Osteoporosis and Sarcopenia最新文献

{"title":"Sarcopenic obesity and sarcopenia in relation to frailty, independent of locomotive syndrome: the DETECt-L cross-sectional study","authors":"Naoki Deguchi ,&nbsp;Tomoyuki Akita ,&nbsp;Yasushi Uchiyama ,&nbsp;Ryo Tanaka","doi":"10.1016/j.afos.2025.11.003","DOIUrl":"10.1016/j.afos.2025.11.003","url":null,"abstract":"<div><h3>Objectives</h3><div>Frailty among community-dwelling older adults increases the risk of adverse health outcomes. Sarcopenic obesity (SO), characterized by low muscle mass combined with excess adiposity, may worsen frailty. Locomotive syndrome (LS) shares features with frailty and sarcopenia. This study examined whether LS modifies the association between body composition and frailty.</div></div><div><h3>Methods</h3><div>We analyzed cross-sectional data of 481 adults aged ≥ 40 years from the DETECt-L cohort in Japan. Frailty was defined according to the Japanese Cardiovascular Health Study criteria. Body composition was measured using bioelectrical impedance, based on skeletal muscle mass and body fat, to categorize participants into normal, sarcopenia, obesity, or SO phenotypes. Logistic regression-estimated odds ratios for comparing prefrailty/frailty with robustness were calculated. Model 1 was unadjusted; Model 2 (fully adjusted) adjusted for age, sex, pain, fall history, and Timed Up-and-Go and single-leg standing tests; and Model 3 additionally included body mass index (BMI) (sensitivity).</div></div><div><h3>Results</h3><div>Overall, 41.6% of participants were classified as prefrail or frail. The distribution of body composition phenotypes was as follows: normal (42.8%), sarcopenic (31.2%), obese (15.8%), and SO (10.2%). In Model 2, both sarcopenia (odds ratio [OR], 2.24; 95% confidence interval [CI], 1.38–3.63) and SO (OR, 2.51; 95% CI, 1.21–5.24) were associated with increased odds of prefrailty/frailty. These associations remained robust after adjusting for BMI. However, LS did not significantly affect these associations.</div></div><div><h3>Conclusions</h3><div>Sarcopenia and SO were independently associated with prefrailty/frailty regardless of LS status. Integrating muscle function and adiposity metrics may support early risk detection in community settings.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"12 1","pages":"Pages 44-50"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147584460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-assisted screening reveals high prevalence of osteoporosis in Vietnamese adults using pelvic and hip radiographs","authors":"Dat Minh Nguyen ,&nbsp;Chih-Hsing Wu ,&nbsp;Tuan Van Nguyen ,&nbsp;Lan T. Ho-Pham ,&nbsp;Kim Thi Hoang Dang ,&nbsp;Hy Van Nguyen ,&nbsp;Sung-Yen Lin ,&nbsp;Chung-Hwan Chen ,&nbsp;Ta-Wei Tai","doi":"10.1016/j.afos.2026.01.002","DOIUrl":"10.1016/j.afos.2026.01.002","url":null,"abstract":"<div><h3>Objectives</h3><div>Osteoporosis is a silent disease with low screening rates in many developing countries. This study aimed to evaluate the feasibility of using an artificial intelligence (AI)-based system to screen osteoporosis from pelvic and hip radiographs in Vietnam.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study at a tertiary medical center in Central Vietnam in 2023. A total of 2000 consecutive pelvic and hip radiographs from patients aged ≥ 40 years were collected. After excluding poor-quality images, 1987 radiographs were analyzed using an AI-based software designed to estimate bone mineral density (BMD) from plain radiographs and derive T-scores. Osteoporosis was defined as a T-score ≤ −2.5. Patient characteristics, radiographic findings, and risk factors for osteoporosis were analyzed.</div></div><div><h3>Results</h3><div>Among 1987 patients (mean age 66.4 ± 15.1 years; 41.3% men), osteoporosis was identified in 872 patients (43.9%). The prevalence increased with age and was higher in women than in men (58.7% vs 22.8%, P &lt; 0.001). Osteoporosis was associated with femoral neck (OR = 3.8, 95% CI: 2.7–5.2) and intertrochanteric fractures (OR = 7.0, 95% CI: 4.5–11.0). Patients with lower T-scores had a higher risk of hip fractures, especially those with T-scores ≤ −3.0 (OR = 11.5, 95% CI: 5.5–24.5).</div></div><div><h3>Conclusions</h3><div>AI-based analysis of pelvic and hip radiographs is a feasible and effective tool for osteoporosis screening in Vietnam. The prevalence of osteoporosis in this hospital-based setting was high, particularly among elderly women. AI-assisted screening may offer an accessible strategy for early detection of osteoporosis in resource-limited settings.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"12 1","pages":"Pages 18-25"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147584478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness of opportunistic osteoporosis screening using artificial-intelligence assisted chest radiographs in Japan","authors":"Jean-Yves Reginster ,&nbsp;Takahiko Hamasaki ,&nbsp;Saeko Fujiwara ,&nbsp;Majed Alokail ,&nbsp;Mickael Hiligsmann","doi":"10.1016/j.afos.2025.10.003","DOIUrl":"10.1016/j.afos.2025.10.003","url":null,"abstract":"<div><h3>Objectives</h3><div>Osteoporosis is often undiagnosed due to the shortcomings of conventional screening, resulting in missed chances for early treatment. Advances in artificial intelligence (AI), particularly deep learning applied to chest X-rays, offer a new opportunity for opportunistic screening. This study assesses the cost-effectiveness of this approach in Japanese women aged ≥ 50 years.</div></div><div><h3>Methods</h3><div>An economic model estimated the cost per quality-adjusted life year (QALY) gained (in 2024 Japanese Yen, ¥) for a strategy involving AI-assisted chest X-ray screening followed by treatment, compared to no screening. Patient trajectories were modeled using the AI system's diagnostic performance and aligned with the Japanese osteoporosis guidelines. Analyses were conducted for Japan overall, in Kure City (a high-fracture-incidence area), and in a lower-incidence scenario. Real-world medication persistence, the probabilities of dual-energy X-ray absorptiometry examination after screening detection, and treatment initiation rates were incorporated.</div></div><div><h3>Results</h3><div>Nationwide in Japan, the cost per QALY gained from opportunistic osteoporosis screening was estimated at ¥189,713 for women aged ≥ 50, substantially lower than the accepted cost-effectiveness threshold of ¥5 million. In Kure City, opportunistic screening was dominant (lower total costs for more QALYs). In the lower-incidence scenario, 25% below the national average, the cost per QALY was ¥1,055,095, remaining below the threshold. Results were robust across all age-specific populations and in sensitivity analyses.</div></div><div><h3>Conclusions</h3><div>Leveraging AI-assisted chest X-rays for incidental osteoporosis detection demonstrates strong economic viability for older Japanese women. This approach also proves to be a dominant strategy in areas with elevated fracture rates.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 4","pages":"Pages 127-136"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asian Federation of Osteoporosis Societies 2025 consensus on atypical femoral fractures in patients with osteoporosis","authors":"Thanut Valleenukul ,&nbsp;Thawee Songpatanasilp ,&nbsp;Unnop Jaisamrarn ,&nbsp;Surapong Anuraklekha ,&nbsp;Varalak Srinonprasert ,&nbsp;Sumapa Chaiamnuay ,&nbsp;Aasis Unnanuntana ,&nbsp;Lalita Wattanachanya ,&nbsp;Hataikarn Nimitphong ,&nbsp;Noratep Kulachote ,&nbsp;Ong-art Phruetthiphat ,&nbsp;Rahat Jarayabhand ,&nbsp;Tanawat Amphansap ,&nbsp;Ekasame Vanitcharoenkul ,&nbsp;Pojchong Chotiyarnwong ,&nbsp;Satoshi Mori ,&nbsp;Kwang-kyoun Kim ,&nbsp;Swan Sim Yeap ,&nbsp;Sharmila Sunita Paramasivam ,&nbsp;Linsey Gani ,&nbsp;Natthinee Charatcharoenwitthaya","doi":"10.1016/j.afos.2025.11.001","DOIUrl":"10.1016/j.afos.2025.11.001","url":null,"abstract":"<div><div>Atypical femoral fractures (AFFs) are a rare but serious complication of prolonged anti-resorptive therapy for osteoporosis. This study aimed to develop consensus-based recommendations for the clinical management of AFFs across the Asian Federation of Osteoporosis Societies (AFOS), for harmonizing practice and improving patient outcomes.</div><div>A structured questionnaire covering ten key domains related to AFFs was distributed to expert representatives from the 10 AFOS member countries or regions. Responses were analyzed to identify areas of consensus and variation in regional practice. A concurrent narrative review of the literature was conducted to inform evidence-based recommendations.</div><div>Survey responses were obtained from 8 of 10 participating AFOS member nations or regions. Among these, Thailand, Malaysia, South Korea, and Hong Kong reported established national guidelines or position statements on AFFs. Contributing risk factors include extended anti-resorptive therapy, femoral geometry, comorbidities, and specific pharmacologic exposures. Diagnosis depends on clinical suspicion and multimodal imaging, with high concordance in diagnostic criteria across regions. Screening emphasizes full-length femoral imaging in high-risk individuals. Incomplete AFFs are managed conservatively or with prophylactic fixation, while complete AFFs typically require intramedullary nailing, tailored to anatomic variations such as femoral bowing. Post-fracture care involves discontinuation of anti-resorptives, assessment for secondary osteoporosis, and potential initiation of anabolic therapy, including teriparatide, abaloparatide, and romosozumab.</div><div>This AFOS-led initiative highlights the importance for early detection, individualized management, and region-specific strategies. A multidisciplinary, patient-centered approach—encompassing risk assessment, imaging surveillance, surgical intervention, and tailored pharmacologic treatment—is crucial to reduce AFFs impact and improve skeletal health outcomes across Asia.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 4","pages":"Pages 111-120"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia and sarcopenic obesity in rheumatoid arthritis patients: prevalence and their relationship with joint damage and functional impairment","authors":"Iris Paola Guzmán-Guzmán ,&nbsp;José Rafael Villafan-Bernal ,&nbsp;Ilse Adriana Gutiérrez-Pérez ,&nbsp;Ramcés Falfán-Valencia ,&nbsp;Héctor Ugo Rojas-Delgado ,&nbsp;Antonio Alarcón-Paredes ,&nbsp;Andrés Felipe Villaquiran-Hurtado ,&nbsp;Gustavo Adolfo Alonso-Silverio ,&nbsp;Oscar Zaragoza-García","doi":"10.1016/j.afos.2025.10.004","DOIUrl":"10.1016/j.afos.2025.10.004","url":null,"abstract":"<div><h3>Objectives</h3><div>Sarcopenia and sarcopenic obesity are associated with a depletion of muscle mass, strength, and performance in rheumatoid arthritis (RA). We aimed to determine the prevalence of sarcopenia and sarcopenic obesity, as well as the clinical factors.</div></div><div><h3>Methods</h3><div>A cross-sectional study was carried out with 262 patients suffering from RA (230 women and 32 men). Demographic data, anthropometric measurements, clinical features, and previous medication were recorded. Sarcopenia was defined based on the 2019 consensus of the Asian Working Group for Sarcopenia. The combination of sarcopenia and an excess of body fat mass was classified as sarcopenic obesity. Multivariable-adjusted regression analysis was used to explore potential factors associated with sarcopenia phenotypes in RA patients.</div></div><div><h3>Results</h3><div>Among the study participants, 49.6% had sarcopenia; of those, 66.9% had sarcopenic obesity. Subjects with sarcopenia were significantly older, had a longer duration of illness, more morning stiffness, higher radiological grade, and elevated erythrocyte sedimentation rate levels. Additionally, female sex and the use of combinations of disease-modifying antirheumatic drugs were significantly more common in the sarcopenia group compared to patients without sarcopenia (all P &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>The prevalence of sarcopenia and sarcopenic obesity is high among Mexican patients with RA, and the current study shows that sarcopenia phenotypes are linked to worse functional impairment and significantly higher joint damage score. Early detection, nutritional intervention, and treatment of muscle dysfunction could enhance the quality of life and outcomes for RA patients.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 4","pages":"Pages 145-151"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and tolerability of electrical muscle stimulation during rehabilitation in older adults with osteoporotic vertebral fractures","authors":"Yuko Fujiwara ,&nbsp;Toshifumi Fujiwara ,&nbsp;Seiichi Kamo","doi":"10.1016/j.afos.2025.10.002","DOIUrl":"10.1016/j.afos.2025.10.002","url":null,"abstract":"<div><h3>Objectives</h3><div>In the context of Japan's rapidly aging population, osteoporotic vertebral fractures are becoming increasingly prevalent, creating greater demands for rehabilitation amid healthcare labor shortages. This study aimed to evaluate the feasibility and potential efficacy of abdominal electrical muscle stimulation (EMS) as an adjunct to rehabilitation in older adults with osteoporotic vertebral fractures, focusing on muscle thickness and bowel function.</div></div><div><h3>Methods</h3><div>Thirty-four elderly patients (mean age: 85 years) hospitalized for osteoporotic vertebral fractures underwent conventional physical and occupational therapy combined with abdominal EMS four times per week. Rectus abdominis muscle thickness was assessed by ultrasound, and bowel function was evaluated using bowel movement frequency and laxative usage. Interrater reliability for ultrasound measurement was high (ICC = 0.97; 95% CI: 0.90–0.99).</div></div><div><h3>Results</h3><div>Rectus abdominis muscle thickness increased significantly by 0.5 mm (P = 0.001). A non-significant trend toward increased spontaneous bowel movements was observed (5–6 times/week; P = 0.058), and laxative use decreased significantly (P = 0.0172). No EMS-related adverse events were reported, and all participants completed the intervention as scheduled.</div></div><div><h3>Conclusions</h3><div>Abdominal EMS is a feasible, safe, and potentially effective adjunct to conventional rehabilitation for older adults with osteoporotic vertebral fractures, even during periods of bed rest. It may contribute to muscle maintenance and support bowel function. These findings support further investigation in larger prospective studies to confirm efficacy and explore long-term outcomes.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 4","pages":"Pages 152-158"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary analysis of combined romosozumab and denosumab versus teriparatide and denosumab on bone mineral density","authors":"Ming-Hung Chiang ,&nbsp;Tian-Sin Fan ,&nbsp;Chia-Che Lee ,&nbsp;Tzu-Hao Tseng ,&nbsp;Hung-Kuan Yen ,&nbsp;Chih-Chien Hung ,&nbsp;Yi-Chien Lu ,&nbsp;Ning-Huei Sie ,&nbsp;Chen-Yu Wang ,&nbsp;Shau-Huai Fu","doi":"10.1016/j.afos.2025.11.002","DOIUrl":"10.1016/j.afos.2025.11.002","url":null,"abstract":"<div><h3>Objectives</h3><div>The effectiveness of combining romosozumab (ROMO) with denosumab (Dmab) remains uncertain. We compare the six-month effects of Dmab plus monthly ROMO versus Dmab plus daily teriparatide (TPTD) on bone mineral density (BMD) in treatment-naïve postmenopausal women with osteoporosis.</div></div><div><h3>Methods</h3><div>This retrospective cohort study analyzed 26 treatment-naïve postmenopausal women with primary osteoporosis. Participants received either a monthly regimen of ROMO and Dmab (N = 14) or a daily regimen of TPTD plus Dmab (N = 12). BMD at the lumbar spine, total hip, and femoral neck was measured at baseline, 3 months, and 6 months by dual-energy X-ray absorptiometry. Serum levels of C-terminal telopeptide (CTX) and procollagen type I N-terminal propeptide (P1NP) were assessed at the same intervals.</div></div><div><h3>Results</h3><div>Both regimens significantly improved lumbar spine BMD at 6 months (ROMO + Dmab: +9.75%; TPTD + Dmab: +7.42%). Improvements in total hip and femoral neck BMD were modest and similar between groups (∼2%). Serum CTX and P1NP were significantly suppressed in both groups at 3 months, but P1NP suppression waned in the TPTD + Dmab group by 6 months. No statistically significant differences in BMD or marker changes were detected between the two regimens.</div></div><div><h3>Conclusions</h3><div>Both combination therapies effectively improve lumbar spine BMD over 6 months. The ROMO + Dmab regimen yielded numerically greater increases with fewer injections.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 4","pages":"Pages 137-144"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthopedic referral rates following osteoporosis screening using dental panoramic radiography in female patients: A three-year prospective study","authors":"Noriyuki Sugino ,&nbsp;Hiroko Kuroiwa ,&nbsp;Hizuru Osanai ,&nbsp;Shinichiro Yamada ,&nbsp;Kozue Mori ,&nbsp;Hirokazu Kobayashi ,&nbsp;Daisuke Higuchi ,&nbsp;Nobuyuki Udagawa ,&nbsp;Akira Taguchi","doi":"10.1016/j.afos.2025.10.001","DOIUrl":"10.1016/j.afos.2025.10.001","url":null,"abstract":"<div><h3>Objectives</h3><div>Although osteoporosis affects approximately 15.9 million people in Japan, screening rates remain low. Dental panoramic radiographs (DPRs), routinely used in general dental practice, may facilitate opportunistic screening, yet referrals based on these images are not widely implemented. This study evaluated referral rates to orthopedic departments of patients with suspected osteoporosis identified using DPRs.</div></div><div><h3>Methods</h3><div>Among 3237 female patients aged ≥ 50 who underwent DPRs between February 2022 and October 2024, 328 without a prior osteoporosis diagnosis were identified as suspected cases. Their primary dentists referred these patients to our hospital's orthopedic department. Additionally, trained oral radiologists optionally provided information on osteoporosis. We assessed (1) the overall referral rate, (2) differences in referral rates based on whether an explanation by oral radiologist was provided, (3) referral rates stratified by age group, and (4) the prevalence of osteoporosis, osteopenia, and asymptomatic vertebral fractures among referred patients.</div></div><div><h3>Results</h3><div>Of the 328 patients, 53 (16.2%) visited the orthopedic department. Referral rates were significantly higher among patients who received explanations from trained oral radiologists (50.9%) than among patients who did not (9.1%). Referral rates peaked among patients in their 60s (23.7%). Among referred patients, 60.4% were diagnosed with osteoporosis and 37.7% with osteopenia; five patients had asymptomatic vertebral fractures.</div></div><div><h3>Conclusions</h3><div>Despite easy access to orthopedic care, referral rates remained low, likely due to limited awareness. Explanations by trained oral radiologists significantly improved referral rates, highlighting the importance of dentist-led education and interdisciplinary collaboration in promoting osteoporosis screening in general dental practice.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 4","pages":"Pages 121-126"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differing mechanisms of anabolic effects between Teriparatide and Romosozumab: A bone histomorphometric assessment","authors":"Noriaki Yamamoto ,&nbsp;Kimihiko Sawakami ,&nbsp;Kei Watanabe ,&nbsp;Kazuhiro Hasegawa ,&nbsp;Taketoshi Shimakura ,&nbsp;Hideaki E. Takahashi","doi":"10.1016/j.afos.2025.08.008","DOIUrl":"10.1016/j.afos.2025.08.008","url":null,"abstract":"","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 3","pages":"Page 3"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Postponement of Fracture” as a novel metric for expressing anti-fracture efficacy: An IPD meta-analysis","authors":"Thach S. Tran ,&nbsp;Nick Tran ,&nbsp;Tuan V. Nguyen","doi":"10.1016/j.afos.2025.08.009","DOIUrl":"10.1016/j.afos.2025.08.009","url":null,"abstract":"","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 3","pages":"Page 3"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}