Osteoarthritis and Cartilage最新文献

{"title":"DOES FAT MASS CONTRIBUTE TO KNEE OSTEOARTHRITIS RISK BEYOND WEIGHT ITSELF? DATA FROM THE MULTICENTER OSTEOARTHRITIS STUDY","authors":"Kristine Godziuk , Sarah Tilley , Michael LaValley , Douglas P. Kiel , Michael C. Nevitt , Cora E. Lewis , James Torner , Tuhina Neogi","doi":"10.1016/j.joca.2026.01.026","DOIUrl":"10.1016/j.joca.2026.01.026","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 ","pages":"Pages S36-S37"},"PeriodicalIF":9.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147732829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TIBIAL ACCELERATION WHILE WALKING IS NOT ASSOCIATED WITH 2-YEAR CHANGES IN KNEE PAIN: THE MULTICENTER OSTEOARTHRITIS STUDY","authors":"Samantha Price , Joshua Stefanik , David Felson , Nene Ukonu , Michael LaValley , Michael C. Nevitt , Cora E. Lewis , James Torner , Patrick Corrigan","doi":"10.1016/j.joca.2026.01.066","DOIUrl":"10.1016/j.joca.2026.01.066","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 ","pages":"Pages S66-S67"},"PeriodicalIF":9.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147732911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Varus Alignment and BMI Jointly Accelerate Medial Femoral Cartilage Thinning: Data from the Osteoarthritis Initiative","authors":"McKenzie S. White , Feliks Kogan , Scott L. Delp , Garry Gold , Akshay Chaudhari , Anthony Gatti","doi":"10.1016/j.joca.2026.01.067","DOIUrl":"10.1016/j.joca.2026.01.067","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 ","pages":"Pages S67-S68"},"PeriodicalIF":9.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147732912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent joint contact in anterior cruciate ligament injury induces cartilage micro-injury and subchondral bone sclerosis, resulting in knee osteoarthritis","authors":"Kei Takahata ,&nbsp;Yu-Yang Lin ,&nbsp;Benjamin Osipov ,&nbsp;Kohei Arakawa ,&nbsp;Saaya Enomoto ,&nbsp;Blaine A. Christiansen ,&nbsp;Takanori Kokubun","doi":"10.1016/j.joca.2025.06.007","DOIUrl":"10.1016/j.joca.2025.06.007","url":null,"abstract":"<div><h3>Objective</h3><div>Anterior cruciate ligament (ACL) injury initiates post-traumatic osteoarthritis (PTOA) via two distinct processes: initial direct contact injury of the cartilage surface during ACL injury, and secondary joint instability due to the ACL deficiency. Using the well-established Compression-induced ACL-rupture and a novel Non-Compression ACL-rupture mice model, we aimed to reveal the individual effects of cartilage compression and joint instability on PTOA progression.</div></div><div><h3>Design</h3><div>Twelve-week-old C57BL/6J males (n = 118) were divided to three experimental groups: Compression ACL-rupture, Non-Compression ACL-rupture, and Intact. Following ACL injury, we performed joint laxity testing and microscopic analysis of the articular cartilage surface at 0 days, in vivo optical imaging of matrix-metalloproteinase (MMP) activity at 3 and 7 days, and histological and microCT analysis at 0, 7, 14, and 28 days.</div></div><div><h3>Results</h3><div>The Compression ACL-R group exhibited a significant increase in cartilage roughness immediately after injury compared with the Non-Compression group (p = 0.047). At 7 days, the Compression group increased MMP-induced fluorescence intensity slightly but showed no significant differences, and MMP-13 positive cell ratio of chondrocytes compared with the Non-Compression group (p &lt; 0.001, 95% confidence interval = [−18.328, −7.154]). Moreover, histological cartilage degeneration was observable in the Compression group at the same time point. Sclerosis of the tibial subchondral bone in the Compression group was more significantly developed than in the Non-Compression group at 28 days (p = 0.027).</div></div><div><h3>Conclusions</h3><div>Joint contact during ACL rupture caused initial micro-damage on the cartilage surface and initiated early MMP activity, which could accelerate subchondral bone sclerosis compared to ACL injury without concurrent joint contact.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 4","pages":"Pages 523-535"},"PeriodicalIF":9.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “E1K, a disease-modifying drug candidate for knee osteoarthritis, alleviates pain and regenerates cartilage simultaneously by inhibiting TGF-β1-mediated SMAD1/5/9 signaling in osteoarthritis models” [Osteoarthr. Cartil. 34 (2) (2026) 240–250]","authors":"Eun-Joung Moon ,&nbsp;Ji Ae Kim ,&nbsp;Yunsil Jang ,&nbsp;Hyeon-Jeong Kim ,&nbsp;Sang-Je Park ,&nbsp;Cheolmin Lee ,&nbsp;Nam Sook Kang ,&nbsp;Hae-Jin Kim","doi":"10.1016/j.joca.2026.01.632","DOIUrl":"10.1016/j.joca.2026.01.632","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 4","pages":"Pages 641-642"},"PeriodicalIF":9.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146106461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for structural progression of knee osteoarthritis: data from the KHOALA cohort","authors":"Augustin Latourte ,&nbsp;Anne-Christine Rat ,&nbsp;Maud Wieczorek ,&nbsp;Alice Courties ,&nbsp;Jérémie Sellam ,&nbsp;Christian Roux ,&nbsp;Alain Saraux ,&nbsp;Joël Coste ,&nbsp;Francis Guillemin ,&nbsp;Pascal Richette","doi":"10.1016/j.joca.2026.01.032","DOIUrl":"10.1016/j.joca.2026.01.032","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 ","pages":"Pages S42-S43"},"PeriodicalIF":9.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147732532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LLP2A-Ale, a Novel PDC Drug, Attenuates Osteoarthritis Progression by Modulating Subchondral Bone Remodeling and Chondroprotective Pathways in Osteoarthritis Models","authors":"Yonglong Cai ,&nbsp;Xuexiang Xiang ,&nbsp;Min Jiang ,&nbsp;Charles Chen ,&nbsp;Jiwei Chen ,&nbsp;Nancy Lane ,&nbsp;Wei Yao","doi":"10.1016/j.joca.2026.01.059","DOIUrl":"10.1016/j.joca.2026.01.059","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 ","pages":"Pages S61-S62"},"PeriodicalIF":9.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147732536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reparative activities of raav-mediated overexpression of FGF-2 and TGF-β delivered via pnass-grafted PCL film-guided in experimental injured human ACL","authors":"Mostafa A. Rabie ,&nbsp;Jagadeesh K. Venkatesan ,&nbsp;Gertrud Schmitt ,&nbsp;Henning Madry ,&nbsp;Véronique Migonney ,&nbsp;Magali Cucchiarini","doi":"10.1016/j.joca.2026.01.098","DOIUrl":"10.1016/j.joca.2026.01.098","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 ","pages":"Pages S89-S90"},"PeriodicalIF":9.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147732607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATION OF SARCOPENIC OBESITY WITH INCREASED RISK FOR KNEE OSTEOARTHRITIS INCIDENCE AND SUBSEQUENT KNEE REPLACEMENT: EVIDENCE FROM TWO INDEPENDENT, MATCHED COHORT STUDIES","authors":"Zhipeng Wang ,&nbsp;Xiaoshuai Wang ,&nbsp;Jian Wang ,&nbsp;Changhai Ding ,&nbsp;Jia Li","doi":"10.1016/j.joca.2026.01.017","DOIUrl":"10.1016/j.joca.2026.01.017","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 ","pages":"Pages S30-S31"},"PeriodicalIF":9.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147732727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral administration of Setanaxib delays osteoarthritis progression in a DMM murine model.","authors":"Félix Renaudin ,&nbsp;Elodie Zocola ,&nbsp;Cynthia Diabanza ,&nbsp;Zohra Bouchemla ,&nbsp;Thomas Laumonier ,&nbsp;Didier Hannouche","doi":"10.1016/j.joca.2026.01.049","DOIUrl":"10.1016/j.joca.2026.01.049","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 ","pages":"Page S55"},"PeriodicalIF":9.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147732731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}