Osteoarthritis and Cartilage最新文献

Plasma Lipoprotein Subclasses and Risk of Incident Knee Osteoarthritis: A Population-Based Cohort Study. 血浆脂蛋白亚类与膝骨关节炎发生的风险：一项基于人群的队列研究。

IF 7 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-08-01 DOI: 10.1016/j.joca.2025.07.013

Cheng Li,Jing Wu,Yuqing Zhang,Hongyi He,Ying Hu,Jie Wei,Guanghua Lei,Chao Zeng

{"title":"Plasma Lipoprotein Subclasses and Risk of Incident Knee Osteoarthritis: A Population-Based Cohort Study.","authors":"Cheng Li,Jing Wu,Yuqing Zhang,Hongyi He,Ying Hu,Jie Wei,Guanghua Lei,Chao Zeng","doi":"10.1016/j.joca.2025.07.013","DOIUrl":"https://doi.org/10.1016/j.joca.2025.07.013","url":null,"abstract":"OBJECTIVELipoprotein subclasses play diverse roles in health and disease. Although lipoproteins have been implicated in knee osteoarthritis (KOA), the relationship between lipoprotein subclasses and KOA remains unexplored.METHODWe conducted a cohort study using UK Biobank data to examine the associations of 85 plasma lipoprotein subclasses, defined by combinations of density (high, low, intermediate, very-low), size (extremely-large, very-large, large, medium, small, very-small), and composition (triglyceride, free cholesterol, cholesteryl ester, phospholipid), with incident KOA in metabolome-wide analysis. Data were analyzed using Cox proportional hazards models, correcting for multiple tests (0.05/9). Targeted analyses were subsequently conducted to examine the association between key lipoprotein subclasses and the risk of knee replacement.RESULTSAmong 115,237 participants followed for a median of 12.8 years, 38 lipoprotein subclasses were statistically significantly associated with incident KOA. Higher concentrations of very-large and large high-density lipoproteins (HDL), excluding triglyceride, were associated with a lower risk of incident KOA (hazard ratios [HRs] ranging from 0.87 to 0.94 per 1-standard deviation increase in log-transformed lipoprotein subclasses concentrations). Conversely, higher concentrations of small HDL, irrespective of composition, were associated with higher risks of incident KOA (HRs ranging from 1.04 to 1.09). After adjusting for body mass index as a continuous variable, differential effects among HDL subclasses remained evident, except for the association between large HDL and KOA. Similar associations were observed for targeted analysis in knee replacement.CONCLUSIONWe provided novel evidence of diverse associations between lipoprotein subclasses and incident KOA and knee replacement, indicating the distinct effects of HDL subclasses.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"28 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Booster sessions for maintaining the effect of neuromuscular exercise and progressive resistance training in hip osteoarthritis: 12-month follow-up from a multicenter cluster-randomized controlled trial. 维持神经肌肉锻炼和进行性抗阻训练对髋关节骨关节炎疗效的强化训练：一项多中心集群随机对照试验的12个月随访

IF 9 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-07-23 DOI: 10.1016/j.joca.2025.07.012

Troels Kjeldsen, Ulrik Dalgas, Søren T Skou, Lisa U Tønning, Kim G Ingwersen, Sara Birch, Pætur M Holm, Mette Garval, Claus Varnum, Jacob Callesen, Frederik Foldager, Bo M Bibby, Inger Mechlenburg

{"title":"Booster sessions for maintaining the effect of neuromuscular exercise and progressive resistance training in hip osteoarthritis: 12-month follow-up from a multicenter cluster-randomized controlled trial.","authors":"Troels Kjeldsen, Ulrik Dalgas, Søren T Skou, Lisa U Tønning, Kim G Ingwersen, Sara Birch, Pætur M Holm, Mette Garval, Claus Varnum, Jacob Callesen, Frederik Foldager, Bo M Bibby, Inger Mechlenburg","doi":"10.1016/j.joca.2025.07.012","DOIUrl":"10.1016/j.joca.2025.07.012","url":null,"abstract":"Objective: To investigate if exercise booster sessions (EBS) are superior to no further intervention (CON) in prolonging effects on functional performance after supervised exercise in patients with hip osteoarthritis (OA).Methods: Multicenter, cluster-randomized, controlled, parallel-group, assessor-blinded, superiority trial conducted at hospitals and physiotherapy clinics. EBS participants were offered one group-based exercise session supervised by a physiotherapist at 1, 3, 5 and 7 months after the initial 3-month intervention. At each EBS, exercise complications were addressed and modifications were provided. CON participants received no further intervention. The primary outcome was change in the 30-second Chair Stand Test (30s-CST) from 3 to 12 months. Key secondary outcomes were changes in Pain and hip-related Quality of Life (QoL) subscales from the Hip disability and Osteoarthritis Outcomes Score (HOOS).Results: 160 participants with clinically diagnosed hip OA enrolled from January 18th 2021 to April 28th 2023 and were cluster-randomized to EBS (N=84) or CON (N=76). The mean change (95% CI) from 3- to 12-month follow-up in 30s-CST was 0.8 (0.1; 1.5) chair stands in EBS and 0.5 (-0.1; 1.1) chair stands in CON (difference: 0.3 [-0.6; 1.2]), for HOOS pain it was 4.0 (-0.8; 8.7) points in EBS and 1.1 (-3.6; 5.7) points in CON (difference: 2.9 [-3.8; 9.6]), for HOOS QoL it was 6.8 (1.4; 12.2) points in EBS and 1.5 (-3.8; 6.8) points in CON (difference: 5.3 [-2.2; 12.9]).Conclusions: EBS were not superior to CON for maintaining effects for functional performance, hip pain or hip-related quality of life at 12 months.Registration: Clinicaltrials.gov (NCT04714047).","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the editor concerning 'A decade of exposure: long-term air pollution and its impact on osteoarthritis: a nationwide cohort study in Taiwan'. 致编辑关于“十年暴露：长期空气污染及其对骨关节炎的影响：台湾一项全国性队列研究”的信。

IF 7 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-07-21 DOI: 10.1016/j.joca.2025.07.010

Cheng Li

引用次数: 0

The osteoarthritis associated sphingolipid sphingomyelin 34:1 causes inflammatory pain in mice 骨关节炎相关鞘脂鞘磷脂34:1引起小鼠炎性疼痛

IF 7 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-07-19 DOI: 10.1016/j.joca.2025.07.011

Rebecca H. Rickman, Luke A. Pattison, Lanhui Qiu, Maya Dannawi, Fraser Welsh, Ewan St. John Smith

引用次数: 0

Response to letter regarding 'A decade of exposure: long-term air pollution and its impact on osteoarthritis: a nationwide cohort study in Taiwan'. 对“十年暴露：长期空气污染及其对骨关节炎的影响：台湾一项全国性队列研究”的回复。

IF 7 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-07-14 DOI: 10.1016/j.joca.2025.07.009

Yi-Chuan Chan,Yen-Wei Huang,Shu-Han Chuang,Yi-Jie Kuo,Yu-Pin Chen

引用次数: 0

Resolving Microenvironment Complexity and Cellular Heterogeneity in Osteoarthritis via Spatial Transcriptomics. 通过空间转录组学解决骨关节炎微环境复杂性和细胞异质性。

IF 7 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-07-14 DOI: 10.1016/j.joca.2025.07.007

Peng Xie,Antonia RuJia Sun,Feng Gao,Lin Li,Ross Crawford,Indira Prasadam

{"title":"Resolving Microenvironment Complexity and Cellular Heterogeneity in Osteoarthritis via Spatial Transcriptomics.","authors":"Peng Xie,Antonia RuJia Sun,Feng Gao,Lin Li,Ross Crawford,Indira Prasadam","doi":"10.1016/j.joca.2025.07.007","DOIUrl":"https://doi.org/10.1016/j.joca.2025.07.007","url":null,"abstract":"Osteoarthritis (OA) is a multifactorial joint disease characterized by complex tissue interactions, spatially compartmentalized pathology, and diverse cellular phenotypes. Traditional transcriptomic approaches have provided valuable insights into OA pathogenesis but lack the spatial resolution required to understand how cellular behaviour is influenced by local tissue context. Spatial transcriptomics (ST) has emerged as a transformative tool that enables in situ gene expression profiling while preserving the anatomical architecture of tissues. In this review, we explore recent advances in ST technologies and highlight their application across key joint compartments in OA, including cartilage, synovium, subchondral bone, and periarticular tissues. We discuss how ST is uncovering zonal gene expression patterns, pathogenic cell states, fibroblast-immune cell interactions, and signalling gradients that drive disease progression. We also outline current technical limitations and propose future directions for integrating spatial data with other omics and imaging modalities. As ST platforms continue to evolve, they hold immense promise for redefining OA phenotypes, identifying novel therapeutic targets, and advancing precision medicine approaches for joint disease.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"10 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing classification criteria for spine osteoarthritis: is it the right time? 制定脊柱骨关节炎的分类标准：时机合适吗？

IF 7 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-07-12 DOI: 10.1016/j.joca.2025.07.008

Alessandro Chiarotto, Sita MA Bierma-Zeinstra, Katie de Luca, Jan Hartvigsen, Christopher B Little, Raja Rampersaud, Frances MK Williams, Manuela L Ferreira

引用次数: 0

Research priorities for physical activity and exercise management of people with knee and hip osteoarthritis: a multi-stage international priority-setting study from the OARSI Rehabilitation Discussion Group. 膝关节和髋关节骨关节炎患者身体活动和运动管理的研究重点：来自OARSI康复讨论组的多阶段国际优先设置研究。

IF 7 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-07-10 DOI: 10.1016/j.joca.2025.07.006

Kim L Bennell,Rachel K Nelligan,Jesse J Pardo,Sarah Stratulate,Melanie A Holden,Belinda J Lawford,Louise M Thoma,Daniel K White,Elizabeth Wellsandt,Hiral Master,Jesper Bie Larsen,Kate Button,Natalie J Collins,Søren T Skou,Yves Henrotin,Rana S Hinman

{"title":"Research priorities for physical activity and exercise management of people with knee and hip osteoarthritis: a multi-stage international priority-setting study from the OARSI Rehabilitation Discussion Group.","authors":"Kim L Bennell,Rachel K Nelligan,Jesse J Pardo,Sarah Stratulate,Melanie A Holden,Belinda J Lawford,Louise M Thoma,Daniel K White,Elizabeth Wellsandt,Hiral Master,Jesper Bie Larsen,Kate Button,Natalie J Collins,Søren T Skou,Yves Henrotin,Rana S Hinman","doi":"10.1016/j.joca.2025.07.006","DOIUrl":"https://doi.org/10.1016/j.joca.2025.07.006","url":null,"abstract":"OBJECTIVETo identify research priorities for physical activity and exercise management of knee and hip osteoarthritis (OA).DESIGNWe used a multi-stage process involving an international multi-disciplinary panel of 276 experts (150 consumers, 69 clinicians spanning 5 disciplines, 54 researchers, and 3 funder/consumer organisation representatives) from 26 countries. The process included: 1) compiling a list of unanswered research questions from existing research; 2) assembling the panel and generating additional questions from members via an online survey; 3) consolidating research questions (eg. removing duplicates); 4) scoring questions for priority by the panel on an 11-point numeric rating scale (0='not a priority at all; 10='highest priority') via another online survey; and 5) ranking the top 20 priority questions by the panel via an online discrete choice experiment (1000Minds).RESULTSA list of 61 research questions was compiled from the literature and the panel generated an additional 346 questions. Following consolidation, 178 questions remained and were scored by 150 of the original panelists (54%), with mean priority scores from 5.0 to 8.4. 153 (55%) panelists completed the discrete choice experiment. The top three research priorities were: 1) investigating the impact of physical activity and exercise on delaying/avoiding joint replacement, 2) developing effective interventions to promote long-term exercise adherence, and 3) stratifying people to the most appropriate form of exercise support.CONCLUSIONWe identified research priorities about physical activity and exercise management of knee and hip OA. These will guide the international research agenda with the aim of improving outcomes for people with OA.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"109 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histone demethylase KDM5C is critical for cartilage development and protects against osteoarthritis by increasing HIF-1α to maintain mitochondrial function. 组蛋白去甲基化酶KDM5C对软骨发育至关重要，并通过增加HIF-1α来维持线粒体功能，从而预防骨关节炎。

IF 7 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-07-10 DOI: 10.1016/j.joca.2025.07.005

Lingli Ding,Yage Zhang,Zhao Gao,Shengnan Qin,Siluo Wu,Yamei Liu,Weiping Lin,Haibin Wang,Gang Li,Yonghui Hou,Liangliang Xu

{"title":"Histone demethylase KDM5C is critical for cartilage development and protects against osteoarthritis by increasing HIF-1α to maintain mitochondrial function.","authors":"Lingli Ding,Yage Zhang,Zhao Gao,Shengnan Qin,Siluo Wu,Yamei Liu,Weiping Lin,Haibin Wang,Gang Li,Yonghui Hou,Liangliang Xu","doi":"10.1016/j.joca.2025.07.005","DOIUrl":"https://doi.org/10.1016/j.joca.2025.07.005","url":null,"abstract":"OBJECTIVEWith age-related incidence and prevalence, osteoarthritis (OA) is becoming a major source of disability with an increased medical burden worldwide. Lysine Demethylase 5C (KDM5C) mutation causes abnormalities of epilepsy and short stature. Our previous study has demonstrated KDM5C is indispensable for osteogenesis and bone formation. However, the role of KDM5C in cartilage development and OA remains unknown.METHODSWe used KDM5C chondrocyte-specific knockout mice model to investigate its role in cartilage development and OA. Western blotting, quantitative RT-PCR, immunofluorescence staining, RNA-seq, and immune-precipitation assay were applied to detect the levels of genes or proteins. Destabilization of the medial meniscus (DMM) model was used to investigate the effect of KDM5C overexpression on OA progression.RESULTSIn this study, we found decreased expression of KDM5C in chondrocytes of murine and human OA samples. Meanwhile, KDM5C was indispensable for chondrogenic differentiation. The RNAseq analysis showed KDM5C knockout impaired mitochondrial function with inhibition of the oxidative phosphorylation, tricarboxylic acid cycle, and hypoxia-inducible factor-1α (HIF-1α) signaling pathway. We further demonstrated that KDM5C interacted with and increased HIF-1α in chondrocytes. The deletion of KDM5C significantly decreased HIF-1α, leading to increased ROS production and impaired mitochondrial function, which finally disturbed cartilage homeostasis and promoted OA progression. Most importantly, intra-articular injection of lentiviral vector expressing KDM5C could inhibit OA progression in mice.CONCLUSIONSKDM5C plays a critical role in cartilage development and OA progression. It maintains mitochondrial function and articular cartilage homeostasis by increasing HIF-1α.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"698 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of pre- and post-surgery physical activity interventions on physical activity and sedentary behaviour levels following knee and hip arthroplasty: a systematic review and meta-analysis of randomised controlled trials. 术前和术后身体活动干预对膝关节和髋关节置换术后身体活动和久坐行为水平的影响：随机对照试验的系统回顾和荟萃分析

IF 7 2区医学

Osteoarthritis and Cartilage Pub Date : 2025-07-10 DOI: 10.1016/j.joca.2025.07.003

Noah d'Unienville,Ben Singh,Bethany Gower,Kimberley Szeto,Heather Badger,Matilda Krywanio,Carol Maher,Dominic Thewlis

{"title":"Effects of pre- and post-surgery physical activity interventions on physical activity and sedentary behaviour levels following knee and hip arthroplasty: a systematic review and meta-analysis of randomised controlled trials.","authors":"Noah d'Unienville,Ben Singh,Bethany Gower,Kimberley Szeto,Heather Badger,Matilda Krywanio,Carol Maher,Dominic Thewlis","doi":"10.1016/j.joca.2025.07.003","DOIUrl":"https://doi.org/10.1016/j.joca.2025.07.003","url":null,"abstract":"OBJECTIVETo evaluate general exercise and behavioural interventions designed to improve physical activity (PA) or reduce sedentary behaviour in total knee or hip arthroplasty (TKA/THA) patients.DESIGNA systematic review and meta-analysis were conducted on randomised controlled trials reporting PA or sedentary behaviour changes in TKA/THA patients, with effects calculated using standardised mean differences (SMD). Subgroup analyses assessed whether effects differed based on intervention characteristics, arthroplasty timing, outcome type, and follow-up duration. Risk of bias and certainty of evidence were assessed using the PEDro scale and GRADE, respectively.RESULTSTwenty-three trials were included, with meta-analyses including 1265 and 270 participants for PA and sedentary behaviour outcomes, respectively. PA interventions did not decrease sedentary behaviour (SMD=-0.19; 95% CI: -0.66 to 0.29; very low certainty of evidence), but did improve PA (SMD=0.16; 95% CI: 0.01 to 0.30; high certainty of evidence). This included improvements in step count (SMD=0.22; 95% CI: 0.05 to 0.40), but not moderate-to-vigorous PA (SMD=-0.01, 95% CI: -0.33 to 0.30). Interventions were most effective when they integrated wearable activity trackers (e.g., Fitbits; SMD=0.38; 95% CI: 0.18 to 0.57), behaviour change techniques (SMD=0.20, 95% CI: 0.01 to 0.39), and began less than two weeks after surgery (SMD=0.32, 95% CI: 0.14 to 0.50).CONCLUSIONPA interventions, particularly those integrating behavioural strategies and wearable technology, promote PA in arthroplasty patients, but their effects on sedentary behaviour are unclear. These findings suggest that implementing evidence-based PA interventions be considered an essential component of acute arthroplasty care to enhance overall patient health.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"63 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0