Dong Wang , Yanli Pan , Wenzhe Chen , Du He , Weihui Qi , Jiali Chen , Wenhua Yuan , Yimin Yang , Di Chen , Pinger Wang , Hongting Jin
{"title":"Nanodrugs Targeting Key Factors of Ferroptosis Regulation for Enhanced Treatment of Osteoarthritis","authors":"Dong Wang , Yanli Pan , Wenzhe Chen , Du He , Weihui Qi , Jiali Chen , Wenhua Yuan , Yimin Yang , Di Chen , Pinger Wang , Hongting Jin","doi":"10.1016/j.joca.2025.03.049","DOIUrl":"10.1016/j.joca.2025.03.049","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 795-796"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The relationship between self-reported physical activity and the Timed Up and Go test in patients who underwent total hip arthroplasty: a multicenter cross-sectional study","authors":"Shigeharu Tanaka","doi":"10.1016/j.joca.2025.03.090","DOIUrl":"10.1016/j.joca.2025.03.090","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Page 822"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karin Magnusson , Aleksandra Turkiewicz , Andrea Dell'Isola , Ali Kiadaliri , Martin Englund
{"title":"Metformin and incident osteoarthritis: Causal inference from a co-twin control study","authors":"Karin Magnusson , Aleksandra Turkiewicz , Andrea Dell'Isola , Ali Kiadaliri , Martin Englund","doi":"10.1016/j.joca.2025.03.040","DOIUrl":"10.1016/j.joca.2025.03.040","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 789-790"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrik Kovács , Zhangzheng Wang , Judit Vágó , Roland Takács , Krisztián Z. Juhász , Tibor Hajdú , Szilárd Póliska , Péter Szentesi , Csaba Matta
{"title":"Simulated microgravity has a dual effect on chondrocytes during chondrogenesis","authors":"Patrik Kovács , Zhangzheng Wang , Judit Vágó , Roland Takács , Krisztián Z. Juhász , Tibor Hajdú , Szilárd Póliska , Péter Szentesi , Csaba Matta","doi":"10.1016/j.joca.2025.03.065","DOIUrl":"10.1016/j.joca.2025.03.065","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Page 808"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaochun wei, Jie Yuan, Pengcui Li, Li Guo, Ruxing Liu, Tao Zhang
{"title":"Regional Variability and Structural Characterization of the Superficial Layer in Articular Cartilage: Validation of the 'Three-Layer Structure' Hypothesis","authors":"Xiaochun wei, Jie Yuan, Pengcui Li, Li Guo, Ruxing Liu, Tao Zhang","doi":"10.1016/j.joca.2025.03.035","DOIUrl":"10.1016/j.joca.2025.03.035","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Page 787"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High-speed Centrifugation Efficiently Removes Immunogenic Elements in Osteochondral Allografts","authors":"Yongsheng Ma , Wangping Duan , Xiaochun wei","doi":"10.1016/j.joca.2025.03.059","DOIUrl":"10.1016/j.joca.2025.03.059","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 802-803"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Catherine Yuh , Michel P. Laurent , Peter A. Torzilli , Steven P. Mell , Suzanne A. Maher , Susanna Chubinskaya , Markus A. Wimmer
{"title":"Effects of kinematic and kinetic variables on articular cartilage mechanical and biological properties","authors":"Catherine Yuh , Michel P. Laurent , Peter A. Torzilli , Steven P. Mell , Suzanne A. Maher , Susanna Chubinskaya , Markus A. Wimmer","doi":"10.1016/j.joca.2025.02.790","DOIUrl":"10.1016/j.joca.2025.02.790","url":null,"abstract":"<div><h3>Objective</h3><div>During daily activity, the knee joint experiences a range of complex joint motion and loading patterns. However, few studies have investigated the effects of combined motion and load to understand how interactions between these factors may affect articular hyaline cartilage at the tissue and cell level. Our objective was to quantify the effects of varying combinations of physiologically relevant analogs of specific knee movements and loading on cartilage mechanical and biological properties.</div></div><div><h3>Design</h3><div>Using response surface methodology applied to an established bioreactor-indenter workflow, we quantified the effect of load (20–60N, or ∼1–3 MPa), sliding speed (1–100 mm/s) and migrating contact frequency (0.00–0.2 Hertz) on changes in cartilage stiffening ratio, cartilage deformation (i.e., surface height displacement), cell viability, histopathological score, and gene expression. All kinetic and kinematic input ranges were chosen to fall within established physiological ranges in the knee. Bioreactor testing was conducted using a ceramic counterface and a testing lubricant of culture medium.</div></div><div><h3>Results</h3><div>Cartilage stiffening ratio increased after loading – the magnitude of the change was affected by load and sliding speed. Minimum cartilage deformation occurred at low load and high sliding speed. Superficial cell death was driven by an interaction of load and sliding speed, with the highest percentages of cell death at high loads. No terms were observed to have significant effects on histopathological score.</div></div><div><h3>Conclusions</h3><div>Our findings provide a better understanding of how kinematic and kinetic factors modulate cartilage responses at the matrix and the cell level, by quantifying the cartilage response using physiological input parameters.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 710-720"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu-Yang Lin , Elias H. Jbeily , Priscilla M. Tjandra , Michael C. Pride , Michael Lopez-Torres , Seif B. Elmankabadi , Connor M. Delman , Kristin K. Biris , Heejung Bang , Jill L. Silverman , Cassandra A. Lee , Blaine A. Christiansen
{"title":"Corrigendum to: Surgical restabilization reduces the progression of post-traumatic osteoarthritis initiated by ACL rupture in mice [J Osteoarthr Cartil (2024) 909–920]","authors":"Yu-Yang Lin , Elias H. Jbeily , Priscilla M. Tjandra , Michael C. Pride , Michael Lopez-Torres , Seif B. Elmankabadi , Connor M. Delman , Kristin K. Biris , Heejung Bang , Jill L. Silverman , Cassandra A. Lee , Blaine A. Christiansen","doi":"10.1016/j.joca.2025.03.002","DOIUrl":"10.1016/j.joca.2025.03.002","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Page 735"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Methotrexate for osteoarthritis—Ready for clinical use and in whom?","authors":"Anna Døssing , Robin Christensen","doi":"10.1016/j.joca.2025.04.005","DOIUrl":"10.1016/j.joca.2025.04.005","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 663-665"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}