疼痛评分是绝经后类风湿性关节炎患者发生脆性骨折的预测因素:一项回顾性病例对照研究

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM
Ichiro Yoshii , Naoya Sawada , Tatsumi Chijiwa
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引用次数: 0

摘要

目的骨脆性骨折(BFF)是类风湿关节炎(RA)治疗中的严重并发症。我们假设RA治疗期间的疼痛程度与BFF事件相关,并验证疼痛如何影响BFF事件(包括BFF)。方法招募治疗至少3年的绝经后RA患者。研究的主要终点是发展成非闺蜜关系。随访从第一次骨密度测量(基线)开始,一直持续到第一个BFF的发展或研究结束。采用Cox回归分析、受试者操作特征(ROC)、Kaplan-Meier生存曲线分析(K-M)和卡方检验对基线临床指标进行统计学分析,包括疼痛评分(PS-VAS)。结果共纳入239例患者。使用多变量Cox回归分析,基线的PS-VAS和流行BFF (pr-BFF)显示出显著更高的风险比。ROC方面,pr-BFF和PS-VAS的截断指数(COI)为正(21.0),曲线下面积为0.692 (P <;0.001)和0.616 (P <;分别为0.01)。PS-VAS祝辞使用K-M时,COI风险比PS-VAS≤COI高2.24倍。当这两种情况合并时,pr- bff阳性和ps - vas阳性患者对inc-BFF的敏感性为42.3%,特异性为88.8%。PS-VAS祝辞无pr-BFF亚组COI风险比无统计学意义,而存在pr-BFF的PS-VAS≤COI风险比显著升高。结论RA治疗期间的PS-VAS评分可以很好地预测绝经后RA患者的无bff。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pain score as a predictor of subsequent fragility fracture in postmenopausal patients with rheumatoid arthritis: A retrospective case-control study

Objectives

Bone fragility fracture (BFF) is a serious incident in treating rheumatoid arthritis (RA). We hypothesized that pain degree during treatment RA correlated with incident BFF and validated how pain affects incident BFF (inc-BFF).

Methods

Postmenopausal RA patients treated for at least 3 years were recruited. The primary endpoint was the development of inc-BFF. Follow-up began with the first bone mineral density measurement (baseline) and continued until the development of the first BFF or termination of the study. Clinical indicators at baseline, including pain score using a visual analog scale (PS-VAS), were analyzed statistically using Cox regression analysis, receiver operation characteristics (ROC), Kaplan-Meier survival curve analysis (K-M), and chi-square test.

Results

A total of 239 patients were recruited. Using a multivariate Cox regression analysis, the baseline's PS-VAS and prevalent BFF (pr-BFF) demonstrated significantly higher risk ratios. For ROC, pr-BFF and PS-VAS had significant cutoff index (COI) (positive, 21.0) and an area under-curve of 0.692 (P < 0.001) and 0.616 (P < 0.01), respectively. PS-VAS > COI had a 2.24-fold higher hazard ratio than PS-VAS ≤ COI using K-M. When these 2 conditions were combined, patients with pr-BFF-positive and PS-VAS-positive had a sensitivity of 42.3% and a specificity of 88.8% for the inc-BFF. PS-VAS > COI had no statistical significance in the subgroup without pr-BFF, whereas the existence of pr-BFF had a significantly higher risk ratio in the PS-VAS ≤ COI.

Conclusions

The PS-VAS during RA treatment is a good indicator for predicting the inc-BFF in postmenopausal RA patients with pr-BFF.
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来源期刊
Osteoporosis and Sarcopenia
Osteoporosis and Sarcopenia Orthopedics, Sports Medicine and Rehabilitation, Endocrinology, Diabetes and Metabolism, Obstetrics, Gynecology and Women's Health, Geriatrics and Gerontology
自引率
5.00%
发文量
23
审稿时长
66 days
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