Osteoporosis and Sarcopenia最新文献

Are there associations between bone turnover and hip geometry in the general population? 在一般人群中，骨转换和髋关节几何形状之间是否存在关联？

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-06-01 DOI: 10.1016/j.afos.2025.05.007

Cornelius Sebastian Fischer , Till Ittermann , Sarah Kalmbach , Moritz Herbst , Tina Histing , Jörn Lange , Anke Hannemann

{"title":"Are there associations between bone turnover and hip geometry in the general population?","authors":"Cornelius Sebastian Fischer , Till Ittermann , Sarah Kalmbach , Moritz Herbst , Tina Histing , Jörn Lange , Anke Hannemann","doi":"10.1016/j.afos.2025.05.007","DOIUrl":"10.1016/j.afos.2025.05.007","url":null,"abstract":"<div><h3>Objectives</h3><div>While impaired bone remodeling contributes to osteoporosis and probably to osteoarthritis, the relations between bone turnover and key hip geometry measures such as center-edge angle (CE), neck-shaft angle (NSA) or alpha angle remain unknown. We here examined the presence of associations between two bone turnover markers with hip geometric measures in adults from the general population.</div></div><div><h3>Methods</h3><div>Data from 2037 participants (50% women) in the Study of Health in Pomerania-TREND were examined. Hip geometric parameters were obtained using magnetic resonance imaging. Serum concentrations of carboxy-terminal telopeptide of Type I collagen (CTX, bone resorption) and intact amino-terminal propeptide of Type I procollagen (P1NP, bone formation) were measured to assess bone turnover.</div></div><div><h3>Results</h3><div>In sex-specific linear regression models adjusted for age, body mass index and physical inactivity, positive associations between CTX or P1NP and CE and inverse associations with NSA were detected. The latter were restricted to men. Thus, an increase in bone formation or resorption is related to less dysplastic (both sexes). Additionally, men with more valgus hips have lower bone turnover markers. For the alpha angle, no significant association was present.</div></div><div><h3>Conclusions</h3><div>The observed associations between bone turnover markers and hip geometry confirm the presence of relevant relations between bone properties and hip geometry. This knowledge may aid in detection of vulnerable groups with respect to osteoarthritis and fracture risk.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 2","pages":"Pages 50-56"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for osteoporosis 系统可用药全基因组孟德尔随机化确定骨质疏松症的治疗靶点

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-06-01 DOI: 10.1016/j.afos.2025.06.001

Chiyun Sun , Ruikang Liu , Jiaming Hu , Weiming Fan , Chuanrui Sun , Pengcheng Shan , Xu Wei

{"title":"Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for osteoporosis","authors":"Chiyun Sun , Ruikang Liu , Jiaming Hu , Weiming Fan , Chuanrui Sun , Pengcheng Shan , Xu Wei","doi":"10.1016/j.afos.2025.06.001","DOIUrl":"10.1016/j.afos.2025.06.001","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study was to find potential drug targets of osteoporosis (OP) through systematic druggable genome-wide Mendelian randomization (MR) analysis.</div></div><div><h3>Methods</h3><div>Combining the multi-omics data, we utilized drug target MR and mediation MR to search for potential drug targets of OP and their possible pathways. Functional enrichment analyses were used to identify metabolic pathways of potential drug targets. In addition, we performed a two-sample MR analysis to investigate the causal relationship between immunoexpression and OP. Finally, we conducted Phe-MR analysis and drug prediction to determine the indications, potential side effects, and pharmacological activities of previously tested targets.</div></div><div><h3>Results</h3><div>We screened three potential targets of OP-TAS1R3, TMX2, and SREBF1. Mediation MR analysis revealed that body mass index, type 2 diabetes, and chemokine C-C motif ligand 4 may be mediators for the above targets to act on OP. The Steiger Filtering test did not find a reverse causality. The results of functional enrichment analysis showed that the identified target genes may affect OP through lipid metabolism, immune expression, and insulin resistance. Two-sample MR analysis showed that HLA-DR expression in multiple monocyte subpopulations was associated with OP. The five drugs including sucrose, mirtazapine, aspartame, ginsenoside and ezetimibe are identified as the most probable candidates for the treatment of OP. Phe-MR found that TAS1R3 was associated with lower systolic blood pressure, TMX2 with neurologic and lipid metabolism, and SREBF1 with muscle power.</div></div><div><h3>Conclusions</h3><div>Our study provides evidence support for TAS1R3, TMX2, and SREBF1 as drug targets for OP.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 2","pages":"Pages 57-64"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FM - Editorial Board FM -编委会

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-06-01 DOI: 10.1016/S2405-5255(25)00038-X

引用次数: 0

Hypophosphatasia in childhood: Diagnosis to management 儿童低磷症：诊断到治疗

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-06-01 DOI: 10.1016/j.afos.2025.05.003

Minji Im, Sung Yoon Cho

引用次数: 0

Molecular crosstalk in SP7-mediated osteogenesis: Regulatory mechanisms and therapeutic potential 分子串扰在sp7介导的成骨：调控机制和治疗潜力

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-06-01 DOI: 10.1016/j.afos.2025.04.003

Jun Lang , Vivek Kumar Morya , Mi-Kyung Kwak , Sin-Hye Park , Kyu-Cheol Noh

{"title":"Molecular crosstalk in SP7-mediated osteogenesis: Regulatory mechanisms and therapeutic potential","authors":"Jun Lang , Vivek Kumar Morya , Mi-Kyung Kwak , Sin-Hye Park , Kyu-Cheol Noh","doi":"10.1016/j.afos.2025.04.003","DOIUrl":"10.1016/j.afos.2025.04.003","url":null,"abstract":"<div><div>SP7, also known as Osterix, is a zinc finger-containing transcription factor, plays a crucial role in osteoblast differentiation and bone formation. This review examines the molecular mechanisms underlying SP7's regulatory functions, highlighting its interactions with key signaling pathways such as BMP-SMAD, Wnt/β-catenin, and HIF-1α. SP7 acts downstream of RUNX2 to regulate osteogenic gene expression, including collagen Type I Alpha 1 (COL1A1), alkaline phosphatase (ALP) and osteocalcin (OCN). The review also explores the role of post-translational modifications, such as phosphorylation and ubiquitination, in modulating SP7's stability and activity. Emerging therapeutic strategies targeting SP7, including gene editing, RNA-based approaches, and small-molecule modulators, are discussed as innovative solutions for treating osteoporosis and other skeletal disorders. The potential for future research into SP7's interactions with non-coding RNAs and angiogenesis pathways is emphasized, underscoring its significance in skeletal health and regenerative medicine. This comprehensive overview consolidates current knowledge of SP7's molecular functions, therapeutic potential, and its pivotal role in bone biology.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 2","pages":"Pages 31-37"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fracture risk in Korean postmenopausal women: The influence of BMI, age, and bone density 韩国绝经后妇女骨折风险：BMI、年龄和骨密度的影响

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-06-01 DOI: 10.1016/j.afos.2025.03.001

Junghwa Shin , Kwang Yoon Kim , Joo-hyun Park , Sangmi Lee , O Kyu Noh , Yong Jun Choi , Yoon-Sok Chung , Bom-Taeck Kim

{"title":"Fracture risk in Korean postmenopausal women: The influence of BMI, age, and bone density","authors":"Junghwa Shin , Kwang Yoon Kim , Joo-hyun Park , Sangmi Lee , O Kyu Noh , Yong Jun Choi , Yoon-Sok Chung , Bom-Taeck Kim","doi":"10.1016/j.afos.2025.03.001","DOIUrl":"10.1016/j.afos.2025.03.001","url":null,"abstract":"<div><h3>Objectives</h3><div>Fracture risk in postmenopausal women is influenced by bone mineral density (BMD), age, and body mass index (BMI). However, fracture prevention strategies primarily focus on low BMD, often overlooking other key factors.</div></div><div><h3>Methods</h3><div>This retrospective cohort study analyzed 18,151 Korean postmenopausal women aged 50 or older who underwent dual-energy X-ray absorptiometry (DXA) at Ajou University Hospital from years of 2006–2014. Fracture risk was assessed using multivariable Cox proportional hazard models, adjusted for BMI, BMD, and age.</div></div><div><h3>Results</h3><div>The median age of the cohort was 59.1 years, and the overall fracture incidence was 2.3 per 1,000 person-years. Fracture risk significantly increased with age, with hazard ratios (HRs) of 1.36 (95% CI: 1.08–1.70) for women aged 60–69 and 2.10% (95% CI: 1.62–2.73) for those aged 70 or older, compared to the reference group (50–59 years). Underweight women exhibited the highest fracture cumulative incidence (3.3%), though their risk increase was not statistically significant. Overweight and obese women demonstrated higher BMD but did not show significant fracture risk reductions.</div></div><div><h3>Conclusions</h3><div>These findings highlight age as a dominant predictor of fracture risk, while BMI plays a complex, less pronounced role. The discrepancy between osteoporosis prevalence and actual fracture risk, particularly in obese elderly women, suggests limitations in BMD-focused assessments. Simple, measurable parameters like age and BMI should complement BMD in fracture risk evaluation to better target high-risk populations and enhance preventive strategies in clinical practice.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 2","pages":"Pages 65-68"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Femoral bone mineral density reference values by sex and ethnicity: Findings from the Qatar Biobank study 性别和种族的股骨骨密度参考值：来自卡塔尔生物银行研究的结果

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-06-01 DOI: 10.1016/j.afos.2025.05.006

Fawziya Al-Baker , Mujahed Shraim , Amal Al-Haidose , Atiyeh M. Abdallah

{"title":"Femoral bone mineral density reference values by sex and ethnicity: Findings from the Qatar Biobank study","authors":"Fawziya Al-Baker , Mujahed Shraim , Amal Al-Haidose , Atiyeh M. Abdallah","doi":"10.1016/j.afos.2025.05.006","DOIUrl":"10.1016/j.afos.2025.05.006","url":null,"abstract":"<div><h3>Objectives</h3><div>Low bone mineral density (BMD) is a major global health concern due to fracture-related morbidity and mortality. BMD is currently assessed by dual-energy X-ray absorptiometry (DXA) against a US reference population. The aim of the study was to establish an ethnicity- and sex-specific reference for calculating BMD at different femoral sites including femoral trochanter, Ward's triangle and femoral neck in Qatar.</div></div><div><h3>Methods</h3><div>This cross-sectional study analyzed BMD in 4727 (2277 females and 2450 males) healthy Qatari aged between 20 and 82 years participating in the Qatar Biobank (QBB) study. Standard T-scores provided by the densitometer (T<sub>DXA</sub>) were compared with ethnicity- and sex-specific T-scores for the Qatari population (T<sub>QA</sub>) calculated using data from the 20-29-year age group for different femoral sites as the reference. The concordance between T<sub>DXA</sub> and T<sub>QA</sub> was analyzed using kappa statistics.</div></div><div><h3>Results</h3><div>Males consistently exhibited higher BMD values for the femoral trochanter, Ward's triangle, and the femoral neck across all age groups compared with females. Using T<sub>QA</sub> rather than T<sub>DXA</sub> as a reference at any site classified fewer individuals as having osteoporosis and osteopenia, especially for females. Agreement between T<sub>DXA</sub> and T<sub>QA</sub> was higher in males than in females.</div></div><div><h3>Conclusions</h3><div>These findings underscore the need for local ethnicity- and sex-specific BMD reference values. The use of T<sub>QA</sub> significantly reduced overdiagnosis of osteopenia and osteoporosis compared with T<sub>DXA</sub>, thereby decreasing overtreatment and impacting participant recruitment decisions into clinical studies.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 2","pages":"Pages 43-49"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FM - Editorial Board FM -编委会

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-03-01 DOI: 10.1016/S2405-5255(25)00008-1

引用次数: 0

Dental panoramic radiographs by dental students versus artificial intelligence 牙科学生的牙科全景x光片与人工智能

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-03-01 DOI: 10.1016/j.afos.2025.02.002

Yoon-Sok Chung

引用次数: 0

Comparing mortality rates, risk, and trends of hip fracture and common cancers in Hong Kong, 2010–2020: A population-based study 比较 2010-2020 年香港髋部骨折和常见癌症的死亡率、风险和趋势：以人口为基础的研究

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-03-01 DOI: 10.1016/j.afos.2024.12.001

Xiaowen Zhang , Chor-Wing Sing , Philip CM Au , Kathryn Choon-Beng Tan , Ian Chi-Kei Wong , Ching-Lung Cheung

{"title":"Comparing mortality rates, risk, and trends of hip fracture and common cancers in Hong Kong, 2010–2020: A population-based study","authors":"Xiaowen Zhang , Chor-Wing Sing , Philip CM Au , Kathryn Choon-Beng Tan , Ian Chi-Kei Wong , Ching-Lung Cheung","doi":"10.1016/j.afos.2024.12.001","DOIUrl":"10.1016/j.afos.2024.12.001","url":null,"abstract":"<div><h3>Objectives</h3><div>Hip fracture is a global public concern exhibiting high mortality rates but often underrecognized. We compared the mortality rates, risk, and secular trend of hip fractures with common cancers in females and males, aiming to call attention to hip fractures.</div></div><div><h3>Methods</h3><div>In 2010–2020, 193,767 patients with the first diagnosed hip fractures and the top 5 prevalent cancers in each sex and aged 50 years and above were included. Age-standardized mortality rates were adjusted to the WHO Standard Population and the sex-specific relative risk of mortality was computed using Cox proportional hazards models, adjusted for potential confounders. The trend analyses used joinpoint regression to compute annual percent changes in age-standardized mortality rates.</div></div><div><h3>Results</h3><div>The 1-year and 5-year age-standardized mortality rates and sex-specific mortality risk of hip fracture are greater than those of breast cancer (hazard ratio [HR]: 0.93, 95% confidence interval [CI]: 0.90 to 0.97) and thyroid cancer (HR: 0.55, 95% CI: 0.47 to 0.64) in females and prostate cancer (HR: 0.56, 95% CI: 0.53 to 0.58) in males. Moreover, mortality rates in lung cancer, male liver cancer, female breast cancer, and male prostate cancer have decreased in the past decade. For hip fracture, the mortality rates have significantly decreased in females, while in males, we observed only a decreasing trend in 1-year hip fracture mortality, not in 5-year</div></div><div><h3>Conclusions</h3><div>Hip fractures exhibit higher mortality compared to female breast and thyroid cancers and male prostate cancer. More attention is needed to enhance the management and prevention of hip fractures.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 1","pages":"Pages 15-21"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0