Open Medicine最新文献

{"title":"Corrigendum to \"The progress of autoimmune hepatitis research and future challenges\".","authors":"Yang Zhang, Dehe Zhang, Ling Chen, Jing Zhou, Binbin Ren, Haijun Chen","doi":"10.1515/med-2025-9993","DOIUrl":"10.1515/med-2025-9993","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1515/med-2023-0823.].</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20259993"},"PeriodicalIF":1.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular genotyping of multi-system rare blood types in foreign blood donors based on DNA sequencing and its clinical significance.","authors":"Jianli Gong, Xianguo Xu, Jianrong Zhu","doi":"10.1515/med-2025-1234","DOIUrl":"10.1515/med-2025-1234","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To establish a multi-level blood type identification system, comprehensively analyze the distribution characteristics and genetic polymorphisms of multi-system rare blood types in foreign blood donors, explore the application value of DNA sequencing technology in rare blood type screening, and evaluate its clinical significance in complex transfusion patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Blood samples from 277 foreign blood donors who participated in voluntary blood donation in Yiwu City were prospectively collected from June 2021 to March 2023. Serological typing of 24 antigens from 11 red blood cell blood group systems (ABO, Rh, Duffy, MNS, Kidd, Kell, Lutheran, P1PK, Lewis, H, and Diego) was performed using microcolumn agglutination and tube methods. First-generation sequencing technology was used to perform whole-exome sequencing of Duffy, Kell, Ss/GYPB, and Diego genes on screened rare phenotype samples to analyze genetic polymorphism characteristics. Key mutation sites were verified using multiplex PCR-sequencing. A rare blood type DNA database was established and compared with the international blood group gene database (BGMUT). Confirmed rare blood type units were preserved through programmed freezing, and their clinical application effects were tracked and analyzed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The 277 foreign blood donors were primarily from the Middle East and South Asia (71.8%), with major source countries including Syria (56 cases, 20.22%), Yemen (49 cases, 17.69%), Pakistan (24 cases, 8.66%), Iraq (20 cases, 7.22%), India (15 cases, 5.42%), Iran (14 cases, 5.05%), Mali (11 cases, 3.97%), and Jordan (10 cases, 3.61%). In blood type distribution, Fya antigen expression was highest among Indian (100%) and Pakistani (87.50%) donors; 63 cases of Fy(a-b-) were found, most commonly in donors from Mali and Yemen. S antigen expression was highest in donors from Syria (60.71%), India (60.00%), and Pakistan (58.33%); 47 cases of S+s- were detected. Additionally, 12 cases of Lua+ were found, distributed among Syria (3 cases), Iraq (2 cases), Yemen (2 cases), Jordan (2 cases), etc.; 5 cases of Kpa+ were from Yemen (2 cases), Pakistan, Iraq, and Jordan (1 case each). DNA sequencing revealed that GATA-1 promoter region mutation (c.-67T&gt;C) in the Duffy gene was the primary molecular basis for the Fy(a-b-) phenotype, accounting for 96.8% (61/63). Multivariate analysis demonstrated significant clustering of blood group phenotypes by geographical regions (&lt;i&gt;p&lt;/i&gt; &lt; 0.001), with the first two principal components explaining 78.3% of the variance in distribution patterns. Genotype-phenotype correlation analysis showed a concordance rate of 99.2% (248/250). During the study period, 41 rare phenotype blood units (74U) were screened and cryopreserved, including 14 units (24.5U) of Fy(a-b-), 25 units (45.5U) of Fy(a-b+), and 2 units (4.0U) of s(-). In clinical application, these units were successfully used in three di","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251234"},"PeriodicalIF":1.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The identification of novel missense variant in <i>ChAT</i> gene in a patient with gestational diabetes denotes plausible genetic association.","authors":"Oluwafemi G Oluwole, Afolake Arowolo, Ezekiel Musa, Naomi Levitt, Mushi Matjila","doi":"10.1515/med-2025-1225","DOIUrl":"10.1515/med-2025-1225","url":null,"abstract":"<p><strong>Introduction: </strong>Gestational diabetes mellitus (GDM), the most common metabolic complication of pregnancy, is associated with a 50% increase in subsequent risk for type 2 diabetes. There is increasing interest in identifying biomarkers that may facilitate the stratification of subsequent type 2 diabetes risk among women with GDM. In this study, we considered the choline acetyltransferase (<i>ChAT</i>) gene. CHAT plays a critical role in acetylcholine synthesis and regulates insulin secretion from the pancreatic islet to maintain glucose homeostasis.</p><p><strong>Methods: </strong>We screened for deleterious variants in the <i>ChAT</i> gene in 12 GDM patients and 10 ethnically matched controls from a South African cohort. We isolated DNA from the placental samples of these patients and performed DNA sequencing of the protein-coding region of the <i>ChAT</i> gene. Sequence alignments and variant annotations were done using UGENE software and Ensembl VEP.</p><p><strong>Results: </strong>A novel heterozygous missense variant in exon 8 of the <i>ChAT</i> gene was identified. The plausible phenotypic impact of the variant <i>ChAT</i> (NM_020549.5):c.1213C>G (p.Leu405Val) can be explained by haploinsufficiency, changing protein activities, strong transcription activity, and epigenetic repression activities of the variant. Also, structurally, the variant is located 18bp in-frame to a stop-gained variant (p.Gly411Ter). The RegulomeDB DNase expression data clearly show the identified variant in a peak expression in the spleen and placenta. This observation corroborates that the <i>ChAT</i> gene may play an essential role in GDM.</p><p><strong>Conclusion: </strong>Taken together, the metric scores for this variant show that it could affect the functions of the gene, but more functional studies are necessary to validate these effects. Consequently, this study sets the stage for the future screening of a larger cohort and functional validation of deleterious variants to underpin the <i>ChAT</i> gene and GDM association.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251225"},"PeriodicalIF":1.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings.","authors":"Vesna G Marjanovic, Ivana Z Budic, Maja D Zecevic, Marija M Stevic, Dusica M Simic","doi":"10.1515/med-2025-1244","DOIUrl":"10.1515/med-2025-1244","url":null,"abstract":"<p><strong>Background: </strong>Intra-abdominal hypertension (IAH)/abdominal compartment syndrome (ACS) is one of the rarer clinical entities in the pediatric population, carrying a high degree of morbidity and mortality. The focus of this review is on assessing pathophysiological changes of organ systems in pediatric patients with risk factors for the occurrence of IAH/ACS based on the evaluation of diagnostic modalities and therapeutic strategies.</p><p><strong>Methodology: </strong>A comprehensive literature search of indexed databases was performed, aiming to identify, review, and evaluate published articles on IAH/ACS. The search was focused on studies examining pathophysiology, risk factors, diagnostic approaches, and management strategies.</p><p><strong>Results: </strong>The main risk factors encompass diminished abdominal wall compliance, increased intraluminal and abdominal contents, and capillary leak/fluid resuscitation. Diagnostic tools include clinical and imaging findings, intra-abdominal pressure (IAP) monitoring, and parameters of tissue perfusion. Therapeutic strategies involve non-surgical and surgical management of IAH/ACS in pediatric patients.</p><p><strong>Conclusion: </strong>Timely and continuous evaluation of IAP and parameters of tissue perfusion is crucial for the early diagnosis of IAH/ACS and implementing non-surgical procedures, reducing the need for surgical procedures. Future research should focus on the usefulness of advanced non-invasive monitoring technologies and the identification of predictors of increased IAP in the early implementation of personalized therapeutic strategies.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251244"},"PeriodicalIF":1.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of succinyl carnitine in the association between CD39⁺ CD4⁺ T cell and ulcerative colitis: A Mendelian randomization study.","authors":"Li Chen, Ying Yi, Yun Zhu","doi":"10.1515/med-2025-1240","DOIUrl":"10.1515/med-2025-1240","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the potential causal relationship between immune cell and the risk of ulcerative colitis (UC), and to explore whether serum metabolites may mediate this association, thereby suggesting potential biomarkers or therapeutic targets.</p><p><strong>Methods: </strong>We conducted a Mendelian randomization (MR) analysis using summary statistics from genome-wide association studies to evaluate both the direct effects and potential mediating roles of 731 immune cells and 1,400 serum metabolites in relation to UC. Instrumental variables were rigorously selected based on genome-wide significance and linkage disequilibrium thresholds. The primary analytical method was inverse variance weighted, supplemented by MR-Egger regression and weighted median methods to ensure robustness. Cochran's <i>Q</i> test, MR-Egger intercept, and leave-one-out analysis were employed to evaluate heterogeneity and pleiotropy. Mediation MR analysis was conducted to examine potential metabolite-mediated pathways.</p><p><strong>Results: </strong>We identified a statistically significant positive causal effect of CD39⁺ CD4⁺ T cell on UC risk (OR = 1.05, 95% CI = 1.03-1.08, <i>beta_all</i> = 0.05). Sensitivity analyses confirmed the robustness of this association, and reverse MR analysis indicated no causal effect of UC on CD39⁺ CD4⁺ T cell, suggesting a unidirectional relationship. Mediation analysis further revealed that succinyl carnitine (C4DC) partially mediated the effect of CD39⁺ CD4⁺ T cell on UC, with a mediation proportion of 3.3%.</p><p><strong>Conclusion: </strong>Our findings suggest that CD39⁺ CD4⁺ T cell may increase the risk of UC, potentially by modulating the levels of succinyl carnitine (C4DC). These results indicate a potential immunometabolic pathway in UC pathogenesis and highlight CD39⁺ CD4⁺ T cell and C4DC as promising targets for further research. However, additional experimental validation is required to confirm these findings and assess their clinical relevance.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251240"},"PeriodicalIF":1.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curdione protects vascular endothelial cells and atherosclerosis via the regulation of DNMT1-mediated ERBB4 promoter methylation.","authors":"Yingbiao Wu, Can Jin, Luoning Zhu, Xiaogang Zhang, Xinpeng Cong, Budian Xing, Zhongping Ning","doi":"10.1515/med-2025-1223","DOIUrl":"10.1515/med-2025-1223","url":null,"abstract":"<p><p>Atherosclerosis (AS) is initiated by the activation of the endothelial cells, which is followed by a series of events that trigger the narrowing of blood vessels and the activation of inflammation. This study aimed to investigate <i>in vitro</i> the roles and underlying mechanisms of curdione in AS. Human umbilical vein endothelial cells (HUVECs) were stimulated with oxidized low-density lipoprotein (ox-LDL) and then treated with curdione, after which the growth of the HUVECs and the related mechanisms were determined. HUVECs with ERBB4 overexpression were constructed to explore the role of ERBB4 in curdione-mediated AS. The interaction among ERBB4, methylation, and curdione was confirmed by chromatin immunoprecipitation (ChIP)-quantitative PCR (qPCR) and dual luciferase reporter gene assays. Both curdione and ERBB4 overexpression individually and significantly enhanced viability and proliferation while suppressing apoptosis of the ox-LDL-induced HUVECs, and the combination of curdione and ERBB4 overexpression had better effects. Compared with the ox-LDL-induced HUVECs, both curdione and ERBB4 overexpression individually decreased the levels of IL-6, IL-1β, and IL-8 (<i>P</i> < 0.05). They also upregulated Bax, caspase-3, E-cadherin, and F-actin while downregulating Bcl-2 and VEGF (<i>P</i> < 0.05). Additionally, the ERBB4 bound to the DNMT1 gene, and the curdione participated in AS via the ERBB4 gene. The study demonstrated that either curdione or ERBB4 overexpression individually may ameliorate AS development by inhibiting apoptosis, inflammation, and the EndMT of HUVECs. In addition, curdione may protect the vascular endothelial cells and AS by regulating the DNMT1-mediated ERBB4 promoter methylation.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251223"},"PeriodicalIF":1.7,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of computed tomography and guided bronchoscopy in the diagnosis of pulmonary nodules: A systematic review and meta-analysis.","authors":"Yilin Wang, Xianhe Liang, Haitao Zhang, Jinhua Hao, Min Wei","doi":"10.1515/med-2024-1108","DOIUrl":"10.1515/med-2024-1108","url":null,"abstract":"<p><strong>Objective: </strong>To compare the diagnostic effects of computed tomography (CT) and bronchoscopy guided biopsy on pulmonary nodules.</p><p><strong>Methods: </strong>\"Subject words + free words\" were used to search four literature databases including Pubmed, Embase, Cochrane Library, and Web of Science. The subject words were CT, bronchoscope-guided biopsy, pulmonary nodules, and diagnosis. The search is up to August 25, 2023. The retrieved literature was screened, and the literature with duplicate, review, incomplete data or article content and inconsistent with our research was deleted. Revman 5.4 was used for bias analysis of the literatures included in the analysis, and forest map, funnel map, and ROC curve were drawn to compare the accuracy, specificity, and sensitivity of the two diagnostic methods.</p><p><strong>Results: </strong>A total of 2,622 articles were retrieved, and 8 articles were included in the study after screening. Bias analysis and funnel plot showed that eight included articles had higher quality and smaller bias. The sensitivity and specificity of the forest map were both 95% CI, and the sensitivity of CT diagnosis was better than that of bronchoscopy diagnosis, with similar specificity between the two groups. The funnel plot shows some heterogeneity in the literature on pulmonary nodules. The ROC curve shows that CT diagnosis is significantly superior to bronchoscopy diagnosis, with diagnostic accuracy approaching 100%.</p><p><strong>Conclusion: </strong>CT has significant advantages in detecting and diagnosing pulmonary nodules, as it can detect nodules in various parts of the lungs. However, bronchoscopy has significant advantages in diagnosing small pulmonary nodules.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20241108"},"PeriodicalIF":1.7,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationship between asthma and ankylosing spondylitis: A bidirectional two-sample univariable and multivariable Mendelian randomization study.","authors":"Yiming Yao, Shiqiang Zhou, Yumin Fang, Wenxing Zeng, Shaofeng Zhan","doi":"10.1515/med-2025-1177","DOIUrl":"10.1515/med-2025-1177","url":null,"abstract":"<p><strong>Background: </strong>Previous research has indicated a possible association between asthma and ankylosing spondylitis (AS).</p><p><strong>Methods: </strong>We pinpointed single nucleotide polymorphisms linked to various forms of asthma and AS, employing them as instrumental variables for a bidirectional two-sample Mendelian randomization (TSMR) analysis. Our TSMR analysis focused on European populations to minimize racial confounding. Multivariate adjustments for body mass index (BMI), smoking, and alcohol use were performed to control for confounders. Colocalization analysis was used to validate MR findings and explore genetic links between asthma and AS.</p><p><strong>Results: </strong>Individuals with asthma and eosinophilic asthma exhibited a relatively higher risk of AS (asthma: OR 1.31, 95% CI 1.07-1.62, <i>P</i> = 0.008; eosinophilic asthma: OR 1.24, 95% CI 1.005-1.544, <i>P</i> = 0.044). Allergic asthma, childhood-onset asthma, and obesity-related asthma showed no causal relationship with AS (allergic asthma: IVW <i>P</i> = 0.27; childhood-onset asthma: IVW <i>P</i> = 0.66; obesity-related asthma: IVW <i>P</i> = 0.53). After adjusting for cigarette smoking, alcohol consumption, and BMI, the results supported a direct causal effect of asthma on the increased risk of AS onset (IVW <i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>This study revealed that a positive causal connection between asthma, specifically eosinophilic asthma, and AS.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251177"},"PeriodicalIF":1.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations of health literacy with individuals' understanding and use of medications in Southern Taiwan.","authors":"Pin-Tzu Chen, Min-Li Chen, Li-Chun Chang, Chin-Ho Kuo, Yu-Hsiang Kuan","doi":"10.1515/med-2025-1203","DOIUrl":"10.1515/med-2025-1203","url":null,"abstract":"<p><strong>Background: </strong>Investigated the relationship between health literacy and treatment adherence and compliance due to incorrect medication use resulting from low health literacy in southern Taiwan.</p><p><strong>Methods: </strong>A cross-sectional study in Chiayi, Taiwan (Sep-Nov 2013) used randomized sampling to survey 300 adults. Health literacy was assessed via the test of functional health literacy in adults, and medication knowledge/behavior was assessed via a validated questionnaire (KR-20 = 0.83). Data were analyzed using SPSS (chi-square, <i>t</i>-tests, ANOVA, Pearson's correlation, <i>P</i> < 0.05).</p><p><strong>Results: </strong>It was found that 97.9% of the respondents had adequate health literacy. Age negatively correlated with health literacy (<i>r</i> = -0.395; <i>P</i> < 0.0001) and positively with medication knowledge (<i>r</i> = 0.121; <i>P</i> = 0.038). Women exhibited higher health literacy and medication knowledge than men. Higher education levels and living with health professionals were associated with better health literacy. Patients with chronic diseases had lower health literacy than those without (mean scores: 31.5 vs 32.7). Significant correlations were observed between health literacy and treatment adherence and compliance and use.</p><p><strong>Conclusions: </strong>Targeted health literacy interventions are required across different ages, genders, and education levels to improve medication use and health outcomes. Future research should examine the long-term effects of these interventions.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251203"},"PeriodicalIF":1.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of serum calprotectin with outcome of acute cerebral infarction.","authors":"HaiYan Li, KaiMeng Zhao, WenWen Yu","doi":"10.1515/med-2025-1207","DOIUrl":"10.1515/med-2025-1207","url":null,"abstract":"<p><strong>Objective: </strong>This study was to investigate the correlation between serum calprotectin (Cal) and the severity and outcome of patients with acute cerebral infarction (ACI).</p><p><strong>Methods: </strong>Clinical data and serum Cal data were collected from 160 ACI patients and 60 healthy individuals. ACI patients were grouped according to their prognosis. Clinical data, biochemical indicators, and Cal levels were measured. Correlations between serum Cal and National Institute of Health stroke scale (NIHSS) scores, Glasgow Coma Scale (GCS) scores, and hematocrit (HCT) were analyzed.</p><p><strong>Results: </strong>In ACI patients, elevated serum Cal levels were observed. These levels were positively correlated with NIHSS scores and inversely correlated with GCS scores and HCT. The receiver operating characteristic curve showed that serum Cal had an area under the curve of 0.770 for predicting poor outcomes, with a diagnostic cutoff of 18.01 mg/L. Serum Cal levels over 18.01 mg/L were independently related to poor prognosis for ACI and were identified as an independent risk factor for adverse outcomes.</p><p><strong>Conclusion: </strong>Serum Cal shows high expression in patients with ACI. Serum Cal has a good predictive value for the outcome of ACI.</p>","PeriodicalId":19715,"journal":{"name":"Open Medicine","volume":"20 1","pages":"20251207"},"PeriodicalIF":1.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}