Osteoporosis and Sarcopenia最新文献_第9页

Addressing challenges in osteoporosis management in Vietnam 应对越南骨质疏松症管理的挑战

IF 2.8

Osteoporosis and Sarcopenia Pub Date : 2025-09-01 Epub Date: 2025-09-12 DOI: 10.1016/j.afos.2025.08.043

Tuan V. Nguyen

引用次数: 0

Bone health evaluation among staff at Pham Ngoc Thach University of Medicine 范玉达医科大学员工骨骼健康评估

IF 2.8

Osteoporosis and Sarcopenia Pub Date : 2025-09-01 Epub Date: 2025-09-12 DOI: 10.1016/j.afos.2025.08.033

Binh V. Dang , Lan T. Ho-Pham , Son T. Tran , Nhu Huynh , Huy G. Nguyen

引用次数: 0

Anticholinergic burden in older patients presenting with hip fracture in Brunei Darussalam 文莱达鲁萨兰国老年髋部骨折患者的抗胆碱能负担

IF 2.8

Osteoporosis and Sarcopenia Pub Date : 2025-09-01 Epub Date: 2025-09-12 DOI: 10.1016/j.afos.2025.08.040

Muhammad Amirsalman Nor Azman , Chia Wei Tan

引用次数: 0

Are there associations between bone turnover and hip geometry in the general population? 在一般人群中，骨转换和髋关节几何形状之间是否存在关联？

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-06-01 Epub Date: 2025-06-07 DOI: 10.1016/j.afos.2025.05.007

Cornelius Sebastian Fischer , Till Ittermann , Sarah Kalmbach , Moritz Herbst , Tina Histing , Jörn Lange , Anke Hannemann

{"title":"Are there associations between bone turnover and hip geometry in the general population?","authors":"Cornelius Sebastian Fischer , Till Ittermann , Sarah Kalmbach , Moritz Herbst , Tina Histing , Jörn Lange , Anke Hannemann","doi":"10.1016/j.afos.2025.05.007","DOIUrl":"10.1016/j.afos.2025.05.007","url":null,"abstract":"<div><h3>Objectives</h3><div>While impaired bone remodeling contributes to osteoporosis and probably to osteoarthritis, the relations between bone turnover and key hip geometry measures such as center-edge angle (CE), neck-shaft angle (NSA) or alpha angle remain unknown. We here examined the presence of associations between two bone turnover markers with hip geometric measures in adults from the general population.</div></div><div><h3>Methods</h3><div>Data from 2037 participants (50% women) in the Study of Health in Pomerania-TREND were examined. Hip geometric parameters were obtained using magnetic resonance imaging. Serum concentrations of carboxy-terminal telopeptide of Type I collagen (CTX, bone resorption) and intact amino-terminal propeptide of Type I procollagen (P1NP, bone formation) were measured to assess bone turnover.</div></div><div><h3>Results</h3><div>In sex-specific linear regression models adjusted for age, body mass index and physical inactivity, positive associations between CTX or P1NP and CE and inverse associations with NSA were detected. The latter were restricted to men. Thus, an increase in bone formation or resorption is related to less dysplastic (both sexes). Additionally, men with more valgus hips have lower bone turnover markers. For the alpha angle, no significant association was present.</div></div><div><h3>Conclusions</h3><div>The observed associations between bone turnover markers and hip geometry confirm the presence of relevant relations between bone properties and hip geometry. This knowledge may aid in detection of vulnerable groups with respect to osteoarthritis and fracture risk.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 2","pages":"Pages 50-56"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutrition and exercise for sarcopenia treatment 营养和运动治疗肌肉减少症

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-06-01 Epub Date: 2025-06-18 DOI: 10.1016/j.afos.2025.05.008

Hunkyung Kim , Jiwan Kim , Chahee Lee , Seohee Kim

{"title":"Nutrition and exercise for sarcopenia treatment","authors":"Hunkyung Kim , Jiwan Kim , Chahee Lee , Seohee Kim","doi":"10.1016/j.afos.2025.05.008","DOIUrl":"10.1016/j.afos.2025.05.008","url":null,"abstract":"<div><div>Sarcopenia, the age-related loss of muscle mass, strength, and performance, is a significant concern in the aging population. Despite extensive research, no consensus exists on its prevention and treatment. Sarcopenia increases the risk of functional disability, falls, hospitalization, long-term care, morbidity, and mortality among older adults.</div><div>Currently, no approved pharmacological treatments for sarcopenia exist, making exercise and nutrition the most effective interventions. Evidence indicates that targeted exercise reduces risk factors, preventing or treating sarcopenia in older adults. Progressive, moderate-intensity exercise, alone or combined with nutritional supplementation, is recommended to mitigate muscle deterioration associated with aging. While non-pharmacological interventions are the primary approach, conflicting evidence exists regarding the most effective exercise and nutrition strategies. This review highlights that single intervention, such as exercise or nutritional supplementation alone, provide limited benefits for preventing or treating sarcopenia. In contrast, combined interventions, comprehensive exercise training and nutritional supplementation, effectively improve clinical indicators, including muscle mass, strength, and gait speed, in older adults with sarcopenia.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 2","pages":"Pages 54-64"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for osteoporosis 系统可用药全基因组孟德尔随机化确定骨质疏松症的治疗靶点

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-06-01 Epub Date: 2025-06-07 DOI: 10.1016/j.afos.2025.06.001

Chiyun Sun , Ruikang Liu , Jiaming Hu , Weiming Fan , Chuanrui Sun , Pengcheng Shan , Xu Wei

{"title":"Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for osteoporosis","authors":"Chiyun Sun , Ruikang Liu , Jiaming Hu , Weiming Fan , Chuanrui Sun , Pengcheng Shan , Xu Wei","doi":"10.1016/j.afos.2025.06.001","DOIUrl":"10.1016/j.afos.2025.06.001","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study was to find potential drug targets of osteoporosis (OP) through systematic druggable genome-wide Mendelian randomization (MR) analysis.</div></div><div><h3>Methods</h3><div>Combining the multi-omics data, we utilized drug target MR and mediation MR to search for potential drug targets of OP and their possible pathways. Functional enrichment analyses were used to identify metabolic pathways of potential drug targets. In addition, we performed a two-sample MR analysis to investigate the causal relationship between immunoexpression and OP. Finally, we conducted Phe-MR analysis and drug prediction to determine the indications, potential side effects, and pharmacological activities of previously tested targets.</div></div><div><h3>Results</h3><div>We screened three potential targets of OP-TAS1R3, TMX2, and SREBF1. Mediation MR analysis revealed that body mass index, type 2 diabetes, and chemokine C-C motif ligand 4 may be mediators for the above targets to act on OP. The Steiger Filtering test did not find a reverse causality. The results of functional enrichment analysis showed that the identified target genes may affect OP through lipid metabolism, immune expression, and insulin resistance. Two-sample MR analysis showed that HLA-DR expression in multiple monocyte subpopulations was associated with OP. The five drugs including sucrose, mirtazapine, aspartame, ginsenoside and ezetimibe are identified as the most probable candidates for the treatment of OP. Phe-MR found that TAS1R3 was associated with lower systolic blood pressure, TMX2 with neurologic and lipid metabolism, and SREBF1 with muscle power.</div></div><div><h3>Conclusions</h3><div>Our study provides evidence support for TAS1R3, TMX2, and SREBF1 as drug targets for OP.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 2","pages":"Pages 57-64"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing muscle aging and sarcopenia research through spatial transcriptomics 通过空间转录组学推进肌肉老化和肌肉减少症的研究

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-06-01 Epub Date: 2025-06-12 DOI: 10.1016/j.afos.2025.05.002

Byeong-Don Min , Chae Young Hwang , Doyeong Kim , Sang-Yun Kim , Jayasinghage Nirmani Chathurangika Jayasinghe , Minh Nhat Tran , Sang-Min Park , Ki-Sun Kwon

{"title":"Advancing muscle aging and sarcopenia research through spatial transcriptomics","authors":"Byeong-Don Min , Chae Young Hwang , Doyeong Kim , Sang-Yun Kim , Jayasinghage Nirmani Chathurangika Jayasinghe , Minh Nhat Tran , Sang-Min Park , Ki-Sun Kwon","doi":"10.1016/j.afos.2025.05.002","DOIUrl":"10.1016/j.afos.2025.05.002","url":null,"abstract":"<div><div>Sarcopenia, defined as a decline of muscle mass and function with aging, poses significant health challenges. This decline is driven by multiple factors including cellular dysfunction, mitochondrial impairments, oxidative stress, and chronic inflammation, all of which collectively disrupt muscle homeostasis and regeneration. Despite the lack of approved treatments for sarcopenia, the search for effective therapies continues as various pharmacological interventions are currently in the early stage of development. Recent advances in transcriptomics have enhanced our understanding of the molecular and cellular mechanisms underlying skeletal muscle aging. In particular, spatial transcriptomics (ST) has revolutionized the field of sarcopenia research by capturing the spatial context of gene expression to uncover site-specific regulation and cellular interactions within tissues. In this review, we explore the current knowledge of sarcopenia, the mechanisms underlying muscle aging, and recent developments in therapeutic strategies. Furthermore, we examine recent studies employing ST that have provided critical insights into the spatial heterogeneity of muscle aging and atrophy, revealing novel cellular and molecular targets for intervention. By connecting muscle pathophysiology with spatial information, ST holds promise for guiding the development of novel sarcopenia therapies, ultimately improving outcomes for aging populations worldwide.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 2","pages":"Pages 22-31"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcopenic obesity in the Asia-Pacific region: Epidemiology, risk factors, and management 亚太地区肌肉减少型肥胖：流行病学、危险因素和管理

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-06-01 Epub Date: 2025-05-21 DOI: 10.1016/j.afos.2025.05.001

Chun-Feng Huang , Chih-Hsing Wu

{"title":"Sarcopenic obesity in the Asia-Pacific region: Epidemiology, risk factors, and management","authors":"Chun-Feng Huang , Chih-Hsing Wu","doi":"10.1016/j.afos.2025.05.001","DOIUrl":"10.1016/j.afos.2025.05.001","url":null,"abstract":"<div><div>Sarcopenic obesity (SO), characterized by the concurrent presence of sarcopenia and obesity, is an emerging public health challenge in the Asia–Pacific region. With rapid population aging and increasing obesity rates, the prevalence of SO is increasing, particularly among individuals over 60 years of age. This condition results from a complex interplay of muscle loss, fat accumulation, chronic inflammation, hormonal changes, and metabolic dysregulation, leading to heightened risks of frailty, disability, cardiovascular disease, and mortality.</div><div>Region-specific risk factors, including dietary transitions, reduced physical activity, and socioeconomic disparities, further contribute to its increasing prevalence. While pharmacological options are under investigation, lifestyle modifications remain the cornerstone of prevention and management. Regular resistance training, adequate protein intake, and balanced nutrition are essential for preserving muscle mass while promoting fat reduction. Community-based interventions, such as structured exercise programs, public health campaigns, and urban planning that encourage active aging, are crucial for sustainable long-term outcomes.</div><div>The current inconsistency in diagnostic criteria has led to numerous challenges, highlighting the urgent need for consensus. In addition, targeted policies focusing on nutritional education, elderly friendly infrastructure, and access to preventive healthcare are essential to alleviating the burden of SO. A comprehensive approach that integrates lifestyle interventions, clinical advancements, and supportive policies is crucial for effectively addressing the growing impact of SO in the Asia–Pacific region and improving health outcomes for the aging population.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 2","pages":"Pages 40-49"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FM - Editorial Board FM -编委会

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-06-01 Epub Date: 2025-06-27 DOI: 10.1016/S2405-5255(25)00038-X

引用次数: 0

Hypophosphatasia in childhood: Diagnosis to management 儿童低磷症：诊断到治疗

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-06-01 Epub Date: 2025-06-09 DOI: 10.1016/j.afos.2025.05.003

Minji Im, Sung Yoon Cho

引用次数: 0