Osteoporosis and Sarcopenia最新文献_第7页

Efficacy of plain cholecalciferol versus ergocalciferol in raising serum vitamin D level in Thai female healthcare workers 普通胆钙化醇与麦角钙化醇在提高泰国女性卫生保健工作者血清维生素D水平中的疗效

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-12-01 DOI: 10.1016/j.afos.2022.12.001

Tanawat Amphansap, Atiporn Therdyothin, Nitirat Stitkitti, Lertkong Nitiwarangkul, Vajarin Phiphobmongkol

{"title":"Efficacy of plain cholecalciferol versus ergocalciferol in raising serum vitamin D level in Thai female healthcare workers","authors":"Tanawat Amphansap, Atiporn Therdyothin, Nitirat Stitkitti, Lertkong Nitiwarangkul, Vajarin Phiphobmongkol","doi":"10.1016/j.afos.2022.12.001","DOIUrl":"10.1016/j.afos.2022.12.001","url":null,"abstract":"<div><h3>Objectives</h3><p>To compare the efficacy of cholecalciferol and ergocalciferol in raising 25-hydroxyvitamin D (25(OH)D) level in Thai female healthcare workers.</p></div><div><h3>Methods</h3><p>A randomized control trial was conducted in healthy female healthcare workers. Randomization allocated the participants into vitamin D2 group (N = 43), receiving ergocalciferol 20,000 IU weekly and vitamin D3 group (N = 40), receiving cholecalciferol 1000 IU daily for 12 months. Venous blood sample was collected at baseline, 6 and 12 months for serum 25(OH)D, parathyroid hormone and calcium. Compliance was also assessed.</p></div><div><h3>Results</h3><p>The mean age of the participants was 50.6 ± 9.9 and 50.9 ± 8.4 years in vitamin D2 and D3 groups (P = 0.884). The mean 25(OH)D levels were 16.91 ± 6.07 ng/mL and 17.62 ± 4.39 ng/mL (P = 0.547), respectively. Both groups had significant improvement in 25(OH)D level at 6 months (from 16.91 ± 6.07 to 21.67 ± 5.11 ng/mL and 17.62 ± 4.39 to 26.03 ± 6.59 ng/mL in vitamin D2 and D3 group). Improvement was significantly greater with cholecalciferol (P = 0.018). The level plateaued afterwards in both groups. Only cholecalciferol could increase 25(OH)D in participants without vitamin D deficiency (6.88 ± 4.20 ng/mL increment). Compliance was significantly better in vitamin D2 group (P = 0.025).</p></div><div><h3>Conclusions</h3><p>Daily cholecalciferol supplementation resulted in a larger increase in serum 25(OH)D level during the first 6 months comparing to weekly ergocalciferol. While vitamin D3 could increase serum 25(OH)D level in all participants, vitamin D2 could not do so in participants without vitamin D deficiency.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"8 4","pages":"Pages 145-151"},"PeriodicalIF":2.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/07/65/main.PMC9805961.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10494385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Reply on “Treatment adherence and risk of vertebral fracture” 关于“治疗依从性与椎体骨折风险”的答复

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-12-01 DOI: 10.1016/j.afos.2022.11.003

Seihee Kim, Yoon-Sok Chung, Yunhwan Lee

引用次数: 0

TOC

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-12-01 DOI: 10.1016/S2405-5255(22)00076-0

引用次数: 0

Trabecular bone score as an additional therapeutic decision tool in osteoporosis and osteopenia 骨小梁评分作为骨质疏松和骨质减少的额外治疗决策工具

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-09-01 DOI: 10.1016/j.afos.2022.09.001

Atiporn Therdyothin , Tanawat Amphansap , Kamonchalat Apiromyanont

{"title":"Trabecular bone score as an additional therapeutic decision tool in osteoporosis and osteopenia","authors":"Atiporn Therdyothin , Tanawat Amphansap , Kamonchalat Apiromyanont","doi":"10.1016/j.afos.2022.09.001","DOIUrl":"10.1016/j.afos.2022.09.001","url":null,"abstract":"<div><h3>Objectives</h3><p>To evaluate the role of trabecular bone score (TBS), in addition to bone mineral density (BMD), and to aid decision making to initiate anti-osteoporotic treatment in postmenopausal women with osteopenia.</p></div><div><h3>Methods</h3><p>TBS was assessed in a cohort of Thai postmenopausal women with BMD of femoral neck (FN), total hip (TH), and lumbar spine (LS) performed at the Police General Hospital, Bangkok, Thailand from July 2019 to October 2020. We retrospectively reviewed hospital database for underlying diseases, medication, and fractures, including relevant imaging and vertebral fracture assessment (VFA). Patients with previous osteoporosis treatment, skeletal malignancy, high-energy trauma, and uninterpretable BMD were excluded.</p></div><div><h3>Results</h3><p>In total there were 407 postmenopausal women, including 115 with osteoporotic fractures. The mean TBS of the cohort was 1.264 ± 0.005. The proportion of osteoporotic subjects ranged from 9.1% by TH BMD to 27.0% by lowest BMD. In fractured patients, 21.7%–54.8% were found to have osteoporosis while osteopenia was found in 37.4%–43.5%. Among subjects with osteopenia and degraded TBS, fractures ranged from 21.7 to 50.9%. Addition of osteopenic subjects with degraded microarchitecture yielded a significantly higher number of subjects eligible for treatment with 3.25-fold increase in non-fractured participants, and 7 to 11 additional osteopenic patients should be treated to detect 1 fracture.</p></div><div><h3>Conclusions</h3><p>Addition of TBS helped capturing osteopenic women with high risk of fracture. Decision to treat osteopenic women with degraded TBS increased the number of patients receiving treatment. We recommend evaluating TBS in osteopenic women without fractures to aid therapeutic decision on treatment initiation.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"8 3","pages":"Pages 123-130"},"PeriodicalIF":2.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/55/32/main.PMC9577428.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40648496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Adherence of bisphosphonate and decreased risk of clinical vertebral fracture in osteoporotic patients: A propensity score matching analysis 骨质疏松症患者坚持使用双膦酸盐和降低临床椎体骨折风险:倾向评分匹配分析

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-09-01 DOI: 10.1016/j.afos.2022.05.004

Seihee Kim , Yoon-Sok Chung , Yunhwan Lee

{"title":"Adherence of bisphosphonate and decreased risk of clinical vertebral fracture in osteoporotic patients: A propensity score matching analysis","authors":"Seihee Kim , Yoon-Sok Chung , Yunhwan Lee","doi":"10.1016/j.afos.2022.05.004","DOIUrl":"10.1016/j.afos.2022.05.004","url":null,"abstract":"<div><h3>Objectives</h3><p>Bisphosphonate is associated with a decreased risk of vertebral fractures due to osteoporosis. However, there are limited studies on how poor compliance with bisphosphonate affects the risk of vertebral fractures in a nationwide cohort. We aim to evaluate whether adherence to bisphosphonate affects the risk of fracture in osteoporosis patients.</p></div><div><h3>Methods</h3><p>We used the data of the Korean National Health Insurance Service Senior Cohort. A total of 33,315 (medication possession ratio [MPR]: 50) osteoporosis patients were matched using the propensity score matching method: those who received low-dose bisphosphonate and those who received high-dose bisphosphonate. Twenty-two confounding variables, including age, socioeconomic status, medications prescribed, and underlying diseases that may affect the risk of fracture were adjusted for propensity score matching. The risk of vertebral fracture was assessed by Cox proportional hazards regression.</p></div><div><h3>Results</h3><p>Patients with a higher MPR showed a decreased vertebral fracture risk than those with a lower MPR (MPR 50 = hazard ratio [HR] 0.909; 95% confidence interval [CI] 0.877–0.942 P < 0.001; MPR 70 = HR: 0.874, 95% CI: 0.838–0.913, P < 0.001; MPR 90 = HR: 0.822, 95% CI: 0.780–0.866, P < 0.001). MPR was associated with a decreased vertebral fracture risk in both groups with or without history of fracture. In the subgroup analysis, MPR was associated with a decreased vertebral fracture risk in women, in all ages, with or without T2DM, and with or without hypertension.</p></div><div><h3>Conclusions</h3><p>Higher MPR is associated with a lower vertebral fracture risk.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"8 3","pages":"Pages 98-105"},"PeriodicalIF":2.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ac/55/main.PMC9577186.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40648490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Changes in bone mineral density in unconscious immobile stroke patients from the acute to chronic phases of brain diseases 脑疾病急性期至慢性期无意识卒中患者骨密度的变化

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-09-01 DOI: 10.1016/j.afos.2022.08.001

Shoko Merrit Yamada

{"title":"Changes in bone mineral density in unconscious immobile stroke patients from the acute to chronic phases of brain diseases","authors":"Shoko Merrit Yamada","doi":"10.1016/j.afos.2022.08.001","DOIUrl":"10.1016/j.afos.2022.08.001","url":null,"abstract":"<div><h3>Objectives</h3><p>Decreased bone mineral density (BMD) is observed in immobile stroke patients. But it is not clarified yet how rapidly BMD reduction occurs or what the most influencing factor to BMD loss is.</p></div><div><h3>Methods</h3><p>BMDs in the lumbar vertebrae and the proximal femur of the paralyzed side were measured in 100 immobile stroke patients at 1 week (0 month), 1 month, and 2 months after admission. The levels of serum calcium, phosphorous, 25-hydroxyvitamin D, and urine cross-linked N-telopeptide of type I collagen (NTx) were also measured.</p></div><div><h3>Results</h3><p>The average age of patients was 75.0 ± 11.4 years (31–94 years). No BMD reduction was identified in the lumbar vertebrae in 2 months; however, BMD in the femur significantly decreased in 2 months in female patients (P < 0.05). Serum calcium and phosphorous levels remained within the normal range during hospitalization, and 25-hydroxyvitamin D value rose in 2 months. Urine NTx significantly increased in both males and females in 2 months (male: P < 0.05, female: P < 0.01).</p></div><div><h3>Conclusions</h3><p>While there was no significant change in lumbar spine BMD in the 2 month period of immobilization after stroke, BMD in the proximal femur showed a significant reduction, particularly in women. The differential loss of BMD in the 2 regions of interest could possibly be due to the physical forces acting on different body parts during mobilization and nutritional factors. More studies are needed with larger study samples and prolonged follow-up to check the accuracy of these observations.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"8 3","pages":"Pages 106-111"},"PeriodicalIF":2.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/64/6f/main.PMC9577216.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40648495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply on “Significant change for body composition data” 关于“身体成分数据发生重大变化”的回复。

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-09-01 DOI: 10.1016/j.afos.2022.09.004

Dahan da Cunha Nascimento, Diane Nogueira Paranhos Amorim, Vicente Paulo Alves, Karla Helena Coelho Vilaça e Silva, Whitley Stone

引用次数: 1

Significant change for body composition data 身体成分数据发生了重大变化

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-09-01 DOI: 10.1016/j.afos.2022.09.005

Joseph C. Lee, Alaa Alghamry

引用次数: 1

Support vector machines are superior to principal components analysis for selecting the optimal bones’ CT attenuations for opportunistic screening for osteoporosis using CT scans of the foot or ankle 支持向量机优于主成分分析，可以选择最佳的骨骼CT衰减，从而利用足部或踝关节的CT扫描进行骨质疏松症的机会筛查

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-09-01 DOI: 10.1016/j.afos.2022.09.002

Ronnie Sebro , Cynthia De la Garza-Ramos

{"title":"Support vector machines are superior to principal components analysis for selecting the optimal bones’ CT attenuations for opportunistic screening for osteoporosis using CT scans of the foot or ankle","authors":"Ronnie Sebro , Cynthia De la Garza-Ramos","doi":"10.1016/j.afos.2022.09.002","DOIUrl":"10.1016/j.afos.2022.09.002","url":null,"abstract":"<div><h3>Objectives</h3><p>To use the computed tomography (CT) attenuation of the foot and ankle bones for opportunistic screening for osteoporosis.</p></div><div><h3>Methods</h3><p>Retrospective study of 163 consecutive patients from a tertiary care academic center who underwent CT scans of the foot or ankle and dual-energy X-ray absorptiometry (DXA) within 1 year of each other. Volumetric segmentation of each bone of the foot and ankle was done in 3D Slicer to obtain the mean CT attenuation. Pearson's correlations were used to correlate the <span>CT</span> attenuations with each other and with DXA measurements. Support vector machines (SVM) with various kernels and principal components analysis (<span>PCA</span>) were used to predict osteoporosis and osteopenia/osteoporosis in training/validation and test datasets.</p></div><div><h3>Results</h3><p>CT attenuation measurements at the talus, calcaneus, navicular, cuboid, and cuneiforms were correlated with each other and positively correlated with BMD T-scores at the L1-4 lumbar spine, hip, and femoral neck; however, there was no significant correlation with the L1-4 trabecular bone scores. A CT attenuation threshold of 143.2 Hounsfield units (HU) of the calcaneus was best for detection of osteoporosis in the training/validation dataset. SVMs with radial basis function (RBF) kernels were significantly better than the PCA model and the calcaneus for predicting osteoporosis in the test dataset.</p></div><div><h3>Conclusions</h3><p>Opportunistic screening for osteoporosis is possible using the CT attenuation of the foot and ankle bones. SVMs with RBF using all bones is more accurate than the CT attenuation of the calcaneus.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"8 3","pages":"Pages 112-122"},"PeriodicalIF":2.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/11/main.PMC9577430.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40648493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

TOC 技术选择委员会

IF 2

Osteoporosis and Sarcopenia Pub Date : 2022-09-01 DOI: 10.1016/S2405-5255(22)00055-3

引用次数: 0