NeuroRehabilitation最新文献

{"title":"Optimal Parameter Analysis of Repetitive Transcranial Magnetic Stimulation on Motor Function in Patients with Incomplete Spinal Cord Injury: A Meta-Analysis.","authors":"Yu Liang, Liyun Xue, Saoying Yang, Chen Wang, Xifang Liu","doi":"10.1177/10538135251325435","DOIUrl":"10.1177/10538135251325435","url":null,"abstract":"<p><p>BackgroundRepetitive transcranial magnetic stimulation (rTMS) has shown potential in rehabilitating patients with incomplete spinal cord injury (iSCI). However, the evidence is mainly based on small-scale studies with varying protocols.ObjectiveTo summarize the impact of rTMS on motor function deficits in individuals with iSCI and identify optimal stimulation parameters through a meta-analysis.MethodsA systematic literature search was conducted in multiple databases from inception to July 31, 2024. Randomized controlled trials investigating rTMS effects on motor function in iSCI were included. Study quality was assessed using the RoB 2 and PEDro scale. RESULTS: Eleven studies with 345 participants were included. rTMS applied at 100-110% of resting motor threshold (SMD = 0.81, <i>P</i> = 0.0005), with over 15 stimulation sessions (SMD = 0.66, <i>P</i> = 0.04) and a cumulative pulse count of 1800 (SMD = 0.50, <i>P</i> = 0.04), significantly enhanced motor function recovery in iSCI patients. Four studies reported mild, transient adverse effects in 11 patients.ConclusionrTMS may enhance motor function in iSCI patients with certain parameters. However, given study limitations, conclusions should be viewed as exploratory.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":"56 4","pages":"423-437"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tolerating Uncertainty as a Transdiagnostic Construct and Treatment Target in Functional Motor Disorder.","authors":"Beth K Rush, Katie J Traver, Elizabeth N Geissler, Mariah K Travis, Barbara Lubrano di Ciccone, Margaret A Moutvic-Wasz, Mohit Chauhan","doi":"10.1177/10538135251325460","DOIUrl":"10.1177/10538135251325460","url":null,"abstract":"<p><p>BackgroundIntolerance of Uncertainty (IU) has never been explored in functional motor disorder (FMD) or any functional neurological disorder but perceptions of control are theoretically relevant.ObjectiveTo evaluate if IU changes in people with FMD completing intensive 1-week motor retraining treatment, and if IU change associates with outcome.MethodsA consecutive cohort of 45 FMD patients completed a 1-week intensive outpatient motor retraining treatment. At program beginning and end, patients self-rated IU using the Intolerance of Uncertainty Scale-12 (IUS-12) and four functional impairment measures. Paired t-tests analyzed program changes in IU and functional outcomes. Linear regressions analyzed association strength between IU change and outcome.ResultsIU improved with FMD treatment (p < 0.001). Pre- to post-treatment IU was improved in 32/45 (71%), stable in 5/45 (11%), and worsened in 8/45 (18%). Age, symptom duration, and FMD phenotype did not predict IU improvement. Self-rated function improved across measures with treatment (p < 0.001). Program change in IU positively predicted outcome on 3 of 4 measures.ConclusionsIU improves with FMD rehabilitation, even without explicit psychological focus of treatment, regardless of age or FMD phenotype. Improving IU associates with positive FMD treatment outcomes suggesting an important treatment target in FMD.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":"56 4","pages":"501-510"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Psychotropic Medication and Falls Among Older Rehabilitation Inpatients with Varied Activity Levels.","authors":"Xiaoping Li, Jie Yan, Qingfang Zhang, Jianjun Long, Linlin Shan, Jia Cao, Chengting Wang, Yulong Wang","doi":"10.1177/10538135251327115","DOIUrl":"10.1177/10538135251327115","url":null,"abstract":"<p><p>BackgroundFalls are a common risk in older rehabilitation inpatients, with psychotropic medications potentially increasing fall risk. This study aims to assess the correlation between falls and the use of psychotropic medications in older inpatients at different activity levels in rehabilitation departments.MethodsA multi-center cross-sectional study analyzed patient characteristics, medications, fall incidents, and physical levels using the Longshi Scale. Chi-square tests, ANOVA, and binary logistic regression were applied.ResultsThis study enrolled a total of 6,425 patients, among them 711 cases (11.07%) experienced falls, and 333 cases (5.18%) had a history of psychotropic medication use. Psychotropic use was an independent fall risk factor <i>P </i>< 0.05), with significant correlation in bedridden (OR = 1.77, 95% CI: 1.18-2.64) and domestic (OR = 1.99, 95% CI: 1.12-3.53) groups, but not in the community group (<i>P </i>> 0.05).ConclusionBedridden and domestic group individuals, as per Longshi Scale classification, are vulnerable to psychotropic-induced falls. Targeted prevention and monitoring are necessary for these groups.Trial RegistrationThe study is approved by the Regional ethical committee and registered at Chinese Clinical Trial Registry (https://www.chictr.org.cn), ChiCTR-2000034067.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":"56 4","pages":"560-570"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation of Vertical Gaze Palsy and Impaired Eye Proprioception Following Bilateral Thalamic Infarcts: A Case Report.","authors":"Charlotte Bellear, Khalil Ali, Nicola Hawko","doi":"10.1177/10538135251325747","DOIUrl":"10.1177/10538135251325747","url":null,"abstract":"<p><p>IntroductionThalamic infarctions, which account for .6% of all ischemic strokes, are characterized by altered mental status, vertical gaze palsy, and memory impairment. There is only one other case report on the rehabilitation of a vertical gaze palsy due to thalamic lesions. Although rehabilitation strategies for vertical gaze palsy have been documented, the role of eye proprioception in this condition was not discussed.Case ReportA man in his late 50 s presented to outpatient occupational therapy following bilateral thalamic infarcts with bilateral vertical gaze palsy, preserved vestibular ocular reflex (VOR), and cognitive impairments. These impairments impeded his performance of functional activities including feeding, dressing, driving, and navigating obstacles during functional ambulation. During rehabilitation, it was revealed that he was unable to identify his line of sight creating the potential for impaired eye proprioception. Interventions included oculomotor exercises, VOR cancellation strategies, and functional adaptations.DiscussionThis case discusses the potential impact of eye proprioception in the rehabilitation of vertical gaze palsy following thalamic infarcts. Two theories for impaired proprioception are explored: damage to thalamic structures and impaired proprioceptive input from the extraocular muscles. Interventions to address eye proprioception led to improved vertical eye movements and functional abilities.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":"56 4","pages":"571-576"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Is the Evidence on Immunomodulators and Immunosuppressants for Progressive Multiple Sclerosis? - A Cochrane Review Summary with Commentary.","authors":"Antimo Moretti","doi":"10.1177/10538135251346351","DOIUrl":"10.1177/10538135251346351","url":null,"abstract":"<p><p>BackgroundMultiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system and is a major cause of disability in adults, particularly in those affected by progressive MS. A variety of drugs with different effects, some carrying significant risks, are currently available, making evidence-based approach essential for clinicians treating MS patients.ObjectiveTo compare the efficacy and safety of immunomodulators and immunosuppressants for progressive multiple sclerosis (PMS).MethodsA systematic search was performed in CENTRAL, MEDLINE, Embase, and trials registers on 8 august 2022, including RCTs comparing immunomodulators and immunosuppressants versus placebo or another drug.ResultsThe network meta-analysis (NMA) included 23 RCTs (with 10,167 participants). Moderate certainty of evidence suggests that rituximab probably not reduce the risk of relapse at 2 years, while interferon beta-1b probably reduces the risk of relapses at 3 years (-18%) compared to placebo in PMS people. Regarding SAE, low-to-very-low certainty of evidence for no increased risk with disease-modifying therapies (DMTs) versus placebo is available, except for immunoglobulins that seem to have a 7-fold increased risk of serious adverse events (SAEs). Only low-to-very low certainty of evidence is available about disability progression and SAEs in PMS people treated with DMTs versus placebo. On the other side, the risk for treatment discontinuation due to AEs is increased with interferon beta-1a by 2.93-fold, and probably increased with interferon-beta-1b, glatiramer acetate, and fingolimod by 2.98-fold, 3.98-fold, and 2.29-fold, respectively. Also, rituximab, natalizumab, siponimod, and ocrelizumab probably do not increase the risk for treatment discontinuation due to AEs, while laquinimod may not increase the risk treatment discontinuation due to AEs.ConclusionsCompared with placebo, two-, and three-year treatment with rituximab or interferon beta-1b, respectively, probably slightly reduce relapses in PMS people. A slight increase of treatment discontinuation due to AEs has been reported for rituximab, interferon beta-1b, interferon beta-1a, immunoglobulins, glatiramer acetate, natalizumab, fingolimod, siponimod, and ocrelizumab. No reliable evidence is available for disability progression and SAEs with available DMTs compared to placebo.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"577-580"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Physical Activity Among People with Multiple Sclerosis in Jordan: Which Clinical Characteristics are Important?","authors":"Hanan Khalil, Lina Jallad, Alham Al-Shorman, Shada Khazaaleh, Khalid El-Salem, Laila Elkhoty, Lolwa AlBaker, Marya Saeed, Mozza Almusallam, Suhaila Abdalllah, Jennifer Allen, Mariem Latrous, Saddam F Kannan","doi":"10.1177/10538135251336067","DOIUrl":"https://doi.org/10.1177/10538135251336067","url":null,"abstract":"<p><p>BackgroundPhysical activity (PA) enhances mental and physical functioning of people with multiple sclerosis (PwMS). Yet, PwMS often do not engage in sufficient PA in the Middle East region.ObjectiveTo explore PA-associated factors according to The International Classification of Functioning, Disability and Health (ICF) framework among PwMS in Jordan.MethodsA cross-sectional study was conducted on 97 PwMS. PA levels were measured using The International Physical Activity Questionnaire (IPAQ). Potential associated factors with PA were determined using the ICF framework. Multiple linear regression was used to identify the factors that explain IPAQ's total score.ResultsThe Mean age of the participants was 36.09 years (SD = 10.9), 71.7% females. IPAQ was negatively associated with disease severity, history of falling, fatigue, family social support, and participation in social activities (P < 0.05). Anxiety levels and participation in instrumental activities of daily living were positively associated with IPAQ (P < 0.05).ConclusionsThe study suggests that factors contributing to PA levels in PwMS in the Middle East are multifactorial. A comprehensive rehabilitation plan that addresses those factors is essential to enhance PA levels in this population. Further research is needed to understand the clinical, personal, and cultural factors associated with PA among PwMS in the Middle East.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"10538135251336067"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between prefrontal cortex activation, standing balance, and fatigue in people post-stroke: A fNIRS study.","authors":"Sarthak Kohli, Laura K Fitzgibbon-Collins, Siying Luan, Nathan Durand, Laura Brunton, Jamie Fleet, Anita Christie, Ricardo Viana, Robert Teasell, Sue Peters","doi":"10.1177/10538135251341124","DOIUrl":"https://doi.org/10.1177/10538135251341124","url":null,"abstract":"<p><p>BackgroundBalance impairments and fatigue are common after stroke and impact physical therapy assessments and treatments. Reasons are multifactorial and include motor dysfunction and changes to cortical activation poststroke. The prefrontal cortex (PFC) is involved in motor control; yet, limited research has explored cortical activation during common physical therapy balance tasks or the link with fatigue.ObjectivesDuring standing balance tasks, the objective was to determine whether PFC activation levels: (1) change between tasks, (2) are asymmetric, and (3) are associated with fatigue.MethodsPatients with hemiparesis were recruited from an inpatient stroke unit and functional near-infrared spectroscopy was applied bilaterally over the PFC to measure cortical activation during balance tasks. Fatigue was assessed using the Fatigue Severity Scale (FSS).ResultsNine participants were included. PFC activation during semi-tandem stance showed greater amplitude than during double-leg stance, indicating more cortical activation. Bilateral PFC activation was observed during both tasks. Participants with greater fatigue (higher FSS score) showed more activation in the ipsilesional PFC than the contralesional PFC.ConclusionPFC activation may occur when performing more challenging balance postures, potentially indicating compensatory activation, and may be linked with greater fatigue.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":" ","pages":"10538135251341124"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Brain Lesion Affecting Dysphagia in Patient with Supratentorial Stroke.","authors":"Jeon-Woong Kang, Seong-Hoon Lim, Dae-Hyun Jang, Min-Wook Kim, Jaewon Kim","doi":"10.1177/10538135251315631","DOIUrl":"https://doi.org/10.1177/10538135251315631","url":null,"abstract":"<p><p>BackgroundDysphagia is a common sequela of stroke. However, specific swallowing impairments associated with brain lesions at different sites are not well characterized.ObjectiveThis study aimed to determine the relationship between the location of supratentorial brain lesions and the features of dysphagia.MethodsMedical records of patients with first-ever supratentorial stroke who underwent videofluoroscopic swallowing studies within 4 weeks of onset were retrospectively analyzed.ResultsA total of 158 patients (92 men and 66 women) were included. The lesions in internal capsule were associated with prolonged pharyngeal delay time (odds ratio [OR] 4.02, 95% confidence interval [CI] 1.13-14.28) and were inversely associated with post-swallowing vallecular residue (OR 0.55, 95% CI 0.32-0.95). The lesions in the insular cortex were associated with premature spillage and prolonged pharyngeal delay time (OR 2.27, 95% CI 1.08-4.76; OR 2.29, 95% CI 1.05-4.99, respectively). The lesions in the frontal lobe were associated with oral residue, vallecular residue, and pyriformis residue (OR 3.16, 95% CI 1.63-6.10; OR 3.06, 95% CI 1.55-6.02; OR 2.57, 95% CI 1.28-5.15, respectively).ConclusionsThis study revealed specific patterns of swallowing associated with specific brain lesions. Our findings may help elucidate the correlation between dysphagia patterns and the sites of brain lesions.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":"56 3","pages":"340-347"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parents' Reports of Colombian Children's Neurobehavioral Symptoms Before, During, and After COVID-19 Infection.","authors":"Sofia Catalina Arango-Lasprilla, Natalia Albaladejo-Blázquez, Jack D Watson, Oswaldo Moreno, Paul B Perrin, Rosario Ferrer-Cascales, Juan Carlos Arango-Lasprilla","doi":"10.1177/10538135241312599","DOIUrl":"https://doi.org/10.1177/10538135241312599","url":null,"abstract":"<p><p>BackgroundCOVID-19 disproportionately affected individuals from marginalized and underserved communities, and little research has investigated how COVID-19 might have impacted neurobehavioral symptoms in children from Latin America. What little research suggests that COVID-19 had a negative effect on neurobehavioral symptoms and that this effect was worse for individuals who were younger, had lower education, or other chronic conditions.ObjectiveThe purpose of the current study was to examine the change (before, during, and after) in neurobehavioral symptoms for a sample of Colombian children who tested positive for COVID-19 and to identify key predictors of post-COVID neurobehavioral impairments.MethodsThe Neurobehavioral Symptom Inventory was administered to caregivers (92.90% female) of 85 children (51.80% female) by researchers in Colombia. Data was collected after the child had recovered from COVID-19 with retrospective questions about the child's function before and during COVID-19, as well as at the time of data collection.ResultsAt the domain level, caregivers reported large increases in children's somatic symptoms, a medium increase in affective symptoms, and a small increase in cognitive symptoms before vs. during COVID-19. Caregivers also noted a large increase in children's somatic symptoms, a medium increase in affective symptoms, and a small increase in cognitive symptoms before vs after COVID-19. The somatic symptom domain was the only category to see an improvement following infection (during vs after). Three separate linear regressions indicated that greater COVID-19 severity during the infection significantly predicted greater current (after COVID-19) somatic symptom severity, and the presence of a pre-existing respiratory disease significantly predicted greater current cognitive and affective symptom severity.ConclusionThis study highlights the importance of evaluating and treating neurobehavioral symptoms post-COVID-19 among children in Colombia and identifies this need in an underserved and under-researched population. Future research may examine whether early intervention and rehabilitation strategies help improve post-COVID-19 neurobehavioral symptoms for this group.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":"56 3","pages":"315-324"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Cognitive Training on Balance and Motor Symptoms in Parkinson's Disease: An Exploratory Randomized Controlled Trial.","authors":"Aída Arroyo-Ferrer, Marcos Moreno-Verdú, Francisco José Sánchez-Cuesta, Yeray González-Zamorano, Arturo Ugalde-Canitrot, Juan Pablo Romero","doi":"10.1177/10538135251313716","DOIUrl":"https://doi.org/10.1177/10538135251313716","url":null,"abstract":"<p><p>BackgroundCognitive rehabilitation is a potential intervention for cognitive but also motor disorders in Parkinson's disease (PD).ObjectiveTo investigate the effects of cognitive rehabilitation on balance and motor symptoms in PD.MethodsA randomized controlled trial in a community setting, in people with mild-to-moderate PD (Hoehn and Yahr ≤ III) without cognitive impairment (MoCA ≥ 24) was conducted. Thirty-nine participants were randomly allocated to receive a cognitive intervention (Experimental Group, n = 20) or no intervention (Control Group, n = 19). The experimental protocol involved self-administered cognitive rehabilitation using the NeuronUP platform, focusing on sustained attention and information processing speed training (30 min/day, 3 days/week, 4 weeks). The Berg Balance Scale (BBS) was the main outcome. Motor variables included UPDRS-III, Percentage of Limits of Stability (%LOS) and Timed Up and Go Test (TUG). Neuropsychological variables included TMT-A, TMT-B, Processing Speed (Digit Symbol-Coding and Symbol Search) and Stroop test.ResultsAt post-intervention, marginal improvements were observed in BBS (Mean Difference = 2.23 points, 95%CI [-0.03, 4.49], p = 0.053) and significant improvements in the UPDRS-III (Mean Difference = -4.02 points, 95%CI [-7.82, -0.23], p = 0.039). No significant improvements were found in the rest of the motor and cognitive variables.ConclusionsSelf-administered cognitive training did not improve balance or cognition but significantly reduced motor symptom severity in PD. The effect of more intensive or in-person cognitive rehabilitation protocols on balance needs to be evaluated.</p>","PeriodicalId":19717,"journal":{"name":"NeuroRehabilitation","volume":"56 3","pages":"394-405"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}