Otology & NeurotologyPub Date : 2025-03-01Epub Date: 2025-01-29DOI: 10.1097/MAO.0000000000004412
Miranda Morrison, Aurelia Bucciarelli, Athanasia Korda, Leonie Sarah Goetz, Marco D Caversaccio, Dominik Obrist, Georgios Mantokoudis
{"title":"Impact of Vibrations and Rapid Decelerations on SemontPLUS Maneuver Efficacy: An In Vitro Study.","authors":"Miranda Morrison, Aurelia Bucciarelli, Athanasia Korda, Leonie Sarah Goetz, Marco D Caversaccio, Dominik Obrist, Georgios Mantokoudis","doi":"10.1097/MAO.0000000000004412","DOIUrl":"10.1097/MAO.0000000000004412","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to investigate the effect of adding \"rapid decelerations\" and \"vibrations\" during a SemontPLUS maneuver on the dynamics of the inner ear and the success rate of canalolithiasis repositioning.</p><p><strong>Methods: </strong>We used a previously described upscaled (5×) in vitro model of the posterior semicircular canal of the inner ear to analyze the trajectory of a single and clumped surrogate otolith particle (metallic sphere) during a SemontPLUS maneuver (-60 degrees below earth horizontal) on a repositioning chair (TRV). We compared the angular displacement of these particles with and without the application of \"vibrations\" or \"rapid decelerations\" using TRV. We recorded the success rates of the SemontPLUS maneuver for each condition.</p><p><strong>Results: </strong>After the first step of the SemontPLUS, the application of \"vibrations\" increased the angular displacement of single particles from 119.9 to 125.9 degrees and clumps from 106.7 to 122.8 degrees. Clumps traveled shorter distances than single particles. \"Rapid decelerations\" also increased the angular displacement from 119.9 to 123.4 degrees and from 106.7 to 111.7 degrees for singles and clumps, respectively. \"Vibrations\" and \"rapid decelerations\" applied on the in vitro model resulted in enhanced repositioning success rates to 60 and 73%, respectively.</p><p><strong>Conclusions: </strong>Adding \"rapid decelerations\" or \"vibrations\" to the SemontPLUS maneuver increased otolith particle displacement and improved the repositioning success rates in an in vitro model. However, the effect size of these additional modalities on angular displacement is small, and their use in clinics to improve repositioning in the SemontPLUS would have to be supported by further clinical trials.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"e81-e87"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Otology & NeurotologyPub Date : 2025-03-01Epub Date: 2025-01-22DOI: 10.1097/MAO.0000000000004418
Madison V Epperson, Sara Hughes, Carla V Valenzuela, Emily Z Stucken
{"title":"Otologic Symptoms Following Teprotumumab Administration in Patients with Thyroid Eye Disease.","authors":"Madison V Epperson, Sara Hughes, Carla V Valenzuela, Emily Z Stucken","doi":"10.1097/MAO.0000000000004418","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004418","url":null,"abstract":"<p><strong>Objective: </strong>Comprehensively characterize subjective otologic adverse events following teprotumumab administration with standardized patient reported outcome metrics. Understand the impact on patients' quality of life and perception of the medication.</p><p><strong>Study design: </strong>Retrospective case series.</p><p><strong>Setting: </strong>Tertiary referral center.</p><p><strong>Patients: </strong>Thirty-two adults with thyroid eye disease treated with teprotumumab from 2020 to 2023.</p><p><strong>Main outcome measures: </strong>Subjective hearing loss, tinnitus, dizziness (Dizziness Handicap Inventory), patulous eustachian tube (Eustachian Tube Dysfunction Questionnaire-7, Patulous Eustachian Tube Handicap Inventory-10), effect of hearing loss on quality of life, and decisional regret.</p><p><strong>Results: </strong>Half reported hearing loss (n = 16, 50%) while receiving teprotumumab. Onset was gradual in 75% of patients with onset at the sixth [IQR 5-7] infusion. It was nonfluctuating (93.8%), bilateral (100%), and did not return to baseline (93.8%). Of those reporting hearing loss, 37.5% reported dizziness and 87.5% reported tinnitus; 87.5% felt it affected quality of life, and 33.3% would opt to not receive the medication again. The median DHI score was 9 [0-35] in those with hearing loss compared to 0 [0-5] in those without hearing loss (p = 0.02, Wilcoxon rank sum). Based on the ETDQ-7, 37.5% of patients experienced eustachian tube dysfunction; 15.6% experienced symptoms of a patulous eustachian tube with a median PHI-10 score of 15 [3-24], indicating a mild handicap.</p><p><strong>Conclusions: </strong>Many patients experience subjective hearing loss following teprotumumab administration, typically gradual in onset, nonfluctuating, bilateral, persistent, and significantly affecting quality of life. Patients may also experience comorbid vertigo and symptoms of eustachian tube dysfunction or patulous eustachian tube with variable severity.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":"46 3","pages":"330-335"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Auditory Brainstem Response (ABR) Recording of Simultaneous Electric-Acoustic Stimulation between Round Window Membrane and Basal Part of Cochlear Bone in guinea Pigs.","authors":"Yi-Chen Lin, Nai-Hsin Huang, Yu-Fu Chou, Bo-Cheng Chen, Lian-Jie Lin, Wei-Chung Hsu, Chia-Fone Lee","doi":"10.1097/MAO.0000000000004406","DOIUrl":"10.1097/MAO.0000000000004406","url":null,"abstract":"<p><strong>Hypothesis: </strong>Extracochlear electric-acoustic stimulation (EAS) between the round window membrane and the basal part of the cochlear bone exhibits distinct auditory brainstem response (ABR) characteristics.</p><p><strong>Background: </strong>The use of EAS in individuals with residual hearing is becoming increasingly common in clinical settings. Ongoing research has explored the characteristics of EAS-induced responses in hearing cochleae.</p><p><strong>Methods: </strong>This study explored a novel extracochlear EAS approach using round window membrane-cochlear bone stimulation to maintain cochlear integrity. The electrodes stimulate the basal part of the cochlea and spare the apex, making the model ideal for EAS candidates with profound high-frequency hearing loss and residual low-frequency hearing. ABR analyses of EAS were conducted to compare responses to acoustic, electrical, and combined stimulations.</p><p><strong>Results: </strong>The threshold of EAS was higher than that of acoustic stimulation (AS) or electric stimulation (ES). The maximum peak height of the amplitude (MPHA) in the EAS showed sound pressure level (SPL)- and electric current-dependent changes, with superior performance at higher SPLs. The MPHA latency shift index analysis demonstrated significant differences between the EAS and the AS or ES only. In the context of EAS, neural responses occurring before 4 ms are defined as early responses, which are related to the stimulus. Late responses, occurring after 4 ms, suggest distinct physiological mechanisms that may involve synaptic actions or specific interactions within the EAS.</p><p><strong>Conclusion: </strong>Extracochlear EAS provides insights into its physiological implications, proposes a method for clinical application, and offers a potential avenue for improving hearing preservation and performance.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"321-329"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Otology & NeurotologyPub Date : 2025-03-01Epub Date: 2025-01-02DOI: 10.1097/MAO.0000000000004411
Tyler M Rist, Jourdan T Holder, Robert F Labadie
{"title":"Use of Photon-Counting Detector Computed Tomography (PCD-CT) in a Revision Cochlear Implant.","authors":"Tyler M Rist, Jourdan T Holder, Robert F Labadie","doi":"10.1097/MAO.0000000000004411","DOIUrl":"10.1097/MAO.0000000000004411","url":null,"abstract":"","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"e88-e90"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Otology & NeurotologyPub Date : 2025-03-01Epub Date: 2025-02-04DOI: 10.1097/MAO.0000000000004426
Dylan Severson, Nadav Brumer, Chantel Hazlewood, Elizabeth Elkins, Jake Hillyer, Alexandra Parbery-Clark
{"title":"Cochlear Implant Outcomes: A Focused Way of Looking at Speech Perception and Health-Related Quality of Life.","authors":"Dylan Severson, Nadav Brumer, Chantel Hazlewood, Elizabeth Elkins, Jake Hillyer, Alexandra Parbery-Clark","doi":"10.1097/MAO.0000000000004426","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004426","url":null,"abstract":"<p><strong>Introduction: </strong>The relationship between health-related quality of life (HRQoL) and speech perception in cochlear implant (CI) users is inconsistent across existing research. To investigate this relationship, we assessed HRQoL using the Glasgow Benefit Inventory (GBI) and speech perception using the Minimum Speech Test Battery (MSTB). The present study proposes an additional subscore to the GBI: CI global outcomes.</p><p><strong>Methods: </strong>Seventeen bimodal CI users between the ages of 55 and 85 years participated in the study. All participants completed the GBI as well as the MSTB (e.g., AzBio sentence test in quiet and noise, the Bamford-Kowal-Bench Speech-in-Noise test [BKB-SIN], and the Consonant-Nucleus-Consonant test [CNC]). Correlations were calculated between HRQoL and speech perception measures.</p><p><strong>Results: </strong>Improvement in QoL as measured by the GBI CI global outcomes subscore significantly related to better performance on the AzBio in noise. No other significant relationships between the GBI and CI speech perception ability were observed.</p><p><strong>Conclusion: </strong>CI global outcomes significantly related to speech perception ability in noise (AzBio), suggesting that this novel metric may be useful for capturing bimodal CI patient-reported outcomes.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":"46 3","pages":"287-294"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Otology & NeurotologyPub Date : 2025-03-01Epub Date: 2025-01-22DOI: 10.1097/MAO.0000000000004414
Yanzhen Li, Ge Zhang, Yan Su, Zhikai Liu, Jie Zhang, Xuexi Zhang, Qiaoyin Liu, Nian Sun, Zhiyong Liu, Xiaodan Li, Junlong Tan, Lin Mei, Yuwei Liu, Tingting Ji, Shengcai Wang, Xin Ni
{"title":"Rhabdomyosarcoma of the Middle Ear and Mastoid in Children: Experience of the Beijing Children's Hospital-BCH.","authors":"Yanzhen Li, Ge Zhang, Yan Su, Zhikai Liu, Jie Zhang, Xuexi Zhang, Qiaoyin Liu, Nian Sun, Zhiyong Liu, Xiaodan Li, Junlong Tan, Lin Mei, Yuwei Liu, Tingting Ji, Shengcai Wang, Xin Ni","doi":"10.1097/MAO.0000000000004414","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004414","url":null,"abstract":"<p><strong>Objectives: </strong>To conduct a retrospective analysis of the clinical characteristics and prognosis of rhabdomyosarcoma of the middle ear and mastoid (MERMS) in children.</p><p><strong>Methods: </strong>Treatment and outcome of 37 children with MERMS from Beijing Children's Hospital (July 2016-April 2023) were evaluated.</p><p><strong>Results: </strong>The median age of this cohort was 54 months. Initially, 9 children were misdiagnosed with otitis media and/or granulomas, whereas 11 underwent anti-infective therapy. The disease manifested with a high level of local aggressiveness (T2; 83.8%), often accompanied by meningeal invasion (MI; 27 of 37), encompassing cranial base bone erosion (CBBE; 27 of 27), intracranial extension (ICE; 14 of 27), and cranial nerve paralysis (CNP; 22 of 27), with a predominance of facial nerve involvement in CNP cases. The primary treatment modality for this region was a combination of radiation and chemotherapy. The early response to neoadjuvant chemotherapy emerged as a prognostic factor, significantly impacting 5-year event-free survival (EFS) and overall survival (OS): complete response (CR), 85.7 and 100%; partial response (PR), 43.7 and 65.2%; and progressive disease/stable disease (PD/SD), 16.7 and 16.7% (p = 0.019 and 0.001, respectively). A total of 13 patients passed away, with 4 fatalities attributed to the dissemination of tumor cells in the cerebrospinal fluid and 9 resulting from intracranial progression that impacted the central nervous system. The 5-year OS and EFS were (67.1 ± 7.8%) and (51.1 ± 9.1%), respectively.</p><p><strong>Conclusion: </strong>MERMS is a highly aggressive malignancy with complex clinical manifestations and frequent cranial nerve involvement. Early recognition, aggressive multimodal treatment, and close monitoring for treatment response are crucial for improving survival outcomes.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":"46 3","pages":"314-320"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryan Long, Wihan Kim, Marcela Morán, Frank D Macías-Escrivá, Patricia M Quiñones, John S Oghalai, Brian E Applegate
{"title":"Optical Coherence Tomography as a Tool for Quantitative Imaging of the Tympanic Membrane and Middle Ear.","authors":"Ryan Long, Wihan Kim, Marcela Morán, Frank D Macías-Escrivá, Patricia M Quiñones, John S Oghalai, Brian E Applegate","doi":"10.1097/MAO.0000000000004441","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004441","url":null,"abstract":"<p><strong>Objective: </strong>Advances in optical coherence tomography have improved diagnostic imaging for otologic pathologies. We investigated handheld OCT (HHOCT) otoscopic device's ability to quantitatively analyze the middle ear and provide valuable information for the management of middle ear pathologies.</p><p><strong>Study design: </strong>Cross-sectional cohort.</p><p><strong>Methods: </strong>Eleven healthy patients, 5 patients with unilateral pathology, 6 patients with retraction pockets, and 1 patient undergoing ossiculoplasty were imaged using HHOCT in the clinic. Middle ear distances and retraction pocket depth were calculated using OCT volumes and compared to those on CT and in literature. Partial ossicular replacement prosthesis length was calculated before surgery and compared to the length chosen by an expert otologist. Data were characterized using descriptive statistics and paired t-tests. Volumes were analyzed and postprocessed using Amira (Thermofisher Scientific, Waltham, MA) and Fiji (NIH).</p><p><strong>Results: </strong>HHOCT could image and obtain quantitative measurements of the middle ear at the point of care with greater resolution and precision than traditional imaging modalities. Mean incus diameter on OCT was 0.728 ± 0.089 mm, in agreement with cadaver studies. Measured middle ear distances and retraction pocket depths were not statistically significantly different from those measured on CT. The predicted prosthesis size for the ossiculoplasty patient was 2.46 mm, closely matching the 2-mm length chosen by an expert otologist.</p><p><strong>Conclusion: </strong>OCT can provide reliable measurements of the tympanic membrane and middle ear structures not readily available through traditional imaging modalities. Pre- or intrasurgical measurements with OCT may be beneficial for guidance on size and placement of ossicular prosthetics and may improve hearing outcomes.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matteo Alicandri-Ciufelli, Edoardo Serafini, Maria Rosini, Carlotta Liberale, Francesca De Cecco, Elke Loos, Paolo Garofalo, Nicolò Cardobi, Alessia Rubini, Daniele Marchioni
{"title":"Radiologic Findings after Transpromontorial Approach: Clinical and Pathophysiological Considerations.","authors":"Matteo Alicandri-Ciufelli, Edoardo Serafini, Maria Rosini, Carlotta Liberale, Francesca De Cecco, Elke Loos, Paolo Garofalo, Nicolò Cardobi, Alessia Rubini, Daniele Marchioni","doi":"10.1097/MAO.0000000000004483","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004483","url":null,"abstract":"<p><strong>Objectives: </strong>Transpromontorial approaches require obliteration of the surgical cavity and the eustachian tube, along with cul-de-sac external auditory canal closure, without obliteration of the mastoid air cells. This study aims to evaluate the clinical and radiological implications of tympanic cavity obliteration when the mastoid air cell system is preserved.</p><p><strong>Study design: </strong>Retrospective observational study.</p><p><strong>Setting: </strong>Tertiary referral center.</p><p><strong>Patients: </strong>Thirty-one adult patients with unilateral vestibular schwannoma.</p><p><strong>Intervention: </strong>Patients underwent resection of a vestibular schwannoma through either an exclusive endoscopic transcanal transpromontorial approach (endoTTA) or an expanded transcanal transpromontorial approach (expTTA).</p><p><strong>Main outcome measure: </strong>Postoperative radiologic mastoid and surgical cavity content and clinical outcomes.</p><p><strong>Results: </strong>Thirty-one patients met the inclusion criteria. The mean radiological follow-up was 54 months. Regarding mastoid content, air was present in 13 patients (42%) and trapped fluid in 18 patients (58%). Surgical cavity content revealed air in 14 patients (45%), trapped fluid in 8 patients (26%), total fat obliteration in 5 patients (16%), and partial fat obliteration in 4 patients (13%). No cases of mucocele, cholesterol granuloma, or iatrogenic cholesteatoma were observed. Three main radiological patterns were identified by combining mastoid and surgical cavity findings. EndoTTA was found to be significantly associated with postoperative radiological air content in the mastoid cavity (p value = 0.013), while no association was found between the type of radiological pattern and the development of complications or symptoms at the last follow-up.</p><p><strong>Conclusions: </strong>EndoTTA and expTTA are safe and effective procedures, with no increased risk of meningitis or CSF leak, even in cases where obliteration tissue is reabsorbed.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andreas Radeloff, Katrin Radeloff, Rolf-Peter Henke, Sarah Hahnke, Maureen Loewenthal
{"title":"Cholesterol Granuloma Mimicking CSF Otorrhea by beta-Trace-Protein Production.","authors":"Andreas Radeloff, Katrin Radeloff, Rolf-Peter Henke, Sarah Hahnke, Maureen Loewenthal","doi":"10.1097/MAO.0000000000004471","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004471","url":null,"abstract":"<p><strong>Objective: </strong>To report a patient who was misdiagnosed and operated on for cerebrospinal fluid (CSF) otorrhea and to demonstrate that cholesterol granulomas mimic CSF leakage by secreting beta-trace protein (BTP).</p><p><strong>Patients: </strong>Eleven consecutive patients undergoing ear surgery in whom cholesterol granulomas were discovered intraoperatively.</p><p><strong>Intervention: </strong>Biochemical and histologic analysis of liquid and solid fractions of cholesterol granulomas.</p><p><strong>Main outcome measures: </strong>BTP and beta-2-transferrin concentrations and BTP mRNA levels in surgical specimens.</p><p><strong>Results: </strong>Cholesterol granulomas produce BTP and express high levels of BTP mRNA, but do not produce beta-2-transferrin.</p><p><strong>Conclusions: </strong>Beta-2 transferrin analysis is preferable to BTP analysis for the detection of CSF otorrhea because BTP may be false positive in the presence of cholesterol granulomas.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael H Freeman, Nathan R Lindquist, James R Dornhoffer, Kristen L Yancey, Ankita Patro, Benjamin D Lovin, Taimur Siddiqui, Aniket A Saoji, Jourdan R Holder, Walter Kutz, Alex D Sweeney, David S Haynes, Matthew L Carlson, Marc L Bennett
{"title":"A Multi-Institutional Analysis of Device Failures in a Recent Cochlear Implant Series.","authors":"Michael H Freeman, Nathan R Lindquist, James R Dornhoffer, Kristen L Yancey, Ankita Patro, Benjamin D Lovin, Taimur Siddiqui, Aniket A Saoji, Jourdan R Holder, Walter Kutz, Alex D Sweeney, David S Haynes, Matthew L Carlson, Marc L Bennett","doi":"10.1097/MAO.0000000000004438","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004438","url":null,"abstract":"<p><strong>Objective: </strong>To assess Advanced Bionics (AB) HiRes Ultra and Ultra 3D initial version (V1) cochlear implant electrode failures over time at four large cochlear implant programs.</p><p><strong>Study design: </strong>Retrospective cohort.</p><p><strong>Setting: </strong>Four tertiary referral centers.</p><p><strong>Patients: </strong>Patients receiving AB HiRes Ultra and Ultra 3D initial version (V1) devices as of December 31, 2022.</p><p><strong>Main outcome measures: </strong>Failure rate, revision surgery, speech recognition scores.</p><p><strong>Results: </strong>Over a span of 7 years, 205 (42.6%) of 483 implanted V1 devices have failed. Device failure rate varied across institutions from 32 to 67%. Of the 205 detected failures, 163 (79%) have undergone revision surgery, with 94% of revisions being performed with Advanced Bionics devices. Average time from implantation to diagnosis of device failure was 2.7 ± 1.2 years. Most patients (89.8%) with available testing were matched or exceeded their best prefailure speech performance after implant revision. After revision, patients had an average CNC score improvement of 24.7 percentage points over their most recent pre-revision scores and demonstrated average datalogging of 12.7 ± 4.1 h/d at most recent evaluation.</p><p><strong>Conclusions: </strong>Comparison of patients across multiple high-volume implant centers confirms the presence of ongoing device failures. There is variability across institutions in the rate of revision surgery once a patient is diagnosed with a V1 device failure, as well as in the rate of device failure detection. Inter-institutional variability in failure rates may be explained by the variation in the routine use of electrical field imaging. Reimplantation with a new device typically results in a return to prefailure peak performance.</p><p><strong>Professional practice gap educational need: </strong>To our knowledge, a comparison of AB HiRes (V1) device failures across multiple institutions has not been conducted.</p><p><strong>Learning objective: </strong>To identify device failure rate across multiple institutions with different testing protocols.</p><p><strong>Desired result: </strong>Providers will have an improved understanding of the trajectory of device failures for HiRes (V1) devices over time.</p><p><strong>Level of evidence: </strong>Level IV-Historical cohort or case-controlled studies.</p><p><strong>Indicate irb or iacuc: </strong>IRB #230017; IRB #22-000183; IRB #STU-032018-085; IRB #H-49479.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}