Osteoporosis and Sarcopenia最新文献

{"title":"Reply on “teriparatide treatment for postmenopausal women with sacral insufficiency fracture”","authors":"Yao-Chun Yang, Min-Hong Hsieh, Jui-Teng Chien, Keng-Chang Liu, Chang-Chen Yang","doi":"10.1016/j.afos.2023.05.004","DOIUrl":"10.1016/j.afos.2023.05.004","url":null,"abstract":"","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"9 2","pages":"Page 77"},"PeriodicalIF":2.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f6/9c/main.PMC10366424.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TOC","authors":"","doi":"10.1016/S2405-5255(23)00038-9","DOIUrl":"https://doi.org/10.1016/S2405-5255(23)00038-9","url":null,"abstract":"","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"9 2","pages":"Page v"},"PeriodicalIF":2.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49763915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teriparatide treatment for postmenopausal women with sacral insufficiency fracture","authors":"Young-Hoon Kim","doi":"10.1016/j.afos.2023.05.003","DOIUrl":"10.1016/j.afos.2023.05.003","url":null,"abstract":"","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"9 2","pages":"Page 76"},"PeriodicalIF":2.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/32/ec/main.PMC10366427.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Summary of the Thai Osteoporosis Foundation (TOPF) Clinical Practice Guideline on the diagnosis and management of osteoporosis 2021","authors":"Natthinee Charatcharoenwitthaya ,&nbsp;Unnop Jaisamrarn ,&nbsp;Thawee Songpatanasilp ,&nbsp;Vilai Kuptniratsaikul ,&nbsp;Aasis Unnanuntana ,&nbsp;Chanika Sritara ,&nbsp;Hataikarn Nimitphong ,&nbsp;Lalita Wattanachanya ,&nbsp;Pojchong Chotiyarnwong ,&nbsp;Tanawat Amphansap ,&nbsp;Ong-Art Phruetthiphat ,&nbsp;Thanut Valleenukul ,&nbsp;Sumapa Chaiamnuay ,&nbsp;Aisawan Petchlorlian ,&nbsp;Varalak Srinonprasert ,&nbsp;Sirakarn Tejavanija ,&nbsp;Wasuwat Kitisomprayoonkul ,&nbsp;Piyapat Dajpratham ,&nbsp;Sukanya Chaikittisilpa ,&nbsp;Woraluk Somboonporn","doi":"10.1016/j.afos.2023.06.001","DOIUrl":"10.1016/j.afos.2023.06.001","url":null,"abstract":"<div><h3>Objectives</h3><p>The Thai Osteoporosis Foundation (TOPF) is an academic organization that consists of a multidisciplinary group of healthcare professionals managing osteoporosis. The first clinical practice guideline for diagnosing and managing osteoporosis in Thailand was published by the TOPF in 2010, then updated in 2016 and 2021. This paper presents important updates of the guideline for the diagnosis and management of osteoporosis in Thailand.</p></div><div><h3>Methods</h3><p>A panel of experts in the field of osteoporosis was recruited by the TOPF to review and update the TOPF position statement from 2016. Evidence was searched using the MEDLINE database through PubMed. Primary writers submitted their first drafts, which were reviewed, discussed, and integrated into the final document. Recommendations are based on reviews of the clinical evidence and experts' opinions. The recommendations are classified using the Grading of Recommendations, Assessment, Development, and Evaluation classification system.</p></div><div><h3>Results</h3><p>The updated guideline comprises 90 recommendations divided into 12 main topics. This paper summarizes the recommendations focused on 4 main topics: the diagnosis and evaluation of osteoporosis, fracture risk assessment and indications for bone mineral density measurement, fracture risk categorization, management according to fracture risk, and pharmacological management of osteoporosis.</p></div><div><h3>Conclusions</h3><p>This updated clinical practice guideline is a practical tool to assist healthcare professionals in diagnosing, evaluating, and managing osteoporosis in Thailand.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"9 2","pages":"Pages 45-52"},"PeriodicalIF":2.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c7/ae/main.PMC10366425.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone microarchitecture and bone mineral density in Graves’ disease","authors":"Hiya Boro ,&nbsp;Rakhi Malhotra ,&nbsp;Suraj Kubihal ,&nbsp;Saurav Khatiwada ,&nbsp;Vinay Dogra ,&nbsp;Velmurugan Mannar ,&nbsp;Ashok Kumar Ahirwar ,&nbsp;Vandana Rastogi","doi":"10.1016/j.afos.2023.05.001","DOIUrl":"10.1016/j.afos.2023.05.001","url":null,"abstract":"<div><h3>Objectives</h3><p>Graves' disease (GD) is the most common cause of thyrotoxicosis. There are many studies that have evaluated bone mineral density (BMD) in Graves’ disease. However, the strength of a bone also depends on its microarchitecture which can be assessed by various techniques. Trabecular bone score (TBS) is a new method for assessing bone microarchitecture that is non-invasive and easily performed.</p></div><div><h3>Methods</h3><p>The present study was a cross-sectional study that involved 50 patients with active GD and 50 healthy controls. Both groups were subjected to an assessment of biochemical parameters followed by measurement of BMD and TBS on the same dual energy X-ray absorptiometry (DXA) machine.</p></div><div><h3>Results</h3><p>The mean age of patients with active GD (N = 50) was 31.9 ± 10.9 years while that of controls was 31.2 ± 4.9 years (P = 0.640). The female: male ratio was the same for both groups (F = 31, M = 19). The mean lumbar spine BMD, femoral neck BMD, total hip BMD, and distal radius BMD were significantly reduced in GD when compared to that in controls. The mean absolute lumbar spine TBS in GD was 1.263 ± 0.101 while that in controls was 1.368 ± 0.073 (P &lt; 0.001). On multivariate regression analysis, the factors that predicted TBS were serum thyroxine (T4) and L₁-L₄ BMD.</p></div><div><h3>Conclusions</h3><p>Patients with Graves’ disease had reduced bone density at all sites and degraded microarchitecture. Long-term studies are required to understand the pattern of recovery of bone microarchitecture after the restoration of euthyroidism.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"9 2","pages":"Pages 70-75"},"PeriodicalIF":2.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/19/main.PMC10366428.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current issues in evaluation and management of osteoporosis in Thailand","authors":"Nipith Charoenngam ,&nbsp;Chatlert Pongchaiyakul","doi":"10.1016/j.afos.2023.05.002","DOIUrl":"10.1016/j.afos.2023.05.002","url":null,"abstract":"<div><p>Osteoporosis is a major public health issue in Thailand, which increased morbidity, mortality, and health-care utilization. The objective of this review is to provide current perspectives on epidemiology, evaluation and management of osteoporosis in Thailand. According to epidemiologic data, the prevalence of osteoporosis and the incidence of hip fracture were comparable to the rest of the world. However, among Thai postmenopausal women, the prevalence of asymptomatic vertebral fracture was disproportionately high. In addition to established risk factors, conditions that may affect the risk of osteoporosis in the Thai population include certain genetic variants, thalassemia, vitamin D deficiency, and low dietary calcium intake, which requires further investigations to draw conclusions. In 2021, the Thai Osteoporosis Foundation released a new Clinical Practice Guideline that provides up-to-date evidence-based recommendations for evaluation and management of osteoporosis. Nonetheless, more research is required to provide local evidence in a variety of areas to guide management of osteoporosis in Thailand. These include epidemiology of distal radial fracture, the optimal intervention threshold of the Thai-specific Fracture Risk Assessment Tool model, screening for asymptomatic vertebral fracture, and the economic evaluation of osteoporosis management options, including fracture liaison service.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"9 2","pages":"Pages 53-59"},"PeriodicalIF":2.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b7/05/main.PMC10366423.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A summary of the Malaysian Clinical Practice Guidelines on the management of postmenopausal osteoporosis, 2022","authors":"Terence Ing Wei Ong ,&nbsp;Lee Ling Lim ,&nbsp;Siew Pheng Chan ,&nbsp;Winnie Siew Swee Chee ,&nbsp;Alan Swee Hock Ch’ng ,&nbsp;Elizabeth Gar Mit Chong ,&nbsp;Premitha Damodaran ,&nbsp;Fen Lee Hew ,&nbsp;Luqman bin Ibrahim ,&nbsp;Hui Min Khor ,&nbsp;Pauline Siew Mei Lai ,&nbsp;Joon Kiong Lee ,&nbsp;Ai Lee Lim ,&nbsp;Boon Ping Lim ,&nbsp;Sharmila Sunita Paramasivam ,&nbsp;Jeyakantha Ratnasingam ,&nbsp;Yew Siong Siow ,&nbsp;Alexander Tong Boon Tan ,&nbsp;Nagammai Thiagarajan ,&nbsp;Swan Sim Yeap","doi":"10.1016/j.afos.2023.06.002","DOIUrl":"10.1016/j.afos.2023.06.002","url":null,"abstract":"<div><h3>Objectives</h3><p>The aim of these Clinical Practice Guidelines is to provide evidence-based recommendations to assist healthcare providers in the screening, diagnosis and management of patients with postmenopausal osteoporosis (OP).</p></div><div><h3>Methods</h3><p>A list of key clinical questions on the assessment, diagnosis and treatment of OP was formulated. A literature search using the PubMed, Medline, Cochrane Databases of Systematic Reviews, and OVID electronic databases identified all relevant articles on OP based on the key clinical questions, from 2014 onwards, to update from the 2015 edition. The articles were graded using the SIGN50 format. For each statement, studies with the highest level of evidence were used to frame the recommendation.</p></div><div><h3>Results</h3><p>This article summarizes the diagnostic and treatment pathways for postmenopausal OP. Risk stratification of patients with OP encompasses clinical risk factors, bone mineral density measurements and FRAX risk estimates. Non-pharmacological measures including adequate calcium and vitamin D, regular exercise and falls prevention are recommended. Pharmacological measures depend on patients’ fracture risk status. Very high-risk individuals are recommended for treatment with an anabolic agent, if available, followed by an anti-resorptive agent. Alternatively, parenteral anti-resorptive agents can be used. High-risk individuals should be treated with anti-resorptive agents. In low-risk individuals, menopausal hormone replacement or selective estrogen receptor modulators can be used, if indicated. Patients should be assessed regularly to monitor treatment response and treatment adjusted, as appropriate.</p></div><div><h3>Conclusions</h3><p>The pathways for the management of postmenopausal OP in Malaysia have been updated. Incorporation of fracture risk stratification can guide appropriate treatment.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"9 2","pages":"Pages 60-69"},"PeriodicalIF":2.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/55/5a/main.PMC10366466.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BONEcheck: a digital tool for personalized bone health assessment","authors":"D. T. Nguyen, T. Ho-Le, L. Pham, V. P. Ho-Van, T. Hoang, T. Tran, S. Frost, T. Nguyen","doi":"10.1101/2023.05.10.23289825","DOIUrl":"https://doi.org/10.1101/2023.05.10.23289825","url":null,"abstract":"Background and Aim: Osteoporotic fracture is a significant public health burden associated with increased mortality risk and substantial healthcare costs. Accurate and early identification of high-risk individuals and mitigation of their risks is a core part of the treatment and prevention of fractures. We aimed to introduce a digital tool called 'BONEcheck' for personalized bone health assessment. Methods: The development of BONEcheck primarily utilized data from the prospective population-based Dubbo Osteoporosis Epidemiology Study and the Danish Nationwide Registry. BONEcheck has 3 modules: input data, risk estimates, and risk context. Input variables include age, gender, prior fracture, fall incidence, bone mineral density (BMD), comorbidities, and genetic variants associated with BMD. By utilizing published methodologies, BONEcheck generates output related to the likelihood of fracture and its associated outcomes. The vocabulary utilized to convey risk estimation and management is tailored to individuals with a reading proficiency at level 8 or above. Results: The tool is designed for men and women aged 50 years and older who either have or have not sustained a fracture. Based on the input variables, BONEcheck estimates the probability of any fragility and hip fracture within 5 years, skeletal age, subsequent fracture, genetic risk score, and recommended interval for repeating BMD. The probability of fracture is shown in both numeric and human icon array formats. The risk is also presented in the context of treatment and management options based on Australian guidelines. Skeletal age was estimated as the sum of chronological age and years of life lost due to a fracture or exposure to risk factors that elevate mortality risk. In its entirety, BONEcheck is a system of algorithms translated into a single platform for personalized osteoporosis and fracture risk assessment. Conclusions: BONEcheck is a new system of algorithms that aims to offer not only fracture risk probability but also contextualize the efficacy of anti-fracture measures concerning the survival benefits. The tool can enable doctors and patients to engage in well-informed discussions and make decisions based on the patient's risk profile. Public access to BONEcheck is available via https://bonecheck.org and in Apple Store (iOS) and Google Play (Android).","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45188661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of the Chinese osteoporosis screening algorithm (COSA) in identification of people with high risk of osteoporosis","authors":"Ching-Lung Cheung ,&nbsp;Gloria HY. Li ,&nbsp;Hang-Long Li ,&nbsp;Constance Mak ,&nbsp;Kathryn CB. Tan ,&nbsp;Annie WC. Kung","doi":"10.1016/j.afos.2023.03.009","DOIUrl":"10.1016/j.afos.2023.03.009","url":null,"abstract":"<div><h3>Objectives</h3><p>To enhance the public awareness and facilitate diagnosis of osteoporosis, we aim to develop a new Chinese Osteoporosis Screening Algorithm (COSA) to identify people at high risk of osteoporosis.</p></div><div><h3>Methods</h3><p>A total of 4747 postmenopausal women and men aged ≥ 50 from the Hong Kong Osteoporosis Study were randomly split into a development (N = 2373) and an internal validation cohort (N = 2374). An external validation cohort comprising 1876 community-dwelling subjects was used to evaluate the positive predictive value (PPV).</p></div><div><h3>Results</h3><p>Among 11 predictors included, age, sex, weight, and history of fracture were significantly associated with osteoporosis after correction for multiple testing. Age- and sex-stratified models were developed due to the presence of significant sex and age interactions. The area under the curve of the COSA in the internal validation cohort was 0.761 (95% CI, 0.711–0.811), 0.822 (95% CI, 0.792–0.851), and 0.946 (95% CI, 0.908–0.984) for women aged &lt; 65, women aged ≥ 65, and men, respectively. The COSA demonstrated improved reclassification performance when compared to Osteoporosis Self-Assessment Tool for Asians. In the external validation cohort, the PPV of COSA was 40.6%, 59.4%, and 19.4% for women aged &lt; 65, women aged ≥ 65, and men, respectively. In addition, COSA &gt; 0 was associated with an increased 10-year risk of hip fracture in women ≥ 65 (OR, 4.65; 95% CI, 2.24–9.65) and men (OR, 11.51; 95% CI, 4.16–31.81).</p></div><div><h3>Conclusions</h3><p>We have developed and validated a new osteoporosis screening algorithm, COSA, specific for Hong Kong Chinese.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"9 1","pages":"Pages 8-13"},"PeriodicalIF":2.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111958/pdf/main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9385452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply on “Exploring optimal supplementation for people with vitamin D deficiency”","authors":"Tanawat Amphansap,&nbsp;Atiporn Therdyothin,&nbsp;Nitirat Stitkitti,&nbsp;Lertkong Nitiwarangkul,&nbsp;Vajarin Phiphobmongkol","doi":"10.1016/j.afos.2023.03.007","DOIUrl":"10.1016/j.afos.2023.03.007","url":null,"abstract":"","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"9 1","pages":"Pages 40-41"},"PeriodicalIF":2.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111936/pdf/main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9754520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}