Osteoporosis and Sarcopenia最新文献_第10页

Screening of fracture risk and osteoporosis among older long-term care residents: A before–after intervention study 老年长期护理居民骨折风险和骨质疏松症筛查：一项干预前后研究

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2023-12-01 DOI: 10.1016/j.afos.2023.11.011

Shau-Huai Fu , Cheng-Yo Lai , Chen-Yu Wang , Chih-Chien Hung , Jian-De Ye , Chih-Hsing Wu , Li-Jung Elizabeth Ku , Tsung Yu , Rong-Sen Yang , Fei-Yuan Hsiao , Chung-Yi Li

引用次数: 0

The effect of combined hormonal contraceptives usage on bone turnover markers: A systematic review and meta-analysis 联合使用激素避孕药对骨转换标志物的影响：系统回顾和荟萃分析

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2023-12-01 DOI: 10.1016/j.afos.2023.11.037

Dhawinee Kritsernvong , Sutira Uaamnuichai , Rada Poolkumlung , Lalita Wattanachanya , Paweena Susantitaphong , Jiayu Li , Sukanya Chaikittisilpa , Somsook Santibenchakul , Unnop Jaisamrarn

引用次数: 0

Sequential therapy with denosumab and zoledronate for osteoporosis management a randomized controlled trial 地诺单抗和唑来膦酸钠序贯治疗骨质疏松症：随机对照试验

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2023-12-01 DOI: 10.1016/j.afos.2023.11.004

Hung-Kuan Yen , Chen-Yu Wang , Chia-Che Lee , Shau-Huai Fu , Olivier Q. Groot

引用次数: 0

A nomogram for prediction of 1-year postoperative mortality risk in geriatric patients with a hip fracture 预测老年髋部骨折患者术后1年死亡风险的nomogram

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2023-12-01 DOI: 10.1016/j.afos.2023.11.014

Cheng-Yi Wu , Yu-Teng Wang , Ching-Fang Tsai , Hsin-Yi Yang

引用次数: 0

TOC TOC

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2023-12-01 DOI: 10.1016/S2405-5255(24)00029-3

引用次数: 0

Nonalcoholic fatty liver disease is associated with decreased bone mineral density in adults: A systematic review and meta-analysis 非酒精性脂肪性肝病与成人骨密度降低相关：一项系统综述和荟萃分析

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2023-12-01 DOI: 10.1016/j.afos.2023.11.035

Ying-Hao Su , Kuo-Liong Chien , Shu-Hua Yang , Wei-Tso Chia , Jen-Hau Chen , Yen-Ching Chen

引用次数: 0

Comprehensive geriatric assessment for identifying mortality risk in older patients after hip fracture surgery 髋部骨折术后老年患者死亡风险的综合老年评估

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2023-12-01 DOI: 10.1016/j.afos.2023.11.015

Nai-Chen Shih , Cheng-Hung Lee , Kun-Hui Chen , Shih-Yi Lin

引用次数: 0

BONEcheck: A digital tool for personalized bone health assessment BONEcheck:用于个性化骨骼健康评估的数字工具

IF 2

Osteoporosis and Sarcopenia Pub Date : 2023-09-01 DOI: 10.1016/j.afos.2023.08.002

Dinh Tan Nguyen , Thao P. Ho-Le , Liem Pham , Vinh P. Ho-Van , Tien Dat Hoang , Thach S. Tran , Steve Frost , Tuan V. Nguyen

{"title":"BONEcheck: A digital tool for personalized bone health assessment","authors":"Dinh Tan Nguyen , Thao P. Ho-Le , Liem Pham , Vinh P. Ho-Van , Tien Dat Hoang , Thach S. Tran , Steve Frost , Tuan V. Nguyen","doi":"10.1016/j.afos.2023.08.002","DOIUrl":"https://doi.org/10.1016/j.afos.2023.08.002","url":null,"abstract":"<div><h3>Objectives</h3><p>Osteoporotic fracture is a significant public health burden associated with increased mortality risk and substantial healthcare costs. Accurate and early identification of high-risk individuals and mitigation of their risks is a core part of the treatment and prevention of fractures. Here we introduce a digital tool called 'BONEcheck' for personalized assessment of bone health.</p></div><div><h3>Methods</h3><p>The development of BONEcheck primarily utilized data from the prospective population-based Dubbo Osteoporosis Epidemiology Study and the Danish Nationwide Registry. BONEcheck has 3 modules: input data, risk estimates, and risk context. Input variables include age, gender, prior fracture, fall incidence, bone mineral density (BMD), comorbidities, and genetic variants associated with BMD.</p></div><div><h3>Results</h3><p>Based on the input variables, BONEcheck estimates the probability of any fragility fracture and hip fracture within 5 years, subsequent fracture risk, skeletal age, and time to reach osteoporosis. The probability of fracture is shown in both numeric and human icon array formats. The risk is also contextualized within the framework of treatment and management options on Australian guidelines, with consideration given to the potential fracture risk reduction and survival benefits. Skeletal age was estimated as the sum of chronological age and years of life lost due to a fracture or exposure to risk factors that elevate mortality risk.</p></div><div><h3>Conclusions</h3><p>BONEcheck is an innovative tool that empowers doctors and patients to engage in well-informed discussions and make decisions based on the patient's risk profile. Public access to BONEcheck is available via <span>https://bonecheck.org</span><svg><path></path></svg> and in Apple Store (iOS) and Google Play (Android).</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"9 3","pages":"Pages 79-87"},"PeriodicalIF":2.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49763914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between masticatory ability and lower Timed Up & Go Test performance among community-dwelling Japanese aging men and women: The Toon Health Study 日本社区老年男性和女性咀嚼能力与较低时间Up & Go测试成绩之间的关系:香椿健康研究

IF 2

Osteoporosis and Sarcopenia Pub Date : 2023-09-01 DOI: 10.1016/j.afos.2023.08.001

Saori Miyazaki , Koutatsu Maruyama , Kiyohide Tomooka , Shinji Nishioka , Noriko Miyoshi , Ryoichi Kawamura , Yasunori Takata , Haruhiko Osawa , Takeshi Tanigawa , Isao Saito

{"title":"The association between masticatory ability and lower Timed Up & Go Test performance among community-dwelling Japanese aging men and women: The Toon Health Study","authors":"Saori Miyazaki , Koutatsu Maruyama , Kiyohide Tomooka , Shinji Nishioka , Noriko Miyoshi , Ryoichi Kawamura , Yasunori Takata , Haruhiko Osawa , Takeshi Tanigawa , Isao Saito","doi":"10.1016/j.afos.2023.08.001","DOIUrl":"10.1016/j.afos.2023.08.001","url":null,"abstract":"<div><h3>Objectives</h3><p>Few studies examined the association between deterioration of masticatory ability assessed by objective marker and physical function. Therefore, we examined the association between salivary flow rate which is one of the objective and surrogate marker of masticatory ability and lower Timed Up & Go (TUG) performance which is one of major measurement of physical function among aging Japanese.</p></div><div><h3>Methods</h3><p>This cross-sectional study enrolled 464 Japanese aged 60–84 years old. Participants chewed tasteless and odorless gum for 5 min, calculated stimulated salivary flow rate (g/min) during all chews. The 3 m TUG was conducted, and 75th percentile value (6.8 s for men and 7.0 s for women) or higher was defined as lower TUG performance. Logistic regression analysis was used to examine the association between stimulated salivary flow rate and lower TUG performance.</p></div><div><h3>Results</h3><p>We found that the stimulated salivary flow rate tended to be negatively associated with the TUG time. We also observed significant negative association between stimulated salivary flow rate and lower TUG performance; the multivariable-adjusted OR (95% confidence interval, CIs) of lower TUG performance for the highest quartile of stimulated salivary flow rate compared with the lowest quartile was 0.34 (0.16–0.69, P for trend = 0.02). Further adjusting for BMI, the association was attenuated but remaind significant; the OR (95% CIs) in highest quartile was 0.37 (0.18–0.76, P for trend = 0.04).</p></div><div><h3>Conclusions</h3><p>Higher stimulated salivary flow, which means well masticatory ability, was inversely associated with lower TUG performance in the aging Japanese population.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"9 3","pages":"Pages 94-98"},"PeriodicalIF":2.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42401529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring molecular mechanisms underlying the pathophysiological association between knee osteoarthritis and sarcopenia 探讨膝关节骨关节炎和肌肉减少症之间病理生理关联的分子机制

IF 2

Osteoporosis and Sarcopenia Pub Date : 2023-09-01 DOI: 10.1016/j.afos.2023.08.005

Jiyong Yang , Tao Jiang , Guangming Xu , Shuai Wang , Wengang Liu

{"title":"Exploring molecular mechanisms underlying the pathophysiological association between knee osteoarthritis and sarcopenia","authors":"Jiyong Yang , Tao Jiang , Guangming Xu , Shuai Wang , Wengang Liu","doi":"10.1016/j.afos.2023.08.005","DOIUrl":"https://doi.org/10.1016/j.afos.2023.08.005","url":null,"abstract":"<div><h3>Objectives</h3><p>Accumulating evidence indicates a strong link between knee osteoarthritis (KOA) and sarcopenia. However, the mechanisms involved have not yet been elucidated. This study primarily aims to explore the molecular mechanisms that explain the connection between these 2 disorders.</p></div><div><h3>Methods</h3><p>The gene expression profiles for KOA and sarcopenia were obtained from the Gene Expression Omnibus database, specifically from GSE55235, GSE169077, and GSE1408. Various bioinformatics techniques were employed to identify and analyze common differentially expressed genes (DEGs) across the 3 datasets. The techniques involved the analysis of Gene Ontology and pathways to enhance understanding, examining protein-protein interaction (PPI) networks, and identifying hub genes. In addition, we constructed the network of interactions between transcription factors (TFs) and genes, the co-regulatory network of TFs and miRNAs for hub genes, and predicted potential drugs.</p></div><div><h3>Results</h3><p>In total, 14 common DEGs were found between KOA and sarcopenia. Detailed information on biological processes and signaling pathways of common DEGs was obtained through enrichment analysis. After performing PPI network analysis, we discovered 4 hub genes (FOXO3, BCL6, CDKN1A, and CEBPB). Subsequently, we developed coregulatory networks for these hub genes involving TF-gene and TF-miRNA interactions. Finally, we identified 10 potential chemical compounds.</p></div><div><h3>Conclusions</h3><p>By conducting bioinformatics analysis, our study has successfully identified common gene interaction networks between KOA and sarcopenia. The potential of these findings to offer revolutionary understanding into the common development of these 2 conditions could lead to the identification of valuable targets for therapy.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"9 3","pages":"Pages 99-111"},"PeriodicalIF":2.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49744289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0