Osteoarthritis and Cartilage最新文献

{"title":"Local Ozone Therapy in Complex Treatment of Venous Leg Ulcers: Ozone therapy for venous leg ulcers.","authors":"Jarosław Pasek, Sebastian Szajkowski, Grzegorz Cieślar","doi":"10.1177/15347346221104611","DOIUrl":"10.1177/15347346221104611","url":null,"abstract":"<p><p>A significant health problem in many countries of the world is the occurrence of hard to heal leg ulcers. In recent years modern methods of physical medicine in comprehensive treatment have been used often including ozone therapy. The study included 54 patients, 25 male and 29 female in age between 39 and 87 years (mean age: 66.7 ± 11.9 years) with venous leg ulcers who underwent a cycle of local ozone therapy. The progress in wound healing was evaluated by computerized planimetry and pain intensity was assessed with use a visual analog scale (VAS) . As a result of the applied local ozone therapy a statistically significant reduction of the ulcer area was achieved from median 7.1 (5.6-9.4) cm² to 4.4 (3-7) cm² (<i>P</i> = .000001), which was on median 38.74 (27.27-51.42)% compared to the baseline values ​​before the start of the therapy. In 2 patients (3.7%) the ulcers were completely healed. 18 patients (33.3%) achieved a reduction in ulcer area of ​​more than 50% of the baseline value and the remaining 34 patients (63%) also achieved a reduction in ulcer area. A statistically significant in the percentage of surface area was observed in the group of 19 patients suffering from > 5 years of age compared to the group of 35 patients suffering from ≤5 years (median 50 (32.03-67.16)% versus 33.96 (23.71-45); <i>P</i> = .033178), while percentage changes in ulcer surface area did not differ significantly between all other subgroups of patients. There was also a statistically significant reduction in the intensity of pain in VAS scale in all patients, median 6 (5-7) points before treatment versus 4.4 (3-7) points after treatment, <i>P</i> = .000001). Local ozone therapy of venous leg ulcers accelerate the healing process of ulcers in objective planimetric assessment and reduce the intensity of pain ailments.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"22 1","pages":"478-487"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76520755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testosterone and osteoarthritis in women: the devil is in the detail.","authors":"Susan R Davis","doi":"10.1016/j.joca.2025.05.006","DOIUrl":"https://doi.org/10.1016/j.joca.2025.05.006","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone marrow adiposity in osteoarthritis: significance for skeletal and hematopoietic system.","authors":"Drenka Trivanović","doi":"10.1016/j.joca.2025.05.009","DOIUrl":"https://doi.org/10.1016/j.joca.2025.05.009","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidating the Initial Symptoms and Experiences of Knee Osteoarthritis: An International Patient Survey.","authors":"Lauren K King, Armaghan Mahmoudian, Jean W Liew, Qiuke Wang, Ian Stanaitis, Dieuwke Schiphof, Leigh F Callahan, David J Hunter, C Thomas Appleton, Aleksandra Turkiewicz, Martin Englund, L Stefan Lohmander, Ida K Haugen, Gillian A Hawker, Tuhina Neogi, Jos Runhaar","doi":"10.1016/j.joca.2025.05.008","DOIUrl":"https://doi.org/10.1016/j.joca.2025.05.008","url":null,"abstract":"<p><strong>Objectives: </strong>Within the first phase of developing classification criteria for Early-stage Symptomatic Knee Osteoarthritis (EsSKOA), among individuals with knee osteoarthritis (OA) we explored: 1) symptoms within the first year of noticing their knee(s); 2) features that indicated OA was the cause; and 3) timing and reasons that initially prompted seeking healthcare.</p><p><strong>Design: </strong>We conducted a cross-sectional online survey of individuals with knee OA recruited from Australia, Canada, the Netherlands, and the USA. Only individuals who indicated they recalled their first symptoms were eligible. Using free-text, participants described changes in how their knee looked, felt, moved, their overall state within the first year of noticing their knee(s), features perceived to indicate knee OA was the cause, and reasons for initially seeking healthcare. We assessed timing of seeking care by an ordinal scale. Data were analyzed using descriptive statistics and summative content analysis.</p><p><strong>Results: </strong>We included 92 participants (median age 67 years [IQR 59,75], 69% women, median BMI 26 kg/m² [IQR 24,30]). Within the first year from onset, frequently reported symptoms were knee pain (70%), swelling (58%), crepitus (42%), stiffness (29%), and instability (24%). While few could provide specific clinical features, approximately half (53%) perceived medical imaging as important to indicate OA. Only 35% sought healthcare within the first year of experiencing symptoms.</p><p><strong>Conclusions: </strong>Individuals with knee OA recalled varied knee symptoms within the first year and few sought healthcare. We were unable to ascertain, from the perspective of patients, specific clinical features that indicated they had OA and not another condition.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OARSI Initiative to Develop Classification Criteria for Early-Stage Symptomatic Knee OA (EsSKOA): What conditions should be considered in the differential diagnosis of EsSKOA?","authors":"Gillian A Hawker,Lauren K King,Jean W Liew,Qiuke Wang,Armaghan Mahmoudian,Nuria E J Jansen,Ian Stanaitis,Francis Berenbaum,Siddharth Das,Changhai Ding,Carolyn A Emery,Stephanie R Filbay,Marc C Hochberg,Muneaki Ishijima,Margreet Kloppenburg,Nancy E Lane,Elena Losina,Ali Mobasheri,Jos Runhaar,C Thomas Appleton,Aleksandra Turkiewicz,Martin Englund,L Stefan Lohmander,Ida K Haugen,Tuhina Neogi,","doi":"10.1016/j.joca.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.joca.2025.05.005","url":null,"abstract":"OBJECTIVEClassification criteria for early-stage symptomatic knee osteoarthritis (EsSKOA) should discriminate individuals with EsSKOA from those with other causes of knee symptoms. We sought to identify conditions in the differential diagnosis of EsSKOA in adults with knee symptoms.DESIGNWe conducted an online survey of clinicians. Those consulting monthly on at least five people with undiagnosed knee symptoms were eligible. From qualitative work and clinical experience, we developed three case scenarios representing possible EsSKOA: 1. 40-year-old with 1-month of knee stiffness and swelling; 2. 50-year-old with 8-months of knee discomfort while walking; and 3. 60-year-old with intense knee discomfort getting out of a car 1 week ago. For each scenario, participants indicated conditions on a pre-defined list that they would consider in the differential diagnosis, and the top three diagnoses based on clinical experience. The proportions that considered each condition and among the top three diagnoses for each scenario were summarized overall and by clinical discipline.RESULTS127 clinicians responded (43% female, 48% in practice ≤15 years, 50% university-affiliated practice, 7 clinical disciplines). Knee OA and meniscal injuries were among the top three conditions in the differential diagnosis for all three scenarios, followed by immune-mediated and crystal-induced inflammatory arthritis (scenario 1), patellofemoral pain syndrome (scenario 2), and collateral ligament injuries (scenario 3).CONCLUSIONThe differential diagnosis for EsSKOA in adults presenting with undiagnosed knee symptoms includes symptomatic established radiographic knee OA, patellofemoral pain syndrome, meniscal and collateral ligament injuries, and immune-mediated and crystal-induced inflammatory arthritis.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"139 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Application of Epigenetic Clocks in Degenerative musculoskeletal diseases: A Systematic Review.","authors":"Chuncha Bao,Wenyi Zhu,Tianjie Bao,Yue Hou,Tao Wu,Jiapeng Huang,Chengqi He","doi":"10.1016/j.joca.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.joca.2025.05.003","url":null,"abstract":"OBJECTIVEEpigenetic clocks have emerged as powerful tools for quantifying biological aging. Degenerative musculoskeletal disorders (e.g., osteoarthritis, osteoporosis) represent a group of age-related conditions characterized by progressive tissue deterioration. While their epidemiological association with aging is well-established, the precise relationship with epigenetic aging markers remains to be systematically elucidated. This review synthesizes current evidence on the application of epigenetic clocks as biomarkers and their clinical potential in managing these conditions.METHODSWe systematically searched four major biomedical databases (PubMed, PMC, Web of Science, ScienceDirect) from inception through December 2024 for observational studies examining the association between the epigenetic clock and degenerative musculoskeletal diseases using controlled vocabulary (e.g., DNA methylation age) combined with disease-specific terms. The protocol was registered with PROSPERO (CRD42024623554).RESULTSAfter screening, 14 studies (case-control, cross-sectional, cohort) were included. We identified eight epigenetic clocks (based on cartilage, bone, and blood biomarkers) for assessing degenerative musculoskeletal diseases. DunedinPACE showed significant associations with cLBP pain severity (r = 0.39-0.45) and functional impairment, while Horvath's clock revealed tissue-specific epigenetic aging in OA cartilage (ΔAge = 3.7 years). GrimAge exhibited the strongest correlations with chronic pain (ρ = 0.47) and mediated socioeconomic influences (β = 0.81).CONCLUSIONSThis systematic review of 14 clinical studies establishes epigenetic clocks as promising biomarkers for degenerative musculoskeletal diseases. The differential associations observed across epigenetic metrics highlight the need for disease-specific algorithm development. Future research should prioritize longitudinal validation and mechanistic investigations into socioeconomic influences on epigenetic aging.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"22 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Total and Regional Fat-To-Muscle Mass Ratio and Osteoarthritis Incidence: A Prospective Cohort Study.","authors":"Jufeng Luo,Qiao Xiang,Taiping Lin,Rui Liang,Yuzhao Dai,Tingting Jiang,Jianhong Xu,Jirong Yue,Chenkai Wu","doi":"10.1016/j.joca.2025.04.014","DOIUrl":"https://doi.org/10.1016/j.joca.2025.04.014","url":null,"abstract":"OBJECTIVETo investigate the associations between total and regional fat-to-muscle mass ratio (FMR) and incident osteoarthritis among adults.DESIGNThis prospective cohort study included 328,549 participants from the UK Biobank. FMR was calculated as the ratio of fat mass to muscle mass for the whole body, trunk, arms, and legs using a body composition analyzer. Incident osteoarthritis was identified via ICD-10 codes. Cox proportional-hazard regression models were used to identify the association between each type of FMR separately and incident osteoarthritis. Subgroup analyses by age,sex and specific joint sites were conducted.RESULTSDuring a median follow-up of 14.4 years, 48,997 incident osteoarthritis cases were identified. We found an increasing trend in incident osteoarthritis with higher FMRs, particularly among females. In the fully adjusted models, each one standard deviation increase in arm FMR was associated with a 6% higher hazard in males and 11% in females. For leg FMR, the corresponding increases were 5% in males and 14% in females, respectively. Whole-body and trunk FMR were significantly associated with osteoarthritis risk only in women.CONCLUSIONSFMR was generally positively associated with osteoarthritis risk, with significant associations for arm and leg FMR remaining independent of body mass index across sex and age subgroups. These findings highlight FMR as a valuable marker for identifying those at risk of incident osteoarthritis.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"9 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural, functional, and proteomic based sex differences in murine post-traumatic osteoarthritis development following mechanical anterior cruciate ligament injury.","authors":"Emily M Van Zeeland,Brandon Kassel,Travis Montoya,Anthony J Saviola,Lindsey H Burton,Jeremiah T Easley,Brad B Nelson,Kelly S Santangelo,Katie J Sikes","doi":"10.1016/j.joca.2025.05.004","DOIUrl":"https://doi.org/10.1016/j.joca.2025.05.004","url":null,"abstract":"OBJECTIVEPost-traumatic osteoarthritis (PTOA) is known to be influenced by sex. This study aimed to comprehensively characterize PTOA development in male and female mice following anterior cruciate ligament (ACL) injury through longitudinal mobility assessments, radiographic imaging, histologic evaluation, and untargeted proteomics.DESIGNAt 12 weeks of age, 110 C57BL6J mice (70 males, 70 females) underwent unilateral mechanical ACL rupture to induce PTOA. 30 mice (15 males, 15 females) served as naïve controls. Symptoms of PTOA development were assessed weekly for 56-days post-injury through voluntary cage monitoring, gait analysis, and static weight bearing. PTOA pathology was evaluated through longitudinal radiographs and histopathology at multiple endpoints. ACL proteomes were analyzed using untargeted label-free protein quantification at 3-, 7-, and 14-days post-injury, with intact ACLs serving as controls.RESULTSPost-injury, male mice showed significant reductions in overall activity compared to females, including decreased head distance traveled (mean difference 56d: -3.81[95%CI:-7.45 to -0.18]). Males exhibited wider hindlimb stance (mean difference 56d: 0.28[95%CI:0.01 to 0.56]) and persistent hindlimb offloading (mean difference 56d: 0.30[95%CI:0.08 to 0.52]). Longitudinal radiographic analysis revealed no significant sex-based differences. Histological assessments revealed more severe joint pathology in males (mean difference 56d: 49.97[95%CI:5.78 to 94.15]). Females also demonstrated a robust proteomic response peaking at 3-days, with notable pathways related to inflammation, the coagulation cascade, and estrogen signaling.CONCLUSIONThis study revealed increased progression of PTOA in male mice evidenced by mobility impairments, worsened histologic scores, and divergent proteomic responses. These insights will enhance future research on therapeutic strategies for PTOA prevention.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"49 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between injury-related factors and cartilage T2 relaxation time in the subacute phase in patients after anterior cruciate ligament injury.","authors":"Bashir Edwardsson Tajik,Joanna Kvist,Håkan Gauffin,Riccardo Cristiani,Richard Frobell,Miika Nieminen,Victor Casula,Martin Englund","doi":"10.1016/j.joca.2025.05.002","DOIUrl":"https://doi.org/10.1016/j.joca.2025.05.002","url":null,"abstract":"OBJECTIVETo investigate associations between meniscal tear, bone marrow lesions (BMLs), and post-injury knee loading, with cartilage T2 relaxation times on knee magnetic resonance imaging (MRI) in the subacute phase following acute anterior cruciate ligament (ACL) injury.DESIGNWe studied both knees of 128 patients with ACL injury. The presence of meniscal tears and BMLs were determined on subacute MRI (mean 29 days [SD 13] post injury), and post-injury knee loading was measured using an accelerometer. Manual cartilage segmentation and T2 relaxation time mapping of tibiofemoral cartilage was performed on both knees. We used multiple linear regression models adjusted for age, sex, body mass index, and time from injury to MRI to evaluate the association between exposures and cartilage T2 relaxation times in the ACL injured knee between individuals. We also performed paired t-tests for comparisons with the individual's non-ACL injured contralateral knee free of the exposure of interest.RESULTSThere was an association between ipsilateral meniscal tear and prolonged T2 relaxation time in the superficial cartilage of posterior tibia in both compartments (beta-coefficient medial: 2.88, [95% CI 1.16-4.61], beta-coefficient lateral: 1.88, [0.17-3.58]). Findings were confirmed in the paired analyses with contralateral knees (mean T2 difference 1.43, [0.33-2.53] and 2.10 [0.48-3.71] respectively). We found no essential associations for the other cartilage subregions or for BMLs and knee loading.CONCLUSIONIn the subacute phase after ACL injury, ipsilateral meniscal tear is associated with prolonged cartilage T2 relaxation time in the posterior tibia. This finding highlights the importance of meniscus function in the ACL-injured knee.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"54 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"The physician is constantly referring to the biologist for a scientific basis for geriatrics, and finding that it is not there\" Alex Comfort1.","authors":"David Gems","doi":"10.1016/j.joca.2025.05.001","DOIUrl":"https://doi.org/10.1016/j.joca.2025.05.001","url":null,"abstract":"Late-life diseases result from the poorly understood process of senescence (aging), that is largely genetically determined. According to a recently proposed evolutionary physiology-based account, the multifactorial model, senescence is largely caused by evolved but non-adaptive programmatic mechanisms specified by the wild-type (i.e. normal) genome. These act together with disruptions to wild-type function (due e.g. to infectious pathogens, mechanical injury and malnutrition) in a variety of combinations to generate diverse late-life diseases. Here I explore the utility of this model by testing its capacity to provide an account of one complex, late-life disease, osteoarthritis (OA), and suggest a framework for understanding OA etiology. In this cartilage-focused framework, a core OA disease mechanism is a futile (non-adaptive) developmental program of endochondral ossification, in which hypertrophic articular cartilage chondrocytes alter joint architecture. Programmatic changes prime chondrocytes for futile program activation, which can be triggered by secondary causes of OA (e.g. joint mechanical injury). I suggest that an evolutionary cause of this priming, involving antagonistic pleiotropy, is selection to maximize early life tissue repair benefits at the expense of late-life programmatic costs.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"83 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}