Osteoarthritis and Cartilage最新文献

{"title":"Gene expression analyses in mouse sensory ganglia determine a crucial role of NGF/TrkA in knee osteoarthritis chronification","authors":"Daniel Cañada-García, Laura Calvo-Enrique, Silvia Lisa, Joao Sousa-Valente, Marta López-García, Ivan Arisi, Mara D’Onofrío, Carlos Prieto, Juan Carlos Arévalo","doi":"10.1016/j.joca.2025.06.004","DOIUrl":"https://doi.org/10.1016/j.joca.2025.06.004","url":null,"abstract":"Osteoarthritis (OA) can be experimentally induced by injecting mono-iodoacetate (MIA) in the knee capsule of mice. Our aim was to assess the role of NGF/TrkA axis in OA identifying differentially expressed genes (DEGs) and functional pathways in knee-innervating dorsal root ganglia (DRG) from WT and hypersensitive TrkAP782S (KI) mice after MIA injection.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"263 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144305215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of tamoxifen on fetal cartilage development, adult cartilage metabolism and endochondral ossification in mice.","authors":"Rongdong Liao,Jianglong Li,Chao Xie,Qinnan Yan,Donghao Gan,Guozhi Xiao,Lijun Lin","doi":"10.1016/j.joca.2025.06.003","DOIUrl":"https://doi.org/10.1016/j.joca.2025.06.003","url":null,"abstract":"OBJECTIVETamoxifen (TAM) has been used to treat human breast cancer and induce gene knockout in the Cre/lox system in mice. However, the effects of TAM as a CreER recombinase inducer on bone metabolism, cartilage metabolism, and endochondral ossification have not been thoroughly evaluated.METHODSMice received 5 intraperitoneal TAM injections in trauma and age-induced OA model and the fracture model. The samples were harvested and underwent micro-computed tomography, histological and immunofluorescence analyses. Pregnant mice at gestation day 15.5 were administered with TAM, and their P0 offspring were used for alcian blue and alizarin red S staining. MLO-Y4 cells and primary chondrocytes were used to determine the effects of TAM on bone and cartilage homeostasis.RESULTSTAM caused growth plate complete loss and increased the volume of calcified meniscus and synovium (95%CI 0.1789 to 1.31) in aged mice. TAM also decreased the cartilage area in the trauma-induced OA group compared to control group (95%CI -0.04054 to -0.002148). Besides, TAM significantly increased the expression of Aggrecan (95%CI 1.335 to 10.15) and Col2a1 (95%CI 1.524 to 7.019) in the callus, which indicated the fracture healing process were impaired. However, the skeletal phenotype of new-born mice did not significantly alter. In vitro, TAM altered the metabolism of extracellular matrix in chondrocytes, while significantly altering gene expression in osteocytes.CONCLUSIONSTAM significantly affected bone and cartilage homeostasis. In transgenic mice experiments using the Cre/loxp system, the control should be injected with TAM to avoid off-target effects or the doses should be optimized.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"22 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relation of activity patterns with incident slow gait speed over 4 years in adults with knee osteoarthritis: Data from the Osteoarthritis Initiative.","authors":"Nurten Gizem Tore, Sydney Liles, David M Werner, Rebecca J Cleveland, Tom Videitch Bye, Yvonne Golightly, Jason T Jakiela, Daniel White","doi":"10.1016/j.joca.2025.06.002","DOIUrl":"10.1016/j.joca.2025.06.002","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to describe activity patterns in adults with knee osteoarthritis (OA) and to examine the relation of patterns with incident slow gait speed over 4 years.</p><p><strong>Design: </strong>Using data from the Osteoarthritis Initiative, we included adults with or at high risk of knee OA who walked > 1.0 m/s during a 20-meter walk at baseline, i.e., did not have slow gait speed. To determine activity patterns, we reduced the dimensions of accelerometer data (ActiGraph GTM1) using a multidimensional Multilevel Functional Principal Components Analysis to calculate between-subject principal component (PC) scores. We estimated the association of the top and bottom tertiles' PC scores with incident slow gait speed over 4 years (risk ratios with 95% confidence intervals) referenced to the middle tertile, adjusting for potential confounders.</p><p><strong>Results: </strong>We identified four activity patterns (PCs): 1) high activity, 2) high evening activity, 3) high morning and evening activity, and 4) very high morning activity. Those whose daily activity patterns best matched with the pattern PC2 or PC4, were found to have 0.60 [0.37, 0.96] and 0.39 [0.22, 0.71] times the risk of developing slow gait speed, respectively; while those whose daily activity patterns least matched PC3, were found to have 1.77 [1.19, 2.62] times the risk.</p><p><strong>Conclusions: </strong>Daily activity patterns may be related to the development of slow gait speed in adults with or at risk for knee OA.</p><p><strong>Trial registration: </strong>NCT00080171.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium pyrophosphate deposition disease is associated with increased risk of fractures: A retrospective cohort study using electronic health record data.","authors":"Sizheng Steven Zhao, Weijie Liu, Stuart Johnston, Uazman Alam, Shuguang Gao","doi":"10.1016/j.joca.2025.06.001","DOIUrl":"10.1016/j.joca.2025.06.001","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the risk of fractures in older adults with calcium pyrophosphate deposition (CPPD) disease and osteoarthritis (OA) compared to those with OA alone, and to assess site- and gender-specific fracture risk.</p><p><strong>Methods: </strong>Using predominantly North American electronic health record data from 2005-2025, we defined CPPD as patients aged ≥60 years with ≥2 administrative codes for CPPD plus OA, excluding other inflammatory arthritides. Comparators were defined analogously with ≥2 OA codes but without CPPD. The primary outcome was any fracture of spine, upper limb, lower limb. We used Cox proportional hazards models 1:1 propensity score-matched for demographics, comorbidities, and medications. Subgroup analyses assessed gender-specific outcomes and site-specific fractures. Sensitivity analyses excluded individuals with prior exposure to glucocorticoids or anti-osteoporosis medications or prior fracture history.</p><p><strong>Results: </strong>Among 20,176 matched pairs (mean age 73 years, 59% female) with 4015 and 3349 fracture events over 81,291 and 85,802 patient-years, CPPD was associated with 29% increased hazard of any fracture (HR 1.29, 95%CI 1.23, 1.35) which was consistent in males (HR 1.36, 95%CI 1.23, 1.49) and females (HR 1.30, 95%CI 1.23, 1.38). Site-specific analyses similarly showed elevated fracture risks at the upper limb (HR 1.37; 1.28, 1.46), lower limb (HR 1.31; 1.23, 1.39), and spine (HR 1.18; 1.11, 1.26). Results were similar across all sensitivity analyses.</p><p><strong>Conclusion: </strong>CPPD disease is associated with increased fracture risk across gender and fracture sites. Clinicians should consider screening for bone health in these patients. Future research should clarify underlying mechanisms and refine targeted interventions.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of Tai Chi on pain and other health indicators in people with osteoarthritis: An updated systematic review and dose-response meta-analysis","authors":"Anni Zhao, Wendy J. Brown, Jeff S. Coombes, Xin Liu","doi":"10.1016/j.joca.2025.05.013","DOIUrl":"https://doi.org/10.1016/j.joca.2025.05.013","url":null,"abstract":"To update and critically examine evidence on the effects of Tai Chi on pain and other health indicators in adults with osteoarthritis (OA). The secondary objective was to assess possible dose-response relationships between Tai Chi and changes in health indicators.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"82 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanoepigenetics in musculoskeletal disease","authors":"Clarissa R. Coveney, Terence D. Capellini","doi":"10.1016/j.joca.2025.05.012","DOIUrl":"https://doi.org/10.1016/j.joca.2025.05.012","url":null,"abstract":"This review explores the intricate interplay between genetic variants, mechanical forces, and the epigenetic landscape (defined as ‘mechanoepigenetics’), particularly in the context of musculoskeletal (MSK) diseases such as osteoarthritis. Whilst our understanding of Mendelian monogenic disease has progressed with exome sequencing and the generation of novel gene therapies, common complex diseases characterized by difficult-to-pinpoint non-coding genetic variants have posed significant challenges. The recent implementation of techniques such as ChIP-seq, ATAC-seq, and chromatin capture (Hi-C) has been pivotal in understanding how enhancers, promoters, and repressors interact with target genes to control gene expression. However, the data they generate are only more recently being used to filter non-coding variants for regulatory impacts. Even more pressing is that the epigenome and long-range interactions can be modified by environmental factors such as mechanical forces, and this is poorly understood, especially with respect to impacts on variant function. Here, we highlight the role of the dynamic mechanical environment in the regulation of the epigenome to identify mechanically mediated regulatory region interactions to streamline the identification of variant activity and how they might be impacted. We also explore the potential for targeting mechanically responsive loci with epigenome-modifying drugs. By integrating genetic, epigenetic, and mechanical insights, this review aims to advance understanding of disease mechanisms and propel the development of novel therapeutic strategies for MSK diseases, drawing parallels with emerging approaches in other fields.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"20 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-processed food consumption is associated with knee osteoarthritis: Data from the Osteoarthritis Initiative","authors":"Zehra Akkaya, Wynton M. Sims, John A. Lynch, Maximillian T. Löffler, Felix Gassert, Michael Nevitt, Charles E. McCulloch, Nancy E. Lane, Valentina Pedoia, Katharina Ziegeler, Thomas M. Link, Gabby B. Joseph","doi":"10.1016/j.joca.2025.05.011","DOIUrl":"https://doi.org/10.1016/j.joca.2025.05.011","url":null,"abstract":"To explore the relationship between ultra-processed food (UPF) intake and knee osteoarthritis (KOA)-related imaging and clinical outcomes in men and women.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"6 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Borderline acceleration in blood epigenetic age of unclear biological importance in knee OA progression: Specimens and data from the Osteoarthritis Initiative and Johnston County Osteoarthritis Project","authors":"Cindy Miranda Brawner, Cassandra Sturdy, Liubov Arbeeva, Yvonne M. Golightly, Amanda E. Nelson, Matlock A. Jeffries","doi":"10.1016/j.joca.2025.05.010","DOIUrl":"https://doi.org/10.1016/j.joca.2025.05.010","url":null,"abstract":"Aging is among the strongest risk factors for osteoarthritis (OA). Although epigenetics plays a role in OA, previous studies have not found accelerated peripheral blood epigenetic aging among OA patients overall. The goal of this study was to evaluate peripheral blood epigenetic aging rates among various types of OA progressors and non-progressors (NPs).","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"10 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical loading rescues mechanoresponsiveness in a human osteoarthritis explant model despite Wnt activation","authors":"R. Castro-Viñuelas ,&nbsp;N. Viudes-Sarrión ,&nbsp;A.V. Rojo-García ,&nbsp;S. Monteagudo ,&nbsp;R.J. Lories ,&nbsp;I. Jonkers","doi":"10.1016/j.joca.2024.02.945","DOIUrl":"10.1016/j.joca.2024.02.945","url":null,"abstract":"<div><h3>Objectives</h3><div><span>Optimizing rehabilitation strategies for osteoarthritis<span> necessitates a comprehensive understanding of chondrocytes’ mechanoresponse in both health and disease, especially in the context of the interplay between loading and key pathways involved in osteoarthritis (OA) development, like canonical </span></span>Wnt signaling<span>. This study aims to elucidate the role of Wnt signaling in the mechanoresponsiveness of healthy and osteoarthritic human cartilage.</span></div></div><div><h3>Methods</h3><div>We used an ex-vivo model involving short-term physiological mechanical loading of human cartilage explants<span>. First, the loading protocol for subsequent experiments was determined. Next, loading was applied to non-OA-explants with or without Wnt activation with CHIR99021. Molecular read-outs of anabolic, pericellular matrix and matrix remodeling markers were used to assess the effect of Wnt on cartilage mechanoresponse. Finally, the same set-up was used to study the effect of loading in cartilage from patients with established OA.</span></div></div><div><h3>Results</h3><div>Our results confirm that physiological loading maintains expression of anabolic genes in non-OA cartilage, and indicate a deleterious effect of Wnt activation in the chondrocyte mechanoresponsiveness. This suggests that loading-induced regulation of chondrocyte markers occurs downstream of canonical Wnt signaling. Interestingly, our study highlighted contrasting mechanoresponsiveness in the model of Wnt activation and the established OA samples, with established OA cartilage maintaining its mechanoresponsiveness, and mechanical loading rescuing the chondrogenic phenotype.</div></div><div><h3>Conclusion</h3><div>This study provides insights into the mechanoresponsiveness of human cartilage in both non-OA and OA conditions. These findings hold the potential to contribute to the development of strategies that optimize the effect of dynamic compression by correcting OA pathological cell signaling.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 692-702"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140143930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor concerning ‘Diagnostic performance of self-reported knee crepitus using a Knee injury and Osteoarthritis Outcome Score item’","authors":"Li Liu","doi":"10.1016/j.joca.2025.02.784","DOIUrl":"10.1016/j.joca.2025.02.784","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Page 770"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}