Osteoarthritis and Cartilage最新文献

{"title":"Do rates of femorotibial cartilage loss in Kellgren-Lawrence 2 and 3 knees differ between those with mild-moderate vs. severe patellofemoral structural damage? - Data from the FNIH and IMI-APPROACH cohorts.","authors":"Frank W Roemer,Mylène Jansen,Susanne Maschek,Simon Mastbergen,Anna Wisser,Harrie H Weinans,Francisco J Blanco,Francis Berenbaum,Margreet Kloppenburg,Ida K Haugen,David J Hunter,Ali Guermazi,Wolfgang Wirth","doi":"10.1016/j.joca.2025.10.003","DOIUrl":"https://doi.org/10.1016/j.joca.2025.10.003","url":null,"abstract":"BACKGROUNDThe aim was to assess whether rates of quantitative femorotibial (FT) cartilage loss are increased for knees with semiquantitatively (sq)-defined severe patellofemoral (PF) cartilage damage and/or large bone marrow lesions (BMLs) vs. those without over a period of 24 months.METHODS626 knees with Kellgren-Lawrence 2 and 3 from the FNIH and IMI-APPROACH studies were included. MRI assessment was performed using the MRI Osteoarthritis Knee Score (MOAKS) instrument. Baseline FT cartilage damage severity was defined as mild, moderate, or severe. PF cartilage damage was defined as mild-moderate vs. severe. A 2nd definition was based on the presence or absence of large BMLs. Quantitative cartilage thickness loss (defined as the difference from baseline to follow-up in mean cartilage thickness in the medial and in the lateral femorotibial joint, which were computed by summing the cartilage thickness measures observed in the respective cartilage plates) was derived from baseline and 24-month manual segmentations. Between-group comparisons were performed using analysis of covariance (ANCOVA) adjusting for age, sex and body mass index.RESULTS410 (65%) knees were categorized as mild, 92 (15%) as moderate, and 124 (20%) as severe medial FT cartilage damage. For almost all categories of FT cartilage damage, the difference in quantitative medial FT cartilage loss was not statistically significant. Only for the category of knees with moderate medial FT cartilage damage, statistically higher rates of FT cartilage loss were observed for those with large PF BMLs compared to those without (mean adjusted difference -0.128 mm, 95% confidence interval [-0.238, -0.018], p=0.023).CONCLUSIONSScreening for PF cartilage damage and BMLs does not appear to be required in a disease-modifying OA drug trial.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"28 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibroblast and Myeloid Cells with High Mitochondrial RNA Content Represent Biologically Significant Populations within the OA Synovium.","authors":"Wesley Tran,Garth Blackler,Rebecca Luo,C Thomas Appleton,Matthew W Grol","doi":"10.1016/j.joca.2025.10.002","DOIUrl":"https://doi.org/10.1016/j.joca.2025.10.002","url":null,"abstract":"OBJECTIVESStandard scRNA-seq QC often excludes cells with high mitochondrial RNA content (pMT), assuming they reflect low viability or dissociation-induced stress. Emerging evidence suggests high-pMT cells may represent disease-relevant cell populations. This study investigates how exclusion of high-pMT cells affects the transcriptional landscape of knee OA synovium and explores their potential role in disease pathobiology.DESIGNSeven published human and mouse scRNA-seq datasets were reanalyzed using QC thresholds and quantile-based filtering to include high-pMT cells. Analyses included pMT distribution, dissociation-induced stress scores, cell death-related and mitochondrial apoptotic gene signatures. Dissociation-induced stress was assessed using a gene set from three published studies, while cell death and mitochondrial signatures were derived from established GSEA gene sets. Focusing on a single human knee OA synovial dataset stratified by pain (GSE248453), differential gene expression and pathway enrichment were compared between conventionally filtered and high-pMT inclusive pipelines.RESULTSAcross all datasets, pMT showed no correlation with dissociation-induced stress scores (R= -0.036). High-pMT cells showed no association with apoptosis pathways, suggesting that they are not actively undergoing cell death. High-pMT cells primarily localized to fibroblast and myeloid subsets. High-pMT synovial fibroblasts were enriched in ECM remodeling processes, while high-pMT myeloid cells were linked to inflammatory signaling and immune activation.CONCLUSIONSThese findings suggest high-pMT cells are viable and potentially disease relevant, with their exclusion possibly obscuring key aspects of OA pathophysiology. This highlights the necessity of context-specific QC strategies in OA research and further exploration of high-pMT fibroblast and myeloid populations as potential disease drivers.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"9 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in incident osteoarthritis between sexual minority and heterosexual adults: findings from a large cohort study.","authors":"Tingting Sha,Yilun Wang,Yuqing Zhang,Jian Zhang,Cong Lu,Jie Wei,Guanghua Lei,Chao Zeng","doi":"10.1016/j.joca.2025.10.001","DOIUrl":"https://doi.org/10.1016/j.joca.2025.10.001","url":null,"abstract":"OBJECTIVESexual minorities, including lesbian, gay, and bisexual individuals, experience persistent health disparities due to chronic exposure to minority stressors; however, its relation to osteoarthritis (OA) risk remains unexplored. This study aims to investigate the association between sexual orientation and OA risk and evaluate the mediating effect of health behaviors and psychosocial factors in related disparities.METHODSWe conducted a prospective cohort study of 346,320 UK Biobank participants without OA at baseline (2006-2010), followed through December 2021. Coarsened exact matching was applied to balance age, birth cohort, and ethnicity. Sex-stratified Cox models (using age as the time scale) were used to estimate hazard ratios (HRs) for OA risk. Mediation analyses examined the roles of modifiable factors, including BMI, socioeconomic status, lifestyle behaviors, and mental health.RESULTSOver a median follow-up of 11.3 years, 40,728 participants developed OA. Both bisexual and lesbian women had a higher OA risk than heterosexual women (adjusted hazard ratio [HR]: 1.17, 95%CI: 1.07-1.28 and HR: 1.36, 95%CI: 1.10-1.68, respectively). Mediation analysis identified BMI, Townsend index, smoking, and depression as potential mediators, with mediation proportions ranging from 12.1% to 34.2%. In men, gay individuals had lower OA risk (HR: 0.72, 95%CI: 0.60-0.85), with BMI and education explaining 17.5% to 18.4% of the reduction; no significant difference was observed for bisexual men.CONCLUSIONSexual orientation is associated with OA risk, with bisexual and lesbian women showing higher risk and gay men lower risk than heterosexuals. These disparities are partially explained by BMI, smoking, depression, and socioeconomic status.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"122 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145277328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dampened inflammation and reduced risk of osteoarthritis among non-industrialized societies.","authors":"Ian J Wallace,David T Felson,Virginia B Kraus,Tuhina Neogi,Ida K Haugen,Janet L Huebner,Cecilia M T Sena,Tracy L Kivell,Nicholas B Holowka,Steven Worthington,Yvonne A L Lim,Vivek V Venkataraman,Thomas S Kraft,Amanda J Lea","doi":"10.1016/j.joca.2025.09.014","DOIUrl":"https://doi.org/10.1016/j.joca.2025.09.014","url":null,"abstract":"OBJECTIVESAnthropological research suggests that people in non-industrialized societies (hunter-gatherers, subsistence farmers, pastoralists) are at lower risk of osteoarthritis than people in industrialized societies. Here, we propose that this may be due to people in non-industrialized societies having dampened inflammatory activity, a key factor in osteoarthritis pathogenesis.DESIGNThis narrative review focuses on evidence that four environmental variables common among non-industrialized societies contribute to dampening inflammatory activity and thus potentially lowering OA risk: low levels of adiposity, high physical activity levels, diets consisting of minimally processed foods, and infections from helminths.RESULTSAlthough people in non-industrialized societies experience intermittent, pathogen-induced spikes in inflammation, they do not typically experience the chronic, low-grade pattern of inflammation implicated in osteoarthritis pathogenesis. Excess adipose tissue is well documented to be a potent source of pro-inflammatory mediators involved in osteoarthritis pathogenesis; thus, the rarity of obesity among non-industrialized societies is likely a major reason for any reduced osteoarthritis risk. Physical activity and diet among non-industrialized societies have the potential to curb inflammation and osteoarthritis through several mechanistic pathways, yet the relative importance of each pathway has yet to be fully resolved. A role for helminths in dampening inflammation and lowering OA risk is theoretically plausible but speculative based on current evidence.CONCLUSIONSMore research among non-industrialized societies will be required to rigorously investigate the links proposed here between industrialization, inflammation, and risk of osteoarthritis. Opportunities to do so are disappearing, as lifestyles among such societies are rapidly changing.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"122 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145261224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of peptidergic innervation of the subchondral bone in a murine model of MIA-induced osteoarthritis.","authors":"Jason Ivanusic,Wendy Imlach,Jenny Thai,Jacob Bos,Jackson Hart,John-Paul Fuller-Jackson","doi":"10.1016/j.joca.2025.09.016","DOIUrl":"https://doi.org/10.1016/j.joca.2025.09.016","url":null,"abstract":"OBJECTIVEIn the present study, we aimed to determine how osteoarthritis (OA) affects the morphology and distribution of nociceptive nerve endings in the subchondral bone of animals with mono-iodoacetate (MIA)-induced OA.DESIGNWe used a modified version of the immunolabelling-enabled imaging of solvent-cleared organs (iDISCO/iDISCO+) protocol to visualize peptidergic (CGRP+) nerve terminal labelling in 3D volumes of subchondral bone around the murine knee joint. Total nerve length, number of branch points, and number of endings were derived from manual filament tracing, and were used to quantify changes in animals with MIA-induced OA vs control animals. Von Frey testing was used to assay pain behavior.RESULTSIn control animals, peptidergic nerves were distributed extensively throughout the condyles of both the tibia and femur. There was a decrease in innervation of the subchondral bone in animals injected with MIA, relative to those injected with saline (n=4/group, Mann-Whitney U-test, P<0.05), that was more obvious in the tibia (filament length, saline mean 47556 [min. 21442, max. 86615], MIA mean 4037 [min. 663, max. 10813]) than the femur (filament length, saline mean 37321 [min. 31630, max.44530], MIA mean 18665 [min. 8670, max. 31557]). The extent of pain behavior was associated with decreased innervation in the tibia, but not the femur.CONCLUSIONSOur findings offer unprecedented 3D insight into the full extent of innervation of subchondral bone around the murine knee joint and indicate that there is a loss of peptidergic innervation in the subchondral bone around knee joints of animals with MIA-induced OA.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contextualizing unnormalized vertical ground reaction force and knee OA: association does not imply mechanical causation.","authors":"Karl Morgan","doi":"10.1016/j.joca.2025.09.017","DOIUrl":"https://doi.org/10.1016/j.joca.2025.09.017","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"111 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partitioning Knee Osteoarthritis Genetic Variants Based on BMI Association to Improve Polygenic Risk Prediction.","authors":"Bahar Sedaghati-Khayat,Katerina Trajanoska,Cindy G Boer,Fernando Rivadeneira,André G Uitterlinden,Joyce B J van Meurs,Jeroen G J van Rooij","doi":"10.1016/j.joca.2025.09.018","DOIUrl":"https://doi.org/10.1016/j.joca.2025.09.018","url":null,"abstract":"INTRODUCTIONPolygenic risk scores (PRSs) show promise for improving knee osteoarthritis (KOA) risk prediction. However, many KOA-associated variants are also linked to body mass index (BMI)-a major KOA risk factor-complicating the combined use of PRS and BMI in predictive models. This study aimed to disentangle BMI-mediated from BMI-independent genetic contributions to KOA by partitioning the KOA-PRS.METHODUsing data from 345,080 white European participants in the UK Biobank, we refined a KOA-PRS based on 146 genome-wide significant variants identified by the GO consortium. KOA variants were partitioned into BMI-associated (KOA-BMI PRS), and BMI-independent (KOA-nonBMI PRS) groups based on linkage disequilibrium with BMI-associated variants from the GIANT consortium. We assessed associations of each PRS with prevalent and incident KOA (with and without BMI adjustment), with BMI in cases and controls, and with KOA across BMI strata.RESULTSOf the 146 KOA-associated variants, 73 were classified as BMI-associated. The KOA-BMI PRS was associated with incident KOA (OR per SD:1.23;95%CI:1.20to1.26), attenuated after BMI adjustment (1.18;1.15to1.21). In contrast, the KOA-nonBMI PRS remained robust to BMI adjustment (1.24 before vs.1.23 after-adjustment). KOA-nonBMI PRS was negatively associated with BMI in KOA cases (β=-0.09;95%CI:-0.17to-0.01), but not in controls. Stratified analyses showed its effect on KOA diminished in higher BMI strata, while KOA-BMI PRS effects remained stable.CONCLUSIONHalf of KOA-associated variants overlap with BMI loci. Partitioning the KOA-PRS improves interpretation by distinguishing BMI-driven from independent genetic effects-enhancing prediction and informing tailored prevention. Validation in diverse populations is warranted.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"98 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Single Intra-articular injection of JTA-004, a combination of human plasma, hyaluronic acid, and clonidine, versus placebo in symptomatic knee osteoarthritis: A Phase 3 trial.","authors":"Asger Reinstrup Bihlet,Yves Henrotin,Edith Lau Ming Chu,Peter Alexandersen,Olivier Godeaux,Helene Rovsing,François Rieger,Carole Nicco","doi":"10.1016/j.joca.2025.09.015","DOIUrl":"https://doi.org/10.1016/j.joca.2025.09.015","url":null,"abstract":"OBJECTIVESIntra-articular treatments for osteoarthritis (OA) are limited by their efficacy, safety, or duration of response. JTA-004 is a potential novel treatment for OA for intra-articular (IA) injection, combining hyaluronic acid (HA) and clonidine with human plasma to enhance the effects of HA. The objectives of the trial were to evaluate the efficacy and safety of JTA-004 in participants with symptomatic knee OA, where the primary objective was evaluating the efficacy of JTA-004 in terms of WOMAC pain, compared to placebo.DESIGNThe trial was a multicenter, Phase 3, randomized, double-blind, placebo- and active-controlled clinical trial, evaluating the efficacy and safety of a single IA injection of JTA-004, compared to saline (primary hypothesis) and an HA-comparator (Synvisc-One®) (secondary hypothesis) in knee OA with a Kellgren-Lawrence grade of 2 or 3. For the secondary hypothesis, non-inferiority of JTA-004 to active comparator by comparing the 2 treatment groups on the mean differences in WOMAC pain with a non-inferiority margin of Δ = 10 mm. Primary efficacy endpoint was the change from baseline in WOMAC pain to Month 3. The main secondary efficacy endpoints included changes from baseline in WOMAC function and stiffness at Months 3 and 6, OMERACT-OARSI responder rates, global assessments, and use of rescue medication. Safety assessments were based on adverse events (AE) reporting, and post-injection vital signs.RESULTSA total of 746 participants were randomized, of which 687 (92.1%) completed the trial. The results indicated no significant differences in the primary endpoint between JTA-004 and placebo (LSmean difference: -1.50 mm, 95%CI 5.12; 2.12, p= 0.42) or Synvisc-One® (LSmean difference: 2.40, 95% CI: -1.22; 6.02, p=0.20) nor in either of the efficacy outcomes of the main study population. The safety and tolerability of JTA-004 was good, and there were no differences in the frequency of any of the reported AEs or trial discontinuations between the study groups.CONCLUSIONSA single IA injection of JTA-004 was not superior to a saline solution (LSmean difference: -1.50 mm, 95%CI 5.12; 2.12, p= 0.42) or Synvisc-One® (LSmean difference: 2.40, 95% CI: -1.22; 6.02, p=0.20) for the treatment of OA symptoms in the overall study population.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"2 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Definitions and Reporting of Usual Care in Randomized Trials for the Treatment of Knee Osteoarthritis: A Scoping Review.","authors":"Victoria D'Alessandro,Dimitra V Pouliopoulou,Marjan Saeedi,Joy C MacDermid,Nicole Billias,Aidan Loh,Jessica J Wong,Trevor Birmingham,Lauren K King,Tiago V Pereira,Bruno R da Costa,Pavlos Bobos","doi":"10.1016/j.joca.2025.09.013","DOIUrl":"https://doi.org/10.1016/j.joca.2025.09.013","url":null,"abstract":"OBJECTIVE\"Usual care\" is a common comparator in randomized trials (RCTs) evaluating interventions for knee osteoarthritis (OA), but it lacks a standardized definition. This scoping review aimed to systematically map how usual care has been defined and reported in knee OA RCTs, with attention to the terminology, components, and adherence to reporting standards.METHODSWe searched MEDLINE, EMBASE, CENTRAL, CINAHL, and the ClinicalTrials.gov registry from inception to May 2025 for trials involving adults with knee OA that compared a non-surgical intervention to usual care (or similar terms). Paired reviewers independently screened citations and extracted study characteristics, terminology used to describe and components of usual care, care setting, OA severity and diagnosis, intervention type, and references to external guidelines. We summarized findings and assessed reporting quality using the Template for Intervention Description and Replication (TIDieR) and Consensus on Exercise Reporting Template (CERT) checklists, where applicable.RESULTSOf 11804 citations screened, we identified 154 RCTs across 33 countries. \"Usual care\" was the most frequently used descriptor term (53.9%), with definitions that varied considerably. While 68.2% of trials provided detailed descriptions, nearly one-third offered only vague or minimal information. Only 22.7% referenced external guidelines. Usual care content ranged from minimal care to complex multimodal packages, with substantial variation by intervention type. Reporting quality was suboptimal: trials addressed, on average, just over half of TIDieR and approximately two thirds of CERT checklist items. Usual care often lacked transparency, standardization, and reference to best practice recommendations.CONCLUSIONOne in three knee OA trials using usual care as a comparator did not provide a clear, detailed definition of \"usual care.\" Variability in usual care definitions and reporting compromise trial validity, limit evidence synthesis, and hinder clinical translation. There is an urgent need for standardization of detailed reporting of usual care interventions in knee OA trials.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"4 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization rates of hip arthroplasty in OECD countries revised.","authors":"Jonas Backes,Christof Pabinger,Harald Lothaller,Alexander Geissler","doi":"10.1016/j.joca.2025.09.012","DOIUrl":"https://doi.org/10.1016/j.joca.2025.09.012","url":null,"abstract":"OBJECTIVEIn 2014, we reported rising hip arthroplasty utilization across Organization for Economic Co-operation and Development (OECD) countries, particularly among younger patients. Since then, healthcare systems have evolved, demographic shifts are continued, and procedures were impacted by the COVID-19 pandemic. This study aims to reassess these trends through 2022.METHODSWe analyzed hip arthroplasty data from the OECD Health Statistics, U.S. Nationwide Inpatient Sample, and World Bank for 27 countries (2005-2022). We compared relative (compound annual growth rates (CAGR)) and absolute (i.e., mean annual differences (MAD)) procedure numbers, stratified by age (≤64 vs. ≥65), and examined associations with GDP, health expenditure, and life expectancy. Sensitivity analyses were performed to account for uncertainty in U.S.DATARESULTSBetween 2011 and 2022, hip arthroplasty utilization grew more slowly than 2005-2011 (CAGR 1.00% vs. 2.03%; MAD: 1.78 vs. 2.03). Growth from 2011 to 2022 was concentrated among patients aged ≤64 (CAGR 3.08%; MAD: 3.11), while utilization declined among those ≥65 (CAGR -2.27%; MAD: -12.46). Country-level variation narrowed, with the highest-to-lowest ratio falling from 6.65 (2005) to 2.96 (2022). Despite a sharp drop in 2020 due to COVID-19, most countries recovered by 2022. Sensitivity analyses confirmed the robustness of observed OECD trends. BRIC nations showed faster growth, but data limitations hindered comparisons.CONCLUSIONHip arthroplasty utilization continues to increase among younger patients but has declined in older ones. Continued demographic pressure and recovery from COVID-19 disruptions are expected to drive further increases in procedure volume.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"112 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}