Osteoporosis and Sarcopenia最新文献_第2页

Reply on “Dental panoramic radiographs by dental students versus artificial intelligence” 回复“牙科学生拍摄牙科全景x光片与人工智能”

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-03-01 DOI: 10.1016/j.afos.2025.02.003

Akira Taguchi

引用次数: 0

A predictive nomogram for selective screening of asymptomatic vertebral fractures: The Vietnam Osteoporosis Study 选择性筛选无症状椎体骨折的预测图：越南骨质疏松症研究

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-03-01 DOI: 10.1016/j.afos.2024.12.002

Hoa T. Nguyen , Bao T. Nguyen , An V. Tran , Tan T. Nguyen , Long H. Ngo , Tam Vo , Thi H. Nhung Thai , Linh D. Mai , Thach S. Tran , Tuan V. Nguyen , Lan T. Ho-Pham

{"title":"A predictive nomogram for selective screening of asymptomatic vertebral fractures: The Vietnam Osteoporosis Study","authors":"Hoa T. Nguyen , Bao T. Nguyen , An V. Tran , Tan T. Nguyen , Long H. Ngo , Tam Vo , Thi H. Nhung Thai , Linh D. Mai , Thach S. Tran , Tuan V. Nguyen , Lan T. Ho-Pham","doi":"10.1016/j.afos.2024.12.002","DOIUrl":"10.1016/j.afos.2024.12.002","url":null,"abstract":"<div><h3>Objectives</h3><div>Vertebral fractures are associated with disability and mortality, but most vertebral fractures are asymptomatic. The present study aimed to determine the incidence of and develop a predictive nomogram for asymptomatic vertebral fractures in Vietnamese adults.</div></div><div><h3>Methods</h3><div>This cohort study as a part of the Vietnam Osteoporosis Study involved 168 men and 287 women aged 50 years and older without a clinically diagnosed vertebral fracture. Their spine x-rays were taken at the recruitment and subsequent 2-year visit. Vertebral fractures were ascertained using the Genant's semi-quantitative method. We employed the Bayesian Model Averaging method to search for the optimal model for predicting asymptomatic vertebral fractures. A predictive nomogram was also developed to facilitate risk prediction.</div></div><div><h3>Results</h3><div>During a median of 2.38 years of follow-up, 13 men and 16 women developed an asymptomatic vertebral fracture, yielding the overall incidence rate of 28 fractures per 1000 person-years, or 33 fractures/1000 person-years in men and 24 fractures/1000 person-years in women, respectively. Most asymptomatic vertebral fractures were moderate, almost 1.5 times more common than mild fractures. The optimal model for predicting incident asymptomatic vertebral fractures included age, male sex and lower femoral neck T-score. The area under the receiver's operating characteristic curve was 0.91, with 95% CI ranging from 0.86 to 0.96.</div></div><div><h3>Conclusions</h3><div>Asymptomatic vertebral fractures were relatively common among adults in Vietnam. A simple model with sex, age and femoral neck T-score is helpful for selective screening of asymptomatic vertebral fractures in Vietnamese individuals.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 1","pages":"Pages 9-14"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two novel rare variants in the PTH gene found in patients with hypoparathyroidism 在甲状旁腺功能减退症患者中发现了两种新的罕见的PTH基因变异

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-03-01 DOI: 10.1016/j.afos.2025.02.001

Yue Jiang , An Song , Jiajia Wang , Xinqi Cheng , Jing Yang , Yan Jiang , Mei Li , Weibo Xia , Xiaoping Xing , Min Nie , Ou Wang

{"title":"Two novel rare variants in the PTH gene found in patients with hypoparathyroidism","authors":"Yue Jiang , An Song , Jiajia Wang , Xinqi Cheng , Jing Yang , Yan Jiang , Mei Li , Weibo Xia , Xiaoping Xing , Min Nie , Ou Wang","doi":"10.1016/j.afos.2025.02.001","DOIUrl":"10.1016/j.afos.2025.02.001","url":null,"abstract":"<div><h3>Objectives</h3><div>Hypoparathyroidism (HP) is a rare endocrine disorder caused by parathyroid hormone (PTH) deficiency. The <em>PTH</em> is a candidate gene for familial isolated hypoparathyroidism (FIH). This study aimed to investigate the pathogenicity of two novel rare variants (RVs) of <em>PTH</em> through <em>in vitro</em> functional study.</div></div><div><h3>Methods</h3><div>Targeted next-generation sequencing was used to identify candidate gene mutations. Clinical data were retrospectively collected. Wild-type (WT) <em>PTH</em> was used as a template for site-directed mutagenesis to create mutant eukaryotic expression plasmids, which were transfected into cells. Treated with or without 4-phenylbutyric acid (4-PBA), the levels of intact PTH (iPTH) and PTH (1-84) were measured by chemiluminescence, and protein expression was assessed using Western blotting.</div></div><div><h3>Results</h3><div>Two patients carrying <em>PTH</em> mutations (c.154G > A: p.Val52Ile, c.270G > T: p.Leu90Phe) were identified. Patient 1, a 45-year-old male, presented with carpal and pedal numbness, muscle cramps, and low serum calcium (1.29 mmol/L). Patient 2, a 12-year-old female, had muscle twitches, convulsions, low calcium (1.50 mmol/L), and iPTH of 4 pg/mL. The iPTH or PTH (1-84) levels in the medium transfected with mutant Val52Ile and Leu90Phe PTH decreased by 31%–38%, and 51%–96% compared to WT (allP < 0.05), which were not rescued by 4-PBA. No significant changes in intracellular PTH expression were observed.</div></div><div><h3>Conclusions</h3><div>In this study, two novel RVs of <em>PTH (</em>Val52Ile and Leu90Phe) were identified that may impair hormone synthesis and secretion. Our study has broadened the mutation spectrum of the <em>PTH</em> and shed light on potential mechanisms underlying FIH.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 1","pages":"Pages 22-28"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disorders of bone and mineral metabolism in pregnancy and lactation: A case based clinical review 妊娠和哺乳期骨和矿物质代谢紊乱：一个基于病例的临床回顾

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2025-03-01 DOI: 10.1016/j.afos.2025.03.002

Manju Chandran , Sarah Ying Tse Tan

{"title":"Disorders of bone and mineral metabolism in pregnancy and lactation: A case based clinical review","authors":"Manju Chandran , Sarah Ying Tse Tan","doi":"10.1016/j.afos.2025.03.002","DOIUrl":"10.1016/j.afos.2025.03.002","url":null,"abstract":"<div><div>Bone and mineral metabolism in the human body undergoes significant adaptations during pregnancy and lactation to meet the physiological demands of both the mother and fetus. The growing fetus requires approximately 30 g of calcium, with 80% of this transferred from the mother during the third trimester. These adaptations involve complex hormonal changes, such as increased parathyroid hormone-related peptide (PTHrP) and 1,25-dihydroxyvitamin D, ensuring the mother maintains calcium balance despite fetal demands. However, these changes can also exacerbate pre-existing metabolic bone disorders, presenting unique challenges during pregnancy. This narrative review, framed around illustrative case examples, focuses on the management of metabolic bone disorders in pregnancy. Relevant case studies of hypercalcemia, hypocalcemia, hypophosphatemia, and osteoporosis and chronic kidney disease mineral bone disorder are reviewed to illustrate the biochemical changes, clinical implications, and therapeutic strategies available during pregnancy and lactation. We analyze literature from case reports and existing guidelines to provide practical clinical recommendations. The review highlights critical pregnancy-related metabolic adaptations, such as increased intestinal calcium absorption and skeletal resorption. Disorders like primary hyperparathyroidism (PHPT) and familial hypocalciuric hypercalcemia present significant maternal and fetal risks, including miscarriage, growth restriction, and neonatal complications. Early identification and tailored treatment, including hydration, parathyroidectomy, and vitamin D supplementation, mitigate these risks, with surgical interventions in PHPT improving pregnancy outcomes compared to conservative management. Management of metabolic bone disorders during pregnancy and lactation requires a nuanced approach to meet the dual needs of the mother and fetus.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 1","pages":"Pages 1-8"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TOC TOC

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2024-12-01 DOI: 10.1016/S2405-5255(24)00130-4

引用次数: 0

Hip fracture and type 2 diabetes mellitus 髋部骨折和2型糖尿病。

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2024-12-01 DOI: 10.1016/j.afos.2024.11.003

Ji-Young Seo

引用次数: 0

Effects of bone metabolism on hematopoiesis: A Mendelian randomization study 骨代谢对造血的影响：一项孟德尔随机研究。

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2024-12-01 DOI: 10.1016/j.afos.2024.10.001

Shun-Cheong Ho , Gloria Hoi-Yee Li , Anskar Yu-Hung Leung , Kathryn Choon-Beng Tan , Ching-Lung Cheung

{"title":"Effects of bone metabolism on hematopoiesis: A Mendelian randomization study","authors":"Shun-Cheong Ho , Gloria Hoi-Yee Li , Anskar Yu-Hung Leung , Kathryn Choon-Beng Tan , Ching-Lung Cheung","doi":"10.1016/j.afos.2024.10.001","DOIUrl":"10.1016/j.afos.2024.10.001","url":null,"abstract":"<div><h3>Objectives</h3><div>Osteoblast is known to regulate hematopoiesis according to preclinical studies but the causal relationship in human remains uncertain. We aimed to evaluate causal relationships of bone mineral density (BMD) with blood cell traits using genetic data.</div></div><div><h3>Methods</h3><div>Summary statistics from the largest available genome-wide association study were retrieved for total body BMD (TBBMD), lumbar spine BMD (LSBMD), femoral neck BMD (FNBMD) and 29 blood cell traits including red blood cell, white blood cell and platelet-related traits. Using two-sample Mendelian randomization (MR) approach, inverse-variance weighted method was adopted as main univariable MR analysis. Multivariable MR (MVMR) analysis was conducted to evaluate whether the casual effect is independent of confounders.</div></div><div><h3>Results</h3><div>BMD was positively associated with reticulocyte-related traits, including high light scatter reticulocyte count and percentage, immature reticulocyte fraction, reticulocyte count and percentage, with causal effect estimate (beta) ranging from 0.023 to 0.064. Conversely, inverse association of BMD with hematocrit, hemoglobin, and red blood cell count was observed, with beta ranging from −0.038 to −0.019. The association remained significant in MVMR analysis after adjustment for confounders. For white blood cells, BMD was inversely associated with neutrophil count (beta: 0.029 to −0.019) and white blood cell count (beta: 0.024 to −0.02). Results across TBBMD, LSBMD, and FNBMD were consistent.</div></div><div><h3>Conclusions</h3><div>This study suggested bone metabolism had a causal effect on hematopoietic system in humans. Its causal effect on red blood cell traits was independent of confounders. Further studies on how improving bone health can reduce risk of hematological disorders are warranted.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"10 4","pages":"Pages 151-156"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erythropoietin treatment and osteoporotic fracture risk in hemodialysis patients: A nationwide population-based study 血液透析患者的促红细胞生成素治疗和骨质疏松性骨折风险：一项基于全国人群的研究。

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2024-12-01 DOI: 10.1016/j.afos.2024.11.002

Ching-Yu Lee , Fung-Chang Sung , Peir-Haur Hung , Chih-Hsin Muo , Meng-Huang Wu , Tsung-Jen Huang , Chih-Ching Yeh

{"title":"Erythropoietin treatment and osteoporotic fracture risk in hemodialysis patients: A nationwide population-based study","authors":"Ching-Yu Lee , Fung-Chang Sung , Peir-Haur Hung , Chih-Hsin Muo , Meng-Huang Wu , Tsung-Jen Huang , Chih-Ching Yeh","doi":"10.1016/j.afos.2024.11.002","DOIUrl":"10.1016/j.afos.2024.11.002","url":null,"abstract":"<div><h3>Objectives</h3><div>Concerns about erythropoietin (EPO) therapy for anemia in patients with end-stage renal disease (ESRD) contributing to potential bone loss and increased fracture risks are growing. This study investigated the impact of EPO administration on the risk of common osteoporotic fractures in ESRD patients.</div></div><div><h3>Methods</h3><div>This population-based retrospective cohort study compared EPO users and non-EPO users among ESRD patients undergoing hemodialysis, diagnosed with ESRD between 2000 and 2014 identified from the National Health Insurance Research Database of Taiwan. The cohorts were matched at a propensity score ratio of 1:1, resulting in equal sample sizes of 2839. Variables related to comorbidities were considered.</div></div><div><h3>Results</h3><div>EPO users exhibited higher cumulative incidences of major osteoporotic fractures, hip fractures, spine fractures, and wrist fractures compared with the non-EPO user (all P < 0.001). In adjusted Cox regression models, higher adjusted subdistribution hazard ratios (aSHRs) were observed for major osteoporotic fractures (2.41, 95% confidence interval [CI] = 2.01–2.89), osteoporotic hip fractures (2.19, 95% CI = 1.69–2.85), spine fractures (2.50, 95% CI = 1.87–3.34), and wrist fractures (2.34, 95% CI = 1.44–3.78) in EPO users than in non-EPO users. The risk of major osteoporotic fractures significantly increased with increasing EPO doses (P for trend < 0.0001), and a similar trend was observed for the risks of osteoporotic spine and wrist fractures.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that EPO treatment in patients with ESRD undergoing hemodialysis is associated with an increased risk of osteoporotic fractures.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"10 4","pages":"Pages 157-164"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteoporosis in men—East and West: Can the twain meet? A perspective from Asia 男性骨质疏松症——东方和西方：两者能相遇吗？来自亚洲的视角。

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2024-12-01 DOI: 10.1016/j.afos.2024.11.001

Gerald Gui Ren Sng , Jean-Yves Reginster , Majed S. Alokail , Manju Chandran

{"title":"Osteoporosis in men—East and West: Can the twain meet? A perspective from Asia","authors":"Gerald Gui Ren Sng , Jean-Yves Reginster , Majed S. Alokail , Manju Chandran","doi":"10.1016/j.afos.2024.11.001","DOIUrl":"10.1016/j.afos.2024.11.001","url":null,"abstract":"<div><div>Osteoporosis in men remains a significantly underrecognized condition, with notable differences in bone mineral density (BMD) and fracture risk between Asian and Western populations. Despite 30% of hip fractures globally occurring in men, they are less likely to be diagnosed or treated for osteoporosis, especially in resource-limited settings. Given these disparities, a deeper understanding of osteoporosis epidemiology and treatment efficacy in men is essential, particularly in Asian populations.</div><div>This review synthesizes the latest evidence on the epidemiology, screening, and treatment of osteoporosis in men, with a focus on genetic, environmental, and epidemiological disparities between Eastern and Western populations. Additionally, the review examines existing controversies surrounding fracture risk screening in men and evaluates the efficacy and cost-effectiveness of pharmacological treatments such as bisphosphonates, denosumab, and anabolic agents.</div><div>Asian men exhibit lower peak BMD compared to their Caucasian counterparts, leading to potential misdiagnoses when using Caucasian-based BMD reference ranges. Screening tools like the Fracture Risk Assessment Tool (FRAX)® show variability in performance across populations. Data on pharmacological treatment in men remain limited, although studies suggest comparable benefits to those observed in women. Larger studies, particularly in male and Asian populations, are urgently needed to refine diagnostic and therapeutic guidelines.</div><div>Osteoporosis in men is underdiagnosed and undertreated globally, with pronounced disparities between populations. Current diagnostic tools and treatment protocols are not fully tailored to male and Asian populations. There is an urgent need for longitudinal studies focusing on male-specific osteoporosis management to reduce fracture risk and improve outcomes.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"10 4","pages":"Pages 131-144"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply on “Hip fracture and type 2 diabetes mellitus”: Bi-directional relationship between osteoporosis and diabetes “髋部骨折与2型糖尿病”：骨质疏松与糖尿病的双向关系。

IF 2.5

Osteoporosis and Sarcopenia Pub Date : 2024-12-01 DOI: 10.1016/j.afos.2024.11.004

Suhas Krishnamoorthy, Ching-Lung Cheung

引用次数: 0