比较 2010-2020 年香港髋部骨折和常见癌症的死亡率、风险和趋势:以人口为基础的研究

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM
Xiaowen Zhang , Chor-Wing Sing , Philip CM Au , Kathryn Choon-Beng Tan , Ian Chi-Kei Wong , Ching-Lung Cheung
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引用次数: 0

摘要

髋部骨折是全球关注的高死亡率疾病,但往往未得到充分认识。我们比较了女性和男性髋部骨折与常见癌症的死亡率、风险和长期趋势,旨在引起人们对髋部骨折的关注。方法纳入2010-2020年首次诊断为髋部骨折的患者193,767例,各性别、年龄在50岁及以上。将年龄标准化死亡率调整为WHO标准人群,使用Cox比例风险模型计算特定性别的死亡率相对风险,并对潜在混杂因素进行调整。趋势分析使用连接点回归来计算年龄标准化死亡率的年百分比变化。结果髋部骨折的1年和5年年龄标准化死亡率和性别特异性死亡率高于女性乳腺癌(风险比[HR]: 0.93, 95%可信区间[CI]: 0.90 ~ 0.97)、甲状腺癌(HR: 0.55, 95% CI: 0.47 ~ 0.64)和男性前列腺癌(HR: 0.56, 95% CI: 0.53 ~ 0.58)。此外,肺癌、男性肝癌、女性乳腺癌和男性前列腺癌的死亡率在过去十年中有所下降。对于髋部骨折,女性的死亡率有明显下降,而在男性中,我们观察到只有1年髋部骨折死亡率有下降趋势,而5年髋部骨折死亡率没有下降趋势。结论与女性乳腺癌、甲状腺癌和男性前列腺癌相比,骨折死亡率更高。加强髋部骨折的管理和预防需要更多的关注。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparing mortality rates, risk, and trends of hip fracture and common cancers in Hong Kong, 2010–2020: A population-based study

Objectives

Hip fracture is a global public concern exhibiting high mortality rates but often underrecognized. We compared the mortality rates, risk, and secular trend of hip fractures with common cancers in females and males, aiming to call attention to hip fractures.

Methods

In 2010–2020, 193,767 patients with the first diagnosed hip fractures and the top 5 prevalent cancers in each sex and aged 50 years and above were included. Age-standardized mortality rates were adjusted to the WHO Standard Population and the sex-specific relative risk of mortality was computed using Cox proportional hazards models, adjusted for potential confounders. The trend analyses used joinpoint regression to compute annual percent changes in age-standardized mortality rates.

Results

The 1-year and 5-year age-standardized mortality rates and sex-specific mortality risk of hip fracture are greater than those of breast cancer (hazard ratio [HR]: 0.93, 95% confidence interval [CI]: 0.90 to 0.97) and thyroid cancer (HR: 0.55, 95% CI: 0.47 to 0.64) in females and prostate cancer (HR: 0.56, 95% CI: 0.53 to 0.58) in males. Moreover, mortality rates in lung cancer, male liver cancer, female breast cancer, and male prostate cancer have decreased in the past decade. For hip fracture, the mortality rates have significantly decreased in females, while in males, we observed only a decreasing trend in 1-year hip fracture mortality, not in 5-year

Conclusions

Hip fractures exhibit higher mortality compared to female breast and thyroid cancers and male prostate cancer. More attention is needed to enhance the management and prevention of hip fractures.
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来源期刊
Osteoporosis and Sarcopenia
Osteoporosis and Sarcopenia Orthopedics, Sports Medicine and Rehabilitation, Endocrinology, Diabetes and Metabolism, Obstetrics, Gynecology and Women's Health, Geriatrics and Gerontology
自引率
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审稿时长
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