Osteoarthritis and Cartilage最新文献

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MENSTRUAL BLOOD-DERIVED MESENCHYMAL STROMAL CELL EXTRACELLULAR VESICLES STIMULATE STEM CELL AND CHONDROCYTE FUNCTIONS AND DIMINISH CARTILAGE DEGRADATION IN VITRO 经血源性间充质间质细胞胞外囊泡刺激干细胞和软骨细胞功能,减少软骨降解
IF 7.2 2区 医学
Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.03.038
Ieva Bakutyte , Gabija Kugaudaite , Eiva Bernotiene , Edvardas Bagdonas , Jolita Pachaleva , Raminta Vaiciuleviciute , Ignas Lebedis , Giedrius Kvederas , Ilona Uzieliene
{"title":"MENSTRUAL BLOOD-DERIVED MESENCHYMAL STROMAL CELL EXTRACELLULAR VESICLES STIMULATE STEM CELL AND CHONDROCYTE FUNCTIONS AND DIMINISH CARTILAGE DEGRADATION IN VITRO","authors":"Ieva Bakutyte , Gabija Kugaudaite , Eiva Bernotiene , Edvardas Bagdonas , Jolita Pachaleva , Raminta Vaiciuleviciute , Ignas Lebedis , Giedrius Kvederas , Ilona Uzieliene","doi":"10.1016/j.joca.2025.03.038","DOIUrl":"10.1016/j.joca.2025.03.038","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 788-789"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanodrugs Targeting Key Factors of Ferroptosis Regulation for Enhanced Treatment of Osteoarthritis 靶向铁下垂调节关键因子的纳米药物增强骨关节炎的治疗
IF 7.2 2区 医学
Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.03.049
Dong Wang , Yanli Pan , Wenzhe Chen , Du He , Weihui Qi , Jiali Chen , Wenhua Yuan , Yimin Yang , Di Chen , Pinger Wang , Hongting Jin
{"title":"Nanodrugs Targeting Key Factors of Ferroptosis Regulation for Enhanced Treatment of Osteoarthritis","authors":"Dong Wang , Yanli Pan , Wenzhe Chen , Du He , Weihui Qi , Jiali Chen , Wenhua Yuan , Yimin Yang , Di Chen , Pinger Wang , Hongting Jin","doi":"10.1016/j.joca.2025.03.049","DOIUrl":"10.1016/j.joca.2025.03.049","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 795-796"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship between self-reported physical activity and the Timed Up and Go test in patients who underwent total hip arthroplasty: a multicenter cross-sectional study 全髋关节置换术患者自我报告的体力活动与定时Up和Go测试之间的关系:一项多中心横断面研究
IF 7.2 2区 医学
Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.03.090
Shigeharu Tanaka
{"title":"The relationship between self-reported physical activity and the Timed Up and Go test in patients who underwent total hip arthroplasty: a multicenter cross-sectional study","authors":"Shigeharu Tanaka","doi":"10.1016/j.joca.2025.03.090","DOIUrl":"10.1016/j.joca.2025.03.090","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Page 822"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metformin and incident osteoarthritis: Causal inference from a co-twin control study 二甲双胍和骨关节炎:来自双胎对照研究的因果推断
IF 7.2 2区 医学
Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.03.040
Karin Magnusson , Aleksandra Turkiewicz , Andrea Dell'Isola , Ali Kiadaliri , Martin Englund
{"title":"Metformin and incident osteoarthritis: Causal inference from a co-twin control study","authors":"Karin Magnusson , Aleksandra Turkiewicz , Andrea Dell'Isola , Ali Kiadaliri , Martin Englund","doi":"10.1016/j.joca.2025.03.040","DOIUrl":"10.1016/j.joca.2025.03.040","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 789-790"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simulated microgravity has a dual effect on chondrocytes during chondrogenesis 在软骨形成过程中,模拟微重力对软骨细胞有双重影响
IF 7.2 2区 医学
Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.03.065
Patrik Kovács , Zhangzheng Wang , Judit Vágó , Roland Takács , Krisztián Z. Juhász , Tibor Hajdú , Szilárd Póliska , Péter Szentesi , Csaba Matta
{"title":"Simulated microgravity has a dual effect on chondrocytes during chondrogenesis","authors":"Patrik Kovács , Zhangzheng Wang , Judit Vágó , Roland Takács , Krisztián Z. Juhász , Tibor Hajdú , Szilárd Póliska , Péter Szentesi , Csaba Matta","doi":"10.1016/j.joca.2025.03.065","DOIUrl":"10.1016/j.joca.2025.03.065","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Page 808"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regional Variability and Structural Characterization of the Superficial Layer in Articular Cartilage: Validation of the 'Three-Layer Structure' Hypothesis 关节软骨浅层的区域变异和结构表征:“三层结构”假说的验证
IF 7.2 2区 医学
Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.03.035
Xiaochun wei, Jie Yuan, Pengcui Li, Li Guo, Ruxing Liu, Tao Zhang
{"title":"Regional Variability and Structural Characterization of the Superficial Layer in Articular Cartilage: Validation of the 'Three-Layer Structure' Hypothesis","authors":"Xiaochun wei, Jie Yuan, Pengcui Li, Li Guo, Ruxing Liu, Tao Zhang","doi":"10.1016/j.joca.2025.03.035","DOIUrl":"10.1016/j.joca.2025.03.035","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Page 787"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-speed Centrifugation Efficiently Removes Immunogenic Elements in Osteochondral Allografts 高速离心可有效去除同种异体骨软骨移植物中的免疫原性元素
IF 7.2 2区 医学
Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.03.059
Yongsheng Ma , Wangping Duan , Xiaochun wei
{"title":"High-speed Centrifugation Efficiently Removes Immunogenic Elements in Osteochondral Allografts","authors":"Yongsheng Ma , Wangping Duan , Xiaochun wei","doi":"10.1016/j.joca.2025.03.059","DOIUrl":"10.1016/j.joca.2025.03.059","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 802-803"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of kinematic and kinetic variables on articular cartilage mechanical and biological properties 运动学和动力学变量对关节软骨力学和生物学特性的影响。
IF 7.2 2区 医学
Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.02.790
Catherine Yuh , Michel P. Laurent , Peter A. Torzilli , Steven P. Mell , Suzanne A. Maher , Susanna Chubinskaya , Markus A. Wimmer
{"title":"Effects of kinematic and kinetic variables on articular cartilage mechanical and biological properties","authors":"Catherine Yuh ,&nbsp;Michel P. Laurent ,&nbsp;Peter A. Torzilli ,&nbsp;Steven P. Mell ,&nbsp;Suzanne A. Maher ,&nbsp;Susanna Chubinskaya ,&nbsp;Markus A. Wimmer","doi":"10.1016/j.joca.2025.02.790","DOIUrl":"10.1016/j.joca.2025.02.790","url":null,"abstract":"<div><h3>Objective</h3><div>During daily activity, the knee joint experiences a range of complex joint motion and loading patterns. However, few studies have investigated the effects of combined motion and load to understand how interactions between these factors may affect articular hyaline cartilage at the tissue and cell level. Our objective was to quantify the effects of varying combinations of physiologically relevant analogs of specific knee movements and loading on cartilage mechanical and biological properties.</div></div><div><h3>Design</h3><div>Using response surface methodology applied to an established bioreactor-indenter workflow, we quantified the effect of load (20–60N, or ∼1–3 MPa), sliding speed (1–100 mm/s) and migrating contact frequency (0.00–0.2 Hertz) on changes in cartilage stiffening ratio, cartilage deformation (i.e., surface height displacement), cell viability, histopathological score, and gene expression. All kinetic and kinematic input ranges were chosen to fall within established physiological ranges in the knee. Bioreactor testing was conducted using a ceramic counterface and a testing lubricant of culture medium.</div></div><div><h3>Results</h3><div>Cartilage stiffening ratio increased after loading – the magnitude of the change was affected by load and sliding speed. Minimum cartilage deformation occurred at low load and high sliding speed. Superficial cell death was driven by an interaction of load and sliding speed, with the highest percentages of cell death at high loads. No terms were observed to have significant effects on histopathological score.</div></div><div><h3>Conclusions</h3><div>Our findings provide a better understanding of how kinematic and kinetic factors modulate cartilage responses at the matrix and the cell level, by quantifying the cartilage response using physiological input parameters.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 710-720"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to: Surgical restabilization reduces the progression of post-traumatic osteoarthritis initiated by ACL rupture in mice [J Osteoarthr Cartil (2024) 909–920] 骨前交叉韧带断裂后创伤性骨关节炎的手术复位治疗[J].骨关节炎杂志,2014,29(1):9-9。
IF 7.2 2区 医学
Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.03.002
Yu-Yang Lin , Elias H. Jbeily , Priscilla M. Tjandra , Michael C. Pride , Michael Lopez-Torres , Seif B. Elmankabadi , Connor M. Delman , Kristin K. Biris , Heejung Bang , Jill L. Silverman , Cassandra A. Lee , Blaine A. Christiansen
{"title":"Corrigendum to: Surgical restabilization reduces the progression of post-traumatic osteoarthritis initiated by ACL rupture in mice [J Osteoarthr Cartil (2024) 909–920]","authors":"Yu-Yang Lin ,&nbsp;Elias H. Jbeily ,&nbsp;Priscilla M. Tjandra ,&nbsp;Michael C. Pride ,&nbsp;Michael Lopez-Torres ,&nbsp;Seif B. Elmankabadi ,&nbsp;Connor M. Delman ,&nbsp;Kristin K. Biris ,&nbsp;Heejung Bang ,&nbsp;Jill L. Silverman ,&nbsp;Cassandra A. Lee ,&nbsp;Blaine A. Christiansen","doi":"10.1016/j.joca.2025.03.002","DOIUrl":"10.1016/j.joca.2025.03.002","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Page 735"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methotrexate for osteoarthritis—Ready for clinical use and in whom? 甲氨蝶呤治疗骨关节炎——准备好临床应用了吗?
IF 7.2 2区 医学
Osteoarthritis and Cartilage Pub Date : 2025-06-01 DOI: 10.1016/j.joca.2025.04.005
Anna Døssing , Robin Christensen
{"title":"Methotrexate for osteoarthritis—Ready for clinical use and in whom?","authors":"Anna Døssing ,&nbsp;Robin Christensen","doi":"10.1016/j.joca.2025.04.005","DOIUrl":"10.1016/j.joca.2025.04.005","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 6","pages":"Pages 663-665"},"PeriodicalIF":7.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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