Analysis of serum metabolomics in patients with different types of chronic heart failure.

IF 1.6 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2025-07-23 eCollection Date: 2025-01-01 DOI:10.1515/med-2025-1210

Bingzhang Jie, Qiang Li, Ling Han, Liwei Chen, Ming Yang

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引用次数: 0

Abstract

Background: Heart failure remains a major public health issue, and there are still no reliable biomarkers for left ventricular ejection fraction (LVEF).

Objective: To screen for differential metabolites in the blood of HFpEF, HFmrEF, and HFrEF patients based on metabolomics analysis of their blood samples.

Methods: Total 44 patients in HFpEF group, 30 patients in HFmrEF group, and 36 patients in HFrEF group were selected. The blood metabolites were analyzed by liquid chromatography high-resolution mass spectrometry and classified by principal component analysis, and then potential biomarker were screened. Partial least squares discriminant analysis was used to model and investigate the predictive ability of biomarkers for LVEF.

Results: Blood metabolite profiles of HFpEF, HFmrEF, and HFrEF groups could be well distinguished, and seven potential biomarkers were identified, such as phosphatidylcholine, phosphatidylinositol, lysophosphatidylcholine, lysophosphatidylcholine, ceramide, sphingosine, and sphingomyelin. Four metabolic pathways, such as glycerol phospholipid metabolic pathway, linoleic acid metabolic pathway, purine pyrimidine metabolism pathway, and linolenic acid metabolism pathway were identified, among which glycerol phospholipid metabolism pathway was the most significant.

Conclusion: The changes in glycerol phospholipid metabolism pathway may help identify HFpEF, HFmrEF, and HFrEF.

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不同类型慢性心力衰竭患者血清代谢组学分析。

背景：心力衰竭仍然是一个主要的公共卫生问题，并且仍然没有可靠的左心室射血分数（LVEF）的生物标志物。目的：通过血液样本的代谢组学分析，筛选HFpEF、HFmrEF和HFrEF患者血液中的差异代谢物。方法：选取HFpEF组44例，HFmrEF组30例，HFrEF组36例。采用液相色谱-高分辨率质谱法分析血液代谢物，并用主成分分析法进行分类，筛选潜在生物标志物。采用偏最小二乘判别分析对生物标志物对LVEF的预测能力进行建模和研究。结果：HFpEF、HFmrEF和HFrEF组的血代谢产物谱可以很好地区分，并鉴定出7种潜在的生物标志物，如磷脂酰胆碱、磷脂酰肌醇、溶血磷脂酰胆碱、溶血磷脂酰胆碱、神经酰胺、鞘磷脂和鞘磷脂。鉴定出甘油磷脂代谢途径、亚油酸代谢途径、嘌呤嘧啶代谢途径和亚麻酸代谢途径4条代谢途径，其中甘油磷脂代谢途径最为显著。结论：甘油磷脂代谢途径的变化可能有助于HFpEF、HFmrEF和HFrEF的鉴别。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.