordoñez, José Agustin Caraballo, Jorge Guillermo Cabrera Ortiz, Francisco Gonzalez Eslait, Rafael Jaramillo Saffon, José Gabriel Lora, Santiago Hernandez, Jose Guzman, Luz Adriana Rincon, Byanka Cagnacci Buzo

{"title":"Active Osseointegrated Steady-State Implant System: Surgical and Clinical Performance.","authors":"Leornardo Ordoñez-Ordoñez, José Agustin Caraballo, Jorge Guillermo Cabrera Ortiz, Francisco Gonzalez Eslait, Rafael Jaramillo Saffon, José Gabriel Lora, Santiago Hernandez, Jose Guzman, Luz Adriana Rincon, Byanka Cagnacci Buzo","doi":"10.1097/MAO.0000000000004453","DOIUrl":"10.1097/MAO.0000000000004453","url":null,"abstract":"Purpose: We aimed to investigate the surgical outcomes and clinical performance of an active osseointegration implant system that uses piezoelectric technology.Methods: This national, multicenter, prospective, repeated measures study was approved by the Ethics Committee (opinion no. CEISH 0559-2019). The sample included patients with conductive hearing loss (CHL), mixed hearing loss (MHL), or single-sided deafness (SSD) who were eligible for osseointegrated implant surgery. Surgical parameters were assessed, along with functional and effective gain (FG and EG) and self-perception of benefits, which were evaluated between 3 and 6 months after activation. Participants also completed the Client Oriented Scale of Improvement (COSI) questionnaire to subjectively report expected and perceived benefits.Results: A total of 580 participants aged 5 to 73 years were included in the study between June 2020 and April 2023. Most participants were diagnosed with CHL (58.8%), followed by MHL (28.8%) and SSD. 11.4% of the surgeries involved conversion of other devices to the piezoelectric system. The mean surgery duration was 54 min, and the mean skin thickness was 5.6 mm. Soft tissue reduction was required for 4% of the participants, while 21.2% required bone polishing. The mean PTA (pure tone average) FG was 38.6 dB for participants with CHL, 44.4 dB for those with MHL, and 66.1 dB for those with SSD.Conclusion: These results confirmed the clinical safety, performance, and benefits of an innovative active transcutaneous bone conduction implant with a piezoelectric transducer design for patients with CHL, MHL, or SSD.","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"e109-e116"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11939086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Benefits of Behind-the-Ear Processors Compared With Off-the-Ear Processors in Adult Cochlear Implant Users. 成年人工耳蜗使用者耳后处理器与耳外处理器的功能优势比较。

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-14 DOI: 10.1097/MAO.0000000000004430

Craig D Salvador, Zachary Sinacori, Elizabeth L Camposeo, Ted A Meyer, Theodore R McRackan

{"title":"Functional Benefits of Behind-the-Ear Processors Compared With Off-the-Ear Processors in Adult Cochlear Implant Users.","authors":"Craig D Salvador, Zachary Sinacori, Elizabeth L Camposeo, Ted A Meyer, Theodore R McRackan","doi":"10.1097/MAO.0000000000004430","DOIUrl":"10.1097/MAO.0000000000004430","url":null,"abstract":"Objective: Cochlear implant (CI) devices are fitted with two external processor styles-a behind-the-ear (BTE) or an off-the-ear (OTE) option. Although previous research has predominantly focused on speech recognition abilities between processor styles, the current study aims to examine the potential real-world functional differences between processor types.Study design: Retrospective case-control, matched at a 1:2 ratio.Setting: Tertiary Otolaryngology Referral Center.Patients: Patients with bilateral sensorineural hearing loss.Intervention: Cochlear implantation.Main outcome measures: Cochlear Implant Quality of Life 35 Profile (CIQOL-35 Profile), and CNC word (CNCw) and AzBio sentence (quiet) recognition.Results: A total of 36 patients were included (n = 12 OTE and n = 24 BTE users). The overall study population demonstrated improvements in CNCw ( d = 1.9 [1.3, 2.4]), AzBio sentences in quiet ( d = 2.1 [1.5, 2.6]), and medium-to-large effect sizes for domains of the CIQOL-35 ( d range: 0.5-0.9) after cochlear implantation. Between-group analysis demonstrated that BTE users performed better in CNCw ( d = 0.4 [-0.3, 1.1]) and AzBio quiet ( d = 0.5 [-0.2, 1.2]) than their OTE counterparts. However, there were minimal differences identified between processor types based on CIQOL domain and global scores ( d range: 0.04-0.2).Conclusion: BTE users may have a better speech recognition ability than their OTE counterparts. However, CIQOL domain and global scores are comparable between the two processor types. A prospective, randomized controlled trial will be needed to address the limitations of a retrospective analysis.","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"358-363"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterns of Pneumatization of Parts of Temporal Bone in High-Resolution Computed Tomography and Its Implications. 高分辨率计算机断层扫描颞骨部分气化模式及其意义。

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-04 DOI: 10.1097/MAO.0000000000004440

Reshma Eugine, Abhishek Bhardwaj, Manu Malhotra, Madhu Priya, Sudhir Saxena, Ankita Semwal, G Vetrivel, Anil Kumar

{"title":"Patterns of Pneumatization of Parts of Temporal Bone in High-Resolution Computed Tomography and Its Implications.","authors":"Reshma Eugine, Abhishek Bhardwaj, Manu Malhotra, Madhu Priya, Sudhir Saxena, Ankita Semwal, G Vetrivel, Anil Kumar","doi":"10.1097/MAO.0000000000004440","DOIUrl":"10.1097/MAO.0000000000004440","url":null,"abstract":"Objective: Investigate the pneumatization pattern of parts of the temporal bone in high-resolution computed tomography (HRCT) and their associations with age, gender, and squamous chronic otitis media (COM) in the contralateral ear. To investigate the symmetry of pneumatization and correlations between pneumatization patterns of parts of the temporal bone.Study design: Prospective study.Setting: Tertiary care center.Patients: Two hundred sixty patients who underwent HRCT temporal bone.Interventions and main outcome measures: Evaluation of pneumatization of mastoid and petrous apex as per Han et al. and infralabyrinthine as per Marchioni et al. classification.Results: The commonest pneumatization patterns were group 4 (32.8%), group 1 (69.7%), and type C (76%) for mastoid, petrous apex, and infralabyrinthine parts, respectively. Group 4 pneumatization of the petrous apex ( w = 0.487) and type A infralabyrinthine pneumatization ( w = 0.315) were significantly associated with group 4 mastoid pneumatization ( p < 0.001) but not vice versa. Significant association was observed between age and pattern of mastoid pneumatization ( w = 0.25; p = 0.002) but not for other parts. No significant gender difference was observed in the temporal bone's pneumatization pattern. A significant symmetry was seen in the pneumatization of two ears for all parts. COM in the contralateral ear was significantly associated with group 3 mastoid pneumatization ( w = 0.16; p = 0.036).Conclusion: Mastoid shows hyperpneumatization, and other parts show absent pneumatization as commonest pattern, with only one-way correlation between increased pneumatization of other parts and mastoid. COM in the contralateral ear and age show a significant association with the type of mastoid pneumatization, but not other parts.","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"405-412"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibiotics Use Practices in Otology Procedures: A Nationwide Survey Study. 耳科手术中抗生素使用实践：一项全国性调查研究。

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-14 DOI: 10.1097/MAO.0000000000004448

Azmi Marouf, Samya Konda, De'Andre Warren, Claudia I Cabrera, Sarah Mowry, Alejandro Rivas, Maroun Semaan, Daniel E Killeen

{"title":"Antibiotics Use Practices in Otology Procedures: A Nationwide Survey Study.","authors":"Azmi Marouf, Samya Konda, De'Andre Warren, Claudia I Cabrera, Sarah Mowry, Alejandro Rivas, Maroun Semaan, Daniel E Killeen","doi":"10.1097/MAO.0000000000004448","DOIUrl":"10.1097/MAO.0000000000004448","url":null,"abstract":"Objective: To assess practice patterns regarding antibiotics prophylaxis in otologic surgery in the United States.Study design: Cross-sectional study.Setting: Tertiary care center.Subjects: Members of American Neurotology Society (ANS).Intervention: Nationwide survey.Main outcome measures: Prevalence of antibiotic prescribing among surgeons performing the following six ear surgical procedures: cochlear implantation, tympanoplasty with a clean ear, tympanoplasty with active drainage, cholesteatoma surgery without evidence of infection, cholesteatoma surgery with evidence of infection, and stapedectomy.Results: Seventy-three surgeons completed the survey (15.21% response rate). Twenty-seven percent had more than 25 years in experience, and 18% had 0 to 5 years of experience. Antibiotic prescribing practices varied by procedure: cochlear implantation (64.4%, median 5 d), tympanoplasty (clean ear: 23.3%, median 5 d; active drainage: 53.4%, median 7 d), cholesteatoma surgery (no infection: 30.1%, median 7 d; with infection: 58.9%, median 7 d), and stapedectomy (34.2%, mean 5 d). Cephalosporins were preferred for noninfected procedures, whereas amoxicillin dominated for active infections.Conclusions: Prophylactic oral antibiotics varies for ear surgery, with higher usage for procedures with active infection and a preference for cephalosporins in noninfected cases. These findings underscore the need for the development and dissemination of standardized, evidence-based recommendations.","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"470-475"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant Internal Carotid Artery With Spontaneous Pseudoaneurysm of the Middle Ear. 异常颈内动脉伴自发性中耳假性动脉瘤。

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-04 DOI: 10.1097/MAO.0000000000004434

Hawa M Ali, David M Valencia, John I Lane, Waleed Brinjikji, Matthew L Carlson

引用次数: 0

The Effect of a Notch Filter in Sound Preprocessing of Active Middle Ear Implants on Speech Perception. 有源中耳植入物声音预处理中陷波滤波器对语音感知的影响。

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-20 DOI: 10.1097/MAO.0000000000004454

Philipp Zelger, Viktor Koci, Viktor Weichbold, Franz Muigg, Tobias Raffelsberger, Thomas Keintzel, Joachim Schmutzhard, Josef Seebacher

{"title":"The Effect of a Notch Filter in Sound Preprocessing of Active Middle Ear Implants on Speech Perception.","authors":"Philipp Zelger, Viktor Koci, Viktor Weichbold, Franz Muigg, Tobias Raffelsberger, Thomas Keintzel, Joachim Schmutzhard, Josef Seebacher","doi":"10.1097/MAO.0000000000004454","DOIUrl":"10.1097/MAO.0000000000004454","url":null,"abstract":"Objective: The effect of two different notch filters in sound pre-processing of active middle ear implant (AMEI) on speech perception was studied.Method: Speech perception was tested in 20 adults with AMEI using the Oldenburg sentence test (OLSA) in quiet at a fixed presentation level of 65 dB HL. Three conditions were tested: notch filter option not active, acoustic notch filter activated at a center frequency of 4 kHz and acoustic notch filter activated at a center frequency of 6 kHz.Results: Hearing thresholds were significantly affected by the notch filters at the particular center frequencies. The drop in hearing thresholds at 4 and 6 kHz was about 15 dB HL (median value). Pair comparisons between condition \"notch filter option not activated\" and \"notch filter activated\" reached significance for both center frequencies, i.e. p < 0.01. In contrast, no significant differences were seen between the word recognition scores of the OLSA speech test obtained for each of the three conditions.Conclusion: Speech perception in quiet was not affected while a notch filter at 4 or 6 kHz was activated in sound pre-processing in patients with an AMEI. However, according to subjective feedback from the patients, the listening effort was increased as soon as one of the notch filters was activated.","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":"46 4","pages":"e91-e97"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elective Versus Corrective Cochlear Implant Revision Surgery of Legacy Internal Devices. 选择性与矫正性人工耳蜗翻修手术的比较。

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-14 DOI: 10.1097/MAO.0000000000004444

Samuel P O'Rourke, Margaret T Dillon, Samantha P Scharf, Andrea B Overton, Matthew M Dedmon

{"title":"Elective Versus Corrective Cochlear Implant Revision Surgery of Legacy Internal Devices.","authors":"Samuel P O'Rourke, Margaret T Dillon, Samantha P Scharf, Andrea B Overton, Matthew M Dedmon","doi":"10.1097/MAO.0000000000004444","DOIUrl":"10.1097/MAO.0000000000004444","url":null,"abstract":"Objective: To assess the time course of speech recognition restoration for recipients of legacy devices who underwent cochlear implant revision (CIR) surgery in the presence or absence of device failure.Study design: Retrospective review.Setting: Tertiary academic referral center.Patients: Forty-four adult recipients of a first- or second-generation internal device who underwent CIR surgery.Interventions: Cases were categorized by whether the CIR surgery was elective (n = 18) or corrective due to a hard (n = 7) or soft (n = 19) failure.Main outcome measures: Aided consonant-nucleus-consonant (CNC) word recognition scores were queried for the following visits: best performance pre-CIR and 3, 6, and 12 months post-CIR. A linear mixed effects model evaluated the main effects of visit, CIR category, and age at CIR surgery, and the interaction of interval and revision category on CNC scores.Results: Limited surgical challenges were reported (n = 4), which included one case of incomplete insertion of the new device. Post-CIR CNC scores were similar to the best pre-CIR scores by 6 months post-CIR ( p = 0.055). There was a significant effect of age ( p = 0.006), with better performance observed for younger adults. The time course of speech recognition restoration post-CIR did not differ significantly for cases of corrective CIR due to hard or soft failures or elective CIR ( F(2,40) = 0.08, p = 0.923).Conclusions: Legacy CI users who undergo corrective or elective CIR may experience a similar time course in restoration of speech recognition post-CIR. Legacy device recipients considering elective CIR to access technology upgrades should be counseled on the associated potential risks and benefits.","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"388-392"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0