Osteoporosis and Sarcopenia最新文献

Foot and knee deformities in relation to functional limitations and incident osteoarthritis: A prospective cohort study 足部和膝部畸形与功能限制和骨关节炎的关系：前瞻性队列研究

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2024-09-01 DOI: 10.1016/j.afos.2024.08.002

Jonathan K.L. Mak , Kathryn Choon Beng Tan , Janus Siu Him Wong , Martin Man Ho Chung , Ching-Lung Cheung

{"title":"Foot and knee deformities in relation to functional limitations and incident osteoarthritis: A prospective cohort study","authors":"Jonathan K.L. Mak , Kathryn Choon Beng Tan , Janus Siu Him Wong , Martin Man Ho Chung , Ching-Lung Cheung","doi":"10.1016/j.afos.2024.08.002","DOIUrl":"10.1016/j.afos.2024.08.002","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to investigate the relationships of foot and leg symptoms, structure, and function with functional limitations and osteoarthritis (OA).</div></div><div><h3>Methods</h3><div>We included 1253 participants (mean age 58.1 years) from the Hong Kong Osteoporosis Study who completed an examination on foot posture, function, pain, and presence of deformities such as hallux valgus and varus knee. Using logistic regression, we estimated cross-sectional associations of each foot and knee problem with functional outcomes (slow walking speed, self-reported falls, and functional limitations) and OA. Through linkage to electronic health records, we further examined their associations with incident OA over 8 years using Cox models. All models were adjusted for age, sex, and body mass index.</div></div><div><h3>Results</h3><div>The prevalence of hallux valgus, foot pain, and varus knee were 33.1%, 35.1%, and 25.8%, respectively. Planus foot posture was associated with varus knee, and pronated foot function was associated with hallux valgus. Of the assessed foot problems, only foot pain showed significant associations with functional outcomes, including functional limitations and recurrent falls. Foot pain was also associated with prevalent OA at baseline but not incident OA. Meanwhile, we observed a 3-times increased risk of incident OA associated with varus knee (95% CI = 1.48–6.10), and this association was particularly seen in older adults, women, and obese individuals.</div></div><div><h3>Conclusions</h3><div>In community-dwelling Chinese adults, foot pain, but not the reported foot deformities, is associated with functional limitations and falls, while varus knee is associated with incident OA.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"10 3","pages":"Pages 114-118"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142320048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Is ankle fracture related to low bone mineral density and subsequent fracture? A systematic review” [Osteoporos Sarcopenia 2020 6:151–159] 踝关节骨折与低骨矿密度和后续骨折有关吗？系统综述》 [Osteoporos Sarcopenia 2020 6:151-159] 的更正

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2024-09-01 DOI: 10.1016/j.afos.2024.09.003

Atiporn Therdyothin , Nacharin Phiphopthatsanee , Wiwat Wajanavisit , Patarawan Woratanarat , Sukij Laohajaroensombat , Tulyapruek Tawonsawatruk

引用次数: 0

TOC 技术选择委员会

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2024-09-01 DOI: 10.1016/S2405-5255(24)00104-3

引用次数: 0

Verification of grip strength as an evaluation tool for locomotive syndrome in rheumatoid arthritis 将握力验证作为类风湿性关节炎运动综合征的评估工具

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2024-09-01 DOI: 10.1016/j.afos.2024.07.001

Yasumori Sobue , Mochihito Suzuki , Yoshifumi Ohashi , Ryo Sato , Hironobu Kosugiyama , Yusuke Ohno , Junya Hasegawa , Takaya Sugiura , Kenya Terabe , Shuji Asai , Shiro Imagama

{"title":"Verification of grip strength as an evaluation tool for locomotive syndrome in rheumatoid arthritis","authors":"Yasumori Sobue , Mochihito Suzuki , Yoshifumi Ohashi , Ryo Sato , Hironobu Kosugiyama , Yusuke Ohno , Junya Hasegawa , Takaya Sugiura , Kenya Terabe , Shuji Asai , Shiro Imagama","doi":"10.1016/j.afos.2024.07.001","DOIUrl":"10.1016/j.afos.2024.07.001","url":null,"abstract":"<div><h3>Objectives</h3><div>Locomotive syndrome (LS) leads to reduced physical function and a high risk of becoming bedridden. Grip strength serves as an indicator of upper limb and overall physical function. Rheumatoid arthritis (RA) patients with reduced grip strength frequently show finger and wrist joint inflammation. The purpose of this study was to verify grip strength as an evaluation tool for physical function and LS in RA patients.</div></div><div><h3>Methods</h3><div>As part of an ongoing multicenter observational study, 591 consecutive RA patients whose background information was available, including data for the 25-question Geriatric Locomotive Function Scale (GLFS-25) and grip strength, were examined. LS was defined as a GLFS-25 score ≥ 16 points. Finger and wrist joint inflammation were defined as tender or swollen joints.</div></div><div><h3>Results</h3><div>Among the 591 patients, 244 (41.3%) patients had LS, and 167 (28.3%) were male. Receiver operating characteristic curve analysis yielded cut-off values of grip strength for LS of 24 kg (specificity 72.2%; sensitivity 62.7%) for males and 17 kg (specificity 65.7%; sensitivity 67.6%) for females. Multivariable logistic regression analysis revealed a significant association of grip strength with LS, even after adjusting for finger and wrist joint inflammation.</div></div><div><h3>Conclusions</h3><div>LS was significantly associated with grip strength, even after adjusting for the presence of finger and wrist joint inflammation. We recommend adopting grip strength measurement as a screening tool for evaluating LS and guiding interventions.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"10 3","pages":"Pages 119-125"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply on “Choice of cemented or uncemented stems for displaced femoral neck fractures” 关于 "治疗移位性股骨颈骨折选择骨水泥或非骨水泥柄 "的答复

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2024-09-01 DOI: 10.1016/j.afos.2024.09.002

Yang-Yi Wang, Minh Dat Nguyen, Ta-Wei Tai

引用次数: 0

Surgery for spinal deformity with osteoporosis: Achieving successful fusion 骨质疏松症脊柱畸形手术：成功实现融合

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2024-09-01 DOI: 10.1016/j.afos.2024.06.002

Myung-Sup Ko , Hyung-Youl Park , Young-Il Ko , Sang-Il Kim , Young-Hoon Kim

引用次数: 0

Does intradiscal steroid injection accelerate the histological degeneration of the human disc? 椎间盘内注射类固醇是否会加速人体椎间盘的组织学退化？

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2024-09-01 DOI: 10.1016/j.afos.2024.06.001

Jin Hwan Kim , Sunhee Chang , Byung Ho Kim , Gyu Heon Lee , Sung Tan Cho

{"title":"Does intradiscal steroid injection accelerate the histological degeneration of the human disc?","authors":"Jin Hwan Kim , Sunhee Chang , Byung Ho Kim , Gyu Heon Lee , Sung Tan Cho","doi":"10.1016/j.afos.2024.06.001","DOIUrl":"10.1016/j.afos.2024.06.001","url":null,"abstract":"<div><h3>Objectives</h3><div>Intradiscal steroid injection (ISI) use has been proven as a low-risk and rapid treatment for disc degeneration disease (DDD). However, the histological effects of steroids on human discs remain poorly understood. The purpose of this study is to investigate whether ISI induces histologic degeneration of the disc.</div></div><div><h3>Methods</h3><div>In this study, a histological analysis was carried out on the nucleus pulposus obtained from 150 patients who underwent posterior lumbar interbody fusion. Among these individuals, 59 received ISI before the surgery, while 91 did not. After staining with hematoxylin and eosin, the histological classification was performed based on chondrocyte proliferation (C1, C2, and C3) and granular matrix change (M1 and M2). Logistic regression analysis was used to identify the main factors influencing chondrocyte proliferation and granular matrix change. Additionally, histological differences between the ISI group and the non-ISI group were analyzed.</div></div><div><h3>Results</h3><div>Chondrocyte proliferation and granular matrix changes were not significantly different between the ISI and non-ISI groups. The logistic regression analysis indicated that age is the most significant risk factor for both chondrocyte proliferation (P = 0.02) and granular matrix changes (P < 0.01).</div></div><div><h3>Conclusions</h3><div>The most crucial factor in disc degeneration is age. ISI does not accelerate the histological degeneration of chondrocyte proliferation and granular matrix. Therefore, the ISI could be considered as a histologically safe alternative in patients with DDD.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"10 3","pages":"Pages 108-113"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141697670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of whole-body vibration on bone properties in type 2 diabetes model rats 全身振动对 2 型糖尿病模型大鼠骨骼特性的影响

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2024-09-01 DOI: 10.1016/j.afos.2024.08.001

Akira Minematsu, Yasue Nishii

{"title":"Effects of whole-body vibration on bone properties in type 2 diabetes model rats","authors":"Akira Minematsu, Yasue Nishii","doi":"10.1016/j.afos.2024.08.001","DOIUrl":"10.1016/j.afos.2024.08.001","url":null,"abstract":"<div><h3>Objectives</h3><div>We examined the effects of whole-body vibration (WBV) on bone properties in type 2 diabetes (T2DM) model rats.</div></div><div><h3>Methods</h3><div>Twenty male Hos:ZFDM-<em>Lepr</em><sup><em>fa</em></sup>, <em>fa/fa</em> rats (divided into DM and WBV groups, N = 10 each) and 10 Hos:ZFDM-<em>Lepr</em><sup><em>fa</em></sup>, <em>fa/+</em> rats (as the control (CON) group) were used. The WBV group underwent WBV at 45 Hz frequency, with 0.5 <em>g</em> acceleration (15 min/day, 5 days/week) for 8 weeks. Trabecular and cortical bone mass, trabecular bone microstructure (TBMS), and cortical bone geometry (CBG) were analyzed via micro-computed tomography. Bone mechanical strength (maximum load, break point, and stiffness) was also measured. Additionally, bone metabolic and DM-related markers were determined.</div></div><div><h3>Results</h3><div>The bone mechanical strength of the femur improved in the WBV group, although muscle atrophy and bone deterioration were observed in the DM and WBV groups. The serum levels of bone-specific alkaline phosphatase and tartrate-resistant acid phosphatase-5b were significantly higher in the DM and WBV groups than in the CON group. Serum glucose and blood urea nitrogen levels were significantly lower in the WBV group than in the DM group.</div></div><div><h3>Conclusions</h3><div>This study suggests that WBV potentially improves the decrease in the bone mechanical strength of the femur, although it does not prevent the deterioration of bone mineral content, TBMS, and CBG parameters. Further studies are needed to investigate the effective timing and duration of WBV and the conditions that prevent T2DM and deterioration of bone properties and clarify the mechanism underlying WBV effects on bone properties in DM animals.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"10 3","pages":"Pages 101-107"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142319330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choice of cemented or uncemented stems for displaced femoral neck fractures 治疗股骨颈移位骨折的骨水泥或非骨水泥柄的选择

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2024-09-01 DOI: 10.1016/j.afos.2024.09.001

Kwangkyoun Kim

引用次数: 0

Monoclonal antibodies in patients with osteoporosis and renal insufficiency: An updated systematic review and meta-analysis 骨质疏松症和肾功能不全患者的单克隆抗体：最新系统综述和荟萃分析

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2024-06-01 DOI: 10.1016/j.afos.2024.05.004

Maria L.R. Defante , Victoria Alzogaray , Davi Said Gonçalves Celso , Lucas Antônio Torres , Mayara Bearse , Ana Claudia Frota Machado de Melo Lopes

{"title":"Monoclonal antibodies in patients with osteoporosis and renal insufficiency: An updated systematic review and meta-analysis","authors":"Maria L.R. Defante , Victoria Alzogaray , Davi Said Gonçalves Celso , Lucas Antônio Torres , Mayara Bearse , Ana Claudia Frota Machado de Melo Lopes","doi":"10.1016/j.afos.2024.05.004","DOIUrl":"10.1016/j.afos.2024.05.004","url":null,"abstract":"<div><h3>Objectives</h3><p>There are challenges for the treatment of osteoporosis in patients with kidney failure and monoclonal antibodies (MAb) might be a suitable therapy. However, the efficacy and safety of MAb among patients with osteoporosis and renal insufficiency remains unclear.</p></div><div><h3>Methods</h3><p>We systematically searched PubMed, Embase, and Cochrane Central for studies evaluating the efficacy and safety of the use of MAb in patients with osteoporosis and renal insufficiency. We pooled risk ratios (RR) and 95% confidence intervals (CI) for binary outcomes. Mean difference (MD) was used for continuous outcomes.</p></div><div><h3>Results</h3><p>We included 5 studies with 33,550 patients. MAb therapy decreased the risk of vertebral fractures (RR 0.32; 95% CI 0.26–0.40; P < 0.01) when compared to placebo and no statistical difference was found when comparing to bisphosphonate (RR 0.71; 95% CI 0.49–1.03; P = 0.07). MAb therapy also decreased the risk of nonvertebral fractures (RR 0.79; 95% CI 0.69–0.91; P = 0.0009). Lumbar spine bone mineral density (BMD) was higher in the MAb therapy when compared to both placebo (MD 10.90; 95% CI 8.00–13.80; P < 0.01) and bisphosphonate (MD 7.66; 95% CI 6.19–9.14; P < 0.01). There was no statistically significant difference in the change of estimated glomerular filtration rate and in the incidence of hypocalcemia and serious adverse events between groups.</p></div><div><h3>Conclusions</h3><p>There were reductions in both vertebral and nonvertebral fracture risks, alongside improvements in BMD among patients with renal insufficiency treated with MAb.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"10 2","pages":"Pages 47-53"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405525524000669/pdfft?md5=42d4001696ebe06d6c6d22ac2f728390&pid=1-s2.0-S2405525524000669-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141133677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0