NeuroRehabilitation最新文献

{"title":"Patient-Centered Selection Criteria for Robot-Assisted Gait Training in Subacute Stroke: A Focus of User Satisfaction.","authors":"Jong Weon Lee, Won Hyuk Chang, Tae-Woo Kim, Hyoung Seop Kim, Fazah Akhtar Hanapiah, Seung-Hyeon Han, Chai Wen Jia, Dae Hyun Kim, Deog Young Kim","doi":"10.1177/10538135261436050","DOIUrl":"10.1177/10538135261436050","url":null,"abstract":"<p><p>PurposeTo identify patient-centered selection criteria for exoskeletal wearable robot-assisted gait training (RAGT) by investigating predictors of satisfaction in subacute stroke survivors.Materials and MethodsIn this subgroup analysis of an international, multicenter, randomized controlled trial, 58 inpatients completed a 4-week RAGT program (20 sessions). Satisfaction was assessed using a modified 15-item QUEST 2.0 questionnaire across five domains (appropriateness, effectiveness, convenience, conformance, reliability). Predictors of the mean satisfaction score were analyzed using multiple linear regression.ResultsThe overall satisfaction questionnaire score was 3.9 ± 0.6 (out of 5). The effectiveness domain was rated significantly higher than other domains (p < 0.05). Age was the only significant independent predictor of satisfaction (β = -0.269; 95% CI -0.315 to -0.007; p < 0.05). Participants aged <65 years reported significantly higher overall satisfaction than those aged ≥65 years (p < 0.05). This difference was driven by the appropriateness domain, where older adults reported lower comfort scores (p < 0.05).ConclusionRAGT received high user ratings, particularly for effectiveness. However, younger age predicted greater satisfaction, primarily due to discomfort in older adults. Selection criteria should consider age, and strategies to mitigate discomfort in older adults are needed to maximize adherence.<b>Trial details</b>: ClinicalTrial.gov Identifier NCT05157347 (first registration (10/12/2021)).</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"600-611"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of an 8-Week Combined Aerobic-Resistance Training on Motor Function, Functional Mobility, and Metabolic Parameters in Patients with Parkinson's Disease: A Controlled Study.","authors":"Šimon Janovič, Erik Szabo, Martin Gábor, Igor Straka, Zita Majerníková, Alice Kušnírová, Veronika Boleková, Zuzana Košutzká","doi":"10.1177/10538135261434253","DOIUrl":"10.1177/10538135261434253","url":null,"abstract":"<p><p>Exercise is increasingly recognized as a key component of Parkinson's disease (PD) management, but data on short-term combined aerobic-resistance training (ART) on motor and metabolic parameters remain limited. In this controlled study, 28 patients with PD (median Hoehn & Yahr stage= 2, IQR 1.75-2.0) were allocated to an 8-week supervised ART group (n= 19) or a stretching-only control group (n = 9). Training consisted of two 45-minute sessions weekly. Primary outcomes were MDS-UPDRS-III, Sit-to-Stand Test (STS), and Six-Minute Walk Test (6MWT). Fasting laboratory parameters were exploratory given the small sample size and absence of an a priori power analysis. Between-group post-intervention differences were analyzed using ANCOVA (baseline as covariate); exploratory biochemical outcomes were controlled for multiple comparisons using Benjamini-Hochberg false discovery rate (FDR). ART improved the MDS-UPDRS-III tremor subscore (p = 0.004) and6MWT distance (p = 0.003), with no significant effects on other motor or functional outcomes. In exploratory laboratory analyses, unadjusted between-group differences were observed for HDL cholesterol (p =0.014), vitamin D₃ (p = 0.003), TSH (p = 0.042), and homocysteine (p =0.019); after FDR correction, only vitamin D₃ remained significant (qFDR= 0.039). Total cholesterol, LDL, and VLDL showed non-significant decreases. An eight-week ART program improved tremor and walking endurance inpatients with PD, while other motor outcomes remained unchanged. Exploratory changes in selected biochemical markers were detected (including a decrease in vitamin D₃); their clinical relevance remains unclear and should be evaluated in larger, well-powered randomized studies.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"659-667"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Multi-Domain Telerehabilitation in Patients with Stroke: A Non-Inferiority, Single-Blind, Randomized Controlled Trial.","authors":"Alessandro Picelli, Pawel Kiper, Valentina Varalta, Mirko Filippetti, Anna Righetti, Elisa Evangelista, Rita Di Censo, Cristina Fonte, Sara Federico, Luisa Cacciante, Alessia Carletto, Andrea Turolla, Michela Agostini, Paolo Tonin, Claudia Giacomozzi, Nicola Smania","doi":"10.1177/10538135261445401","DOIUrl":"10.1177/10538135261445401","url":null,"abstract":"<p><p>ObjectiveAlthough telerehabilitation has emerged as a promising and accessible alternative to traditional in-person therapy, robust evidence supporting its clinical effectiveness across multiple functional domains remains limited. We tested the non-inferiority of synchronous multi-domain telerehabilitation for motor, cognitive, language, and disability outcomes in stroke survivors.DesignBicentric, single-blind (assessor-blinded), randomized controlled non-inferiority trial.MethodsFifty-six participants were randomized to home-based telerehabilitation or conventional outpatient therapy. Both groups completed twenty real-time supervised sessions over four weeks. The primary outcome was change in Fugl-Meyer Assessment upper-extremity motor score (0-66); secondary outcomes included Fugl-Meyer Assessment lower-extremity motor (0-34), Aachen Aphasia Test (Italian version) naming/written language/comprehension, Oxford Cognitive Screen orientation and memory subtests, and Barthel Index. Non-inferiority was evaluated using a prespecified margin (Δ=-5.2) and confidence-interval-based linear mixed-effects models (per-protocol primary, intention-to-treat sensitivity); non-inferiority was concluded if the lower bound of the 95% CI for the adjusted between-group contrast at T1 (telerehabilitation minus conventional) was > -Δ.ResultsThe adjusted between-group difference in change for the primary outcome was compatible with non-inferiority at post-treatment, with consistent results in sensitivity analyses. No significant between-group differences were observed in language, cognitive, or functional independence outcomes, and findings were similar at one-month follow-up.ConclusionsSynchronous multi-domain telerehabilitation appears feasible and yields short-term motor recovery comparable to standard outpatient rehabilitation within a prespecified non-inferiority framework. Interpretation is limited by the short follow-up and restricted cognitive outcome coverage.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"591-599"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Balance Recovery Profiles Based on the Berg Balance Scale and Associated Lesion Characteristics in Patients with Subacute Stroke.","authors":"Hiroaki Abe, Yuka Hashimoto, Ryo Sato","doi":"10.1177/10538135261444037","DOIUrl":"10.1177/10538135261444037","url":null,"abstract":"<p><p>BackgroundStroke frequently impairs balance, which critically affects mobility, independence, and fall risk during rehabilitation. However, heterogeneous patterns of balance recovery and their neural substrates remain poorly understood.ObjectiveTo identify inpatient balance recovery profiles using initial performance and subsequent improvement across the 14 Berg Balance Scale items, and to examine associations with lesion characteristics to inform prognostic stratification during neurorehabilitationMethodsWe used data from a retrospective cohort of 115 patients with a first-ever stroke. Berg Balance Scale item-level scores at admission and discharge were standardized, and principal component analysis was applied to identify three underlying components. Recovery patterns were then derived from initial scores and rates of improvement, followed by clustering analysis and lesion overlap analyses to characterize the neuroanatomical features of each profile.ResultsCluster analysis based on principal component scores identified five distinct recovery profiles. The profile with severe balance impairment at admission and minimal improvement showed extensive lesions extending from the peri-Rolandic region into the parietal area, whereas no consistent parietal involvement was observed in other profiles.ConclusionsItem-level Berg Balance Scale data revealed heterogeneous inpatient balance recovery profiles after stroke. The poorest recovery profile was characterized by extensive peri-rolandic and parietal lesions, suggesting the involvement of sensorimotor regions in severe balance dysfunction. These findings may improve our understanding of heterogeneity in post-stroke balance recovery and may help inform rehabilitation planning and risk management; however, their direct implications for treatment selection remain exploratory and require prospective validation.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"562-578"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scoping Review Examining Rehabilitation Practice for Individuals Within Disorders of Consciousness.","authors":"Jenna Neikirk, Ashton Woolum, Cayla Robinson, Jackson Blackburn, Reese DeHaven, Dana Howell","doi":"10.1177/10538135261439931","DOIUrl":"10.1177/10538135261439931","url":null,"abstract":"<p><p>BackgroundDisorders of consciousness (DoC)-including coma, unresponsive wakefulness syndrome, and minimally conscious state-may occur following severe traumatic brain injury (TBI). Occupational therapists (OTs), physical therapists (PTs), and speech-language pathologists (SLPs) play essential roles in recovery; however, discipline-specific evidence to guide assessment and intervention remains limited.ObjectiveTo map existing evidence related to OT, PT, and SLP interventions aimed at improving arousal and supporting emergence in adults with DoC following TBI.MethodsGuided by the Arksey and O'Malley framework and a pre-published protocol, ten databases, PEDro, and gray literature were searched. Eligible studies included adults with TBI-related DoC and reported OT-, PT-, or SLP-led interventions targeting arousal or emergence outcomes. Data extraction was completed independently by two reviewers, with third-party verification.ResultsOf 54,832 records screened, 77 studies met inclusion criteria. PT-focused interventions accounted for 46.8% (n = 36) of studies, OT for 32.5% (n = 25), and SLP for 14.3% (n = 11); 32.5% (n = 25) addressed all three disciplines. Sensory stimulation was the most common intervention, followed by verticalization approaches. The Coma Recovery Scale-Revised was the most frequently used outcome measure.ConclusionsEvidence supports individualized sensory stimulation and early mobilization to promote arousal and emergence; however, interventions targeting DoC have changed little over 55 years. Substantial gaps remain, particularly for self-care and SLP-specific interventions, highlighting the need for stronger discipline-specific research and standardized reporting. The trends described in this scoping review demonstrate areas where evidence is limited or only attributed to one discipline, which is important for guiding future research priorities.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"520-535"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147932465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Study on the Effects of Intensive Speech Therapy Combined with Two Courses of High-Frequency rTMS on Language Function in Patients with Aphasia.","authors":"Minori Yamada, Kensuke Ohara, Yuina Koutou, Yasuhide Nakayama, Ikuo Kimura, Sin Suzuki, Kentaro Yoshida, Masahiro Abo","doi":"10.1177/10538135261439938","DOIUrl":"10.1177/10538135261439938","url":null,"abstract":"<p><p>PurposeThe longitudinal effects of combining intensive speech therapy (ST) with two separate courses of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) for aphasia remain unclear. This study retrospectively investigated longitudinal changes in language function in patients who underwent this combined protocol.MethodsSixteen patients with chronic aphasia underwent two courses of 2-week inpatient treatment combining fMRI-guided HF-rTMS and intensive ST between April 2018 and February 2025. The Standard Language Test of Aphasia (SLTA) total and modality-specific raw scores were assessed at four time points: at the 1st admission, 3 months after the 1st discharge, at the 2nd admission, and 3 months after the 2nd discharge.ResultsThe mean SLTA total raw score significantly improved over time: 147 ± 51.6 at the 1st admission, 157 ± 49.9 at 3 months after the 1^st discharge, 159 ± 48.8 at the 2nd admission, and 163 ± 50.2 at 3 months after the 2nd discharge. Significant improvements in speech function were observed in the Overall, Fluent Aphasia, and Non-fluent Aphasia groups. Notably, therapeutic effects were maintained without decline between the two admissions.ConclusionsTwo courses of HF-rTMS combined with intensive ST may be effective for the long-term improvement of language function, particularly speech function, in patients with chronic aphasia.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"651-658"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compensatory Augmentation in the Pre-Supplementary Motor Area Mediates Aspects of Verbal Fluency Recovery Following Cerebellar Stroke: A Multimodal SPECT and f-NIRS Pilot Study.","authors":"Shigeru Obayashi","doi":"10.1177/10538135261434250","DOIUrl":"10.1177/10538135261434250","url":null,"abstract":"<p><p>BackgroundCerebellar lesions commonly induce executive dysfunction; however, the underlying neuroplastic mechanisms remain unclear. The fronto-cerebellar diaschisis model, where focal cerebellar damage disrupts widespread frontal networks, offers a compelling hypothesis. Given the pre-supplementary motor area (pre-SMA)'s established role in executive functions, we investigated its specific contribution to post-stroke impairment and its potential function as a dynamic compensatory node during recovery.MethodsWe employed a multimodal approach: resting-state SPECT imaging assessed brain perfusion, and f-NIRS quantified pre-SMA oxygenated hemoglobin ([oxy-Hb]) during a phonemic verbal fluency task (VFT) in 11 patients and 12 age-matched controls. Patients were stratified into Good (N = 6) and Poor (N = 5) recovery subgroups based on VFT performance to isolate the compensatory process. Longitudinal f-NIRS data tracked neural activity changes concurrent with cognitive recovery.ResultsSPECT revealed widespread perfusion abnormalities consistent with diaschisis. Patients exhibited significantly impaired VFT performance. Crucially, the Good Recovery subgroup exhibited a significantly augmented [oxy-Hb] response in the pre-SMA compared to controls, supporting a specific compensatory mechanism. This pre-SMA augmentation was statistically independent of the strong confounding effect of age (<i>F</i>(1,15) = 5.164, P = 0.038). Consistent with a transient compensatory effort, longitudinal data demonstrated a reduction in pre-SMA activity concurrent with subsequent cognitive recovery, suggesting increased neural efficiency.ConclusionsThis study provides preliminary evidence that verbal fluency deficits post-cerebellar stroke are linked to fronto-cerebellar diaschisis. Our findings suggests that the pre-SMA serve as a pivotal compensatory node supporting functional recovery. These results provide a hypothesis-generating basis for future targeted rehabilitation strategies and neuromodulatory interventions.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"622-635"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Adding Lower Extremity Weights on Balance and Gait Disturbances in Children with Ataxic Cerebral Palsy: A Randomized Controlled Trial.","authors":"Nehad A Abo-Zaid, Heba A Khalifa, Tamer M Shousha, Mohamed Y Abdelsamee, Walaa E Heneidy","doi":"10.1177/10538135261444038","DOIUrl":"10.1177/10538135261444038","url":null,"abstract":"<p><p>BackgroundAtaxic cerebral palsy children have hard times controlling their movements. They exhibit tremors, shakiness and struggle with precise movements, balance as well as pattern of gait.ObjectiveTo examine the influence of adding lower extremity weights on balance and gait disturbances in children diagnosed with ataxic cerebral palsy.MethodsSixty children with ataxic cerebral palsy aged from 7 to 12 years participated in this trial after the eligibility assessment. They were randomly allocated to two equal sized groups. The standard care group underwent a designed treatment protocol, while the added weight group received the same designed treatment protocol along with adding lower extremity weights. Children in both groups underwent the same treatment protocols three times per week for a duration of three consecutive months. Biodex balance system and 3D motion analysis (3DMA) were used to evaluate stability indices as primary outcome (overall, mediolateral and anteroposterior), and spatiotemporal gait parameters as secondary outcome (speed, cadence, base width, step length, stride length, step time, and percentage of double support) respectively in both groups at the beginning and after three months of intervention.ResultsPost intervention findings demonstrated a significant reduction in stability indices, base width, step time, and percentage of double support, as well as significant increase in walking speed, cadence, step length, and stride length, in both groups in favor of added weight group (P < 0.05).ConclusionsAdding small fixed lower extremity weights was associated with improvements in balance and reduced gait disturbances in ambulant ataxic cerebral palsy children.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"579-590"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147932403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Effects of Remotely Supervised Transcranial Direct Current Stimulation on Motor Outcomes in Multiple Sclerosis: A Systematic Review.","authors":"Rehab Aljuhni, Hind Almotiri, Alaa Albishi, Turki Abualait","doi":"10.1177/10538135261436051","DOIUrl":"10.1177/10538135261436051","url":null,"abstract":"<p><p>BackgroundMultiple sclerosis (MS) is an autoimmune, inflammatory, progressive neurological disease. Individuals with MS frequently experience muscle weakness, limited walking endurance, and impaired balance, which collectively reduce functional independence and quality of life. Remotely supervised transcranial direct current stimulation (RS-tDCS) has emerged as a potential adjunct neuromodulation technique to enhance neuroplasticity and improve motor outcomes. However, the effectiveness of RS-tDCS on motor performance in MS remains insufficiently understood.ObjectiveTo systematically evaluate the effects, feasibility, and reporting quality of RS-tDCS interventions targeting motor outcomes in individuals with MS.MethodsA systematic review of the scientific literature from 2015 to 2025 was carried out, using engines of PubMed, EBSCO, CENTRAL, and Web of Science. We identified studies that implemented RS-tDCS to improve motor function or reduce fatigue in MS population. Two reviewers independently screened studies, extracted data, and assessed risk of bias using RoB 2 and ROBINS-I. Intervention reporting quality was evaluated using the TIDieR checklist. A synthesis of the results was conducted following the Synthesis without Meta-Analysis (SWiM) guidelines.ResultsFive studies met the inclusion criteria four randomized controlled trials and one non-randomized study, totaling 370 participants. Reports revealed improvements in gait performance, balance, and manual dexterity, whereas findings related to functional mobility and fatigue were mixed.ConclusionRS-tDCS appears feasible and may benefit select motor domains in MS; however, current evidence remains preliminary. This review highlights key methodological gaps and provides direction for future trials to establish the clinical relevance and scalability of decentralized neuromodulation in MS rehabilitation.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"551-561"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Task-State EEG Reveals Fine Hand Motor Impairment in Acute Ischemic Stroke: A Multidimensional Analysis of Cortical Dynamics.","authors":"Ke Deng, Jie Zhao, Yuqi Liu, Chune Tian, Xiaofei Lin, Xiaoqing Wei, Rui Li, Weiping Liu","doi":"10.1177/10538135261441843","DOIUrl":"10.1177/10538135261441843","url":null,"abstract":"<p><p>PurposeTo systematically characterize the cortical dynamics underlying fine hand motor impairment in patients with acute ischemic stroke (AIS) using a multidimensional task-state electroencephalography (EEG) analysis framework.Materials and MethodsFifteen patients with AIS and sixteen age- and sex-matched healthy controls were enrolled. EEG signals were recorded while participants performed three standardized fine motor tasks, including fist clenching, index finger pointing, and thumb-finger opposition. Source localization, time-frequency analysis, and brain network topology analysis were jointly applied to extract multidimensional electrophysiological features. Correlation analyses were further conducted to examine the relationships between EEG-derived metrics and clinical measures, including muscle strength grading, National Institutes of Health Stroke Scale (NIHSS) scores, and Activities of Daily Living (ADL) scores.ResultsCompared with healthy controls, patients with AIS showed abnormal spatiotemporal cortical dynamics during fine hand movements. These abnormalities included delayed movement-related potentials, a shift of alpha- and beta-band event-related desynchronization from contralateral dominance toward more bilateral and diffuse activation, and altered brain network organization characterized by reduced network efficiency and changes in nodal centrality. In addition, EEG-derived features were significantly associated with clinical measures. Specifically, several event-related desynchronization/event-related synchronization (ERD/ERS)-related amplitudes and small-world properties were significantly correlated with muscle strength grading, NIHSS scores, and ADL scores after false discovery rate correction.ConclusionMultidimensional task-state EEG analysis can characterize cortical activation abnormalities and network reorganization associated with fine hand motor impairment in patients with AIS. The identified EEG-derived metrics may serve as objective markers for post-stroke motor function assessment and recovery monitoring, and may help support individualized rehabilitation evaluation and planning.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"636-650"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}