Osteoarthritis and Cartilage最新文献

{"title":"An Optimized Model of Care for Knee Osteoarthritis in China: Mixed Methods Randomized Controlled Pilot and Feasibility Study","authors":"Ziru Wang , Shuning Duan , Xier Chen , Huili Deng , Guoxin Ni","doi":"10.1016/j.joca.2025.03.033","DOIUrl":"10.1016/j.joca.2025.03.033","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 785-786"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXERCISE INDUCED MID-INFRARED SPECTRAL VARIATIONS IN SERUM SAMPLES OF PATIENTS WITH HIP PAIN AND WITHOUT HIP OSTEOARTHRITIS","authors":"Sarah Malek , Federico Marini , Michael A. Samaan","doi":"10.1016/j.joca.2025.03.024","DOIUrl":"10.1016/j.joca.2025.03.024","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 780-781"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships between serum biomarkers and radiographic features give insight into knee osteoarthritis pathophysiology: The ADVANCE cohort","authors":"Oliver O'Sullivan , Ana Valdes , Stefan Kluzek , Anthony Bull , Alexander Bennett","doi":"10.1016/j.joca.2025.03.025","DOIUrl":"10.1016/j.joca.2025.03.025","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Page 781"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MENISCUS CELL MICROENVIRONMENT EXPERIENCES REGION-SPECIFIC COMPOSITIONAL CHANGES AT DIFFERENT STAGES OF MENISCUS DEGENERATION","authors":"Hanna-Sofia Koivisto , Rasmus K. Hiltunen , Iida Hellberg , Simo Saarakkala , Mikko Finnilä , Martin Englund , Petri Tanska","doi":"10.1016/j.joca.2025.03.061","DOIUrl":"10.1016/j.joca.2025.03.061","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 805-806"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-speed Centrifugation Reduces Immune Rejection by Removing Bone Marrow Elements from Fresh Osteochondral Allografts","authors":"Xiaochun wei , Yongsheng Ma , Wangping Duan","doi":"10.1016/j.joca.2025.03.060","DOIUrl":"10.1016/j.joca.2025.03.060","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 804-805"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum intestinal permeability biomarkers are associated with erosive hand osteoarthritis and radiographic severity: results from the DIGICOD cohort","authors":"Marie Binvignat ,&nbsp;Soraya Fellahi ,&nbsp;Jean-Philippe Bastard ,&nbsp;Alexandra Rousseau ,&nbsp;Sophie Tuffet ,&nbsp;Alice Courties ,&nbsp;Audrey Pigenet ,&nbsp;Kristell Wanherdrick ,&nbsp;Margreet Kloppenburg ,&nbsp;Pascal Richette ,&nbsp;Emmanuel Maheu ,&nbsp;Michel D. Crema ,&nbsp;David Klatzmann ,&nbsp;Harry Sokol ,&nbsp;Encarnita Mariotti-Ferrandiz ,&nbsp;Francis Berenbaum ,&nbsp;Jérémie Sellam","doi":"10.1016/j.joca.2024.09.014","DOIUrl":"10.1016/j.joca.2024.09.014","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the association between intestinal permeability alteration and erosive hand osteoarthritis (EHOA).</div></div><div><h3>Methods</h3><div>Serum concentrations of four intestinal permeability biomarkers (lipopolysaccharide binding protein (LBP), FABP2, sCD14, Zonulin-related proteins (ZRP) along with calprotectin, and high-sensitivity C-Reactive Protein (hs-CRP) were assessed in 410 patients of the DIGICOD cohort. The study compared patients with EHOA (≥ 2 erosion in Verbruggen score N=140) to those without EHOA (N=270) using the Mann-Whitney U test. Logistic regression was performed to adjust for potential covariates. The Spearman rank test was used to investigate the correlation between intestinal permeability biomarkers and seven clinical variables associated with HOA clinical and radiographic severity.</div></div><div><h3>Results</h3><div>Serum levels of LBP and ZRP were found to be higher in patients with EHOA compared to those without EHOA (p=0.001, p=0.04). Additionally, LBP and ZRP remained associated with EHOA in a logistic regression model adjusted for age, body mass index, and sex (p=0.017, p=0.005). ZRP was positively correlated with Verbruggen score and Kellgren-Lawrence sum score of both hands (r=0.14 p=0.005, r=0.12 p=0.023). LBP was positively correlated with the number of erosive joints (r=0.14 p=0.0006). Hs-CRP and LBP were positively correlated with AUSCAN pain (r=0.14 p=0.008, r=0.10 p=0.042).</div></div><div><h3>Conclusions</h3><div>LBP and ZRP were associated with EHOA with clinical and radiographic severity in HOA. These results overall support the role of intestinal permeability in both symptoms and structural alteration in HOA.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 736-744"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative analysis of the efficacy and associated factors of intra-articular hyaluronic acid with respect to osteoarthritis symptoms: A systematic review of randomized trials and model-based meta-analysis","authors":"Ying Cao ,&nbsp;Ruifen Cai ,&nbsp;Shun Han ,&nbsp;Zewei Li ,&nbsp;Kang Ma ,&nbsp;Zhounan Zhou ,&nbsp;Xin Wen ,&nbsp;Weizhong Qi ,&nbsp;Han Cen ,&nbsp;Weiyu Han ,&nbsp;Tianyu Chen ,&nbsp;Shengfa Li ,&nbsp;Lijun Lin ,&nbsp;Lixin Zhu ,&nbsp;Yulong Cao ,&nbsp;Cailiang Shen ,&nbsp;Siu Ngor Fu ,&nbsp;Kim Bennell ,&nbsp;David J. Hunter ,&nbsp;Changhai Ding ,&nbsp;Zhaohua Zhu","doi":"10.1016/j.joca.2025.01.008","DOIUrl":"10.1016/j.joca.2025.01.008","url":null,"abstract":"<div><h3>Objective</h3><div>To quantitatively evaluate hyaluronic acid (HA) efficacy for osteoarthritis (OA) and identify potential responders who would benefit most from HA.</div></div><div><h3>Method</h3><div>Embase, MEDLINE (PubMed), and the Cochrane Library Central Register of Controlled Trials were searched from inception to March 13, 2023. A pharmacodynamic Bateman function model was used to quantitatively evaluate the efficacy characteristics of HA treatments as well as placebo, while a covariate model was employed to identify factors that significantly affected efficacy.</div></div><div><h3>Results</h3><div>In total, 24 101 participants with symptomatic or radiographic OA from 168 studies with aggregate data were included. Simulation analysis from the pharmacodynamic time-effect model showed that HA treatment effects plateaued at approximately 2 months. The final model analysis indicated that intra-articular injection of HA combined with corticosteroids (CS) (the Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC] pain effect size [ES] = 4.4 [95% confidence interval {CI}: 3.0 to 5.7]) or platelet-rich plasma (PRP) (WOMAC pain ES = 4.0 [95% CI: 2.7 to 5.3]) achieved the best efficacy compared with other groups (contrast between meta-analyses: WOMAC pain ES = 1.9 [95% CI: 1.2 to 5.2]). Subgroups analysis showed that younger (age &lt; 65), overweight (body mass index ≥ 25) knee OA patients, with more severe baseline symptoms and a lower Kellgren-Lawrence (KL) grade (≤ 2), could benefit more.</div></div><div><h3>Conclusion</h3><div>The quantitative model suggested that HA interventions were statistically more effective than placebo, with participants receiving HA+ CS or PRP experiencing the best efficacy. Patients with lower age, higher weight, higher severity of baseline symptoms, and lower KL grade appeared to benefit more from HA treatment.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 666-679"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural knee MRI findings are already frequent in a general population-based birth cohort at 33 years of age","authors":"Antti Kemppainen ,&nbsp;Joona Tapio ,&nbsp;Miika T. Nieminen ,&nbsp;Simo Saarakkala ,&nbsp;Mika T. Nevalainen","doi":"10.1016/j.joca.2025.04.008","DOIUrl":"10.1016/j.joca.2025.04.008","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the incidence and severity of knee magnetic resonance imaging (MRI) findings and their associated lifestyle and health factors in a relatively healthy subset of a general population-based birth cohort.</div></div><div><h3>Design</h3><div>The study population (<em>n</em> = 288, 61.1% females, mean age 33.7 years) is a subpopulation of the Northern Finland Birth Cohort 1986 on whom a thorough clinical evaluation, laboratory analyses and knee MRI were conducted at 33 years of age. Knee MRI data was graded using the MRI Osteoarthritis Knee Score system. Descriptive statistics and multivariable regression models were used for data analysis.</div></div><div><h3>Results</h3><div>Subjects were mostly asymptomatic. Detected articular cartilage lesions were mostly small and identified in 56.2% (<em>n</em> = 162) of patellofemoral and 25.3% (<em>n</em> = 63) of tibiofemoral joints. Full-thickness cartilage lesions and bone marrow lesions were mostly located in the patellofemoral joint. Osteophytes, mostly small or doubtful, were detected in 51.7% (<em>n</em> = 146) of patellofemoral and 17.4% (<em>n</em> = 41) of tibiofemoral joints. In finding-specific regression analyses, higher body mass index (BMI) was most frequently associated with knee MRI findings.</div></div><div><h3>Conclusions</h3><div>In this relatively young and asymptomatic population, subtle knee MRI findings were already frequent, especially in the patellofemoral joint. Of analyzed background and clinical parameters, higher BMI was most frequently associated with MRI findings. Based on these results, longitudinal studies are warranted to further identify risk factors and proportions of progressing MRI findings.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 753-763"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THERAPEUTIC POTENTIAL OF HUMAN PLATELET-DERIVED EXTRACELLULAR VESICLES IN KNEE OSTEOARTHRITIS: ISOLATION, CHARACTERIZATION, ANTI-INFLAMMATORY EFFECT AND CLINICAL OUTCOME","authors":"Pan Pan Chong ,&nbsp;Nur Hidayah Hassan ,&nbsp;Jonas Fernandez ,&nbsp;Yang Xia ,&nbsp;Tunku Kamarul","doi":"10.1016/j.joca.2025.03.051","DOIUrl":"10.1016/j.joca.2025.03.051","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Page 797"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPACT OF ANTICHOLINERGIC BURDEN ON AUTONOMIC NERVOUS ACTIVITY, PAIN, AND DISABILITY IN PATIENTS WITH LATE STAGE OSTEOARTHRITIS","authors":"Freya störmann ,&nbsp;Rebecca Sohn ,&nbsp;Tina Assar ,&nbsp;Isabelle Kaufhold ,&nbsp;Marco Brenneis ,&nbsp;Sebastian Braun ,&nbsp;Frank Zaucke ,&nbsp;Jeremie Sellam ,&nbsp;Alice Courties ,&nbsp;Georg Pongratz ,&nbsp;Zsuzsa Jenei-Lanzl","doi":"10.1016/j.joca.2025.03.022","DOIUrl":"10.1016/j.joca.2025.03.022","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 779-780"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}