NeuroRehabilitation最新文献

{"title":"Immediate and Sustained Effects of Contralateral Handgrip Exercise on Hand Edema in Patients with Stroke.","authors":"Hiroyuki Hayashi, Ayana Kato, Naoki Tomiyama, Hibiki Ogihara","doi":"10.1177/10538135261462561","DOIUrl":"10.1177/10538135261462561","url":null,"abstract":"<p><p>BackgroundHand edema is a common post-stroke complication that negatively affects function and quality of life. However, interventions for hand edema remain limited.ObjectiveIn this study, we investigated whether contralateral resistance handgrip exercises performed with the non-paretic hand could immediately and sustainably reduce hand edema in patients with stroke.MethodsThis study used a B-A-B single-case design to explore the effects of the intervention in inpatients more than 3 months post-stroke. During the two 8-day intervention phases, the participants performed rhythmic handgrip exercises at 30% of the maximum voluntary contraction for 5 min daily as part of their occupational therapy sessions. A baseline phase without intervention was interposed. The hand volume was measured by using water displacement before and after exercise sessions to assess immediate and sustained effects.ResultsFour inpatients with paretic hand edema (93-110 days poststroke) participated in this study. Contralateral handgrip exercise resulted in immediate reduction in paretic hand edema in three of the four patients; however, only one patient showed a sustained effect. The intervention was simple and feasible, with responses varying across individuals.ConclusionsThis small single-case study suggests that contralateral handgrip exercise may contribute to reducing hand edema in some patients; however, its sustained benefits remain uncertain. This low-cost approach may serve as a candidate adjunct intervention in rehabilitation, particularly when paretic limb movements are limited. However, given the exploratory nature of this small single-case study, further investigation with larger samples and more rigorous designs is warranted.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"119-125"},"PeriodicalIF":2.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Postoperative Mini-Balance Evaluation Systems Test Scores and Length of Hospital Stay in Patients with Chronic Subdural Hematoma: A Prospective Cohort Study.","authors":"Mutsumi Shiraishi, Shunsuke Ohji, Ryo Onuma","doi":"10.1177/10538135261456307","DOIUrl":"10.1177/10538135261456307","url":null,"abstract":"<p><p>ObjectivesChronic subdural hematoma (CSDH) generally has favorable outcomes; however, some patients develop balance and gait impairments, leading to prolonged hospitalization. This study examined the association between Mini-Balance Evaluation Systems Test (Mini-BESTest) scores, and length of hospital stay (LOS) after CSDH surgery.MethodsThis prospective cohort study was conducted at a single acute care hospital in Japan. Patients aged ≥ 65 years who underwent burr-hole drainage for CSDH were included. Exclusion criteria were orthopedic disease, psychiatric disease, inability to complete the Mini-BESTest, and premorbid modified Rankin Scale ≥ 4. Variables included age, sex, initial National Institutes of Health Stroke Scale, Glasgow Coma Scale, Mini-Mental State Examination-Japanese, residual hematoma thickness, premorbid modified Rankin Scale (mRS), Mini-BESTest score, and LOS. Spearman correlation and multivariable linear regression analyses were performed.ResultsOf 49 patients, 32 were analyzed after exclusions due to comorbidities, inability to complete the assessment, or premorbid disability. Twenty-five patients were men and the mean age was 81.8 ± 5.0 years. The median LOS was 8.5 (interquartile range [IQR] 8-11) days, and the Mini-BESTest was 18.5 (IQR 13.8-23.3). LOS was negatively correlated with Mini-BESTest (r = -0.499) and positively with initial NIHSS (r = 0.376). In multivariable regression, Mini-BESTest (β = -0.488) and initial NIHSS (β = 0.377) scores were associated with LOS.ConclusionsEarly postoperative balance function may be associated with LOS in patients with CSDH. Early Mini-BESTest assessment may help identify patients at risk for prolonged hospitalization and guide rehabilitation and discharge planning.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"160-169"},"PeriodicalIF":2.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148219056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation and Management in Lateral Medullary Stroke (Wallenberg Syndrome): A Scoping Review and Evidence Map.","authors":"Takafumi Izutsu, Nobuo Kutsuna, Syota Toyama, Kasumi Fujiwara, Kosei Goto, Takao Nakamura","doi":"10.1177/10538135261459633","DOIUrl":"10.1177/10538135261459633","url":null,"abstract":"<p><p>ObjectiveTo map rehabilitation interventions and rehabilitation-relevant management reported for lateral medullary stroke (Wallenberg syndrome) and distinguish direct intervention evidence from management and assessment reports.Data sourcesPubMed/MEDLINE, Ichushi-Web, and Web of Science Core Collection were searched from inception to 12 March 2026. Cumulative Index to Nursing and Allied Health Literature was searched on 24 April 2026. Citation tracking was performed.Review methodsReports were eligible if they described rehabilitation, rehabilitation-relevant management, assessment, prognosis, or monitoring relevant to recovery or safety. Two reviewers screened records; charting and classification were verified by a second reviewer using operational definitions. Reports were grouped by clinical phase, target domain, safety management, outcome measures, and primary reporting function.ResultsThe searches identified 741 records; 486 unique records were screened and 78 reports were included. Publication years ranged from 1997 to 2026; 60 reports were case reports or case series. Primary reporting functions were categorized as explicit intervention/program (n = 29), management/procedural pathway (n = 21), assessment/prognostic/monitoring (n = 18), and minimal-detail supportive/diagnostic (n = 10). Dysphagia was addressed in 63 reports, but only 22 were explicit intervention/program reports. No included report explicitly described sensory safety education.ConclusionThe accessible literature is useful but mixed. Interpretation is limited by unretrieved full-text candidates, omitted databases/grey literature, no critical appraisal, and no independent agreement statistic for post hoc reporting-function classification. Future reports should separate therapeutic training from management pathways and describe dosage, safety management, reassessment timing, discharge function, sensory safety education, and daily-life precautions.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"36-47"},"PeriodicalIF":2.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148302710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartphone-Based Semi-Immersive Virtual Reality Enhances Upper Extremity Function in Subacute Stroke: A Randomized Controlled Trial.","authors":"Abd El-Hamied Ibrahim El-Sayed Mohammad El-Sherbini, Shreen Ibrahim Taha, Dany Alphonse Anwar Habib, Hanaa Mohsen Abd-Elfattah, Hager Rasmy Elserougy","doi":"10.1177/10538135261456309","DOIUrl":"10.1177/10538135261456309","url":null,"abstract":"<p><p>BackgroundUpper extremity (UE) recovery in individuals with subacute stroke often plateaus despite conventional physical therapy (CPT). Smartphone-based virtual reality (VR) represents a low-cost, semi-immersive approach that may enhance task-specific training and neuroplasticity.ObjectiveTo determine whether CPT augmented with smartphone-based VR improves UE function more than CPT alone.MethodsFifty-seven participants (28 in the experimental group and 29 in the control group) with stroke in the subacute stage (6 weeks-6 months post-stroke) and moderate UE impairment (Fugl-Meyer Assessment-Upper Extremity [FMA-UE] score 20-50) were randomized to receive either CPT plus smartphone-based VR or CPT alone, five sessions per week for six weeks. Outcomes included motor impairment (FMA-UE), activity-level dexterity (Purdue Pegboard Test), and muscle strength (grip strength).ResultsBoth groups demonstrated significant improvements (p < 0.001). The experimental group showed significantly greater improvements across all outcomes, with large effect sizes.ConclusionSmartphone-based VR providing semi-immersive, gaze-driven interaction with virtual tasks significantly enhances UE recovery and represents a scalable adjunct to rehabilitation.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"74-84"},"PeriodicalIF":2.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148219092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Length of Stay as the Critical Predictor of Functional Improvement in Post-Acute Care for Traumatic Brain Injury: A Retrospective Cohort Study.","authors":"Ju-Lan Yang, Ruoh-Lih Lei, Chih Hao Lin, Ying-Lin Hsu, Chih-Ming Lin","doi":"10.1177/10538135261426535","DOIUrl":"https://doi.org/10.1177/10538135261426535","url":null,"abstract":"<p><p>ObjectivesTraumatic brain injury (TBI) is a leading cause of long-term disability. This study aimed to evaluate the effectiveness of a Post-Acute Care (PAC) program for patients with TBI in Taiwan and to identify the independent predictors associated with the magnitude of their functional recovery.MethodsThis retrospective cohort study included 168 patients with TBI admitted to a PAC program from a tertiary medical center. The primary outcome was the change score in the Barthel Index (BI)(ADL). The Wilcoxon Signed-Rank Test was used to assess changes in functional scores (BI(ADL), IADL, and EQ-5D) from admission to discharge.ResultsPatients demonstrated statistically significant improvements across all functional measures after the PAC intervention, including the BI(ADL), IADL, and EQ-5D (all p < .001). After adjusting for all covariates, length of stay was the sole significant independent predictor of the BI(ADL) change score (B = 0.309, p < .001), indicating that for each additional day of PAC, a patient's BI score was expected to improve by 0.309 points.ConclusionPost-Acute Care is a highly effective intervention for improving functional outcomes in patients with TBI. These findings provide a strong evidence base for clinicians to advocate for sufficient rehabilitation time and for policymakers.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"10538135261426535"},"PeriodicalIF":2.0,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gaming Technology in Pediatric Cerebral Palsy and Related Neuromuscular Conditions: A Scoping Review.","authors":"Jordan Stevenson, Susanna E Martin, Mahala G English, Colleen Pawliuk, Julie M Robillard","doi":"10.1177/10538135261445647","DOIUrl":"10.1177/10538135261445647","url":null,"abstract":"<p><p>BackgroundChildren with cerebral palsy (CP) and related neuromuscular conditions often experience barriers to physical activity due to motor and cognitive impairments. Active video games (AVG), with or without adaptive technologies (AT), have demonstrated potential to improve outcomes in these populations.ObjectiveThis scoping review mapped existing research on AVG and AT in pediatric CP and related neuromuscular conditions, summarizing intervention characteristics and effects on physical, cognitive, and quality of life (QoL) outcomes.MethodsThe review followed PRISMA-ScR guidelines. Four databases were searched up to November 2025 (MEDLINE, Embase, Web of Science, and IEEE Xplore), supplemented by a manual citation search using Google Scholar. Eligible studies included participants under 18 years with CP and related neuromuscular conditions, reported physical, cognitive, or QoL outcomes, employed AVG, virtual/augmented reality, or gamified interventions, and were peer-reviewed and published in English.ResultsA total of 192 studies were included, of which 178 examined the impact of AVG and immersive technology on physical outcomes in children with either CP (n = 173), muscular dystrophy (n = 7), or CP and a mix of related conditions (n = 12). Fewer studies included cognitive (n = 17) and QoL (n = 46) outcome measures. Findings highlighted substantial heterogeneity in study design, outcome measures, gaming devices, and AT implemented, limiting comparability and generalization. Despite this variability, AVG interventions seemed to improve patient outcomes, especially in physical function.ConclusionWe underscore the need for standardized measures to guide the development of gaming interventions that benefit patient outcomes.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"503-519"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148043268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outpatient Occupational Therapy, Physiotherapy, and Speech Language Pathology Interventions for People with Functional Neurologic Disorder: A Scoping Review.","authors":"Elliot J Gann, Alec M Grove, Elizabeth Erb-Trefilek, Julianne Pearson, Meagan Watson, Mark M Mañago","doi":"10.1177/10538135261440539","DOIUrl":"10.1177/10538135261440539","url":null,"abstract":"<p><p>BackgroundFunctional neurologic disorder (FND) is a disabling condition commonly managed by occupational therapists (OT), physiotherapists (PT), and speech-language pathologists (SLP). While consensus recommendations for OT, PT, and SLP provide general principles for assessment and treatment, there is limited understanding of how interventions are delivered or how outcomes are measured, particularly in the outpatient setting.PurposeThis scoping review describes the characteristics (mode, frequency, duration) of outpatient OT, PT, and SLP interventions for individuals with FND, assesses their alignment with consensus FND recommendations, and maps outcome measures to the International Classification of Functioning (ICF) model.MethodsThree electronic databases (Medline, Embase, and CINAHL) were searched for articles that included individuals diagnosed with FND, reported characteristics of outpatient OT, PT, or SLP interventions, and were published in English.ResultsThirty-one studies were included (PT, n = 14, SLP, n = 8, multidisciplinary n = 6, and OT, n = 3). Most studies (n = 22, 71%) included interventions that aligned with FND recommendations and commonly consisted of education, movement retraining with diverted attention, and symptom management plans. Intervention frequency ranged from daily sessions over one week to twice-monthly sessions across three months. The outcome measures were primarily patient-rated, and most frequently mapped to the body structure and function domain of the ICF.ConclusionsOutpatient OT, PT, and SLP interventions predominantly included components of FND recommendations yet varied in mode, frequency, and outcome measure selection. Future research is needed to examine the optimal parameters and modes, compare specific interventions, and identify outcomes that encompass all ICF domains.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"536-550"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recovery Patterns of Postural Control in Patients with Subacute Stroke: A Longitudinal Comparison of Supratentorial Versus Infratentorial Lesions Using the Mini-BESTest.","authors":"Rai Sugiyama, Hisato Nakazono, Takanori Taniguchi, Osuke Shibata, Michihito Mitsuyasu, Maiko Sakamoto, Tsubasa Mitsutake","doi":"10.1177/10538135261433168","DOIUrl":"10.1177/10538135261433168","url":null,"abstract":"<p><p>BackgroundPatients with mild stroke often regain basic mobility, however, subtle postural control deficits may persist, increasing the risk of falls. The Mini-Balance Evaluation Systems Test (Mini-BESTest) is a sensitive measure for detecting such impairments. This study aimed to clarify postural control characteristics and temporal changes by classifying patients with subacute stroke into supratentorial and infratentorial lesion groups.MethodsIn this prospective longitudinal observational study, 38 patients were assessed using the Mini-BESTest at baseline and at 1 month. A three-way mixed-design ANOVA examined lesion location (between-subjects), time, and Mini-BESTest subscales (anticipatory, reactive, sensory orientation, and dynamic gait) (within-subjects). Post-hoc analyses were performed using Shaffer's modified sequentially rejective Bonferroni procedure.ResultsA significant interaction between lesion location and subscales was observed (<i>F</i>(2.42, 80.73) = 6.21, <i>p</i> = .002, η_p² = .14). The supratentorial group demonstrated significantly lower scores in reactive postural control compared with other subscales (<i>p</i> < .001), and this deficit persisted at 1 month despite overall balance improvements. In contrast, the infratentorial group showed balanced improvements across all subcomponents, with no significant domain-specific deficits. Both groups showed significant improvement over time.ConclusionsThe Mini-BESTest is a sensitive tool for identifying lesion-specific postural control deficits, even in high-functioning patients. Although the supratentorial category encompasses functionally heterogeneous structures (e.g., thalamus and putamen), these findings highlight the importance of using the Mini-BESTest to detect residual impairments in reactive postural control in supratentorial stroke, highlighting the need for targeted interventions, such as reactive balance training, to reduce fall risk.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"612-621"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147593590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Centered Selection Criteria for Robot-Assisted Gait Training in Subacute Stroke: A Focus of User Satisfaction.","authors":"Jong Weon Lee, Won Hyuk Chang, Tae-Woo Kim, Hyoung Seop Kim, Fazah Akhtar Hanapiah, Seung-Hyeon Han, Chai Wen Jia, Dae Hyun Kim, Deog Young Kim","doi":"10.1177/10538135261436050","DOIUrl":"10.1177/10538135261436050","url":null,"abstract":"<p><p>PurposeTo identify patient-centered selection criteria for exoskeletal wearable robot-assisted gait training (RAGT) by investigating predictors of satisfaction in subacute stroke survivors.Materials and MethodsIn this subgroup analysis of an international, multicenter, randomized controlled trial, 58 inpatients completed a 4-week RAGT program (20 sessions). Satisfaction was assessed using a modified 15-item QUEST 2.0 questionnaire across five domains (appropriateness, effectiveness, convenience, conformance, reliability). Predictors of the mean satisfaction score were analyzed using multiple linear regression.ResultsThe overall satisfaction questionnaire score was 3.9 ± 0.6 (out of 5). The effectiveness domain was rated significantly higher than other domains (p < 0.05). Age was the only significant independent predictor of satisfaction (β = -0.269; 95% CI -0.315 to -0.007; p < 0.05). Participants aged <65 years reported significantly higher overall satisfaction than those aged ≥65 years (p < 0.05). This difference was driven by the appropriateness domain, where older adults reported lower comfort scores (p < 0.05).ConclusionRAGT received high user ratings, particularly for effectiveness. However, younger age predicted greater satisfaction, primarily due to discomfort in older adults. Selection criteria should consider age, and strategies to mitigate discomfort in older adults are needed to maximize adherence.<b>Trial details</b>: ClinicalTrial.gov Identifier NCT05157347 (first registration (10/12/2021)).</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"600-611"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of an 8-Week Combined Aerobic-Resistance Training on Motor Function, Functional Mobility, and Metabolic Parameters in Patients with Parkinson's Disease: A Controlled Study.","authors":"Šimon Janovič, Erik Szabo, Martin Gábor, Igor Straka, Zita Majerníková, Alice Kušnírová, Veronika Boleková, Zuzana Košutzká","doi":"10.1177/10538135261434253","DOIUrl":"10.1177/10538135261434253","url":null,"abstract":"<p><p>Exercise is increasingly recognized as a key component of Parkinson's disease (PD) management, but data on short-term combined aerobic-resistance training (ART) on motor and metabolic parameters remain limited. In this controlled study, 28 patients with PD (median Hoehn & Yahr stage= 2, IQR 1.75-2.0) were allocated to an 8-week supervised ART group (n= 19) or a stretching-only control group (n = 9). Training consisted of two 45-minute sessions weekly. Primary outcomes were MDS-UPDRS-III, Sit-to-Stand Test (STS), and Six-Minute Walk Test (6MWT). Fasting laboratory parameters were exploratory given the small sample size and absence of an a priori power analysis. Between-group post-intervention differences were analyzed using ANCOVA (baseline as covariate); exploratory biochemical outcomes were controlled for multiple comparisons using Benjamini-Hochberg false discovery rate (FDR). ART improved the MDS-UPDRS-III tremor subscore (p = 0.004) and6MWT distance (p = 0.003), with no significant effects on other motor or functional outcomes. In exploratory laboratory analyses, unadjusted between-group differences were observed for HDL cholesterol (p =0.014), vitamin D₃ (p = 0.003), TSH (p = 0.042), and homocysteine (p =0.019); after FDR correction, only vitamin D₃ remained significant (qFDR= 0.039). Total cholesterol, LDL, and VLDL showed non-significant decreases. An eight-week ART program improved tremor and walking endurance inpatients with PD, while other motor outcomes remained unchanged. Exploratory changes in selected biochemical markers were detected (including a decrease in vitamin D₃); their clinical relevance remains unclear and should be evaluated in larger, well-powered randomized studies.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"659-667"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}