Osteoarthritis and Cartilage最新文献_第8页

Identification of mitochondria-related diagnostic genes and analysis of immune infiltration for knee osteoarthritis chondrocyte based on bioinformatics and experimental validation 基于生物信息学和实验验证的线粒体相关诊断基因鉴定和膝关节骨关节炎软骨细胞免疫浸润分析

IF 7.2 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.03.012

Mengyu Fu

引用次数: 0

COMPARISON OF CLINICAL EFFICACY OF BRANDED AND GENERIC FORMS OF ETORICOXIB IN PATIENTS WITH SYMPTOMATIC KNEE OSTEOARTHRITIS 品牌型和仿制型依托昔布治疗症状性膝骨关节炎的临床疗效比较

IF 7.2 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.03.084

Nataliia Grygorieva , Oleg Iaremenko , Mykola Korzh , Volodymyr Filipenko , Anna Musiienko , Dariia Koliadenko , Zorik Arutiunian , Daryna Kurylo , Alyna Iniushina , Dmytro Dobrianskiy , Alina Sydorova

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The relation of walking forces to structural damage in the knee: The Multicenter Osteoarthritis Study 行走力与膝关节结构损伤的关系：多中心骨关节炎研究。

IF 7.2 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.04.007

Lauren K. Sara , David T. Felson , Sarah Tilley , Michael P. LaValley , Cora E. Lewis , John A. Lynch , Neil A. Segal , Ali Guermazi , Frank Roemer , Joshua J. Stefanik , Cara L. Lewis

{"title":"The relation of walking forces to structural damage in the knee: The Multicenter Osteoarthritis Study","authors":"Lauren K. Sara , David T. Felson , Sarah Tilley , Michael P. LaValley , Cora E. Lewis , John A. Lynch , Neil A. Segal , Ali Guermazi , Frank Roemer , Joshua J. Stefanik , Cara L. Lewis","doi":"10.1016/j.joca.2025.04.007","DOIUrl":"10.1016/j.joca.2025.04.007","url":null,"abstract":"<div><h3>Objective</h3><div>Mechanical loading is an important, modifiable risk factor for knee osteoarthritis. Identifying walking loads associated with disease worsening presents intervention opportunities. Our purpose was to evaluate the longitudinal relation of the baseline vertical ground reaction force (GRF) during walking to worsening bone marrow lesions (BMLs) and cartilage damage using cohort data from the Multicenter Osteoarthritis Study (MOST).</div></div><div><h3>Methods</h3><div>MOST participants with GRF data at baseline and magnetic resonance imaging examinations at baseline and 2-year follow-up were included. Peak impact force (PIF) and average loading rate (ALR) from the vertical GRF were analyzed with respect to four joint regions (i.e., the medial and lateral portions of the tibiofemoral and patellofemoral joints). Analyses used logistic regression with generalized estimating equations and adjusted for relevant covariates.</div></div><div><h3>Results</h3><div>Higher PIF was associated with increased odds of worsening BMLs in the lateral patellofemoral joint (odds ratio (95% confidence interval [CI]): 1.33 (1.11, 1.60)) and worsening cartilage damage in the lateral patellofemoral joint (1.48 (1.24, 1.77)), lateral tibiofemoral joint (1.24 (1.03, 1.50)), and medial tibiofemoral joint (1.25 (1.06, 1.48)). Higher ALR was associated with reduced odds of BML worsening in the lateral tibiofemoral joint (0.60 (0.41,0.87)).</div></div><div><h3>Conclusions</h3><div>Higher peak forces when walking were associated with worsening BMLs in the lateral patellofemoral joint and with worsening cartilage damage in regions of the knee associated with higher contact forces during walking. Higher ALRs were not associated with increased odds of structural worsening (BMLs or cartilage).</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 745-752"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of methotrexate in osteoarthritis: A systematic review and meta-analysis of randomized controlled trials 甲氨蝶呤治疗骨关节炎的疗效和安全性：随机对照试验的系统回顾和荟萃分析。

IF 7.2 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.02.786

Weikiat Wong , Yucheng Huang , Nattaya Wichienwantana , Hailiang Sun , Jian Pang , Ying Shi

{"title":"Efficacy and safety of methotrexate in osteoarthritis: A systematic review and meta-analysis of randomized controlled trials","authors":"Weikiat Wong , Yucheng Huang , Nattaya Wichienwantana , Hailiang Sun , Jian Pang , Ying Shi","doi":"10.1016/j.joca.2025.02.786","DOIUrl":"10.1016/j.joca.2025.02.786","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy and safety of methotrexate (MTX) for osteoarthritis (OA).</div></div><div><h3>Design</h3><div>A systematic search of databases and clinical trial registers was conducted in September 2024 to identify randomized controlled trials (RCTs) comparing MTX with placebo. The evaluation focused on OA symptoms, including pain and function; quality of life; safety and OA-related biomarkers (biochemical and imaging markers). Meta-analysis and the minimal clinically important difference (MCID) were utilized to determine statistical and clinical significance. The risk of bias (RoB) and certainty assessment were evaluated using the RoB 1 tool, the RoB due to missing evidence tool, and the Grades of Recommendation, Assessment, Development and Evaluation Working Group framework.</div></div><div><h3>Results</h3><div>Six RCTs involving 602 participants were included, all with a low RoB. Compared to the placebo, MTX significantly relieved pain (standardized mean difference [SMD], −0.44; 95% confidence interval [95% CI], −0.67 to −0.20, P = 0.0003) in OA patients (knee and hand). Functional improvement with MTX was observed only in knee OA patients (weighted mean difference [WMD], −7.36; 95% CI, −14.34 to −0.38, P = 0.045). The point estimates did not exceed the upper limit of MCID, suggesting the possible clinical significance of the findings. No differences were observed for quality-of-life outcome (SMD, −0.74; 95% CI, −153 to 0.05, P = 0.07). MTX did not increase the incidence of adverse events (risk ratio, 0.88; 95% CI, 0.75 to 1.02, P = 0.09).</div></div><div><h3>Conclusions</h3><div>MTX can alleviate pain in patients with OA and improve functional recovery in knee OA without raising safety concerns.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 680-691"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local Ozone Therapy in Complex Treatment of Venous Leg Ulcers: Ozone therapy for venous leg ulcers. 局部臭氧疗法在静脉性腿溃疡综合治疗中的应用：臭氧疗法治疗腿部静脉溃疡。

IF 7.2 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-06-01 Epub Date: 2022-05-30 DOI: 10.1177/15347346221104611

Jarosław Pasek, Sebastian Szajkowski, Grzegorz Cieślar

{"title":"Local Ozone Therapy in Complex Treatment of Venous Leg Ulcers: Ozone therapy for venous leg ulcers.","authors":"Jarosław Pasek, Sebastian Szajkowski, Grzegorz Cieślar","doi":"10.1177/15347346221104611","DOIUrl":"10.1177/15347346221104611","url":null,"abstract":"<p><p>A significant health problem in many countries of the world is the occurrence of hard to heal leg ulcers. In recent years modern methods of physical medicine in comprehensive treatment have been used often including ozone therapy. The study included 54 patients, 25 male and 29 female in age between 39 and 87 years (mean age: 66.7 ± 11.9 years) with venous leg ulcers who underwent a cycle of local ozone therapy. The progress in wound healing was evaluated by computerized planimetry and pain intensity was assessed with use a visual analog scale (VAS) . As a result of the applied local ozone therapy a statistically significant reduction of the ulcer area was achieved from median 7.1 (5.6-9.4) cm<sup>2</sup> to 4.4 (3-7) cm<sup>2</sup> (<i>P</i> = .000001), which was on median 38.74 (27.27-51.42)% compared to the baseline values before the start of the therapy. In 2 patients (3.7%) the ulcers were completely healed. 18 patients (33.3%) achieved a reduction in ulcer area of more than 50% of the baseline value and the remaining 34 patients (63%) also achieved a reduction in ulcer area. A statistically significant in the percentage of surface area was observed in the group of 19 patients suffering from > 5 years of age compared to the group of 35 patients suffering from ≤5 years (median 50 (32.03-67.16)% versus 33.96 (23.71-45); <i>P</i> = .033178), while percentage changes in ulcer surface area did not differ significantly between all other subgroups of patients. There was also a statistically significant reduction in the intensity of pain in VAS scale in all patients, median 6 (5-7) points before treatment versus 4.4 (3-7) points after treatment, <i>P</i> = .000001). Local ozone therapy of venous leg ulcers accelerate the healing process of ulcers in objective planimetric assessment and reduce the intensity of pain ailments.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"22 1","pages":"478-487"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76520755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Reply to Letter to the Editor 回复给编辑的信。

IF 7.2 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.03.008

Jamon L. Couch , Matthew G. King , Danilo De Oliveira Silva , Jackie L. Whittaker , Thomas J. West , Andrea M. Bruder , Michael A. Girdwood , Christian J. Barton , Kay M. Crossley , Ewa M. Roos , Adam G. Culvenor

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EFFECTS OF ANTIDIABETIC MEDICATIONS LIRAGLUTIDE, CANAGLIFLOZIN, AND METFORMIN ON BONE MARROW ADIPOSE TISSUE IN KNEE OSTEOARTHRITIS: INSIGHTS FROM AN EX VIVO MODEL 降糖药物利拉鲁肽、卡格列净和二甲双胍对膝关节骨性关节炎患者骨髓脂肪组织的影响：来自离体模型的见解

IF 7.2 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.03.052

Léa Loisay , Leonie Reinert , Alexander Antoniadis , thibaut royon , Maja Kaegi , Elke Moradpour , Thomas Hugle , Jeroen Geurts

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NEW SENOTHERAPEUTIC PEPTIDES FOR OSTEOARTHRITIS TREATMENT 用于骨关节炎治疗的新型老年治疗肽

IF 7.2 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.03.053

Iñaki López-Díaz , Varela-Eirín Marta , Carpintero-Fernández Paula , Garcia-Yuste Alejandro , Caeiro José R. , Mayán María D.

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RAFO-4 MRI: SIMULTANEOUS CARTILAGE MORPHOLOGY AND 3D T2 MAPPING WITH MACHINE LEARNING Rafo-4 mri：同时软骨形态和机器学习的3d t2映射

IF 7.2 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.03.044

Krithika Balaji , Michael Mendoza , Pedro M. Vicente , Christoforos Galazis , Simran Kukran , Anil A. Bharath , Peter J. Lally , Neal K. Bangerter

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Bibliometric and Visualization Analysis of Superficial Zone of Articular Cartilage from 2000 to 2024 2000 ~ 2024年关节软骨浅区文献计量与可视化分析

IF 7.2 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.03.017

Xiaochun wei , Fuyang Cao , Pengcui Li , Li Guo

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