Osteoarthritis and Cartilage最新文献

Erratum to "Validity of ultrasound in knee osteoarthritis: A systematic review and meta-analysis" [Osteoarthr. Cartil. 34 (2026) 1007-1016]. 对“超声在膝关节骨关节炎中的有效性：一项系统回顾和荟萃分析”的勘误[骨关节炎]。中华医学杂志，34(2026):1007-1016。

IF 9.2 2区医学

Osteoarthritis and Cartilage Pub Date : 2026-10-19 DOI: 10.1016/j.joca.2026.10.001

Md Abu Bakar Siddiq, Vicky Duong, Jie Jia, James Linklater, Win Min Oo, David J Hunter

引用次数: 0

Optical monitoring of inflammatory response in joint explant cultures using near infrared spectroscopy. 近红外光谱技术在关节外植体培养中炎症反应的光学监测。

IF 9.2 2区医学

Osteoarthritis and Cartilage Pub Date : 2026-10-16 DOI: 10.1016/j.joca.2026.10.010

Nithin Sadeesh, Fatemeh Safari, Abolfazl Jalali, Jovana Zvicer, Arjen Gebraad, Ervin Nippolainen, Susanna Miettinen, Sibylle Grad, Zhen Li, Isaac O Afara

{"title":"Optical monitoring of inflammatory response in joint explant cultures using near infrared spectroscopy.","authors":"Nithin Sadeesh, Fatemeh Safari, Abolfazl Jalali, Jovana Zvicer, Arjen Gebraad, Ervin Nippolainen, Susanna Miettinen, Sibylle Grad, Zhen Li, Isaac O Afara","doi":"10.1016/j.joca.2026.10.010","DOIUrl":"https://doi.org/10.1016/j.joca.2026.10.010","url":null,"abstract":"Objective: To evaluate near-infrared (NIR) spectroscopy combined with machine learning (ML) for detecting and estimating inflammatory and matrix-related biomarkers released into the culture medium of an explant model.Materials and methods: Bovine osteochondral explants and synovial tissues were co-cultured under inflammatory factor-treated (IF-treated) conditions that mimic osteoarthritis (OA) and non-IF-treated conditions. The co-cultures were maintained for seven days with the culture medium collected and replaced daily. The samples were subjected to NIR spectral measurements (900-1700 nm), followed by measurement of sulphated glycosaminoglycans (sGAG), nitric oxide (NO), interleukin (IL)-6, and IL-8 released into the culture. Acquired spectra were preprocessed and analyzed for classification and estimation of biomarkers using ML-based models. Feature importance analyses were performed to identify key wavelength features that contribute to classification and prediction of biomarkers.Results: Biomarker release showed a substantial increase in the OA-like setup compared to the non-IF-treated setup. During classification, the IF-treated and non-IF-treated spectra showed distinct patterns, with noticeable differences in the 1440-1520 nm and 1600-1700 nm regions. Using these spectral variations, the best performing classifier achieved an accuracy of 95.3% in distinguishing OA-like from non-IF-treated samples. The regression analysis also showed good regression performance with R² values of 0.44 (sGAG), 0.48 (NO), 0.42 (IL-6), and 0.36 (IL-8).Conclusions: This study showed that NIR spectroscopy combined with ML can detect and quantify OA-related spectral signatures in explant media, thereby demonstrating its potential as a non-destructive and rapid method for monitoring inflammatory activity in ex vivo OA models.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The challenge of linking tissue-based molecular clusters to osteoarthritis, a complex multi-faceted disease. 骨关节炎是一种复杂的多面性疾病，将组织为基础的分子簇与骨关节炎联系起来的挑战。

IF 9.2 2区医学

Osteoarthritis and Cartilage Pub Date : 2026-10-15 DOI: 10.1016/j.joca.2026.10.004

Rik Lories, Silvia Monteagudo

引用次数: 0

Modeling Progressive Pseudorheumatoid Arthropathy of Childhood: Disease Progression and Cartilage Pathology in CCN6 Knockout Sheep. 儿童期进行性假性风湿性关节病的建模：CCN6基因敲除绵羊的疾病进展和软骨病理。

IF 9.2 2区医学

Osteoarthritis and Cartilage Pub Date : 2026-10-15 DOI: 10.1016/j.joca.2026.10.007

Nereida J Ramirez, Catrina J Silveira, Raine Lunde-Young, Shannon Huggins, Jacob J Giering, Dev R Mehrotra, Henry E Brisebois, Giulia Montagna, Kirby M Sherman, Alyssa Falck, Cole B Dahlstrom, Mark E Westhusin, Jane H Pryor, Michael B Albro, Dana Gaddy, Charles R Long, Matthew L Warman, Larry J Suva, April M Craft

{"title":"Modeling Progressive Pseudorheumatoid Arthropathy of Childhood: Disease Progression and Cartilage Pathology in CCN6 Knockout Sheep.","authors":"Nereida J Ramirez, Catrina J Silveira, Raine Lunde-Young, Shannon Huggins, Jacob J Giering, Dev R Mehrotra, Henry E Brisebois, Giulia Montagna, Kirby M Sherman, Alyssa Falck, Cole B Dahlstrom, Mark E Westhusin, Jane H Pryor, Michael B Albro, Dana Gaddy, Charles R Long, Matthew L Warman, Larry J Suva, April M Craft","doi":"10.1016/j.joca.2026.10.007","DOIUrl":"https://doi.org/10.1016/j.joca.2026.10.007","url":null,"abstract":"Objective: Progressive Pseudorheumatoid Arthropathy of Childhood (PPAC), also known as Progressive Pseudorheumatoid Dysplasia (PPRD), is an autosomal recessive disorder caused by loss-of-function variants in Cellular Communication Network Factor 6 (CCN6, aka, WISP3). Patients with PPAC are asymptomatic at birth but develop polyarticular arthropathy in childhood, requiring multiple arthroplasties before 30 years of age. Currently, no therapy prevents or delays PPAC progression. Furthermore, how loss of CCN6 affects joint development or homeostasis is unknown due to the unavailability of pre-symptomatic patient tissue and the absence of a phenotype in Ccn6 knockout (KO) mice.Methods: CCN6-KO sheep were generated, anticipating that a larger and longer-lived animal would better model human PPAC.Results: Juvenile KO sheep developed clinical signs of joint disease that worsened with age, and histologic examination of KO tissue revealed precocious cartilage damage. Additionally, KO cartilage differed from WT biomechanically, biochemically, and transcriptomically; with KO sheep cartilage sharing multiple transcriptomic features observed in cartilage derived from PPAC patient-induced pluripotent cell lines.Conclusion: These data indicate CCN6-KO sheep recapitulate clinical, histological, and molecular features of PPAC, and can be used to elucidate disease mechanisms and test therapies.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Characterization of a Rat Model of Post-traumatic Ankle Osteoarthritis. 创伤后踝关节骨关节炎大鼠模型的建立与表征。

IF 9.2 2区医学

Osteoarthritis and Cartilage Pub Date : 2026-10-15 DOI: 10.1016/j.joca.2026.10.005

Shotaro Kamijo, Ruiling Xu, Jia-Jun Liu, Silvia Liu, Elizabeth R Kats, Yangfan Lu, Fumiko Yano, Kazuhiro Shibusaka, Yuesong Yin, Jiangyinzi Shang, Kaori Kamijo, Emma A Lee, Peter G Alexander, Jarrett D Cain, MaCalus V Hogan, Hang Lin

{"title":"Development and Characterization of a Rat Model of Post-traumatic Ankle Osteoarthritis.","authors":"Shotaro Kamijo, Ruiling Xu, Jia-Jun Liu, Silvia Liu, Elizabeth R Kats, Yangfan Lu, Fumiko Yano, Kazuhiro Shibusaka, Yuesong Yin, Jiangyinzi Shang, Kaori Kamijo, Emma A Lee, Peter G Alexander, Jarrett D Cain, MaCalus V Hogan, Hang Lin","doi":"10.1016/j.joca.2026.10.005","DOIUrl":"https://doi.org/10.1016/j.joca.2026.10.005","url":null,"abstract":"Objective: The molecular mechanisms contributing to posttraumatic ankle osteoarthritis (PTAOA) remain unclear. Here, we developed a rat model of PTAOA induced by joint instability and evaluated both pain and pathological changes. We paid special attention to the synovial tissue, which acts as a critical, pain-generating structure in OA.Methods: We induced ankle instability by resection of the anterior talofibular ligament (ATFL) and calcaneofibular ligament (CFL) (RAC group). Safranin-O and hematoxylin & eosin staining were conducted to evaluate histological changes. Pain-related behavior was also assessed. Bulk RNA sequencing for dorsal root ganglia (DRG) and single-cell RNA sequencing for synovial tissues were performed to examine molecular changes in PTAOA.Results: Cartilage loss (Mean Difference (MD)=0.52, 95%CI: -0.019 to 1.060) and synovitis (MD=2.24, 95% CI: 1.473 to 3.009) were observed in the ankle joints of RAC rats (n=8), compared to the Sham control (n=8). Pain also developed in PTAOA rats. RNA sequencing revealed that the TGF-β-MAPK/PI3K-Akt-CTGF signaling axis and the THBS2-FN1 axis were activated in PTAOA synovial tissue. In particular, suppressing THBS2 expression decreased fibrosis marker expression in human fibroblast culture. Lastly, systemic administration of meloxicam reduced pain in PTAOA rats compared with the placebo group (MD=50.4, 95% CI: 4.8 to 96.1) (n=8 per group).Conclusion: This study sheds light on the pathological changes in synovial tissue and identifies key pathways involved in PTAOA. The findings suggest novel therapeutic targets for managing PTAOA. Additionally, the PTAOA model developed in this research can be used as a preclinical model to test potential treatments.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to: 'A unicompartmental-enriched comparator in the INKA trial: implications for the non-inferiority conclusion'. 对“INKA试验中单室富集比较剂：对非劣效性结论的影响”的回应。

IF 9.2 2区医学

Osteoarthritis and Cartilage Pub Date : 2026-10-13 DOI: 10.1016/j.joca.2026.10.006

Henning Bliddal, Anders Troelsen, Robin Christensen

引用次数: 0

Osteoarthritis year in review 2026: Biomechanics. 骨关节炎回顾2026：生物力学。

IF 9.2 2区医学

Osteoarthritis and Cartilage Pub Date : 2026-10-09 DOI: 10.1016/j.joca.2026.10.003

Benjamin F Mentiplay, Matthew Savage, Amanda S Ferreira, Thomas A Demirjian, Harvi F Hart, Danilo De Oliveira Silva

{"title":"Osteoarthritis year in review 2026: Biomechanics.","authors":"Benjamin F Mentiplay, Matthew Savage, Amanda S Ferreira, Thomas A Demirjian, Harvi F Hart, Danilo De Oliveira Silva","doi":"10.1016/j.joca.2026.10.003","DOIUrl":"10.1016/j.joca.2026.10.003","url":null,"abstract":"Objective: Altered biomechanics are consistently identified as a modifiable risk factor for osteoarthritis onset and progression. This year-in-review aimed to (i) systematically identify and review biomechanics literature in osteoarthritis published over 12 months, and (ii) generate key themes highlighting current trends in the biomechanics literature.Method: Systematic searches were conducted in two databases (PubMed and Web of Science) for studies published between April 2025 and April 2026. Studies were included if they involved humans or animals with or at risk of osteoarthritis at any joint and evaluated biomechanical measurements during dynamic movement tasks.Results: 176 studies (seven in animals) were included; most were: (i) conducted in China, Japan, or the United States, (ii) human studies focused on the knee joint, (iii) investigating walking biomechanics, and (iv) cross-sectional in design. Four key themes emerged: (i) clear links between movement patterns and both symptomatic and structural osteoarthritis progression; (ii) increased use of advanced tools for real-world biomechanical assessment; (iii) advanced approaches to identifying movement phenotypes and detecting osteoarthritis; and (iv) growing interest in individualised load-modifying interventions.Conclusion: Over the past 12 months, evidence has strengthened links between biomechanics and symptomatic and structural osteoarthritis progression, alongside advances in real-world assessment, movement phenotyping, and personalised interventions. Large-scale and real-world biomechanical measurements are becoming increasingly feasible, and biomechanics-informed randomised controlled trials show promise for improving symptoms and slowing structural progression. Connecting scalable biomechanical assessment with clinically meaningful phenotypes and targeted interventions is a key next step toward personalised, mechanism-based osteoarthritis prevention and management.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of circadian rhythms in articular cartilage by heat pulse. 热脉冲对关节软骨昼夜节律的调节。

IF 9.2 2区医学

Osteoarthritis and Cartilage Pub Date : 2026-10-08 DOI: 10.1016/j.joca.2026.09.018

Cátia F Gonçalves, Dharshika Rj Pathiranage, Anna Paszek, Zeyad El-Houni, Shiyang Li, Gwenllian Tawy, Leela Biant, Judith A Hoyland, Michal Dudek, Qing-Jun Meng

{"title":"Modulation of circadian rhythms in articular cartilage by heat pulse.","authors":"Cátia F Gonçalves, Dharshika Rj Pathiranage, Anna Paszek, Zeyad El-Houni, Shiyang Li, Gwenllian Tawy, Leela Biant, Judith A Hoyland, Michal Dudek, Qing-Jun Meng","doi":"10.1016/j.joca.2026.09.018","DOIUrl":"10.1016/j.joca.2026.09.018","url":null,"abstract":"Objective: Disruption of the circadian clock, such as during ageing, is linked to cartilage degeneration in mice and increased osteoarthritis (OA) risk in humans. This study investigated whether heat pulses can resynchronise dampened circadian rhythms in articular cartilage.Methods: Femoral head cartilage explants were isolated from PER2::LUC circadian reporter mice. Tissues were exposed to heat shock at various temperatures and durations. Circadian bioluminescence from explants was recorded in real-time over several days. Pharmacological compounds were used to investigate the pathways involved in clock resynchronisation.Results: We established that a 60-min pulse at 43 °C resynchronises PER2::LUC rhythms in cartilage explants from young and aged mice. The heat shock was able to counteract circadian disruption caused by IL-1α treatment. Mechanistically, inhibition of HSP90 activity or perturbation of F-actin polymerisation markedly attenuated the heat-induced resynchronisation of circadian rhythms.Conclusion: An acute 43 °C heat pulse enhanced the circadian amplitude and reset the phase of damped PER2::LUC rhythms in ex vivo murine cartilage. Pharmacological sensitivity to 17-DMAG (HSP90 inhibitor) and agents affecting actin/Rho-ROCK signalling implicates these pathways in the response. These findings identify heat as an experimental synchronising cue for cartilage clocks and support further investigations of heating regimens in OA-relevant models.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knee arthroplasty is an effective treatment for people with overweight/obesity and painful knees, but is this the endpoint we want for our patients? 膝关节置换术是治疗超重/肥胖和膝关节疼痛的有效方法，但这是我们希望患者达到的终点吗？

IF 7 2区医学

Osteoarthritis and Cartilage Pub Date : 2026-10-01 DOI: 10.1016/j.joca.2026.10.008

Stephen P Messier

引用次数: 0

Fundamentals of Osteoarthritis: Biomarkers 骨关节炎的基础：生物标志物

IF 7 2区医学

Osteoarthritis and Cartilage Pub Date : 2026-10-01 DOI: 10.1016/j.joca.2026.10.002

Virginia Byers Kraus,Morten A. Karsdal

引用次数: 0