Open Medicine最新文献

{"title":"Impact of lipid profiles and risk factors on all-cause mortality in males and females: insights from a Turkish cohort study.","authors":"Ugurcan Sayili, Busra Albayrak, Kevser Sak, Aysem Kaya, Osman Mutluhan Ugurel, Mehmet Umut Capar, Aysen Fenercioglu, Gunay Can","doi":"10.1515/med-2026-1504","DOIUrl":"10.1515/med-2026-1504","url":null,"abstract":"<p><strong>Objectives: </strong>This study examined associations between lipid profiles, anthropometric measures, and all-cause mortality in a Turkish adult cohort, stratified by sex.</p><p><strong>Methods: </strong>This prospective study analyzed 2,378 participants from the TEKHARF cohort over a median follow-up of 256 months (up to 25 years). All-cause mortality was evaluated using sex-specific Cox proportional hazards regression models and Restricted Cubic Spline analysis to assess non-linear associations with baseline lipid parameters, anthropometric measures, and clinical risk factors.</p><p><strong>Results: </strong>During follow-up, 811 deaths (34.1 %) occurred, with significantly higher mortality in males vs. females (37.5 vs. 30.6 %, p<0.001). Low income, physical inactivity, hypertension, and diabetes were strongly associated with mortality in both sexes. In multivariate models, age, hypertension, and diabetes emerged as the most robust independent predictors of mortality. Although total cholesterol and LDL-C quartiles showed associations with mortality in unadjusted analyses, these became non-significant after adjustment. In males, HDL-C in the third quartile (Q3) was associated with a lower risk of mortality compared to the lowest quartile (HR: 0.759, p=0.045), whereas the highest triglyceride quartile independently predicted mortality only in males (HR: 1.464, p=0.008).</p><p><strong>Conclusions: </strong>Traditional cardiometabolic risk factors, particularly age, hypertension, and diabetes, were the dominant mortality determinants. Notably, in males, triglycerides demonstrated a sex-specific independent effect on mortality risk, while intermediate HDL-C levels were associated with reduced mortality, emphasizing the importance of comprehensive risk assessment integrating lipid parameters with established clinical factors.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261504"},"PeriodicalIF":1.8,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13439538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148679370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a medical-rehabilitation integration model to improve rehabilitation service efficiency in a tertiary rehabilitation hospital.","authors":"Lin Chen, Qi Miao, Yu-Tong Jiang, Hong-Jian Lu","doi":"10.1515/med-2026-1482","DOIUrl":"10.1515/med-2026-1482","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the association of the medical‒rehabilitation services in a tertiary rehabilitation hospital through the implementation of a medical-rehabilitation integration model.</p><p><strong>Methods: </strong>Nantong Rehabilitation Hospital was used as a representative case. The effects of implementing the medical-rehabilitation integration model on medical service delivery models, medical resource utilization, and the operational efficiency of major disease categories were evaluated using comparative data analysis and other analytical approaches.</p><p><strong>Results: </strong>Following implementation of the medical-rehabilitation integration model, which encompassed acute-phase management, early rehabilitation intervention, the rehabilitation phase, and long-term management, continuity across all stages of diagnosis and treatment was achieved. This integrated approach addressed patients' comprehensive and individualized needs related to diagnosis, treatment, and rehabilitation. Indicators of medical resource utilization and the operational efficiency of major disease categories showed significant improvement after implementation.</p><p><strong>Conclusions: </strong>The medical-rehabilitation integration model was associated with enhanced medical resource utilization, optimized the operational efficiency of disease categories, and improved patient satisfaction through multidisciplinary collaboration, early rehabilitation intervention, information support, and process optimization. Strengthening the three-tier rehabilitation service chain, reinforcing the integrated development of clinical practice, education, and research, and ensuring sustained policy and resource support are necessary to promote the long-term development of the medical-rehabilitation integration model.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261482"},"PeriodicalIF":1.8,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13430533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of SARS-CoV-2 Omicron infection on late pregnancy: an analysis of clinical characteristics, pathology of placenta and outcomes in a case-control study.","authors":"Heping Zhang, Hongliang Xu, Shuguang Zhou, Yong Chen, Qin Wang, Caixia Zhao, Man Tang, Weiqin Zhang","doi":"10.1515/med-2026-1444","DOIUrl":"10.1515/med-2026-1444","url":null,"abstract":"<p><strong>Objectives: </strong>This study analyzes clinical features and placental pathology of pregnant women infected with SARS-CoV-2 Omicron variants and conducts a two-year follow-up to assess childbirth risks and newborn health outcomes.</p><p><strong>Methods: </strong>Retrospective analysis of 46 Omicron-infected pregnant women (Omicron group) and 96 uninfected pregnant women (Control group).</p><p><strong>Results: </strong>Omicron group exhibited higher risk of fetal distress rate, lower leukocyte and lymphocyte counts, and higher C-reactive protein levels compared to the control group. Most infected women (93.48 %) were symptomatic, with fever being the most common symptom. Histologically, acute maternal and fetal inflammatory response were observed in 28.26 and 8.70 % of the Omicron group, but no significant difference from the control group. Maternal vascular malperfusion (50.00 %) and fetal vascular malperfusion (4.34 %) were present in the Omicron group at rates comparable to the controls. Among the 39.13 % of newborns tested for SARS-CoV-2 within three days of birth, 33.33 % tseted positive. Of these positive neonates, 83.33 % were symptomatic, universally presenting with fever, and one developed pneumonia.</p><p><strong>Conclusions: </strong>Placental pathological findings were non-specific to the Omicron variant. Notably, the two-year follow-up indicated that neither the Omicron-infected mothers nor their newborns experienced long-term adverse health outcomes.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261444"},"PeriodicalIF":1.8,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13430534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TP63 regulates pyroptosis via NF-κB/NLRP3/caspase-1 signaling in interstitial cystitis: insights from single-cell sequencing.","authors":"Wantong Xue, Minli Shi, Lei Pang","doi":"10.1515/med-2026-1476","DOIUrl":"10.1515/med-2026-1476","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;This study aims to explore the regulatory role of the TP63 gene in interstitial cystitis (IC) and its molecular mechanism of involvement in disease occurrence and development through the pyroptosis pathway through single-cell sequencing and bioinformatics analysis, and evaluate its potential as a therapeutic target and biomarker.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A 6-8 week SPF grade female SD rat IC model was constructed by intraperitoneal injection of cyclophosphamide (n=10/group, repeated 3 times). The model construction effect was verified by the Von Frey fiber tenderness method, urodynamic evaluation, and bladder histopathological analysis. Screening key genes related to apoptosis in bladder tissue of IC rats using single-cell sequencing and bioinformatics analysis. &lt;i&gt;In vitro&lt;/i&gt; experiments were conducted using lipopolysaccharide (LPS) to treat immortalized human ureteral epithelial cells (SV-HUC-1) to establish a cellular inflammation model (n=6/group, repeated 3 times), and the transcription level changes of the TP63 gene were detected by RT-PCR. Western blotting was used to detect the expression of apoptosis-related proteins and NF-κB/NLRP3/caspase-1 signaling pathway proteins (caspase-1, GSDMD, ASC) in the bladder tissue of IC rats. The CCK8 method and EdU experiment were used to evaluate cell survival rate and proliferation ability, respectively. ChIP-qPCR was conducted to detect the binding of TP63 to the RELA promoter region. The role of caspase-1 in the pyroptosis pathway was verified using the caspase-1 inhibitor.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Single-cell sequencing and bioinformatics analysis showed that the TP63 gene was significantly upregulated in the bladder tissue of IC rats (p&lt;0.0001). Western blotting results showed a significant increase in the expression of apoptosis-related proteins in the IC model (p&lt;0.0001), while HE staining showed a significant increase in the infiltration of mast cells, macrophages, and T cells (p&lt;0.05). &lt;i&gt;In vitro&lt;/i&gt; experiments, Western blotting results showed that after LPS intervention, the expression of NLRP3 inflammasome component (ASC) and downstream effector molecule (GSDMD) in SV-HUC-1 increased, the apoptotic characteristic protein caspase-1 was activated, CCK-8 detected a decrease in cell viability, and Edu experiments showed inhibition of cell proliferation. After TP63 siRNA intervention, all the above effects were reversed. ChIP-qPCR confirmed that TP63 directly binds to the RELA promoter region, activating NF-κB signaling. Furthermore, caspase-1 inhibition experiments demonstrated that suppressing caspase-1 significantly alleviated TP63-mediated pyroptosis and inflammatory responses.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;TP63 contributes to the pathogenesis of IC by directly binding to the RELA promoter, activating NF-κB signaling, and subsequently regulating the NLRP3/caspase-1/GSDMD axis to induce bladder epithelial cell pyroptosis. TP63 shows promis","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261476"},"PeriodicalIF":1.8,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13425149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148654211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of post-surgery exercise among middle-aged adults with early lung cancer.","authors":"Ka Ryeong Bae, Garam Bang, Genehee Lee, Juhee Cho, Sunga Kong","doi":"10.1515/med-2026-1467","DOIUrl":"10.1515/med-2026-1467","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to explore post-surgery exercise experiences of middle-aged early lung cancer survivors. This qualitative study used phenomenological methods reflecting Merleau-Ponty's perspectives of the body.</p><p><strong>Methods: </strong>The participants were 22 adults (aged 40-64) with stage I non-small cell lung cancer, who underwent surgery at a university hospital in Seoul, South Korea, between May and October 2017. Data were collected through individual in-depth interviews. Narrative meaning was constructed and basic structure of the research topic was confirmed.</p><p><strong>Results: </strong>Three themes and eight subthemes captured the post-surgery exercise experiences of middle-aged early lung cancer survivors: \"quickly regaining one's daily life at a time of turmoil,\" \"efforts to exercise in a healthy manner,\" and \"conflict between the need to exercise and practical difficulties.\" Participants quickly returned to their daily lives post-surgery and tried to participate in smart exercise regimes to prevent recurrence. However, they experienced obstacles such as psychological pressure, lack of time, and difficulty continuing exercise, due to lack of specific exercise information and guidelines for patients with lung cancer.</p><p><strong>Conclusions: </strong>Customized exercise interventions and education programs considering patients' physical condition and lifestyle environment need to be developed in both clinical and community settings.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261467"},"PeriodicalIF":1.8,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13404429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148605945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In silico</i> dysbiosis-associated neuroprotective metabolite insufficiency in Alzheimer's disease.","authors":"Nehad A Shaer, Nouf S Al-Abbas","doi":"10.1515/med-2026-1484","DOIUrl":"10.1515/med-2026-1484","url":null,"abstract":"<p><p>Perturbation of oral and gut microbiomes has been implicated in alzheimer's disease (AD) along the oral-gut-brain axis; however, the extent of global community restructuring may differ between niches. The present work constitutes a computational interrogation of 16S rRNA profiles from eight-month-old APP/PS1 and wild-type mice, characterizing oral and gut community structure and predicted functional capacity through PICRUSt-driven, KEGG-anchored pathway inference. Comparative taxonomic interrogation disclosed patterns consistent with ectopic occurrence, whereby classically oral genera (<i>Fusobacterium</i>, <i>Streptococcus</i>) were preferentially enriched within intestinal assemblages and gut-typical genera (<i>Muribaculum</i>, <i>Paramuribaculum</i>) emerged as prominent constituents of the oral microbiota in APP/PS1 mice. These cross-niche enrichment patterns, together with significant oral community separation but non-significant gut beta-diversity separation by ANOSIM, were accompanied by predicted decrements in 85 orally enriched enzymes distributed across 25 KEGG pathways, approximately 40 % of which were associated with the biosynthesis of metabolites with reported neuroprotective properties, including glutathione, acetyl-CoA, succinate, malate, formate, lactate, acetate, and monoterpenoids. Systems-level synthesis of these predictions indicated convergent perturbation of antioxidant defenses, bioenergetic circuitry, and one-carbon metabolism, plausibly reflecting metabolic choke points that may favor cognitive deterioration. Although the oral microbiome showed significant inter-cohort separation, the gut microbiome did not, indicating that gut changes are best viewed as taxon-specific shifts within an otherwise stable community. These observations support a hypothesis-generating framework in which oral dysbiosis, selective gut alterations, and cross-niche enrichment patterns are linked to computationally inferred neuroprotective metabolite insufficiency, highlighting specific taxa, enzymes, and pathways as candidates for biomarker and microbiome-targeted therapeutic development in AD.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261484"},"PeriodicalIF":1.8,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of age-specific urinary metabolic biomarkers in Wilson disease using machine learning: a comparative study of ensemble tree models.","authors":"Shuxia Huang, Yuguo Song","doi":"10.1515/med-2026-1415","DOIUrl":"10.1515/med-2026-1415","url":null,"abstract":"<p><strong>Objectives: </strong>The diagnosis of Wilson disease (WD) is complicated by heterogeneous clinical phenotypes and inadequate performance of routine biomarkers. This study sought to screen age-specific urinary metabolic biomarkers to assist WD diagnosis via ensemble tree-based machine learning algorithms.</p><p><strong>Methods: </strong>Sixty participants were enrolled, comprising 30 WD patients (10 pediatric, 20 adult) and 30 healthy controls. Morning urine samples were analyzed using UPLC-Q-TOF-MS in both ionization modes. Orthogonal partial least squares discriminant analysis identified differential metabolites. Four ensemble algorithms (Random Forest, GBDT, XGBoost, LightGBM) were compared using nested cross-validation to minimize overfitting risk. LASSO regression selected optimal metabolite panels. Model performance was evaluated using 5-fold cross-validation with AUC as the primary metric.</p><p><strong>Results: </strong>XGBoost achieved AUC values of 0.87±0.03 (pediatric) and 0.96±0.02 (adult) in nested validation, with permutation testing confirming performance above chance levels (p>0.001). Sixty-eight differential metabolites were identified in pediatric patients versus 109 in adults, with 15 metabolites consistently altered across both age groups. Pathway analysis revealed age-specific disruptions: nucleotide metabolism in pediatric patients and oxidative stress pathways in adults. LASSO feature selection identified 7 metabolites for pediatric and 3 for adult classification while maintaining high diagnostic accuracy.</p><p><strong>Conclusions: </strong>This study successfully developed the first age-specific metabolomics-based diagnostic approach for WD using ensemble machine learning. The distinct metabolic signatures between age groups provide mechanistic insights into WD pathophysiology and support personalized diagnostic strategies for improved patient outcomes. These exploratory findings require independent validation before clinical implementation.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261415"},"PeriodicalIF":1.8,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13392894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between sexual self-concept and sexual function among women who undergone hysterectomy: a cross-sectional study in western Iran.","authors":"Zahra Zamiri Araste, Salman Khazaei, Zahra Karami, Ensiyeh Jenabi","doi":"10.1515/med-2026-1486","DOIUrl":"10.1515/med-2026-1486","url":null,"abstract":"<p><strong>Objectives: </strong>Hysterectomy is one of the most significant gynecological surgeries and can profoundly affect various aspects of women's health. This study aimed to investigate the relationship between sexual self-concept and sexual function in women who have undergone hysterectomy in Hamadan City, western Iran.</p><p><strong>Methods: </strong>This cross-sectional analytical study was conducted from June 2024 to June 2025 at Fatemieh Hospital in Hamadan. A total of 200 women who have undergone hysterectomy were enrolled using convenience sampling. Demographic and obstetric questionnaire, the Female Sexual Function Index (FSFI), and the Multidimensional Sexual Self-Concept Questionnaire (MSSCQ) were completed for all participants. Data analysis was performed using Stata software version 17.</p><p><strong>Results: </strong>In this study, 200 participants were evaluated. The mean age of the participants was 47.84 years (SD=6.75). Sexual function scores were significantly higher in women with higher education levels (p<0.001), employed women (p=0.022), those with higher spousal education levels (p<0.001), those with employed spouses (p<0.001), and across different ethnic backgrounds (p=0.029). Additionally, a strong positive correlation was observed between the total FSFI and total MSSCQ scores (r=0.93, p<0.001).</p><p><strong>Conclusions: </strong>The present study revealed a significant positive correlation between total sexual self-concept scores and sexual function. Preliminary evidence for future longitudinal or interventional sexual research can provide a basis for intervention strategies.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261486"},"PeriodicalIF":1.8,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13386585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic pan-cancer analysis identifies PIK3R3 as a lipid metabolism and immune regulation prognostic biomarker.","authors":"Zhixun Ding, Duandan Li","doi":"10.1515/med-2026-1439","DOIUrl":"10.1515/med-2026-1439","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to explore the critical role of PIK3R3 in pan-cancer, which to facilitate the development of more targeted prognostic markers and therapeutic strategies for these malignancies.</p><p><strong>Methods: </strong>In our study, pan-cancer transcriptome datasets were retrieved from Xena database. Subsequently, utilizing the Wilcoxon test, univariate Cox regression analysis as well as Kaplan-Meier (K-M) survival analysis to identify cancer types with high relevance to PIK3R3. Clinical metadata were stratified for correlation analysis, followed by differential expression gene (DEG) identification, overrepresentation analysis, and various functional analysis methods.</p><p><strong>Results: </strong>Lower-grade glioma (LGG), kidney renal clear cell carcinoma (KIRC), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), and uterine corpus endometrial carcinoma (UCEC) exhibited strong associations with PIK3R3. PIK3R3 was closely linked to tumor grade stratification in LGG and UCEC and likely regulated these cancers via pathways such as lipid metabolism. Notably, UCEC showed high-level PIK3R3 mutations, mainly involving mutation and amplification. Compounds including Tetrachlorodibenzodioxin (TCDD), 1-Methyl-4-phenylpyridinium (MPP+), Estradiol, and Valproic Acid were predicted to target PIK3R3.</p><p><strong>Conclusions: </strong>Our results provide novel insights into the molecular mechanisms underlying PIK3R3-associated tumorigenesis and progression, which may contribute to the development of more targeted prognosis markers and therapeutic strategies for these malignancies.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261439"},"PeriodicalIF":1.8,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13386378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of nomogram for predicting pulmonary hypertension on echocardiography in chronic obstructive pulmonary disease: a single-center retrospective study.","authors":"Aixia Huang, Tianyu Pan, Yang Gao, Guowen Ji, Ruihong Song, Wenjuan Liu","doi":"10.1515/med-2026-1475","DOIUrl":"10.1515/med-2026-1475","url":null,"abstract":"<p><strong>Objectives: </strong>To identify independent predictors of pulmonary hypertension (PH) on echocardiography in chronic obstructive pulmonary disease (COPD) patients during acute exacerbations.</p><p><strong>Methods: </strong>We retrospectively enrolled 151 patients hospitalized for acute COPD exacerbation. Patients were divided by echocardiography into COPD with PH (n=75) and COPD without PH (n=76) groups. LASSO regression screened 17 laboratory indicators to identify the optimal variable subset. Multivariate logistic regression determined independent PH predictors, and a nomogram was constructed. The discrimination and calibration of model were assessed.</p><p><strong>Results: </strong>LASSO regression analysis screened out 6 optimal variables (age, albumin, cystatin C, red blood cell distribution width (RDW), pH, and CD4/CD8 ratio). Multivariate logistic regression analysis revealed that serum albumin, cystatin C, RDW, pH, and age were independent predictors of PH. The nomogram constructed using these six variables (age, serum albumin, cystatin C, RDW, CD4/CD8 ratio, and pH) demonstrated a C-index of 0.800 (95 % CI: 0.731-0.869). The calibration curve showed that the predicted probability of the model was in good agreement with the actual observed values.</p><p><strong>Conclusions: </strong>The nomogram constructed based on 6 variables has good predictive efficacy for PH on echocardiography in COPD patients during acute exacerbations. It can provide a convenient risk stratification tool for clinical practice.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"21 1","pages":"20261475"},"PeriodicalIF":1.8,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13382695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148606001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}