Molecular crosstalk in SP7-mediated osteogenesis: Regulatory mechanisms and therapeutic potential

IF 2.8 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia Pub Date : 2025-06-01 DOI:10.1016/j.afos.2025.04.003

Jun Lang , Vivek Kumar Morya , Mi-Kyung Kwak , Sin-Hye Park , Kyu-Cheol Noh

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Abstract

SP7, also known as Osterix, is a zinc finger-containing transcription factor, plays a crucial role in osteoblast differentiation and bone formation. This review examines the molecular mechanisms underlying SP7's regulatory functions, highlighting its interactions with key signaling pathways such as BMP-SMAD, Wnt/β-catenin, and HIF-1α. SP7 acts downstream of RUNX2 to regulate osteogenic gene expression, including collagen Type I Alpha 1 (COL1A1), alkaline phosphatase (ALP) and osteocalcin (OCN). The review also explores the role of post-translational modifications, such as phosphorylation and ubiquitination, in modulating SP7's stability and activity. Emerging therapeutic strategies targeting SP7, including gene editing, RNA-based approaches, and small-molecule modulators, are discussed as innovative solutions for treating osteoporosis and other skeletal disorders. The potential for future research into SP7's interactions with non-coding RNAs and angiogenesis pathways is emphasized, underscoring its significance in skeletal health and regenerative medicine. This comprehensive overview consolidates current knowledge of SP7's molecular functions, therapeutic potential, and its pivotal role in bone biology.

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分子串扰在sp7介导的成骨：调控机制和治疗潜力

SP7，也被称为Osterix，是一种含锌指的转录因子，在成骨细胞分化和骨形成中起着至关重要的作用。本文综述了SP7调控功能的分子机制，重点介绍了SP7与BMP-SMAD、Wnt/β-catenin和HIF-1α等关键信号通路的相互作用。SP7作用于RUNX2的下游，调控成骨基因的表达，包括I型胶原α 1 （COL1A1）、碱性磷酸酶（ALP）和骨钙素（OCN）。本文还探讨了翻译后修饰，如磷酸化和泛素化，在调节SP7的稳定性和活性中的作用。针对SP7的新兴治疗策略，包括基因编辑、基于rna的方法和小分子调节剂，作为治疗骨质疏松症和其他骨骼疾病的创新解决方案进行了讨论。未来研究SP7与非编码rna和血管生成途径的相互作用的潜力被强调，强调其在骨骼健康和再生医学中的重要性。这篇全面的综述巩固了SP7的分子功能、治疗潜力及其在骨生物学中的关键作用的现有知识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Osteoporosis and Sarcopenia Orthopedics, Sports Medicine and Rehabilitation, Endocrinology, Diabetes and Metabolism, Obstetrics, Gynecology and Women's Health, Geriatrics and Gerontology

自引率

5.00%

发文量

审稿时长

66 days