Yang-Yi Wang , Yi-Chuan Chou , Yuan-Hsin Tsai , Chih-Wei Chang , Yi-Chen Chen , Ta-Wei Tai
{"title":"Unplanned emergency department visits within 90 days of hip hemiarthroplasty for osteoporotic femoral neck fractures: Reasons, risks, and mortalities","authors":"Yang-Yi Wang , Yi-Chuan Chou , Yuan-Hsin Tsai , Chih-Wei Chang , Yi-Chen Chen , Ta-Wei Tai","doi":"10.1016/j.afos.2024.05.005","DOIUrl":"https://doi.org/10.1016/j.afos.2024.05.005","url":null,"abstract":"<div><h3>Objectives</h3><p>Bipolar hemiarthroplasty is commonly performed to treat displaced femoral neck fractures in osteoporotic patients. This study aimed to assess the occurrence and outcomes of unplanned return visits to the emergency department (ED) within 90 days following bipolar hemiarthroplasty for displaced femoral neck fractures.</p></div><div><h3>Methods</h3><p>The clinical data of 1322 consecutive patients who underwent bipolar hemiarthroplasty for osteoporotic femoral neck fractures at a tertiary medical center were analyzed. Data from the patients’ electronic medical records, including demographic information, comorbidities, and operative details, were collected. The risk factors and mortality rates were analyzed.</p></div><div><h3>Results</h3><p>Within 90 days after surgery, 19.9% of patients returned to the ED. Surgery-related reasons accounted for 20.2% of the patient's returns. Older age, a high Charlson comorbidity index score, chronic kidney disease, and a history of cancer were identified as significant risk factors for unplanned ED visits. Patients with uncemented implants had a significantly greater risk of returning to the ED due to periprosthetic fractures than did those with cemented implants (P = 0.04). Patients who returned to the ED within 90 days had an almost fivefold greater 1-year mortality rate (15.2% vs 3.1%, P < 0.001) and a greater overall mortality rate (26.2% vs 10.5%, P < 0.001).</p></div><div><h3>Conclusions</h3><p>This study highlights the importance of identifying risk factors for unplanned ED visits after bipolar hemiarthroplasty, which may contribute to a better prognosis. Consideration should be given to the use of cemented implants for hemiarthroplasty, as uncemented implants are associated with a greater risk of periprosthetic fractures.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"10 2","pages":"Pages 66-71"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405525524000670/pdfft?md5=2711884ce15727a5efbf84469f2e9918&pid=1-s2.0-S2405525524000670-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141480449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas Ying , Pablo Borrelli , Lars Edenbrandt , Olof Enqvist , Reza Kaboteh , Elin Trägårdh , Johannes Ulén , Henrik Kjölhede
{"title":"AI-based fully automatic image analysis: Optimal abdominal and thoracic segmentation volumes for estimating total muscle volume on computed tomography scans","authors":"Thomas Ying , Pablo Borrelli , Lars Edenbrandt , Olof Enqvist , Reza Kaboteh , Elin Trägårdh , Johannes Ulén , Henrik Kjölhede","doi":"10.1016/j.afos.2024.04.001","DOIUrl":"10.1016/j.afos.2024.04.001","url":null,"abstract":"<div><h3>Objectives</h3><p>Evaluation of sarcopenia from computed tomography (CT) is often based on measuring skeletal muscle area on a single transverse slice. Automatic segmentation of muscle volume has a lower variance and may be a better proxy for the total muscle volume than single-slice areas. The aim of the study was to determine which abdominal and thoracic anatomical volumes were best at predicting the total muscle volume.</p></div><div><h3>Methods</h3><p>A cloud-based artificial intelligence tool (<span>recomia.org</span><svg><path></path></svg>) was used to segment all skeletal muscle of the torso of 994 patients who had performed whole-torso CT 2008–2020 for various clinical indications. Linear regression models for several anatomical volumes and single-slice areas were compared with regard to predicting the total torso muscle volume.</p></div><div><h3>Results</h3><p>The muscle volume from the tip of the coccyx and 25 cm cranially was the best of the abdominal volumes and was significantly better than the L3 slice muscle area (R<sup>2</sup> 0.935 vs 0.830, P < 0.0001). For thoracic volumes, the muscle volume between the top of the sternum to the lower bound of the Th12 vertebra showed the best correlation with the total volume, significantly better than the Th12 slice muscle area (R<sup>2</sup> 0.892 vs 0.775, P < 0.0001). Adjusting for body height improved the correlation slightly for all measurements but did not significantly change the ordering.</p></div><div><h3>Conclusions</h3><p>We identified muscle volumes that can be reliably segmented by automated image analysis which is superior to single slice areas in predicting total muscle volume.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"10 2","pages":"Pages 78-83"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S240552552400061X/pdfft?md5=7590e8e315832561e5fca36a44997630&pid=1-s2.0-S240552552400061X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140777585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relationship between the perioperative prognostic nutritional index and postoperative gait function in elderly hip fractures","authors":"Kumiko Yotsuya , Kaoru Yamazaki , Junichiro Sarukawa , Tatsuya Yasuda , Yukihiro Matsuyama","doi":"10.1016/j.afos.2024.05.006","DOIUrl":"https://doi.org/10.1016/j.afos.2024.05.006","url":null,"abstract":"<div><h3>Objectives</h3><p>We investigated the relationship between the perioperative nutritional status and postoperative walking ability in patients with hip fractures.</p></div><div><h3>Methods</h3><p>We included 246 surgically treated elderly patients with hip fractures who were ambulatory before the injury. Patients were divided into two groups: group A, who were able to walk at discharge, and group B, who were unable to walk at discharge. We pair-matched these two groups according to age, preoperative subdivided walking ability, and fracture site to form groups A′ and B'. The prognostic nutritional index (PNI; PNI = 10 × serum albumin (g/dL) + 0.005 × blood total lymphocyte count (/mm³)) before surgery and 1 day, 1 week, and 2 weeks after surgery and energy intake 1 and 2 weeks after surgery were compared.</p></div><div><h3>Results</h3><p>After adjustments for age, preoperative subdivided walking ability, and fracture site, there were 51 patients in group A' (mean age 84.6 years) and 51 patients in group B' (mean age 84.7 years). In group A'/group B′, PNI was 43.38/42.60 (P = 0.19) before surgery, 33.87/33.31 (P = 0.44) 1 day after surgery, 34.99/32.35 (P = 0.01) 1 week after surgery, and 37.33/35.69 (P = 0.15) 2 weeks after surgery. Energy intake was 1380.8/1203.1 kcal (P = 0.01) 1 week after surgery and 1382.0/1335.6 kcal (P = 0.60) 2 weeks after surgery.</p></div><div><h3>Conclusions</h3><p>PNI and energy intake at 1 week postoperatively were associated with early postoperative nutrition and the recovery of walking ability.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"10 2","pages":"Pages 72-77"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405525524000682/pdfft?md5=13f0dfad63e47e188d7bb273b38b70f8&pid=1-s2.0-S2405525524000682-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141480450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regional variation in bone mineral density of the distal radius","authors":"Helen Morgan, Katy Knight, Robert Meertens","doi":"10.1016/j.afos.2024.03.001","DOIUrl":"https://doi.org/10.1016/j.afos.2024.03.001","url":null,"abstract":"<div><h3>Objectives</h3><p>This study investigates the regional variation in areal bone mineral density (aBMD) at the distal radius, a critical site for osteoporosis-related fractures. Understanding aBMD distribution is essential for accurate diagnosis and management of osteoporosis.</p></div><div><h3>Methods</h3><p>The study involved 261 participants aged over 50. Using dual-energy X-ray absorptiometry (DXA) scans, aBMD was recorded across contiguous regions of the distal radius. Factors considered include age, sex, and hand dominance, providing a comprehensive view of aBMD distribution.</p></div><div><h3>Results</h3><p>The findings indicated a consistent pattern in aBMD distribution along the radius, with a plateau around the one-third distance from the wrist. Notably, significant differences in aBMD were observed between age groups, especially among post-menopausal women. The study also recorded minor variations in aBMD between dominant and non-dominant forearms.</p></div><div><h3>Conclusions</h3><p>The study's insights into aBMD variation at the distal radius have implications for osteoporosis research and clinical diagnosis. It highlights the importance of standardized region of interest placement in DXA scans for accurate assessment.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"10 2","pages":"Pages 54-59"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405525524000335/pdfft?md5=c49705993528cc0151df652fec5c76c5&pid=1-s2.0-S2405525524000335-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141480451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Implications of the diagnosis of locomotive syndrome stage 3 for long-term care","authors":"Koichiro Ide , Yu Yamato , Tomohiko Hasegawa , Go Yoshida , Mitsuru Hanada , Tomohiro Banno , Hideyuki Arima , Shin Oe , Tomohiro Yamada , Yuh Watanabe , Kenta Kurosu , Hironobu Hoshino , Haruo Niwa , Daisuke Togawa , Yukihiro Matsuyama","doi":"10.1016/j.afos.2024.05.001","DOIUrl":"https://doi.org/10.1016/j.afos.2024.05.001","url":null,"abstract":"<div><h3>Objectives</h3><p>Locomotive syndrome stage 3 (LS3), which has been established recently, may imply a greater need for care than LS stage 0 (LS0), LS stage 1 (LS1), and LS stage 2 (LS2). The relationship between LS3 and long-term care in Japan is unclear. Therefore, this study aimed to examine this relationship.</p></div><div><h3>Methods</h3><p>A total of 531 patients (314 women and 217 men; mean age, 75 years) who were not classified as requiring long-term care and underwent musculoskeletal examinations in 2012 were grouped according to their LS stage. Group L comprised patients with LS3 and Group N comprised those with LS0, LS1, and LS2. We compared these groups according to their epidemiology results and long-term care requirements from 2013 to 2018.</p></div><div><h3>Results</h3><p>Fifty-nine patients (11.1%) were diagnosed with LS3. Group L comprised more patients (50.8%) who required long-term care than Group N (17.8%) (P < 0.001). Group L also comprised more patients with vertebral fractures and knee osteoarthritis than Group N (33.9% vs 19.5% [P = 0.011] and 78% vs 56.4% [P < 0.001], respectively). A Cox proportional hazards model and Kaplan–Meier analysis revealed a significant difference in the need for nursing care between Groups L and N (log-rank test, P < 0.001; hazard ratio, 2.236; 95% confidence interval, 1.451–3.447).</p></div><div><h3>Conclusions</h3><p>Between 2012 and 2018, 50% of patients with LS3 required nursing care. Therefore, LS3 is a high-risk condition that necessitates interventions. Approaches to vertebral fractures and osteoarthritis of the knee could be key.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"10 2","pages":"Pages 89-94"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405525524000633/pdfft?md5=ea984a478680c6259c3346acd3c75259&pid=1-s2.0-S2405525524000633-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relation of bone mineral density with fat infiltration of paraspinal muscles: The Goutallier classification","authors":"Firuzan Fırat Ozer , Emel Güler","doi":"10.1016/j.afos.2024.04.002","DOIUrl":"10.1016/j.afos.2024.04.002","url":null,"abstract":"<div><h3>Objectives</h3><p>Muscle and bone tissue are interrelated throughout their developmental processes via paracrine and endocrine pathways. Osteosarcopenia has emerged with the growing data proving the high rate of simultaneous occurrence of sarcopenia and osteoporosis. We aimed to evaluate the relationship between osteoporosis, and muscle quality by grading the fatty infiltration in paraspinal muscles according to the Goutallier classification in magnetic resonance imaging (MRI).</p></div><div><h3>Methods</h3><p>Data of postmenopausal patients who underwent MRI for low back pain were analyzed retrospectively. Lumbar spine and femoral neck bone mineral density (BMD) were measured by using dual energy X-ray absorptiometry (DXA). Grade of paraspinal muscle fatty infiltration for each level of lumbar vertebrae including L1-L2, L2-L3, L3-L4, was evaluated separately according to Goutallier classification system.</p></div><div><h3>Results</h3><p>A total of 91 postmenopausal women were included in the study. The mean age of the study population was 60.5 ± 11. Lumbar vertebrae L1-L4 total T-scores and BMD g/cm<sup>2</sup> were lower in patients with higher grades of Goutallier classification (P = 0.031 and P = 0.023, respectively). The distribution of the severity of fatty degeneration was significantly higher in the osteoporosis/osteopenia group at all 3 disc levels. No significant correlation was observed between femoral neck BMD and paraspinal muscle fat infiltration.</p></div><div><h3>Conclusions</h3><p>There is a strong relationship between osteoporosis of the lumbar spine and paraspinal muscle quality, which can be considered as a reflection of osteosarcopenia. The Goutailler classification can be an effective and easy method in the evaluation of muscle quality with MRI.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"10 2","pages":"Pages 84-88"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405525524000621/pdfft?md5=e45b46396421ffa1f435d21b1de8a94c&pid=1-s2.0-S2405525524000621-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140779731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suhas Krishnamoorthy , Casey Tze-Lam Tang , Warrington Wen-Qiang Hsu , Gloria Hoi-Yee Li , Chor-Wing Sing , Xiaowen Zhang , Kathryn Choon-Beng Tan , Bernard Man-Yung Cheung , Ian Chi-Kei Wong , Annie Wai-Chee Kung , Ching-Lung Cheung
{"title":"Hip fracture is associated with a reduced risk of type 2 diabetes: A retrospective cohort study","authors":"Suhas Krishnamoorthy , Casey Tze-Lam Tang , Warrington Wen-Qiang Hsu , Gloria Hoi-Yee Li , Chor-Wing Sing , Xiaowen Zhang , Kathryn Choon-Beng Tan , Bernard Man-Yung Cheung , Ian Chi-Kei Wong , Annie Wai-Chee Kung , Ching-Lung Cheung","doi":"10.1016/j.afos.2024.05.002","DOIUrl":"https://doi.org/10.1016/j.afos.2024.05.002","url":null,"abstract":"<div><h3>Objectives</h3><p>Type 2 diabetes mellitus (T2DM) shares a complex relationship with bone metabolism and few studies investigated the effect of impaired bone health on the risk of T2DM. This study was conducted to investigate the association between hip fractures and the risk of incident T2DM<strong>.</strong></p></div><div><h3>Methods</h3><p>This is a retrospective cohort study using data from the real-world hip fracture cohort. Hong Kong Chinese patients aged ≥ 65 years without T2DM who were admitted to public hospitals due to a fall between 2008 and 2015 were included in the study. Patients who sustained falls with and without hip fractures were matched by propensity score (PS) at a 1:1 ratio. Competing risk regression was used to evaluate the association between hip fracture and incident T2DM, with death being the competing event.</p></div><div><h3>Results</h3><p>A total of 23,314 hip fracture cases were matched to 23,314 controls. The median follow-up time was 5.09 years. The incidence rate of T2DM was 11.947 and 14.505 per 1000 person-years for the hip fracture and control group respectively. After accounting for the competing risk of death, the hip fracture group had a significantly lower risk of developing T2DM (HR: 0.771, 95% CI: 0.719–0.827). Similar results were observed in all subgroups after stratification by age and sex.</p></div><div><h3>Conclusions</h3><p>Hip fracture was found to be associated with a reduced risk of T2DM. These findings provide insight into the topic of bone and glucose metabolism and prompt further research in evaluating the role of bone health in the management of T2DM.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"10 2","pages":"Pages 60-65"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405525524000645/pdfft?md5=861ed4e904b9a08f9fb40cd8d32cab75&pid=1-s2.0-S2405525524000645-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141480448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Min Woo Kim, Young Min Noh, Jung Wook Huh, Han Eol Seo, Dong Ha Lee
{"title":"Discordance between dual-energy X-ray absorptiometry bone mineral density and spinal computed tomography texture analysis: An investigation into low correlation rates","authors":"Min Woo Kim, Young Min Noh, Jung Wook Huh, Han Eol Seo, Dong Ha Lee","doi":"10.1016/j.afos.2024.01.002","DOIUrl":"10.1016/j.afos.2024.01.002","url":null,"abstract":"<div><h3>Objectives</h3><p>This research delves into the application of texture analysis in spine computed tomography (CT) scans and its correlation with bone mineral density (BMD), as determined by dual-energy X-ray absorptiometry (DXA). It specifically addresses the discordance between the 2 measurements, suggesting that certain spinal-specific factors may contribute to this discrepancy.</p></div><div><h3>Methods</h3><p>The study involved 405 cases from a single institution collected between May 6, 2012 and June 30, 2021. Each case underwent a spinal CT scan and a DXA scan. BMD values at the lumbar region (T12 to S1) and total hip were recorded. Texture features from axial cuts of T12 to S1 vertebrae were extracted using gray-level co-occurrence matrices, and a regression model was constructed to predict the BMD values.</p></div><div><h3>Results</h3><p>The correlation between CT texture analysis results and BMD from DXA was moderate, with a correlation coefficient ranging between 0.4 and 0.5. This discordance was examined in light of factors unique to the spine region, such as abdominal obesity, aortic calcification, and lumbar degenerative changes, which could potentially affect BMD measurements.</p></div><div><h3>Conclusions</h3><p>Emerging from this study is a novel insight into the discordance between spinal CT texture analysis and DXA-derived BMD measurements, highlighting the unique influence of spinal attributes. This revelation calls into question the exclusive reliance on DXA scans for BMD assessment, particularly in scenarios where DXA scanning may not be feasible or accurate.</p></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"10 1","pages":"Pages 28-34"},"PeriodicalIF":2.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405525524000189/pdfft?md5=e522d77b69bea67c13dee89b4a7d6e3e&pid=1-s2.0-S2405525524000189-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140084634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}