Osteoporosis and Sarcopenia最新文献_第9页

Recognizing the importance of physical activity on sarcopenia in chronic kidney disease - Reply 认识到体育活动对慢性肾脏病少肌症的重要性-回复

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-03-01 DOI: 10.1016/j.afos.2022.02.001

Avinash Kumar Dubey, Jayaprakash Sahoo, Balasubramanian Vairappan, Sreejith Parameswaran, Priyamvada PS

引用次数: 0

Inverse association between sarcopenia and displacement in the early phase of fragility fractures of the pelvis 骨盆脆性骨折早期肌少症与移位呈负相关

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-03-01 DOI: 10.1016/j.afos.2022.03.002

Shintaro Honda, Satoshi Ota, Shinnosuke Yamashita, Tadashi Yasuda

{"title":"Inverse association between sarcopenia and displacement in the early phase of fragility fractures of the pelvis","authors":"Shintaro Honda, Satoshi Ota, Shinnosuke Yamashita, Tadashi Yasuda","doi":"10.1016/j.afos.2022.03.002","DOIUrl":"10.1016/j.afos.2022.03.002","url":null,"abstract":"<div><h3>Objectives</h3><p>Fragility fractures of the pelvis (FFP) commonly occur in the frail elderly. Displacement in the posterior pelvic ring is recognized as the key sign of instability. This study aims to elucidate the relationship between computer tomography (CT)-based frailty markers and displacement of the posterior pelvic ring within 7 days after injury.</p></div><div><h3>Methods</h3><p>This retrospective study included 49 patients (42 females, 7 males) with FFP (type I 10, type II 24, type III 12, type IV 3). On a CT slice at the level of the third lumbar vertebra, skeletal muscle area, skeletal muscle radiation attenuation, and skeletal muscle index (SMI) were calculated as sarcopenia markers. Osteopenia was measured with trabecular region of interest attenuation technique on the same CT slice.</p></div><div><h3>Results</h3><p>There was no difference in the demographics between non-displaced and displaced FFP. CT-based data showed that patients with FFP had osteopenia. However, no difference was found between non-displaced and displaced FFP. SMI was higher in FFP types III/IV than non-displaced FFP when CT-based data on sarcopenia were compared among all patients. Female patients with FFP demonstrated similar results. Logistic regression analysis using the demographics and CT-based markers on sarcopenia and osteopenia revealed that SMI was a potential determinant of displacement of the posterior pelvic ring fractures.</p></div><div><h3>Conclusions</h3><p>There was inverse association between sarcopenia and displacement of the posterior pelvic ring in the early phase of FFP. Relatively preserved muscle may develop displacement in the elderly with osteopenia.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"8 1","pages":"Pages 24-29"},"PeriodicalIF":2.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405525522000048/pdfft?md5=ee6ae9f5b01ca3410ffa532f4c018109&pid=1-s2.0-S2405525522000048-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46479203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hungry bone syndrome following parathyroidectomy for primary hyperparathyroidism in a developed country in the Asia Pacific. A cohort study 在亚太发达国家原发性甲状旁腺功能亢进的甲状旁腺切除术后的饥饿骨综合征。队列研究

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-03-01 DOI: 10.1016/j.afos.2022.03.004

Manju Chandran , John P. Bilezikian , Nurshazwani Mat Salleh , Hao Ying , Joel Lau , James Lee , Mechteld C. deJong , Aye Chan Maung , Rajeev Parameswaran

{"title":"Hungry bone syndrome following parathyroidectomy for primary hyperparathyroidism in a developed country in the Asia Pacific. A cohort study","authors":"Manju Chandran , John P. Bilezikian , Nurshazwani Mat Salleh , Hao Ying , Joel Lau , James Lee , Mechteld C. deJong , Aye Chan Maung , Rajeev Parameswaran","doi":"10.1016/j.afos.2022.03.004","DOIUrl":"10.1016/j.afos.2022.03.004","url":null,"abstract":"<div><h3>Objectives</h3><p>We sought to assess the incidence of hungry bone syndrome (HBS) following parathyroidectomy (PTX) for primary hyperparathyroidism (PHPT) in a cohort of multi-ethnic patients from a developed country in the Asia Pacific.</p></div><div><h3>Methods</h3><p>One hundred and sixty-four patients who underwent PTX for PHPT between 2012 and 2019 at the 2 largest public hospitals in Singapore were identified. HBS was defined as serum albumin-adjusted calcium ≤ 2.1 mmol/L with normal or raised serum intact parathyroid hormone (iPTH) levels, manifesting on or after the 3rd day, or persisting for more than 3 days post-operatively.</p></div><div><h3>Results</h3><p>Chinese constituted 73.8%, Malays 12.2%, Indians 9.8%, and other races 4.3%. HBS developed in 4 patients (2.4%) (95% CI, 0.8%–6.5%). HBS patients had significantly longer in-hospital stays; 20 days [IQR:15–22] vs 2 days [IQR:1–3]; P < 0.001in those who did not develop HBS. There was no difference in the incidence of HBS stratifying for age, sex, vitamin D status, or use of preoperative anti-resorptive medication use. For every 10 unit increase in iPTH and alkaline phosphatase (ALP) levels, the risk of HBS increased by 14% and 11%; RR (95% CI), 1.14 (1.05–1.21) and 1.11 (1.03–1.18), respectively.</p></div><div><h3>Conclusions</h3><p>The low incidence of HBS in multi-ethnic patients undergoing PTX by multiple surgeons for PHPT at the 2 largest public hospitals that see the most such patients in Singapore, a developed country, is consistent with the asymptomatic/milder form of presentation of PHPT in the developed world.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"8 1","pages":"Pages 11-16"},"PeriodicalIF":2.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405525522000061/pdfft?md5=4a534d5087207de189f4a00df28b3593&pid=1-s2.0-S2405525522000061-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45058675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Role of prolyl hydroxylase domain proteins in bone metabolism 脯氨酸羟化酶结构域蛋白在骨代谢中的作用

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-03-01 DOI: 10.1016/j.afos.2022.03.001

David Wolf , Aruljothi Muralidharan , Subburaman Mohan

{"title":"Role of prolyl hydroxylase domain proteins in bone metabolism","authors":"David Wolf , Aruljothi Muralidharan , Subburaman Mohan","doi":"10.1016/j.afos.2022.03.001","DOIUrl":"10.1016/j.afos.2022.03.001","url":null,"abstract":"<div><p>Cellular metabolism requires dissolved oxygen gas. Because evolutionary refinements have constrained mammalian dissolved oxygen levels, intracellular oxygen sensors are vital for optimizing the bioenergetic and biosynthetic use of dissolved oxygen. Prolyl hydroxylase domain (PHD) homologs 1–3 (PHD1/2/3) are molecular oxygen dependent non-heme dioxygenases whose enzymatic activity is regulated by the concentration of dissolved oxygen. PHD oxygen dependency has evolved into an important intracellular oxygen sensor. The most well studied mechanism of PHD oxygen-sensing is its regulation of the hypoxia-inducible factor (HIF) hypoxia signaling pathway. Heterodimeric HIF transcription factor activity is regulated post-translationally by selective PHD proline hydroxylation of its HIF1α subunit, accelerating HIF1α ubiquitination and proteasomal degradation, preventing HIF heterodimer assembly, nuclear accumulation, and activation of its target oxygen homeostasis genes. <em>Phd2</em> has been shown to be the key isoform responsible for HIF1α subunit regulation in many cell types and accordingly disruption of the <em>Phd2</em> gene results in embryonic lethality. In bone cells <em>Phd2</em> is expressed in high abundance and tightly regulated. Conditional disruption of the <em>Phd1, Phd2 and/or Phd3</em> gene in various bone cell types using different Cre drivers reveals a major role for PHD2 in skeletal growth and development. In this review, we will summarize the state of current knowledge on the role and mechanism of action of PHD2 as oxygen sensor in regulating bone metabolism.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"8 1","pages":"Pages 1-10"},"PeriodicalIF":2.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405525522000036/pdfft?md5=14c58aa6f780a5de7f20126971f9bb7b&pid=1-s2.0-S2405525522000036-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41558935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Epidemiology and postoperative complications of hip fracture during COVID-19 pandemic 新冠肺炎大流行期间髋部骨折的流行病学及术后并发症

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-03-01 DOI: 10.1016/j.afos.2022.03.003

Kwang Kyoun Kim , Soek-Won Lee , Jae-Kyu Choi , Ye-Yeon Won

{"title":"Epidemiology and postoperative complications of hip fracture during COVID-19 pandemic","authors":"Kwang Kyoun Kim , Soek-Won Lee , Jae-Kyu Choi , Ye-Yeon Won","doi":"10.1016/j.afos.2022.03.003","DOIUrl":"10.1016/j.afos.2022.03.003","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aims to analyze the changes in epidemiology and the postoperative outcomes in patients with hip fractures during the COVID-19 pandemic compared to non-pandemic period.</p></div><div><h3>Methods</h3><p>According to the date of declaration of “mandatory social distance”, we separated patients into 2 groups over a 1-year period: Period A and period B. We assessed the overall time to surgery, delay in surgery (> 24 hours, > 36 hours, and > 48 hours), reason of delay, length of hospital stay, type of surgery, and postoperative complications.</p></div><div><h3>Results</h3><p>The number of operated hip fractures and other trauma decreased in period B compared with period A by 17%, and 23%, respectively. The number of patients with delay in surgery by > 24 hours and > 36 hours was significantly higher in period B compared to that in period A (P = 0.035, P = 0.012, respectively). However, no significant difference in the number of delay in surgery > 48 hours and mean overall time to surgery between the 2 groups was observed (P = 0.856, P = 0.399, respectively). There was no difference in the duration of hospital stay, type of surgery, and postoperative complications between periods A and B.</p></div><div><h3>Conclusions</h3><p>During the COVID-19 pandemic, the decrease in hip fractures was relatively fewer compared to the decrease in orthopedic trauma. Although hip fracture surgeries were delayed for over 24 hours and 36 hours, there was no increase in delay for over 48 hours and postoperative complications.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"8 1","pages":"Pages 17-23"},"PeriodicalIF":2.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S240552552200005X/pdfft?md5=5a320a235499020555348e77aa340e15&pid=1-s2.0-S240552552200005X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46091993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Prevalence and determinants of sarcopenia in Indian patients with chronic kidney disease stage 3 & 4 印度慢性肾病3期和4期患者肌肉减少症的患病率和决定因素

IF 2

Osteoporosis and Sarcopenia Pub Date : 2021-12-01 DOI: 10.1016/j.afos.2021.11.003

Avinash Kumar Dubey , Jayaprakash Sahoo , Balasubramaniyan Vairappan , Sreejith Parameswaran , Priyamvada PS

{"title":"Prevalence and determinants of sarcopenia in Indian patients with chronic kidney disease stage 3 & 4","authors":"Avinash Kumar Dubey , Jayaprakash Sahoo , Balasubramaniyan Vairappan , Sreejith Parameswaran , Priyamvada PS","doi":"10.1016/j.afos.2021.11.003","DOIUrl":"10.1016/j.afos.2021.11.003","url":null,"abstract":"<div><h3>Objectives</h3><p>There is limited literature on the prevalence and determinants of sarcopenia in the Indian predialysis chronic kidney disease (CKD) population. The current study attempts to characterize sarcopenia in CKD stages 3 & 4 using 3-compartment model dual-energy X-ray absorptiometry (DXA).</p></div><div><h3>Methods</h3><p>This is secondary data from a randomized trial on bicarbonate supplementation for preserving muscle mass. A 3-compartment DXA was done to assess body composition in 188 subjects aged 18 to 65, with stable kidney function. Sarcopenia was defined by Asian Working Group criteria - appendicular skeletal mass index < 5.4 kg/m<sup>2</sup> in women and < 7 kg/m<sup>2</sup> in men.</p></div><div><h3>Results</h3><p>Sarcopenia was present in 69.1% (n = 130). There was no difference in the prevalence of sarcopenia in CKD stage 3 (n = 62; 72.1%) vs CKD stage 4 (n = 68, 66.7%); P = 0.434. A lower body mass index (BMI) (OR 1.69; 95% CI 1.43, 2.01) and lower bicarbonate levels (OR 1.22; 95% CI 1.02, 1.47), and age (OR 0.95; 95% CI 0.91, 0.98) was independently associated with the muscle mass. A BMI cut-off of 18 failed to identify sarcopenia in 78.4% (n = 102) subjects (Kappa statistic 0.396). The receiver operating characteristic curve for mid-arm muscle circumference for identifying sarcopenia was 0.651 (95% CI 0.561, 0.740).</p></div><div><h3>Conclusions</h3><p>Sarcopenia is highly prevalent in CKD 3 and 4. Sarcopenic individuals are older, with a low BMI and lower bicarbonate levels. The anthropometric parameters and biochemical parameters did not help identify sarcopenia in the predialysis population.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"7 4","pages":"Pages 153-158"},"PeriodicalIF":2.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b5/3a/main.PMC8714469.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39678863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

TOC 技术选择委员会

IF 2

Osteoporosis and Sarcopenia Pub Date : 2021-12-01 DOI: 10.1016/S2405-5255(21)00090-X

引用次数: 0

Analysis of bone in adenine-induced chronic kidney disease model rats 腺嘌呤诱导的慢性肾病模型大鼠骨结构分析

IF 2

Osteoporosis and Sarcopenia Pub Date : 2021-12-01 DOI: 10.1016/j.afos.2021.11.001

Hikaru Saito, Naohisa Miyakoshi, Yuji Kasukawa, Koji Nozaka, Hiroyuki Tsuchie, Chiaki Sato, Kazunobu Abe, Ryo Shoji, Yoichi Shimada

{"title":"Analysis of bone in adenine-induced chronic kidney disease model rats","authors":"Hikaru Saito, Naohisa Miyakoshi, Yuji Kasukawa, Koji Nozaka, Hiroyuki Tsuchie, Chiaki Sato, Kazunobu Abe, Ryo Shoji, Yoichi Shimada","doi":"10.1016/j.afos.2021.11.001","DOIUrl":"10.1016/j.afos.2021.11.001","url":null,"abstract":"<div><h3>Objectives</h3><p>The purpose of this study is to investigate the stage of chronic kidney disease (CKD) in adenine-induced CKD model rats by serum analyses, and to examine bone mineral density (BMD), bone strength, and microstructure of trabecular and cortical bone in these rats.</p></div><div><h3>Methods</h3><p>Eight-week-old, male Wistar rats (n = 42) were divided into 2 groups: those fed a 0.75% adenine diet for 4 weeks until 12 weeks of age to generate CKD model rats (CKD group); and sham rats. The CKD and sham groups were sacrificed at 12, 16, and 20 weeks of age (n = 7 in each group and at 12, 16, and 20 weeks), and various parameters were evaluated, including body weight, renal wet weight, muscle wet weight, renal histology, biochemical tests, BMD, biomechanical testing, and micro-computed tomography (CT). The parameters were compared between the 2 groups at the various time points.</p></div><div><h3>Results</h3><p>In the CKD model rats, at 20 weeks of age, serum creatinine, phosphorus, and intact-PTH levels were elevated, and serum calcium levels were normal, indicating that the CKD was stage IV and associated with secondary hyperparathyroidism. Decreased BMDs of the whole body and the femur were observed as bone changes, and micro-CT analysis showed deterioration of bone microstructure of the cortical bone that resulted in decreased bone strength in the cortical and trabecular bone.</p></div><div><h3>Conclusions</h3><p>These CKD model rats showed stage IV CKD and appear appropriate for evaluating the effects of several treatments for CKD-related osteoporosis and mineral bone disorder.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"7 4","pages":"Pages 121-126"},"PeriodicalIF":2.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/15/22/main.PMC8714473.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39678858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Comparison of bone mineral density and vertebral fracture assessment in postmenopausal women with and without distal radius fractures 绝经后妇女伴桡骨远端骨折与不伴桡骨远端骨折的骨密度和椎体骨折评估比较

IF 2

Osteoporosis and Sarcopenia Pub Date : 2021-12-01 DOI: 10.1016/j.afos.2021.11.004

Tanawat Amphansap , Chayaphong Rattanaphonglekha , Jaruwat Vechasilp , Nitirat Stitkitti , Kamonchalat Apiromyanont , Atiporn Therdyothin

{"title":"Comparison of bone mineral density and vertebral fracture assessment in postmenopausal women with and without distal radius fractures","authors":"Tanawat Amphansap , Chayaphong Rattanaphonglekha , Jaruwat Vechasilp , Nitirat Stitkitti , Kamonchalat Apiromyanont , Atiporn Therdyothin","doi":"10.1016/j.afos.2021.11.004","DOIUrl":"10.1016/j.afos.2021.11.004","url":null,"abstract":"<div><h3>Objectives</h3><p>To compare bone mineral density (BMD) in Thai postmenopausal women with and without distal radius fracture, and to investigate the role of vertebral fracture assessment (VFA) in diagnosing osteoporosis after distal radius fracture.</p></div><div><h3>Methods</h3><p>A cross-sectional study was conducted in Thai postmenopausal women with and without distal radius fracture. BMDs of the femoral neck (FN), total hip (TH), lumbar spine (LS), and VFA were obtained within 2 weeks of injury. BMD were compared between groups. Participants were classified into osteoporosis, osteopenia or normal using BMD alone, and BMD plus VFA, where a mere presence of vertebral compression fracture indicated osteoporosis.</p></div><div><h3>Results</h3><p>Fifty postmenopausal women with distal radius fractures and 111 non-fracture postmenopausal women participated. The mean BMD was significantly lower at all sites in the fracture group (FN BMD 0.590 ± 0.075 vs 0.671 ± 0.090, p = 0.007; TH BMD 0.742 ± 0.103 vs 0.828 ± 0.116, P = 0.009; LS BMD 0.799 ± 0.107 vs 0.890 ± 0.111, P = 0.009 in the fracture vs non-fracture group respectively). VFA increased the prevalence of osteoporosis from 16 (32%) to 23 (46%) in the fracture group, and 7 (6.31%) to 17 (16.22%) in the non-fracture group, with a number needed to treat 9.</p></div><div><h3>Conclusions</h3><p>Postmenopausal women with distal radius fractures had lower BMD. Incorporating VFA into diagnosis of osteoporosis increased the prevalence of osteoporosis in both fracture and non-fracture groups. Postmenopausal women aged 50 years or older with distal radius fracture are a good target for the investigation of osteoporosis.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"7 4","pages":"Pages 134-139"},"PeriodicalIF":2.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1c/91/main.PMC8714471.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39678860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteosarcopenia synergistically increases the risk of falls in patients with rheumatoid arthritis 骨骼肌减少症协同增加类风湿关节炎患者跌倒的风险

IF 2

Osteoporosis and Sarcopenia Pub Date : 2021-12-01 DOI: 10.1016/j.afos.2021.11.002

Masahiro Tada , Yutaro Yamada , Koji Mandai , Yoshinari Matsumoto , Noriaki Hidaka

{"title":"Osteosarcopenia synergistically increases the risk of falls in patients with rheumatoid arthritis","authors":"Masahiro Tada , Yutaro Yamada , Koji Mandai , Yoshinari Matsumoto , Noriaki Hidaka","doi":"10.1016/j.afos.2021.11.002","DOIUrl":"10.1016/j.afos.2021.11.002","url":null,"abstract":"<div><h3>Objectives</h3><p>Osteosarcopenia is defined as osteoporosis with sarcopenia. The impacts of osteosarcopenia on falls and fractures in rheumatoid arthritis (RA) patients were investigated using 4 years of data from a longitudinal study (CHIKARA study).</p></div><div><h3>Methods</h3><p>The patients were divided into 4 groups by their baseline status: no sarcopenia and no osteoporosis (SP-OP-); only sarcopenia (SP + OP-); only osteoporosis (SP-OP+); and both sarcopenia and osteoporosis (SP + OP+). Survival rates and Cox hazard ratios were analyzed using falls and fractures as endpoints, adjusted by age, sex, and body mass index.</p></div><div><h3>Results</h3><p>A total of 100 RA patients (SP-OP-: 44%, SP + OP-: 17%, SP-OP+: 28%, and SP + OP+: 11%) were enrolled; 37 patients had falls, and 19 patients had fractures. The fall-free and fracture-free survival rates were significantly lower in SP + OP+ (36.4%, 54.5%) than in SP-OP- (75.0%, 86.4%). The hazard ratio of falls was significantly increased in SP + OP+, by 3.32-fold (95%CI: 1.01–10.9), whereas in SP + OP- and SP-OP+, there were no differences compared to SP-OP-.</p></div><div><h3>Conclusions</h3><p>The survival rates with the endpoints of falls and fractures in RA patients with osteosarcopenia were lower during 4-year follow-up. The risk of falls increased with the synergistic effect of osteoporosis and sarcopenia.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"7 4","pages":"Pages 140-145"},"PeriodicalIF":2.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0d/73/main.PMC8714468.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39678861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4