Osteoporosis and Sarcopenia最新文献_第8页

Pharmacological options for pain control in patients with vertebral fragility fractures 椎体脆性骨折患者疼痛控制的药理选择

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-09-01 DOI: 10.1016/j.afos.2022.09.003

Nuttan Kantilal Tanna , Terence Ong

引用次数: 1

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IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-06-01 DOI: 10.1016/S2405-5255(22)00034-6

引用次数: 0

Body composition and functional performance of older adults 老年人的身体组成和功能表现

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-06-01 DOI: 10.1016/j.afos.2022.04.002

Diane Nogueira Paranhos Amorim , Dahan da Cunha Nascimento , Whitley Stone , Vicente Paulo Alves , Karla Helena Coelho Vilaça e Silva

{"title":"Body composition and functional performance of older adults","authors":"Diane Nogueira Paranhos Amorim , Dahan da Cunha Nascimento , Whitley Stone , Vicente Paulo Alves , Karla Helena Coelho Vilaça e Silva","doi":"10.1016/j.afos.2022.04.002","DOIUrl":"10.1016/j.afos.2022.04.002","url":null,"abstract":"<div><h3>Objectives</h3><p>To determine if anthropometric variables, body composition, medication and gender are associated with functional performance and to compare these variables between octogenarians with high and low functional performance.</p></div><div><h3>Methods</h3><p>Observational, cross-sectional study. Weight, height, body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) were evaluated. Handgrip strength (HGS) was assessed. Participants’ body composition was assessed by dual-energy X-ray absorptiometry (DXA) and functional performance by Short Physical Performance Battery (SPPB). A binomial logistic regression was performed.</p></div><div><h3>Results</h3><p>One hundred and twenty-two octogenarians were included and separated into high and low function groups. The high function group showed lower values of WHtR (mean difference [MD] = 0.047, P = 0.025) and body fat (BF%) (MD = 3.54, P = 0.032) and higher values of apendicular skeletal muscle mass (ALM) (MD = 3.03, P = 0.001), HGS (MD = 6.11, P = 0.001) and SPPB score (MD = 4.20, P = 0.001). Women were more likely to be classified as low function (OR = 3.66, P = 0.002) and males showed 5.21 odds ratio (P = 0.021) of having high functional performance compared to females. Also, each decrease in age and medication use displayed 1.30 (P = 0.007) and 1.26 odds ratio increases (P = 0.008) in high functional performance.</p></div><div><h3>Conclusions</h3><p>Older males display better functional performance than women, and decrements in age and medications increase the high functional performance odds ratio. Octogenarians with high functional performance displayed lower BF measurements and higher values of muscle mass and strength.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"8 2","pages":"Pages 86-91"},"PeriodicalIF":2.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/c1/main.PMC9263164.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40591724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The impact of sex steroids on osteonecrosis of the jaw 性类固醇对颌骨骨坏死的影响

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-06-01 DOI: 10.1016/j.afos.2022.05.003

Ranhee Kim , Sung Woo Kim , Hoon Kim , Seung-Yup Ku

{"title":"The impact of sex steroids on osteonecrosis of the jaw","authors":"Ranhee Kim , Sung Woo Kim , Hoon Kim , Seung-Yup Ku","doi":"10.1016/j.afos.2022.05.003","DOIUrl":"10.1016/j.afos.2022.05.003","url":null,"abstract":"<div><p>Sex steroid hormones play a major role in bone homeostasis. Therefore, the use of sex hormones or drugs may increase the risk of osteonecrosis of the jaw (ONJ), a complication caused by damaged bone homeostasis. However, few are known the impact of medications changing sex hormone levels on ONJ.</p><p>The pathophysiology of ONJ is not clearly understood and many hypotheses exist: cessation of bone remodeling caused by its anti-resorptive effect on osteoclasts; compromised microcirculation due to medication affecting angiogenesis, including bisphosphonate; and impairment of defense mechanism toward local infection.</p><p>The use of high-dose intravenous bisphosphonate in cancer patients is associated with a high prevalence of ONJ. Exogenous estrogen or androgen replacement was reported to be associated with ONJ. Polycystic ovarian syndrome (PCOS) patients demonstrate an androgen excess status, and androgen overproduction serves as a protective factor in the bone mineral density of young women. To date, there are no reports of ONJ occurrence due to androgen overproduction. In contrast, few reports on the occurrence of ONJ due to estrogen deficiency induced by drugs, such as selective estrogen receptor modulator (SERM), aromatase inhibitors, and gonadotropin-releasing hormone (GnRH) agonists, are available.</p><p>Thus, the role of sex steroids in the development of ONJ is not known. Further studies are required to demonstrate the exact role of sex steroids in bone homeostasis and ONJ progression. In this review, we will discuss the relationship between medication associated with sex steroids and ONJ.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"8 2","pages":"Pages 58-67"},"PeriodicalIF":2.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7c/65/main.PMC9263170.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40614783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

South Asian Working Action Group on SARCOpenia (SWAG-SARCO) – A consensus document 南亚肌肉减少症工作行动小组(SWAG-SARCO) -一份共识文件

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-06-01 DOI: 10.1016/j.afos.2022.04.001

Minakshi Dhar , Nitin Kapoor , Ketut Suastika , Mohammad E. Khamseh , Shahjada Selim , Vijay Kumar , Syed Abbas Raza , Umal Azmat , Monika Pathania , Yovan Parikshat Rai Mahadeb , Sunny Singhal , Mohammad Wali Naseri , IGP Suka Aryana , Subarna Dhoj Thapa , Jubbin Jacob , Noel Somasundaram , Ali Latheef , Guru Prasad Dhakal , Sanjay Kalra

{"title":"South Asian Working Action Group on SARCOpenia (SWAG-SARCO) – A consensus document","authors":"Minakshi Dhar , Nitin Kapoor , Ketut Suastika , Mohammad E. Khamseh , Shahjada Selim , Vijay Kumar , Syed Abbas Raza , Umal Azmat , Monika Pathania , Yovan Parikshat Rai Mahadeb , Sunny Singhal , Mohammad Wali Naseri , IGP Suka Aryana , Subarna Dhoj Thapa , Jubbin Jacob , Noel Somasundaram , Ali Latheef , Guru Prasad Dhakal , Sanjay Kalra","doi":"10.1016/j.afos.2022.04.001","DOIUrl":"10.1016/j.afos.2022.04.001","url":null,"abstract":"<div><p>The South Asian population is rapidly ageing and sarcopenia is likely to become a huge burden in this region if proper action is not taken in time. Several sarcopenia guidelines are available, from the western world and from East Asia. However, these guidelines are not fully relevant for the South Asian healthcare ecosystem. South Asia is ethnically, culturally, and phenotypically unique. Additionally, the region is seeing an increase in non-communicable lifestyle disease and obesity. Both these conditions can lead to sarcopenia. However, secondary sarcopenia and sarcopenic obesity are either not dealt with in detail or are missing in other guidelines. Hence, we present a consensus on the screening, diagnosis and management of sarcopenia, which addresses the gaps in the current guidelines. This South Asian consensus gives equal importance to muscle function, muscle strength, and muscle mass; provides cost-effective clinical and easy to implement solutions; highlights secondary sarcopenia and sarcopenic obesity; lists commonly used biomarkers; reminds us that osteo-arthro-muscular triad should be seen as a single entity to address sarcopenia; stresses on prevention over treatment; and prioritizes non-pharmacological over pharmacological management. As literature is scarce from this region, the authors call for more South Asian research guided interventions.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"8 2","pages":"Pages 35-57"},"PeriodicalIF":2.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/57/main.PMC9263178.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40614781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Effect of denosumab on renal function in women with osteoporosis evaluated using cystatin C 用胱抑素C评价地诺单抗对骨质疏松女性肾功能的影响

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-06-01 DOI: 10.1016/j.afos.2022.05.002

Tsuyoshi Ohishi , Tomotada Fujita , Tatsuya Nishida , Kazuhiro Hagiwara , Reina Murai , Yukihiro Matsuyama

{"title":"Effect of denosumab on renal function in women with osteoporosis evaluated using cystatin C","authors":"Tsuyoshi Ohishi , Tomotada Fujita , Tatsuya Nishida , Kazuhiro Hagiwara , Reina Murai , Yukihiro Matsuyama","doi":"10.1016/j.afos.2022.05.002","DOIUrl":"10.1016/j.afos.2022.05.002","url":null,"abstract":"<div><h3>Objectives</h3><p>To investigate renal function during denosumab therapy using the estimated glomerular filtration rate based on cystatin C (eGFRcys) which is more accurate than creatinine (eGFRcr) for renal function.</p></div><div><h3>Methods</h3><p>Bone mineral densities (BMDs) of lumbar spine and hip regions, eGFRcys, eGFRcr, creatinine clearance (Ccr), and serum total homocysteine (S-Hcy) were measured during 2-year denosumab therapy in 53 women with osteoporosis naïve to anti-osteoporosis drugs (new group) and 64 women who were switched from long-term bisphosphonate treatment to denosumab therapy (switch group).</p></div><div><h3>Results</h3><p>There were no significant differences in age, eGFRcr, Ccr, eGFRcys, and S-Hcy levels at baseline between the groups. BMDs in the lumbar spine, femoral neck, and total hip increased significantly after 2-year denosumab therapy in both groups. eGFRcr decreased in the switch group, and Ccr decreased in both groups; however, eGFRcys and S-Hcy levels did not change significantly in either group. To investigate the causal factors associated with the decrease in eGFRcr and Ccr, multiple regression analysis was performed in all patients. Denosumab initiation within 3 months after fracture and eGFRcr or Ccr at baseline were independent factors for the decrease in eGFRcr or Ccr during the 2-year denosumab therapy. Decline in creatinine-based renal function could be reflected by increased muscle mass during the ongoing recovery from fracture.</p></div><div><h3>Conclusions</h3><p>Renal function was preserved in all patients, including those in the switch group during denosumab therapy. Creatinine-based renal function should be cautiously interpreted during denosumab therapy in patients with recent fractures.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"8 2","pages":"Pages 68-74"},"PeriodicalIF":2.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/70/5f/main.PMC9263171.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40614782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two-year effectiveness of zoledronic acid with or without eldecalcitol in Japanese patients with osteoporosis: A randomized prospective study 唑来膦酸加或不加依地骨糖醇治疗日本骨质疏松症患者的两年疗效:一项随机前瞻性研究

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-06-01 DOI: 10.1016/j.afos.2022.05.001

Takeshi Mochizuki , Koichiro Yano , Katsunori Ikari , Ken Okazaki

{"title":"Two-year effectiveness of zoledronic acid with or without eldecalcitol in Japanese patients with osteoporosis: A randomized prospective study","authors":"Takeshi Mochizuki , Koichiro Yano , Katsunori Ikari , Ken Okazaki","doi":"10.1016/j.afos.2022.05.001","DOIUrl":"10.1016/j.afos.2022.05.001","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aims to examine the 2-year outcomes of zoledronic acid (ZOL) with or without eldecalcitol (ELD) on bone mineral density (BMD) and fracture in Japanese patients with osteoporosis.</p></div><div><h3>Methods</h3><p>The subjects were 98 patients who were randomly (1:1) assigned to treatment with ZOL combined with ELD (ZOL + ELD group; n = 51) and ZOL alone (ZOL group; n = 47). Treatment efficacy was examined based on a comparison of changes in BMD from baseline (ΔBMD) in the lumbar spine, total hip, and femoral neck in the 2 groups.</p></div><div><h3>Results</h3><p>The percent change from baseline in BMD values for the lumbar spine, total hip, and femoral neck at 24 months were 10.8% ± 6.1%, 6.0% ± 6.6%, and 5.1% ± 5.1%, respectively, in the ZOL + ELD group, and 7.7% ± 6.2%, 5.1% ± 5.6%, and 2.9% ± 8.3%, respectively, in the ZOL group. The percent change from baseline BMD for the lumbar spine at 24 months differed significantly between the 2 groups.</p></div><div><h3>Conclusions</h3><p>The effect of a combination of ZOL + ELD on BMD for 24 months was more favorable than that of ZOL alone. This drug combination is promising for the treatment of drug-naïve Japanese patients with primary osteoporosis.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"8 2","pages":"Pages 75-79"},"PeriodicalIF":2.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5e/6a/main.PMC9263174.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40591726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ultrasound for thigh muscle thickness is a valuable tool in the diagnosis of sarcopenia in Indian patients with predialysis chronic kidney disease 超声大腿肌肉厚度是诊断印度透析前慢性肾病患者肌肉减少症的宝贵工具

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-06-01 DOI: 10.1016/j.afos.2022.06.001

Namrata S. Rao , Abhilash Chandra , Sai Saran , Ayush Lohiya

{"title":"Ultrasound for thigh muscle thickness is a valuable tool in the diagnosis of sarcopenia in Indian patients with predialysis chronic kidney disease","authors":"Namrata S. Rao , Abhilash Chandra , Sai Saran , Ayush Lohiya","doi":"10.1016/j.afos.2022.06.001","DOIUrl":"10.1016/j.afos.2022.06.001","url":null,"abstract":"<div><h3>Objectives</h3><p>Patients with chronic kidney disease (CKD) are known to develop sarcopenia, an aging-related disorder, with low muscle mass, strength and physical performance. Ultrasound-derived thigh muscle and rectus femoris thickness (TMT and RFT) can be measured easily in clinical practice, but need validation for use in predialysis CKD (stages III through V) for muscle mass estimation. The study aims to compare ultrasound-derived TMT and RFT with bioelectrical impedance analysis (BIA)-derived muscle mass estimation in the diagnosis of sarcopenia in predialysis CKD.</p></div><div><h3>Methods</h3><p>Patients with stable CKD stage III, IV, V and not yet on dialysis were recruited, and underwent anthropometric assessment, BIA and ultrasound examination of midthigh region. Appendicular skeletal muscle index (ASMI)/height<sup>2</sup> derived from BIA was taken as a standard for the diagnosis of low muscle mass. Gait speed and handgrip were also measured. The Asian Working Group criteria were applied. Cutoff values for low muscle mass by TMT and RFT were obtained using receiver operator curve (ROC) analysis.</p></div><div><h3>Results</h3><p>Of the total of 117 enrolled study participants, 52 (45%) had low muscle mass, 34 (29%) had sarcopenia, of whom 79% were male, majority (38%) were CKD stage IV and had a mean age of 58 years. Using ROC analysis, TMT cutoffs of 19 mm in males and 17 mm in females were computed. Comparison of TMT cutoffs and ASMI/h<sup>2</sup> showed good agreement between the 2 methods using Bland-Altman plots.</p></div><div><h3>Conclusions</h3><p>Ultrasound-derived TMT and RFT can be used for muscle mass estimation in the diagnosis of sarcopenia.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"8 2","pages":"Pages 80-85"},"PeriodicalIF":2.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5d/2d/main.PMC9263162.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40591725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Recognizing the importance of physical activity on sarcopenia in chronic kidney disease 认识到体育活动对慢性肾脏病少肌症的重要性

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-03-01 DOI: 10.1016/j.afos.2022.02.002

Thomas J. Wilkinson, Heitor S. Ribeiro

引用次数: 2

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IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-03-01 DOI: 10.1016/S2405-5255(22)00013-9

引用次数: 0