Otology & Neurotology最新文献

{"title":"Hearing Outcome in Idiopathic Sudden Sensorineural Hearing Loss After COVID-19 Vaccine in Asian Population: A Preliminary Study.","authors":"Pey-Yu Chen, Ting-Chia Young, Che-Yi Lin, Kun-Tai Kang, Chia-Huei Chu, Hsun-Tien Tsai, Hung-Ching Lin","doi":"10.1097/MAO.0000000000004509","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004509","url":null,"abstract":"<p><strong>Objective: </strong>To determine the hearing outcomes in patients with sudden sensorineural hearing loss (SSNHL) after exposure to different brands of vaccines against COVID-19.</p><p><strong>Study design: </strong>Cohort study.</p><p><strong>Setting: </strong>Tertiary referral center.</p><p><strong>Patients: </strong>Patients who met the International Classification of Disease, Tenth Revision code, medications, and procedure criteria for SSNHL in 2021. Patients were classified according to their vaccination status. A total of 128 patients (71 males and 57 females; mean age, 53.9 ± 16.5 yr; range, 7.6-82.1 yr) who met the criteria of idiopathic SSNHL were included.</p><p><strong>Intervention: </strong>Exposure to COVID-19 vaccines in 2021.</p><p><strong>Main outcome measurements: </strong>Hearing outcomes were classified according to the pure-tone audiometry hearing level, including complete recovery (CR), partial recovery (PR), and no recovery (NR). Time to recovery was defined as the point at which the patient achieved CR or PR.</p><p><strong>Results: </strong>Among them, 35, 54, and 39 patients achieved CR, PR, and NR, respectively. The median time to recovery was 22 (interquartile range, 11-37) days. No significant differences were observed in hearing recovery in vaccinated or unvaccinated patients.</p><p><strong>Conclusion: </strong>Our preliminary study failed to show significant differences in hearing recovery among patients with SSNHL regardless of the vaccine exposure status. The administration of COVID-19 vaccines should not be influenced by their potential association with SSNHL, as our findings indicate no significant effect on hearing outcomes. However, as a preliminary study with limited statistical power, future large-scale studies are necessary to validate these results.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exacerbation of Preexisting Otologic Conditions After COVID-19 Infection.","authors":"Víctor de Cos, Omer Baker, Nicollette Pepin, Omid Moshtaghi, Peter R Dixon, Akihiro J Matsuoka, Jeffrey P Harris","doi":"10.1097/MAO.0000000000004492","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004492","url":null,"abstract":"<p><strong>Background: </strong>Since the height of the COVID-19 pandemic, there have been an increasing number of reports of incidence of otologic conditions after infection. We aim to investigate whether a history of otologic conditions was associated with elevated risk of similar or exacerbated symptoms after COVID-19 infection.</p><p><strong>Methods: </strong>Surveys were administered to patients 18 years or older who had tested positive via PCR testing for COVID-19 infection between January 2020 and September 2022. Incidence of otologic symptoms within the 10-day period after COVID-19 infection was compared between participants with a preexisting otologic condition and control participants.</p><p><strong>Results: </strong>Of 1,499 patients who tested positive for COVID-19, 63.2% were female, 87.5% were White, and the mean age was 58 years. Of these, 721 (48%) reported a preexisting otologic condition, with loss of hearing (25.5%) and history of dizziness (18.8%) being most highly represented among this subcohort. Of patients with a preexisting condition, 35.5% subjectively reported that they believed COVID-19 infection had worsened otologic symptoms of their condition. Univariable analysis revealed that individuals were more likely to report dizziness post-COVID-19 infection if they had a preexisting history of dizziness (29.1% versus 17.8%, p < 0.001) or preexisting history of vestibular neuritis (58.8% versus 19.5%, p < 0.001) than those who did not. Similarly, individuals with a history of vestibular migraine were more likely to report migraine symptoms after infection than those who did not (27.9% versus 7.2%, p < 0.001). Multivariable analysis revealed that preexisting history of dizziness, vestibular neuritis, vestibular migraine, and autoimmune conditions increased the odds of several otologic symptoms, although an exception was observed with decreased odds for changes in hearing in patients with preexisting history of dizziness. Younger age and female gender were associated with higher odds for various otologic symptoms after COVID-19 infection.</p><p><strong>Conclusions: </strong>These findings indicate that certain preexisting otologic conditions may be associated with a greater likelihood of exacerbation after COVID-19 infection and may help guide screening protocols for those at greatest risk.</p><p><strong>Level of evidence: </strong>III.</p><p><strong>Irb: </strong>UCSD IRB #801971.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-Assessing the Interpretation of Beta Trace Protein Levels in Middle Ear Fluid in the Assessment for Lateral Skull Base Cerebrospinal Fluid Leaks.","authors":"Katherine Pollaers, John Joseph, Ee Mun Lim, Jafri Kuthubutheen, Stephen Rodrigues","doi":"10.1097/MAO.0000000000004475","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004475","url":null,"abstract":"<p><strong>Hypothesis: </strong>Describe the range of values of BTP obtained in middle ear fluid samples and determine if the level of BTP is a reliable indicator of the presence of a cerebrospinal fluid middle ear effusion.</p><p><strong>Background: </strong>Beta trace protein is a glycoprotein abundant in the CSF. Middle ear fluid samples are tested for the presence of BTP, which provides a numerical representation of the concentration of CSF. A middle ear fluid sample deemed to be positive for CSF has a BTP level of greater than 1.3 mg/L. However, this level is not specific to the middle ear, and there is a paucity of literature regarding interpretation of the BTP level when used in the evaluation for suspected lateral temporal bone CSF leaks.</p><p><strong>Methods: </strong>Retrospective review of all middle and nasal fluid samples sent by otolaryngologists for beta trace protein testing in Western Australia over a 4-year period.</p><p><strong>Results: </strong>A total of 168 patients had a middle ear fluid sample sent for BTP testing; these samples were obtained via tympanocentesis through an intact tympanic membrane with no other ear or temporal bone pathology. Ninety-six (96%) of the middle ear samples (172 of 178) had a BTP level greater than 1.3 mg/L, indicating a positive result and suggesting the presence of cerebrospinal fluid within the sample.</p><p><strong>Conclusion: </strong>The BTP level of middle ear fluid aspirates should be viewed with caution and used in conjunction with radiological findings and clinical impressions in the formulation of a management plan in patients suspected of lateral skull base CSF leaks.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Panic Disorder in Patients With Vestibular Dysfunction: A Systematic Review and Meta-analysis.","authors":"Lauren R McCray, Cory H Kim, Shaun A Nguyen, Erin A Harvey, Ted A Meyer","doi":"10.1097/MAO.0000000000004506","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004506","url":null,"abstract":"<p><strong>Objective: </strong>To assess the prevalence of panic disorder (PD) among patients with vestibular dysfunction.</p><p><strong>Databases reviewed: </strong>CINAHL, Cochrane Library, PubMed, PsycINFO, and SCOPUS.</p><p><strong>Methods: </strong>Databases were searched from inception through August 2024. Observational studies on PD in adults with vestibular dysfunction were included. Studies of patients without a vestibular disorder diagnosis or vertigo arising from trauma or tumors were excluded. Primary outcome measures included continuous measures (mean), proportions (%), and relative risk (RR) with 95% confidence intervals (CI). Two authors extracted data and discrepancies were resolved with a third party. Level of evidence was evaluated using Oxford Centre for Evidence-Based Medicine criteria. Risk of bias was assessed with Risk Of Bias In Non-randomized Studies-of Exposure for cohort studies and Joanna Briggs Institute criteria for case-control and cross-sectional studies.</p><p><strong>Results: </strong>Ten studies (n = 874) on PD and vestibular disorders were included. The mean age was 49.7 years for the vestibular group and 46.0 years for the control group. Although there were no significant differences in the prevalence of anxiety and depression, there was a significantly higher prevalence of PD (7.4% vs. 2.5%) in patients with vestibular dysfunction than the control population (p = 0.02). However, the risk of developing PD among patients with vestibular disorders was not significantly higher (RR = 1.9, 95% CI: 0.4-8.1) than the controls.</p><p><strong>Conclusion: </strong>The prevalence of PD in patients with vestibular dysfunction is nearly three times higher than in people without vestibular dysfunction. This evidence suggests otolaryngologists treating this condition should consider screening for PD.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Stapedectomy: Does Oval Window Packing Matter?","authors":"Maria A Mavrommatis, Jun Yun, Jennifer Ren, Sunder Gidumal, Maura K Cosetti, Enrique Perez, George B Wanna, Zachary G Schwam","doi":"10.1097/MAO.0000000000004496","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004496","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether differences in audiometric outcomes and postoperative vertigo exist among different approaches to oval window packing after endoscopic stapedectomy.</p><p><strong>Study design: </strong>Retrospective chart review.</p><p><strong>Setting: </strong>Academic tertiary care otology-neurotology practice.</p><p><strong>Patients: </strong>Patients who underwent endoscopic stapedectomy from 2017 to 2023.</p><p><strong>Interventions: </strong>Oval window reinforcement was performed with one of five techniques: lobular fat graft, promontory blood patch, both, other autologous patch, or none.</p><p><strong>Main outcome measures: </strong>Our primary outcome measures were subjective postoperative vertigo, change in air-bone gap (ABG; 250-4000 Hz), and air-conduction pure-tone average (PTA; 500/1000/2000/4000 Hz). Patient and surgical variables such as age, sex, laterality, surgeon, primary versus revision surgery, laser versus drill stapedotomy, and prosthesis type and length were secondarily investigated.</p><p><strong>Results: </strong>A total of 256 ears of 220 patients (mean age, 47.8 ± 12.9 yr) were included for analysis: 143 received promontory blood patch; 54, lobular fat graft; 10, both blood patch and fat graft; 2, temporalis fascia or tragal perichondrium; and 47, no reconstruction. There was no difference in incidence of subjective postoperative vertigo between groups at first and most recent follow-up (p = 0.92 and p = 0.76, respectively). Average improvements in ABG and PTA were not significantly different among groups at first (p = 0.35 and p = 0.27, respectively) and most recent audiograms (p = 0.87 and p = 0.99, respectively). Although there were also no significant differences in percentage of patients achieving ABG closure to within 20 or 10 dB at first postoperative audiogram (p = 0.48 and p = 0.51, respectively), blood patch yielded higher ABG closure to within 10 dB (p = 0.048), but not within 20 dB (p = 0.48) at second postoperative visit.</p><p><strong>Conclusions: </strong>Blood patch reconstruction may yield better long-term ABG closure compared with fat graft packing and no reconstruction alternatives to oval window reconstruction after endoscopic stapedectomy.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity and Specificity of Intraoperative TransImpedance Matrix Recordings Compared With X-ray Imaging in Detecting Perimodiolar Cochlear Implant Tip Foldovers: A Multicenter Study.","authors":"Alexandra M Arambula, Robin Piper, Gail Murray, Sarah E Mowry, Alejandro Rivas, Maroun Semaan, Nauman F Manzoor, Daniel E Killeen, David C Kelsall, J Eric Lupo, Allison Biever, Katrina R Stidham, Regina Albinus, Samantha Morgan, Brian J Kaplan, Regina Presley, Sarah Menendez, Viral D Tejani","doi":"10.1097/MAO.0000000000004502","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004502","url":null,"abstract":"<p><strong>Objective: </strong>Characterize the sensitivity and specificity of TransImpedance Matrix (TIM) recordings compared with x-rays in detecting cochlear implant tip foldovers.</p><p><strong>Study design: </strong>Retrospective.</p><p><strong>Setting: </strong>Multi-institutional, academic and private surgery centers.</p><p><strong>Patients: </strong>Patients 6 months and older undergoing cochlear implantation.</p><p><strong>Interventions: </strong>After cochlear implant array insertion, intraoperative TIM recordings and x-rays were conducted to confirm appropriate placement. If a foldover was identified, repeat insertion, followed by TIM and x-ray, was performed.</p><p><strong>Main outcome measures: </strong>Presence of tip foldovers as determined by TIM recordings and x-rays.</p><p><strong>Results: </strong>There were 13 tip foldovers out of 484 insertions, yielding a 2.7% tip foldover rate. Using x-rays as the \"gold standard,\" TIM recordings showed 100% sensitivity, 99.6% specificity, 84.6% positive predictive value (PPV), and 100% negative predicative value in detecting tip foldovers. The x-ray images for two TIM-identified tip foldovers were interpreted as normal intraoperatively (apparent false positives), but then were interpreted as foldovers when presented to the operating surgeon postoperatively in a blinded fashion. If these false positives had been reclassified as true positives, TIM specificity and PPV would both improve to 100%.</p><p><strong>Conclusions: </strong>These results provide further support regarding the utility of TIM recordings to evaluate appropriate cochlear implant electrode array position. Despite the low tip foldover rate reported across the literature and within this study, this multicenter patient group provided a large sample size to calculate the sensitivity and specificity of TIM recordings in identifying tip foldovers. Compared with the reference-standard, x-ray imaging, TIM recordings show equivalent, and in some cases superior, performance in identification of tip foldovers. Thus, use of TIM can potentially preclude the need for routine intraoperative x-rays without compromising patient care.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caloric Test, and Qualitative and Quantitative vHIT Analysis in Vestibular Schwannoma.","authors":"Pasqualina Maria Picciotti, Rolando Rolesi, Giorgia Rossi, Angelo Tizio, Bruno Sergi, Jacopo Galli","doi":"10.1097/MAO.0000000000004503","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004503","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate relationships and discordant results between caloric testing and video head impulse testing (vHIT) among patients with unilateral vestibular schwannoma (VS), trying to establish if caloric testing and vHIT may provide complementary information on vestibular assessment.</p><p><strong>Study design: </strong>Retrospective case review.</p><p><strong>Setting: </strong>Tertiary care academic center.</p><p><strong>Patients: </strong>218 patients affected by unilateral VS and managed by \"wait and scan\" (WS), microsurgery (MS), or fractionated stereotactic radiotherapy (SRT). The analysis included patients' age, tumor size (KOOS stage), hearing level, facial nerve function, vestibular function, tumor control, and complications.The subjects' vestibular function was assessed evaluating the caloric response, vHIT gains for lateral canals and saccades, with and without gain abnormalities.</p><p><strong>Results: </strong>In the 167 eligible patients, the most common finding was both caloric and vHIT abnormal results (74 patients). In 40 cases, caloric test abnormal response was not associated with ipsilesional vestibular oculomotor reflex (VOR) amplitude alterations. In 53 patients, caloric tests and vHIT showed no abnormalities. In the three groups of patients, the number of compensatory saccadic eye movements after head motion was significantly higher, which were strongly correlated with caloric unilateral weakness (UW). Tumor size was significantly associated with an increase both in caloric UW and VOR asymmetry.</p><p><strong>Conclusion: </strong>Results highlight the importance of an accurate vHIT morphological analysis in the context of patients affected by VS. Indeed, given the relationship between vestibular deficit and number of compensatory saccades, our data further suggest that an increase in the generation of late compensatory saccadic events may reveal a vestibular deficit not adequately characterized by VOR gain analysis. A correct vestibular assessment must include the caloric test and the vHIT including both qualitative and quantitative analysis of the saccades in the presence of a normal VOR gain and normal symmetry.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active Osseointegrated Transcutaneous Bone Conduction Implant: Results of a New Surgical Location in Children with Microtia and External Auditory Canal Atresia.","authors":"Carolina Der, Nicolás Pons, Sofia Bravo-Torres, Magdalena Cornejo","doi":"10.1097/MAO.0000000000004457","DOIUrl":"10.1097/MAO.0000000000004457","url":null,"abstract":"<p><strong>Objective: </strong>To present a different location, lateral to the middle fossa, as a new surgical alternative for an active transcutaneous bone conduction implant (ATBCI) in children with microtia and external auditory canal atresia (EACA) who cannot undergo traditional surgery due to altered anatomy or desire for future aesthetic reconstruction.</p><p><strong>Study design: </strong>Prospective, longitudinal, descriptive study. The surgical technique was developed. Preoperative and postoperative information was analyzed.</p><p><strong>Setting: </strong>Tertiary pediatric hospital in Santiago, Chile.</p><p><strong>Patients: </strong>Eight children with unilateral EACA and microtia.</p><p><strong>Intervention: </strong>ATBCI lateral to the middle fossa.</p><p><strong>Main outcome measure: </strong>Surgical, audiological, and quality-of-life outcomes.</p><p><strong>Result: </strong>Eight children with EACA were implanted. Surgery was uneventful except for one seroma. This placement is lateral to the middle fossa, serving as a location marker. Their average age was 13 years old. The average follow-up was 21 months. All patients had conductive hearing loss. The audiological and quality-of-life results were as expected for this device.</p><p><strong>Conclusions: </strong>This location for the ATBCI was proven to be safe and effective for treating pediatric patients with EACA who desire future aesthetic reconstruction. This new surgical technique is safe and faster than the one suggested by the manufacturer due to the flat bone in this region of the skull. The outcomes are comparable to those obtained with the traditional location described for this device.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":"46 4","pages":"425-431"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of the Expression and Role of Striatin-Interacting Protein 2 in Mouse Cochlea.","authors":"Siyu Li, Yue Qiu, Ao Li, Jie Lu, Xinya Ji, Wenli Hao, Cheng Cheng, Xia Gao","doi":"10.1097/MAO.0000000000004449","DOIUrl":"10.1097/MAO.0000000000004449","url":null,"abstract":"<p><strong>Hypothesis: </strong>In this study, we aimed to examine the cochlear expression pattern and function of Striatin-interacting protein 2 (STRIP2) by using animal models.</p><p><strong>Background: </strong>Sensorineural hearing loss often results from genetic defects in hair cell (HC) development and function. STRIP2 is a part of the striatin-interacting phosphatase and kinase (STRIPAK) complex, which plays important regulatory roles in cell fate determination, proliferation, cytoskeletal organization, and cell morphology. A recent study revealed Strip2 as the candidate gene that regulates positive selection in HC lineages. However, its role in the inner ear has not been identified.</p><p><strong>Methods: </strong>Strip2 knockout mouse model was used to examine the cochlear expression pattern and function of STRIP2. Auditory brainstem response test was used to evaluate the hearing function of mice. Immunostaining and scanning electron microscope were used to study hair cells, synapses, and stereocilia of cochlea.</p><p><strong>Results: </strong>Immunostaining showed that cytoplasmic STRIP2 expression in hair cells increased from postnatal day (P) 3 to P14. Despite having normal hearing thresholds, hair cell numbers, and stereocilia morphology until P90, the deletion of Strip2 resulted in a mild reduction in ribbon synapse density, suggesting a late onset of cochlear synaptic defects.</p><p><strong>Conclusion: </strong>Our results revealed that STRIP2 was abundantly expressed in hair cells; however, the hearing function of Strip2-/- mice was comparable to that of control mice until P90, and a mild decrease in ribbon synapse number was detected at P60 and P90. Further studies on STRIP2 and its associated complexes will provide new insights into the pathways involved in inner ear development and function.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"e139-e146"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Speech Outcomes of Cochlear Implantation, from 1983 to Present: A Systematic Review.","authors":"Nia S Brown, Sanjena Venkatesh, Tazheh A Kavoosi, James O Onyeukwu, Jason A Brant, Alexandra E Quimby","doi":"10.1097/MAO.0000000000004468","DOIUrl":"10.1097/MAO.0000000000004468","url":null,"abstract":"<p><strong>Objective: </strong>We sought to assess whether the totality of advancements seen in cochlear implant (CI) design and implementation have translated to significant improvements in speech perception scores.</p><p><strong>Databases reviewed: </strong>EMBASE, PubMed/MEDLINE, and the Cochrane Central Register of Controlled Trials.</p><p><strong>Methods: </strong>A systematic review of all English-language studies in peer-reviewed journals from 1946 to August 2022 was performed based on the Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligible studies were of adult patients who underwent cochlear implantation with Cochlear®, Med-EL, or Advanced Bionics devices with 12 months postoperative sentence recognition testing results. Meta-regression was performed to assess the relationship between speech recognition score and year of implantation. Preimplantation score and unilateral versus bilateral implantation were adjusted for. Subgroup analysis was performed by restricting to studies of <5 years duration and in which outcomes were measured ≤12 months postoperatively to reduce the likelihood of patients with remotely implanted devices having undergone upgrades to more contemporary coding software.</p><p><strong>Results: </strong>A total of 37 studies met criteria for inclusion, representing CIs implanted between 1983 and 2019. No significant association was identified between median study year and scores on 12-month postoperative sentence recognition testing on any of AzBio in quiet, CNC words, or HINT sentences in quiet. Subgroup analysis showed no difference in outcomes across 15 studies including patients implanted from 2007 to 2019.</p><p><strong>Conclusion: </strong>In the absence of improved CI coding strategies since 2007, speech recognition outcomes in quiet have also not improved significantly since this time.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":"46 4","pages":"393-404"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}