Osteoarthritis and Cartilage最新文献

{"title":"Reply to Letter to the Editor.","authors":"Jamon L Couch, Matthew G King, Danilo De Oliveira Silva, Jackie L Whittaker, Thomas J West, Andrea M Bruder, Michael A Girdwood, Christian J Barton, Kay M Crossley, Ewa M Roos, Adam G Culvenor","doi":"10.1016/j.joca.2025.03.008","DOIUrl":"https://doi.org/10.1016/j.joca.2025.03.008","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applying RAND/UCLA appropriateness ratings to shoulder osteoarthritis surgical decisions: The surgical treatment for shoulder OA with an intact rotator cuff and glenoid retroversion.","authors":"Daniel L Riddle, Levent Dumenci","doi":"10.1016/j.joca.2025.03.009","DOIUrl":"10.1016/j.joca.2025.03.009","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: Surgical restabilization reduces the progression of post-traumatic osteoarthritis initiated by ACL rupture in mice [J Osteoarthr Cartil (2024) 909-920].","authors":"Yu-Yang Lin, Elias H Jbeily, Priscilla M Tjandra, Michael C Pride, Michael Lopez-Torres, Seif B Elmankabadi, Connor M Delman, Kristin K Biris, Heejung Bang, Jill L Silverman, Cassandra A Lee, Blaine A Christiansen","doi":"10.1016/j.joca.2025.03.002","DOIUrl":"10.1016/j.joca.2025.03.002","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Effectiveness and safety of intra-articular interventions for knee and hip osteoarthritis based on large randomized trials: A systematic review and network meta-analysis (Pereira et al., 2025)\".","authors":"Alberto Migliore, Ali Mobasheri, Jean-Yves Reginster, Emmanuel Maheu","doi":"10.1016/j.joca.2025.03.007","DOIUrl":"10.1016/j.joca.2025.03.007","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for the development of knee osteoarthritis across the lifespan: a systematic review and meta-analysis.","authors":"Vicky Duong, Christina Abdel Shaheed, Manuela L Ferreira, Sujita W Narayan, Venkatesha Venkatesha, David J Hunter, Jimmy Zhu, Inoshi Atukorala, Sarah Kobayashi, Siew Li Goh, Andrew M Briggs, Marita Cross, Rolando Espinosa-Morales, Kai Fu, Francis Guillemin, Francis Keefe, L Stefan Lohmander, Lyn March, George J Milne, Yifang Mei, Ali Mobasheri, Mosedi Namane, George Peat, May Arna Risberg, Saurab Sharma, Regina Sit, Rosa Weiss Telles, Yuqing Zhang, Cyrus Cooper","doi":"10.1016/j.joca.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.joca.2025.03.003","url":null,"abstract":"<p><strong>Objective: </strong>To identify and quantify risk factors for incident knee osteoarthritis (KOA) across the lifespan.</p><p><strong>Methods: </strong>This systematic review and meta-analysis identified eligible studies from seven electronic databases and three registries. Longitudinal cohort studies or randomised controlled trials evaluating participants who developed incident symptomatic and/or radiographic KOA were included. Two independent reviewers completed data screening and extraction. Estimates were pooled using a random effects model and reported as odds ratio (OR), hazard ratio (HR), or risk ratio (RR) and corresponding 95% confidence intervals (95% CI). Grading of Recommendations, Assessment, Development and Evaluation (GRADE) was used to determine the certainty of evidence. Population attributable fractions (PAFs) were calculated, including risk factors significantly associated with radiographic KOA based on the pooled meta-analysis and where we could determine communality scores using existing clinical datasets.</p><p><strong>Results: </strong>We identified 132 studies evaluating >150 risk factors. Higher body mass index (BMI), previous knee injury, older age and high bone mineral density were associated with an increased risk of incident radiographic KOA based on the pooled analysis [OR (95% CI): 1.56 (1.25, 1.95), 3.02 (1.93, 4.71), 1.15 (1.00, 1.33) and 1.82 (1.12, 2.94), respectively], with moderate-to-high certainty. Two risk factors (overweight/obesity and previous knee injury) accounted for 14% of incident radiographic KOA. Other modifiable risk factors including occupational physical activity also contribute to radiographic or symptomatic KOA.</p><p><strong>Conclusion: </strong>Novel strategies addressing known modifiable risk factors including overweight/obesity, knee injuries and occupational physical activity are needed to reduce overall burden of KOA.</p><p><strong>Systematic review registration: </strong>PROSPERO ID: CRD42023391187 FUNDING: Sydney Musculoskeletal Health, Faculty of Medicine and Health, The University of Sydney.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cartilage-targeting exosomes for delivery of receptor antagonist of interleukin-1 in osteoarthritis treatment","authors":"Tanvi Vinod Pathrikar, Helna M. Baby, Bill Hakim, Hengli Zhang, Héctor A. Millán Cotto, Vineel Kondiboyina, Chenzhen Zhang, Ambika G. Bajpayee","doi":"10.1016/j.joca.2025.02.785","DOIUrl":"https://doi.org/10.1016/j.joca.2025.02.785","url":null,"abstract":"Exosomes are nano-sized cell-secreted vesicles naturally involved in joint tissue crosstalk and hold promise as drug carriers. Their negatively charged lipid bilayer, however, results in electrostatic repulsion from the anionic cartilage matrix limiting their applications in tissue targeting and drug delivery. Here we engineer cartilage targeting exosomes by reversing their net surface charge and use them for sustained delivery of interleukin-1 receptor antagonist (IL-1RA), a disease-modifying osteoarthritis (OA) drug that suffers from rapid joint clearance and poor cartilage uptake.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"216 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative single-cell analysis reveals transcriptional and epigenetic regulatory features of human developmental dysplasia of the hip.","authors":"Peng Xu, Shiqiang Cheng, Xuena Yang, Ke Xu, Weikun Hou, Lin Liu, Kan Peng, Yan Wen, Feng Zhang","doi":"10.1016/j.joca.2025.02.788","DOIUrl":"10.1016/j.joca.2025.02.788","url":null,"abstract":"<p><strong>Objective: </strong>Developmental dysplasia of the hip (DDH) is a developmental disorder that has long-term chronic pain and limited hip joint mobility. The aim of the current study is to understand the specific chondrocyte composition involved in DDH development, identify effective biomarkers for DDH prediction, and elucidate the gene regulatory elements driving DDH progression.</p><p><strong>Method: </strong>In this study, we performed an integrated analysis combining single-cell RNA sequencing and single-cell assay for transposase-accessible chromatin sequencing to investigate the molecular programs and epigenetic changes governing human DDH pathogenesis. Validation of marker genes for distinct chondrocyte populations was performed via immunohistochemical assays, alongside characterization of regulatory elements specific to DDH.</p><p><strong>Results: </strong>Our analysis identified seven molecularly distinct chondrocyte populations in DDH cartilage, including a novel inflammatory chondrocyte population with unique molecular signatures. Furthermore, we reconstructed the differentiation trajectory of chondrocytes, shedding light on their roles in DDH pathogenesis. Integrative analyses of transcriptomic and chromatin accessibility profiles highlighted shared regulatory features and transcriptional programs among chondrocyte subtypes, with several regulatory elements linked to DDH progression. Immunohistochemical validation corroborated the presence of key marker genes in distinct chondrocyte subsets.</p><p><strong>Conclusion: </strong>Our findings contribute to clarifying the cellular heterogeneity of DDH and offer insights into potential early diagnostic and therapeutic strategies for this condition.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of weight loss interventions in overweight and obese adults with knee osteoarthritis: A systematic review and network meta-analysis of randomized trials","authors":"Arashi Shahid ,&nbsp;Aricia Jieqi Thirumaran ,&nbsp;Robin Christensen ,&nbsp;Venkatesha Venkatesha ,&nbsp;Marius Henriksen ,&nbsp;Jocelyn L. Bowden ,&nbsp;David J. Hunter","doi":"10.1016/j.joca.2025.01.003","DOIUrl":"10.1016/j.joca.2025.01.003","url":null,"abstract":"<div><h3>Objective</h3><div>To ascertain the comparative effectiveness of weight-loss strategies for osteoarthritis (OA) to develop rational treatment algorithms aimed at improving OA-related symptoms in overweight/obese individuals.</div></div><div><h3>Method</h3><div>Medline, Embase, CINAHL, Scopus, and Web of Science were searched from inception to June 2023 for observational studies and randomized trials. Network meta-analyses were performed using a frequentist approach. Effect sizes for pain and function were computed as standardized mean differences (SMDs), while weighted mean differences were computed for body weight.</div></div><div><h3>Results</h3><div>14 RCTs on knee OA (KOA) (3215 participants) with 7 interventions: diet (D); exercise (E); diet and exercise (DE); pharmacological (L); psychological (P); psychological, diet, and exercise (PDE); and Mediterranean diets (M) were networked. For weight change (kg), all interventions significantly outperformed control comparators, with benefits ranging from −7.0 kg (95% CI: −12.1 to −2.0 kg) for the most effective approach (PDE) to −4.9 kg (95% CI: −6.8 to −3.0 kg) for the least effective approach (D). In terms of SMDs for pain, only PDE (−1.2, 95% CI: −2.2 to −0.3), and DE (−0.6, 95% CI: −1.0 to −0.2) outperformed control comparators in improving the pain. Regardless of the chosen intervention, prediction intervals from meta-regression analysis indicated that significant pain relief may be anticipated when patients achieve at least a weight reduction of 7.4%.</div></div><div><h3>Conclusions</h3><div>PDE and DE interventions may offer the most effective approach for weight loss, potentially leading to significant improvements in pain and physical function among overweight/obese individuals with KOA if they achieve more than 7.4% weight loss.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 4","pages":"Pages 399-411"},"PeriodicalIF":7.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implication of bone marrow adipose tissue in bone homeostasis during osteoarthritis","authors":"Natalia Zapata-Linares, Indira Toillon, Kristell Wanherdrick, Audrey Pigenet, Fanny Duhalde, Marie Binvignat, Patxi SAN Martin-Uriz, Loïc Louvet, Maria E. Calleja-Cervantes, Olfa Ghali Mhenni, Clément Guibert, Geoffroy Nourissat, Alexis Nogier, Damien Leterme, Odile Broux, Paul Magneron, Felipe Prosper, Christophe Chauveau, Jessem Landoulsi, Francis Berenbaum, Juan R. Rodriguez-Madoz, Marie-Hélène Lafage-Proust, Stéphanie Lucas, Xavier Houard","doi":"10.1016/j.joca.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.joca.2025.03.004","url":null,"abstract":"To explore the role of bone marrow adipocytes (BMAds) in osteoarthritis (OA).","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"4 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maresin 1-LGR6 axis mitigates inflammation and posttraumatic osteoarthritis after transection of the anterior cruciate ligament in mice.","authors":"Chilan B G Leite, Hannah P Fricke, Luciana P Tavares, Robert Nshimiyimana, Julie Mekhail, Elliott Kilgallen, Felix Killick, Janey D Whalen, Jessica A Lehoczky, Charles N Serhan, Julia F Charles, Christian Lattermann","doi":"10.1016/j.joca.2025.03.005","DOIUrl":"10.1016/j.joca.2025.03.005","url":null,"abstract":"<p><strong>Objective: </strong>Anterior cruciate ligament (ACL) tears frequently cause chronic inflammation and posttraumatic osteoarthritis (PTOA), with therapies failing to resolve persistent post-injury inflammation. Specialized pro-resolving mediators (SPMs), including Maresin1 (MaR1), show promise in resolving inflammation and promoting tissue repair. However, their role in PTOA remains underexplored. This study investigated inflammatory markers and MaR1 dynamics post-ACL injury, the role of the MaR1 receptor Leucine-rich Repeat-containing G protein-coupled receptor 6 (LGR6) in PTOA, and MaR1's therapeutic potential in a mouse ACL transection (ACLT) model.</p><p><strong>Design: </strong>Eight-week-old C57BL6/J male mice underwent ACLT, and synovial fluid, periarticular tissue, and tibiofemoral joints were collected at various time points post-surgery for analysis. LGR6-deficient mice were utilized to investigate the role of MaR1 signaling in inflammation resolution. Additionally, the effect of intraarticular MaR1 administration on PTOA progression was assessed.</p><p><strong>Results: </strong>ACLT induced joint inflammation with leukocyte infiltration and elevated pro-inflammatory cytokines. MaR1 levels peaked early post-injury and were associated with a six-fold increase in LGR6 expression. LGR6 deficiency worsened inflammation and PTOA severity with higher histological Osteoarthritis Research Society International (OARSI) scores (mean difference 5.6[95%CI: 2.5-8.6], p<0.001) and microCT OA severity scores (mean difference 4.3[95%CI: 0.7-7.9], p=0.018). Intraarticular MaR1 treatment reduced leukocyte recruitment, suppressed pro-inflammatory gene expression, and ameliorated PTOA development, improving histological OARSI scores (mean difference -3.9[95%CI: -6.9 to -1.0], p=0.012) and microCT scores (mean difference -6.7[95%CI: -10.3 to -3.0], p=0.012).</p><p><strong>Conclusion: </strong>This study suggests a critical role of MaR1 in resolving inflammation post-ACL injury and mitigating PTOA in mice. Targeting SPM pathways, particularly MaR1 and/or MaR1 mimetics, offers a promising strategy to prevent chronic joint inflammation and degeneration after ACL injury.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}