{"title":"Relation of bone mineral density with fat infiltration of paraspinal muscles","authors":"Irza Shaikh, Fiza Shaikh, Syed Hassan Ali, Javed Iqbal","doi":"10.1016/j.afos.2025.08.001","DOIUrl":"10.1016/j.afos.2025.08.001","url":null,"abstract":"","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 3","pages":"Page 107"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiin Seo , Luca Quagliato , Yoon-Sok Chung , Taeyong Lee
{"title":"Gradient-enhanced neural network and extreme gradient boosting modeling for the prediction of the 3D bone mineral density distribution from 2D-DXA scans","authors":"Jiin Seo , Luca Quagliato , Yoon-Sok Chung , Taeyong Lee","doi":"10.1016/j.afos.2025.09.002","DOIUrl":"10.1016/j.afos.2025.09.002","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aims to predict the volumetric bone mineral density (BMD) distribution from a dual-energy X-ray absorptiometry (DXA) scan. By employing machine learning, this study bridges the gap between DXA and computed tomography (CT) in terms of volumetric bone assessment, suggesting an approach for a cost-effective and low-radiation alternative for bone health evaluation in a three-dimensional (3D) fashion from a two-dimensional (2D) scan.</div></div><div><h3>Methods</h3><div>Data from 34 participants included aligned DXA and CT scans for the proximal femur. Intensity values were extracted in Hounsfield units, with 3D information mapped as target variables and 2D information as features. Two machine learning models, Extreme Gradient Boosting (XGB) and Gradient-Enhanced Neural Network (GENN), were trained using 5-fold cross-validation strategy and show an average registration accuracy of 0.89 ± 0.04, assessed thorough structural similarity index measure.</div></div><div><h3>Results</h3><div>Both models were built to predict the statistics of the 3D structure of the bone from a 2D image. The GENN model outperformed XGB, achieving mean absolute percentage errors (MAPE) of 12.98 ± 1.70%, 13.28 ± 2.01%, and 9.63 ± 1.66% for minimum, maximum, and the number of nonzero pixel intensities, respectively. In contrast, XGB's errors exceeded 16% across these metrics. The loss stabilized within 100 epochs, indicating model robustness and reliability across diverse test sets.</div></div><div><h3>Conclusions</h3><div>The proposed GENN framework offers a method for predicting 3D BMD distributions from a 2D-DXA scan, rivaling CT-based assessments. This approach reduces costs and radiation exposure, presenting a viable solution for personalized bone health evaluation and early osteoporosis diagnosis.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 3","pages":"Pages 98-106"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A new dimension of fragility fracture: Mortality","authors":"Tuan V. Nguyen","doi":"10.1016/j.afos.2025.08.042","DOIUrl":"10.1016/j.afos.2025.08.042","url":null,"abstract":"","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 3","pages":"Page 14"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ngoc Huynh , Krisel de Dios , Thach S. Tran , John Kemp , Lan Ho-Pham , Tuan V. Nguyen
{"title":"Novel genetic variants associated with bone mineral density in Asians: The Vietnam osteoporosis study","authors":"Ngoc Huynh , Krisel de Dios , Thach S. Tran , John Kemp , Lan Ho-Pham , Tuan V. Nguyen","doi":"10.1016/j.afos.2025.08.044","DOIUrl":"10.1016/j.afos.2025.08.044","url":null,"abstract":"","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 3","pages":"Pages 14-15"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recovery of bone mineral density following treatments of tenofovir-induced Fanconi syndrome: A case report","authors":"Yotsapon Thewjitcharoen , Soontaree Nakasatien , Thep Himathongkam","doi":"10.1016/j.afos.2025.08.020","DOIUrl":"10.1016/j.afos.2025.08.020","url":null,"abstract":"","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 3","pages":"Page 7"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An AI-agent for personalized time to repeat bone mineral density measurement","authors":"Dinh T. Nguyen , Thach S. Tran , Tuan V. Nguyen","doi":"10.1016/j.afos.2025.08.005","DOIUrl":"10.1016/j.afos.2025.08.005","url":null,"abstract":"","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 3","pages":"Page 2"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md Mizanur Rahman , Zayana Ali , Dhanya Kizhakayil , Khadega Ibrahim , Chiara Cugno
{"title":"DHA co-administration mitigates methylprednisolone therapy associated bone loss by regulating osteoclast and osteoblast activity","authors":"Md Mizanur Rahman , Zayana Ali , Dhanya Kizhakayil , Khadega Ibrahim , Chiara Cugno","doi":"10.1016/j.afos.2025.08.019","DOIUrl":"10.1016/j.afos.2025.08.019","url":null,"abstract":"","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 3","pages":"Pages 6-7"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy and safety of teriparatide in osteoporosis - Real world experience in a specialist hospital clinic","authors":"Abhaya Gupta","doi":"10.1016/j.afos.2025.08.038","DOIUrl":"10.1016/j.afos.2025.08.038","url":null,"abstract":"","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 3","pages":"Pages 12-13"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Type I diabetic patients and associated risk factors for osteoporosis","authors":"Abhaya Gupta","doi":"10.1016/j.afos.2025.08.036","DOIUrl":"10.1016/j.afos.2025.08.036","url":null,"abstract":"","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 3","pages":"Page 12"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}