性别和种族的股骨骨密度参考值:来自卡塔尔生物银行研究的结果

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM
Fawziya Al-Baker , Mujahed Shraim , Amal Al-Haidose , Atiyeh M. Abdallah
{"title":"性别和种族的股骨骨密度参考值:来自卡塔尔生物银行研究的结果","authors":"Fawziya Al-Baker ,&nbsp;Mujahed Shraim ,&nbsp;Amal Al-Haidose ,&nbsp;Atiyeh M. Abdallah","doi":"10.1016/j.afos.2025.05.006","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>Low bone mineral density (BMD) is a major global health concern due to fracture-related morbidity and mortality. BMD is currently assessed by dual-energy X-ray absorptiometry (DXA) against a US reference population. The aim of the study was to establish an ethnicity- and sex-specific reference for calculating BMD at different femoral sites including femoral trochanter, Ward's triangle and femoral neck in Qatar.</div></div><div><h3>Methods</h3><div>This cross-sectional study analyzed BMD in 4727 (2277 females and 2450 males) healthy Qatari aged between 20 and 82 years participating in the Qatar Biobank (QBB) study. Standard T-scores provided by the densitometer (T<sub>DXA</sub>) were compared with ethnicity- and sex-specific T-scores for the Qatari population (T<sub>QA</sub>) calculated using data from the 20-29-year age group for different femoral sites as the reference. The concordance between T<sub>DXA</sub> and T<sub>QA</sub> was analyzed using kappa statistics.</div></div><div><h3>Results</h3><div>Males consistently exhibited higher BMD values for the femoral trochanter, Ward's triangle, and the femoral neck across all age groups compared with females. Using T<sub>QA</sub> rather than T<sub>DXA</sub> as a reference at any site classified fewer individuals as having osteoporosis and osteopenia, especially for females. Agreement between T<sub>DXA</sub> and T<sub>QA</sub> was higher in males than in females.</div></div><div><h3>Conclusions</h3><div>These findings underscore the need for local ethnicity- and sex-specific BMD reference values. The use of T<sub>QA</sub> significantly reduced overdiagnosis of osteopenia and osteoporosis compared with T<sub>DXA</sub>, thereby decreasing overtreatment and impacting participant recruitment decisions into clinical studies.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 2","pages":"Pages 43-49"},"PeriodicalIF":2.5000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Femoral bone mineral density reference values by sex and ethnicity: Findings from the Qatar Biobank study\",\"authors\":\"Fawziya Al-Baker ,&nbsp;Mujahed Shraim ,&nbsp;Amal Al-Haidose ,&nbsp;Atiyeh M. Abdallah\",\"doi\":\"10.1016/j.afos.2025.05.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>Low bone mineral density (BMD) is a major global health concern due to fracture-related morbidity and mortality. BMD is currently assessed by dual-energy X-ray absorptiometry (DXA) against a US reference population. The aim of the study was to establish an ethnicity- and sex-specific reference for calculating BMD at different femoral sites including femoral trochanter, Ward's triangle and femoral neck in Qatar.</div></div><div><h3>Methods</h3><div>This cross-sectional study analyzed BMD in 4727 (2277 females and 2450 males) healthy Qatari aged between 20 and 82 years participating in the Qatar Biobank (QBB) study. Standard T-scores provided by the densitometer (T<sub>DXA</sub>) were compared with ethnicity- and sex-specific T-scores for the Qatari population (T<sub>QA</sub>) calculated using data from the 20-29-year age group for different femoral sites as the reference. The concordance between T<sub>DXA</sub> and T<sub>QA</sub> was analyzed using kappa statistics.</div></div><div><h3>Results</h3><div>Males consistently exhibited higher BMD values for the femoral trochanter, Ward's triangle, and the femoral neck across all age groups compared with females. Using T<sub>QA</sub> rather than T<sub>DXA</sub> as a reference at any site classified fewer individuals as having osteoporosis and osteopenia, especially for females. Agreement between T<sub>DXA</sub> and T<sub>QA</sub> was higher in males than in females.</div></div><div><h3>Conclusions</h3><div>These findings underscore the need for local ethnicity- and sex-specific BMD reference values. The use of T<sub>QA</sub> significantly reduced overdiagnosis of osteopenia and osteoporosis compared with T<sub>DXA</sub>, thereby decreasing overtreatment and impacting participant recruitment decisions into clinical studies.</div></div>\",\"PeriodicalId\":19701,\"journal\":{\"name\":\"Osteoporosis and Sarcopenia\",\"volume\":\"11 2\",\"pages\":\"Pages 43-49\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Osteoporosis and Sarcopenia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405525525000317\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Osteoporosis and Sarcopenia","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405525525000317","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

摘要

由于骨折相关的发病率和死亡率,低骨密度(BMD)是一个主要的全球健康问题。目前,BMD是通过双能x射线吸收仪(DXA)对美国参考人群进行评估的。该研究的目的是建立一个种族和性别特定的参考,用于计算不同股骨部位的骨密度,包括股骨粗隆、沃德三角和卡塔尔的股骨颈。方法本横断面研究分析了4727名(2277名女性和2450名男性)参加卡塔尔生物银行(QBB)研究的年龄在20至82岁之间的健康卡塔尔人的骨密度。将密度计(TDXA)提供的标准t评分与卡塔尔人口(TQA)的种族和性别特异性t评分进行比较,TQA使用20-29岁年龄组不同股骨部位的数据作为参考。采用kappa统计分析TDXA与TQA的一致性。结果在所有年龄组中,男性股骨粗隆、沃德三角和股骨颈的骨密度值均高于女性。在任何地点使用TQA而不是TDXA作为参考,将更少的个体分类为骨质疏松症和骨质减少症,尤其是女性。TDXA和TQA在男性中的一致性高于女性。结论:这些发现强调了对当地种族和性别特异性骨密度参考值的需求。与TDXA相比,TQA的使用显著减少了骨质减少和骨质疏松的过度诊断,从而减少了过度治疗,影响了临床研究中参与者的招募决策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Femoral bone mineral density reference values by sex and ethnicity: Findings from the Qatar Biobank study

Objectives

Low bone mineral density (BMD) is a major global health concern due to fracture-related morbidity and mortality. BMD is currently assessed by dual-energy X-ray absorptiometry (DXA) against a US reference population. The aim of the study was to establish an ethnicity- and sex-specific reference for calculating BMD at different femoral sites including femoral trochanter, Ward's triangle and femoral neck in Qatar.

Methods

This cross-sectional study analyzed BMD in 4727 (2277 females and 2450 males) healthy Qatari aged between 20 and 82 years participating in the Qatar Biobank (QBB) study. Standard T-scores provided by the densitometer (TDXA) were compared with ethnicity- and sex-specific T-scores for the Qatari population (TQA) calculated using data from the 20-29-year age group for different femoral sites as the reference. The concordance between TDXA and TQA was analyzed using kappa statistics.

Results

Males consistently exhibited higher BMD values for the femoral trochanter, Ward's triangle, and the femoral neck across all age groups compared with females. Using TQA rather than TDXA as a reference at any site classified fewer individuals as having osteoporosis and osteopenia, especially for females. Agreement between TDXA and TQA was higher in males than in females.

Conclusions

These findings underscore the need for local ethnicity- and sex-specific BMD reference values. The use of TQA significantly reduced overdiagnosis of osteopenia and osteoporosis compared with TDXA, thereby decreasing overtreatment and impacting participant recruitment decisions into clinical studies.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Osteoporosis and Sarcopenia
Osteoporosis and Sarcopenia Orthopedics, Sports Medicine and Rehabilitation, Endocrinology, Diabetes and Metabolism, Obstetrics, Gynecology and Women's Health, Geriatrics and Gerontology
自引率
5.00%
发文量
23
审稿时长
66 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信