Osteoporosis and Sarcopenia最新文献_第4页

BONEcheck: A digital tool for personalized bone health assessment BONEcheck:用于个性化骨骼健康评估的数字工具

IF 2

Osteoporosis and Sarcopenia Pub Date : 2023-09-01 DOI: 10.1016/j.afos.2023.08.002

Dinh Tan Nguyen , Thao P. Ho-Le , Liem Pham , Vinh P. Ho-Van , Tien Dat Hoang , Thach S. Tran , Steve Frost , Tuan V. Nguyen

{"title":"BONEcheck: A digital tool for personalized bone health assessment","authors":"Dinh Tan Nguyen , Thao P. Ho-Le , Liem Pham , Vinh P. Ho-Van , Tien Dat Hoang , Thach S. Tran , Steve Frost , Tuan V. Nguyen","doi":"10.1016/j.afos.2023.08.002","DOIUrl":"https://doi.org/10.1016/j.afos.2023.08.002","url":null,"abstract":"<div><h3>Objectives</h3><p>Osteoporotic fracture is a significant public health burden associated with increased mortality risk and substantial healthcare costs. Accurate and early identification of high-risk individuals and mitigation of their risks is a core part of the treatment and prevention of fractures. Here we introduce a digital tool called 'BONEcheck' for personalized assessment of bone health.</p></div><div><h3>Methods</h3><p>The development of BONEcheck primarily utilized data from the prospective population-based Dubbo Osteoporosis Epidemiology Study and the Danish Nationwide Registry. BONEcheck has 3 modules: input data, risk estimates, and risk context. Input variables include age, gender, prior fracture, fall incidence, bone mineral density (BMD), comorbidities, and genetic variants associated with BMD.</p></div><div><h3>Results</h3><p>Based on the input variables, BONEcheck estimates the probability of any fragility fracture and hip fracture within 5 years, subsequent fracture risk, skeletal age, and time to reach osteoporosis. The probability of fracture is shown in both numeric and human icon array formats. The risk is also contextualized within the framework of treatment and management options on Australian guidelines, with consideration given to the potential fracture risk reduction and survival benefits. Skeletal age was estimated as the sum of chronological age and years of life lost due to a fracture or exposure to risk factors that elevate mortality risk.</p></div><div><h3>Conclusions</h3><p>BONEcheck is an innovative tool that empowers doctors and patients to engage in well-informed discussions and make decisions based on the patient's risk profile. Public access to BONEcheck is available via <span>https://bonecheck.org</span><svg><path></path></svg> and in Apple Store (iOS) and Google Play (Android).</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"9 3","pages":"Pages 79-87"},"PeriodicalIF":2.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49763914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between masticatory ability and lower Timed Up & Go Test performance among community-dwelling Japanese aging men and women: The Toon Health Study 日本社区老年男性和女性咀嚼能力与较低时间Up & Go测试成绩之间的关系:香椿健康研究

IF 2

Osteoporosis and Sarcopenia Pub Date : 2023-09-01 DOI: 10.1016/j.afos.2023.08.001

Saori Miyazaki , Koutatsu Maruyama , Kiyohide Tomooka , Shinji Nishioka , Noriko Miyoshi , Ryoichi Kawamura , Yasunori Takata , Haruhiko Osawa , Takeshi Tanigawa , Isao Saito

{"title":"The association between masticatory ability and lower Timed Up & Go Test performance among community-dwelling Japanese aging men and women: The Toon Health Study","authors":"Saori Miyazaki , Koutatsu Maruyama , Kiyohide Tomooka , Shinji Nishioka , Noriko Miyoshi , Ryoichi Kawamura , Yasunori Takata , Haruhiko Osawa , Takeshi Tanigawa , Isao Saito","doi":"10.1016/j.afos.2023.08.001","DOIUrl":"10.1016/j.afos.2023.08.001","url":null,"abstract":"<div><h3>Objectives</h3><p>Few studies examined the association between deterioration of masticatory ability assessed by objective marker and physical function. Therefore, we examined the association between salivary flow rate which is one of the objective and surrogate marker of masticatory ability and lower Timed Up & Go (TUG) performance which is one of major measurement of physical function among aging Japanese.</p></div><div><h3>Methods</h3><p>This cross-sectional study enrolled 464 Japanese aged 60–84 years old. Participants chewed tasteless and odorless gum for 5 min, calculated stimulated salivary flow rate (g/min) during all chews. The 3 m TUG was conducted, and 75th percentile value (6.8 s for men and 7.0 s for women) or higher was defined as lower TUG performance. Logistic regression analysis was used to examine the association between stimulated salivary flow rate and lower TUG performance.</p></div><div><h3>Results</h3><p>We found that the stimulated salivary flow rate tended to be negatively associated with the TUG time. We also observed significant negative association between stimulated salivary flow rate and lower TUG performance; the multivariable-adjusted OR (95% confidence interval, CIs) of lower TUG performance for the highest quartile of stimulated salivary flow rate compared with the lowest quartile was 0.34 (0.16–0.69, P for trend = 0.02). Further adjusting for BMI, the association was attenuated but remaind significant; the OR (95% CIs) in highest quartile was 0.37 (0.18–0.76, P for trend = 0.04).</p></div><div><h3>Conclusions</h3><p>Higher stimulated salivary flow, which means well masticatory ability, was inversely associated with lower TUG performance in the aging Japanese population.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"9 3","pages":"Pages 94-98"},"PeriodicalIF":2.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42401529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring molecular mechanisms underlying the pathophysiological association between knee osteoarthritis and sarcopenia 探讨膝关节骨关节炎和肌肉减少症之间病理生理关联的分子机制

IF 2

Osteoporosis and Sarcopenia Pub Date : 2023-09-01 DOI: 10.1016/j.afos.2023.08.005

Jiyong Yang , Tao Jiang , Guangming Xu , Shuai Wang , Wengang Liu

{"title":"Exploring molecular mechanisms underlying the pathophysiological association between knee osteoarthritis and sarcopenia","authors":"Jiyong Yang , Tao Jiang , Guangming Xu , Shuai Wang , Wengang Liu","doi":"10.1016/j.afos.2023.08.005","DOIUrl":"https://doi.org/10.1016/j.afos.2023.08.005","url":null,"abstract":"<div><h3>Objectives</h3><p>Accumulating evidence indicates a strong link between knee osteoarthritis (KOA) and sarcopenia. However, the mechanisms involved have not yet been elucidated. This study primarily aims to explore the molecular mechanisms that explain the connection between these 2 disorders.</p></div><div><h3>Methods</h3><p>The gene expression profiles for KOA and sarcopenia were obtained from the Gene Expression Omnibus database, specifically from GSE55235, GSE169077, and GSE1408. Various bioinformatics techniques were employed to identify and analyze common differentially expressed genes (DEGs) across the 3 datasets. The techniques involved the analysis of Gene Ontology and pathways to enhance understanding, examining protein-protein interaction (PPI) networks, and identifying hub genes. In addition, we constructed the network of interactions between transcription factors (TFs) and genes, the co-regulatory network of TFs and miRNAs for hub genes, and predicted potential drugs.</p></div><div><h3>Results</h3><p>In total, 14 common DEGs were found between KOA and sarcopenia. Detailed information on biological processes and signaling pathways of common DEGs was obtained through enrichment analysis. After performing PPI network analysis, we discovered 4 hub genes (FOXO3, BCL6, CDKN1A, and CEBPB). Subsequently, we developed coregulatory networks for these hub genes involving TF-gene and TF-miRNA interactions. Finally, we identified 10 potential chemical compounds.</p></div><div><h3>Conclusions</h3><p>By conducting bioinformatics analysis, our study has successfully identified common gene interaction networks between KOA and sarcopenia. The potential of these findings to offer revolutionary understanding into the common development of these 2 conditions could lead to the identification of valuable targets for therapy.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"9 3","pages":"Pages 99-111"},"PeriodicalIF":2.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49744289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of people with high risk of osteoporosis in Asia 亚洲骨质疏松症高危人群的识别

IF 2

Osteoporosis and Sarcopenia Pub Date : 2023-09-01 DOI: 10.1016/j.afos.2023.08.004

Jia Wen Chong, Tik S. Chan, Joseph C. Lee

引用次数: 0

Reply on “Identification of people with high risk of osteoporosis in Asia” 关于“亚洲骨质疏松症高危人群的识别”的复函

IF 2

Osteoporosis and Sarcopenia Pub Date : 2023-09-01 DOI: 10.1016/j.afos.2023.08.003

Ching-Lung Cheung

引用次数: 0

TOC TOC

IF 2

Osteoporosis and Sarcopenia Pub Date : 2023-09-01 DOI: 10.1016/S2405-5255(23)00059-6

引用次数: 0

Illicit drug use is associated with lower bone mineral density and bone strength 非法药物使用与骨密度和骨强度降低有关

IF 2

Osteoporosis and Sarcopenia Pub Date : 2023-09-01 DOI: 10.1016/j.afos.2023.09.001

Suhas Krishnamoorthy , Gloria Hoi-Yee Li , Kelvin Shun-Cheong Ho , Yin-Pan Chau , Constance Mak , Donna Ng , Albert Kar-Kin Chung , Jody Kwok-Pui Chu , Kathryn Choon-Beng Tan , Ruby Lai-Chong Hoo , Ching-Lung Cheung

{"title":"Illicit drug use is associated with lower bone mineral density and bone strength","authors":"Suhas Krishnamoorthy , Gloria Hoi-Yee Li , Kelvin Shun-Cheong Ho , Yin-Pan Chau , Constance Mak , Donna Ng , Albert Kar-Kin Chung , Jody Kwok-Pui Chu , Kathryn Choon-Beng Tan , Ruby Lai-Chong Hoo , Ching-Lung Cheung","doi":"10.1016/j.afos.2023.09.001","DOIUrl":"https://doi.org/10.1016/j.afos.2023.09.001","url":null,"abstract":"<div><h3>Objectives</h3><p>To evaluate the association of illicit drug use with bone mineral density (BMD) and hip geometric parameters at the narrow neck.</p></div><div><h3>Methods</h3><p>This is a cross-sectional matched cohort study conducted in the Hong Kong Chinese population. Associations with illicit drug use were estimated using linear regression for BMD (lumbar spine and femoral neck) and hip geometrical parameters (cross-sectional area [CSA], cross-sectional moment of inertia [CSMI], section modulus [SM], average cortical thickness [ACT] and BMD at the narrow neck) after adjusting for age, body mass index (BMI), smoking status, drinking status, physical activity, and history of antipsychotic and antidepressant use. Mean difference and 95% confidence intervals (95% CI) were calculated between 108 illicit drug users and 108 controls using an adjusted linear model and cluster-robust standard errors after matching by age and sex. The false discovery rate was used to correct for multiple testing.</p></div><div><h3>Results</h3><p>Illicit drug users had a significantly lower BMD (g/cm<sup>2</sup>) at the lumbar spine (mean difference: −0.062; 95% CI: −0.108 to −0.015), and femoral neck (mean difference: −0.058; 95% CI: −0.106 to −0.010) in the fully adjusted model. Illicit drug users also had a significantly lower CSA (mean difference: −0.238 cm<sup>2</sup>; 95% CI: −0.462 to −0.013), ACT (mean difference: −0.018 cm; 95% CI: −0.030 to −0.006) and BMD (mean difference: −0.070 g/cm<sup>2</sup>; 95% CI: −0.128 to −0.012) at the narrow neck.</p></div><div><h3>Conclusions</h3><p>Illicit drug use is associated with lower BMD and bone strength. Future studies evaluating the risk of illicit drug use with fragility fracture are warranted.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"9 3","pages":"Pages 88-93"},"PeriodicalIF":2.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49763922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply on “teriparatide treatment for postmenopausal women with sacral insufficiency fracture” 关于“特立帕肽治疗绝经后妇女骶骨功能不全骨折”的答复

IF 2

Osteoporosis and Sarcopenia Pub Date : 2023-06-01 DOI: 10.1016/j.afos.2023.05.004

Yao-Chun Yang, Min-Hong Hsieh, Jui-Teng Chien, Keng-Chang Liu, Chang-Chen Yang