Osteoarthritis and Cartilage最新文献

{"title":"Structural knee MRI findings are already frequent in a general population-based birth cohort at 33 years of age.","authors":"Antti Kemppainen,Joona Tapio,Miika T Nieminen,Simo Saarakkala,Mika T Nevalainen","doi":"10.1016/j.joca.2025.04.008","DOIUrl":"https://doi.org/10.1016/j.joca.2025.04.008","url":null,"abstract":"OBJECTIVETo evaluate the incidence and severity of knee magnetic resonance imaging (MRI) findings and their associated lifestyle and health factors in a relatively healthy subset of a general population-based birth cohort.DESIGNThe study population (n = 288, 61.1% females, mean age 33.7 years) is a subpopulation of the Northern Finland Birth Cohort 1986 (NFBC1986) on whom a thorough clinical evaluation, laboratory analyses and knee MRI were conducted at 33 years of age. Knee MRI data was graded using the MRI Osteoarthritis Knee Score (MOAKS) system. Descriptive statistics and multivariable regression models were used for data analysis.RESULTSSubjects were mostly asymptomatic. Detected articular cartilage lesions were mostly small and identified in 56.2 % (n = 162) of patellofemoral and 25.3 % (n = 63) of tibiofemoral joints. Full thickness cartilage lesions and bone marrow lesions were mostly located in the patellofemoral joint. Osteophytes, mostly small or doubtful, were detected in 51.7 % (n = 146) of patellofemoral and 17.4 % (n = 41) of tibiofemoral joints. In finding-specific regression analyses, higher body mass index (BMI) was most frequently associated with knee MRI findings.CONCLUSIONSIn this relatively young and asymptomatic population, subtle knee MRI findings were already frequent, especially in the patellofemoral joint. Of analyzed background and clinical parameters, higher BMI was most frequently associated with MRI findings. Based on these results, longitudinal studies are warranted to further identify risk factors and proportions of progressing MRI findings.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"28 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cost-effectiveness of guideline recommended treatments for osteoarthritis: A systematic review.","authors":"Stephanie Mathieson,Giovanni Ferreira,Caitlin Jones,Jillian Eyles,Jocelyn L Bowden,Saurab Sharma,Emily Callander,David Hunter,Ilana N Ackerman,Francis Keefe,Manuela L Ferreira,Lyn March,Andrew M Briggs,Regina Ws Sit,Aricia Jieqi Thirumaran,Elena Losina","doi":"10.1016/j.joca.2025.04.003","DOIUrl":"https://doi.org/10.1016/j.joca.2025.04.003","url":null,"abstract":"OBJECTIVETo critically appraise the literature on the cost-effectiveness of guideline recommended treatments for osteoarthritis (OA).DESIGNElectronic databases were searched for studies that provided incremental cost-effectiveness ratios (ICER) for treatments recommended by key international guidelines to manage OA in adults. Treatments were grouped as lifestyle and rehabilitative therapies, pharmacological, injection, or surgical. Primary outcome was ICERs, converted to 2023 US dollars for comparability across studies. Risk of bias was assessed using the Consensus on Health Economic Criteria (CHEC) checklist for trials and the Drummond checklist for modelling studies. Studies were deemed cost-effective based on established country-specific thresholds per quality-adjusted life-year.RESULTSThere were 110 studies that included 33 lifestyle and rehabilitative therapies, 25 pharmacological, 11 injection and 42 surgical studies. Most studies (95%) were conducted in high-income countries. Time horizons varied from 8 weeks to lifetime. Risk of bias domains were frequently scored poorly related to cost methods. Overall, the cost-effectiveness of lifestyle and rehabilitative therapies and non-steroidal anti-inflammatory drugs (NSAIDs) was mixed. Hyaluronic acid injection was cost-effective in knee OA compared to placebo, usual care and paracetamol but not to corticosteroid injections and NSAIDs. Total hip or knee replacement was cost-effective compared to usual care or no surgery, with early access to replacement cost-effective compared to delaying surgery.CONCLUSIONSThere were a diversity of analytical perspectives and clinical heterogeneity of interventions. Policymakers should consider their local context when deciding clinical care and resource allocation.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"37 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home delivery for chondrocytes","authors":"C.H. Evans","doi":"10.1016/j.joca.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.joca.2025.04.004","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"219 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cartilage targeting cationic peptide carriers display deep cartilage penetration and retention in a rabbit model of post-traumatic osteoarthritis.","authors":"Timothy L Boyer,Olivia Chao,Bill Hakim,Luke Childress,Quentin A Meslier,Suhasini M Iyengar,Mary Jo Ondrechen,Ryan M Porter,Ambika G Bajpayee","doi":"10.1016/j.joca.2025.04.001","DOIUrl":"https://doi.org/10.1016/j.joca.2025.04.001","url":null,"abstract":"OBJECTIVEDrug delivery to cartilage is limited by its complex architecture and avascularity. Cationic Peptide Carriers (CPC) have previously been optimized for improved cartilage transport and retention of drugs in vitro. In this study, we evaluated the kinetics, stability, and immunogenicity of CPCs after a single intra-articular injection using a rabbit knee injury model.DESIGNNew Zealand White rabbits were administered a single dose of Cy5-labeled CPCs in knees receiving ACL Transection (ACLT) or Sham surgery. CPC biodistribution and retention within joint tissues and synovial fluid was evaluated 1 and 7 days after administration, and extra-articular kinetics were assessed in blood serum. Histology, immunohistochemistry, and RT-qPCR were performed on joint tissues to assess synovitis and protease activity. Proteolytic analysis of CPCs in the presence of arthritic enzymes was evaluated using synovial fluid size-exclusion filtration, FRET analysis, and computational molecular docking.RESULTSCPCs penetrated the full depth of GAG-rich tissues, notably cartilage, and were retained through the latest timepoint measured (one week) in both Sham and ACLT knees. Compared to ACLT knees, Sham knees had moderately higher joint retention at Day 1 (1.6-fold) and Day 7 (1.8-fold). CPC intra-tissue concentration strongly correlated with tissue GAG density, which did not considerably differ between surgical conditions at these timepoints. However, CPCs exhibited elevated vascular clearance and proteolytic fragmentation in inflammatory conditions. CPCs did not increase macrophage abundance, cytokine expression, or alter tissue morphology in ACLT knees compared to saline injections.CONCLUSIONCPCs target the deep layers of cartilage, even in inflamed joints, and can be utilized to substantially improve the intra-joint bioavailability of therapeutics.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"151 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relation of walking forces to structural damage in the knee: The Multicenter Osteoarthritis Study.","authors":"Lauren K Sara,David T Felson,Sarah Tilley,Michael P LaValley,Cora E Lewis,John A Lynch,Neil A Segal,Ali Guermazi,Frank Roemer,Joshua J Stefanik,Cara L Lewis","doi":"10.1016/j.joca.2025.04.007","DOIUrl":"https://doi.org/10.1016/j.joca.2025.04.007","url":null,"abstract":"OBJECTIVEMechanical loading is an important, modifiable risk factor for knee osteoarthritis (OA). Identifying walking loads associated with disease worsening presents intervention opportunities. Our purpose was to evaluate the longitudinal relation of the baseline vertical ground reaction force (GRF) during walking to worsening bone marrow lesions (BMLs) and cartilage damage using cohort data from the Multicenter Osteoarthritis Study (MOST).METHODSMOST participants with GRF data at baseline and MRI examinations at baseline and 2-year follow-up were included. Peak impact force (PIF) and average loading rate (ALR) from the vertical GRF were analyzed with respect to four joint regions (i.e., the medial and lateral portions of tibiofemoral and patellofemoral joints). Analyses used logistic regression with generalized estimating equations and adjusted for relevant covariates.RESULTSHigher PIF was associated with increased odds of worsening BMLs in the lateral patellofemoral joint (OR (95% CI): 1.33 (1.11, 1.60)) and worsening cartilage damage in the lateral patellofemoral joint (1.48 (1.24, 1.77)), lateral tibiofemoral joint (1.24 (1.03, 1.50)), and medial tibiofemoral joint (1.25 (1.06, 1.48)). Higher ALR was associated with reduced odds of BML worsening in the lateral tibiofemoral joint (0.60 (0.41,0.87)).CONCLUSIONSHigher peak forces when walking were associated with worsening BMLs in the lateral patellofemoral joint and with worsening cartilage damage in regions of the knee associated with higher contact forces during walking. Higher average loading rates were not associated with increased odds of structural worsening (BMLs or cartilage).","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"5 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative analysis of the efficacy and associated factors of intra-articular hyaluronic acid with respect to osteoarthritis symptoms: a systematic review of randomized trials and model-based meta-analysis.","authors":"Ying Cao,Ruifen Cai,Shun Han,Zewei Li,Kang Ma,Zhounan Zhou,Xin Wen,Weizhong Qi,Han Cen,Weiyu Han,Tianyu Chen,Shengfa Li,Lijun Lin,Lixin Zhu,Yulong Cao,Cailiang Shen,Siu Ngor Fu,Kim Bennell,David J Hunter,Changhai Ding,Lujin Li,Zhaohua Zhu","doi":"10.1016/j.joca.2025.01.008","DOIUrl":"https://doi.org/10.1016/j.joca.2025.01.008","url":null,"abstract":"OBJECTIVEThe literature on the efficacy of hyaluronic acid (HA) to treat osteoarthritis (OA) remains controversial, and the applicable subpopulation is unclear. Our study aimed to quantitatively evaluate HA efficacy and identify potential responders who would benefit most from HA.METHODEmbase, MEDLINE (PubMed), and the Cochrane Library Central Register of Controlled Trials were searched from inception to March 13, 2023. A pharmacodynamic Bateman function model was used to quantitatively evaluate the efficacy characteristics of HA treatments as well as placebo, while a covariate model was employed to identify factors that significantly affected efficacy.RESULTSIn total, 24 101 participants with symptomatic or radiographic OA from 168 studies with aggregate data were included. Simulation analysis from the pharmacodynamic time-effect model showed that HA treatment effects plateaued at approximately 2 months. The final model analysis indicated that intra-articular injection of HA combined with corticosteroids (the Western Ontario and McMaster Universities Arthritis Index [WOMAC] pain effect size [ES] = 4.4 [95% CI: 3.0 to 5.7]) or platelet-rich plasma (PRP) (WOMAC pain ES = 4.0 [95% CI: 2.7 to 5.3]) achieved the best efficacy compared with other groups (contrast between meta-analyses: WOMAC pain ES = 1.9 [95% CI: 1.2 to 5.2]). Subgroups analysis showed that younger (age < 65), overweight (BMI ≥ 25) knee OA patients, with more severe baseline symptoms and a lower Kellgren-Lawrence (KL) grade (≤ 2), could benefit more.CONCLUSIONThe quantitative model suggested that HA interventions were statistically more effective than placebo, with participants receiving HA+ corticosteroids (CS) or platelet-rich plasma (PRP) experiencing the best efficacy. Patients with lower age, higher weight, higher severity of baseline symptoms, and lower KL grade appeared to benefit more from HA treatment.DATA AND MATERIALS AVAILABILITYAll data are available in the main text or the supplementary materials.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"16 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methotrexate for osteoarthritis - ready for clinical use and in whom?","authors":"Anna Døssing,Robin Christensen","doi":"10.1016/j.joca.2025.04.005","DOIUrl":"https://doi.org/10.1016/j.joca.2025.04.005","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"26 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between testosterone and knee and hand osteoarthritis among males and females from the general population","authors":"Ingrid A. Szilagyi, Dieuwke Schiphof, Layal Chaker, Cindy G. Boer, Elif Aribas, Maryam Kavousi, M. Arfan Ikram, Sita M.A. Bierma-Zeinstra, Joyce B.J. van Meurs","doi":"10.1016/j.joca.2025.03.006","DOIUrl":"https://doi.org/10.1016/j.joca.2025.03.006","url":null,"abstract":"The aim of this study was to examine the relationship between testosterone levels (total and free) and the prevalence, incidence and progression of radiographic osteoarthritis (OA) and chronic pain outcomes in the knee and hand joints.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"90 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Articular chondrocytes transduce mechanical signals through the Wnt pathway.","authors":"Ronald K June","doi":"10.1016/j.joca.2025.04.002","DOIUrl":"https://doi.org/10.1016/j.joca.2025.04.002","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"108 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of methotrexate in osteoarthritis: A systematic review and meta-analysis of randomized controlled trials.","authors":"Weikiat Wong,Yucheng Huang,Nattaya Wichienwantana,Hailiang Sun,Jian Pang,Ying Shi","doi":"10.1016/j.joca.2025.02.786","DOIUrl":"https://doi.org/10.1016/j.joca.2025.02.786","url":null,"abstract":"OBJECTIVETo evaluate the efficacy and safety of methotrexate (MTX) for osteoarthritis (OA).DESIGNA systematic search of databases and clinical trial registers was conducted in September 2024 to identify randomized controlled trials (RCTs) comparing MTX with placebo. The evaluation focused on OA symptoms, including pain and function; quality of life; safety and OA-related biomarkers (biochemical and imaging markers). Meta-analysis and the minimum clinically important difference (MCID) were utilized to determine statistical and clinical significance. The risk of bias and certainty assessment were evaluated using the RoB 1 tool, the RoB-ME tool, and the Grades of Recommendation, Assessment, Development and Evaluation Working Group (GRADE) framework.RESULTSSix RCTs involving 602 participants were included, all with a low risk of bias. Compared to the placebo, MTX significantly relieved pain (SMD, -0.44; 95% CI, -0.67 to -0.20, P = 0.0003) in patients with OA (knee and hand). Functional improvement with MTX was observed only in patients with knee OA (WMD, -7.36; 95% CI, -14.34 to -0.38, P = 0.045), while not observed in those with hand OA (WMD, -0.70; 95% CI, -2.52 to 1.12, P = 0.45). The point estimates did not exceed the MCID of each scale, suggesting the possible clinical significance of the findings. No differences were observed for quality-of-life outcome (SMD, -0.74; 95% CI, -153 to 0.05, P = 0.07). Besides, MTX did not significantly increase the incidence of adverse events (AEs) compared to placebo (RR, 0.88; 95% CI, 0.75 to 1.02, P = 0.09).CONCLUSIONSMethotrexate can alleviate pain in patients with osteoarthritis and improve functional recovery in knee OA without raising safety concerns.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"90 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}