Osteoarthritis and Cartilage最新文献

{"title":"Making sense of osteoarthritis: A narrative review","authors":"Ben Darlow ,&nbsp;Joletta Belton ,&nbsp;Melanie Brown ,&nbsp;Jane Clark ,&nbsp;Dawn P. Richards ,&nbsp;Naomi Simick Behera ,&nbsp;Samantha Bunzli","doi":"10.1016/j.joca.2024.09.012","DOIUrl":"10.1016/j.joca.2024.09.012","url":null,"abstract":"<div><div>People make sense of osteoarthritis (OA) by drawing on information, beliefs, and knowledge. This narrative review summarises diverse qualitative and quantitative research investigating beliefs and knowledge about OA and the impact these have on behaviour and outcomes. It synthesises evidence and highlights key actions clinicians can take to support people to make sense of OA in helpful ways. Beliefs about OA inform the behaviour of those living with OA and the behaviour of clinicians caring for people with OA. Beliefs about OA often focus on joint degradation and inevitable progression. These impairment-focused fatalistic beliefs can result in reduced offer of, or engagement in, active management strategies. Alternative views focus on health as part of a dynamic ecosystem where people are healthy when they can participate in activities they value. These beliefs are associated with increased engagement in self-management and lifestyle-based interventions. Clinician actions that support people to make sense of OA ways that align with helpful behaviours and support participation in valued activities represent key opportunities to improve health and well-being.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 1","pages":"Pages 17-26"},"PeriodicalIF":7.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PET-MRI: The promise of multi-tissue imaging of early disease mechanisms in osteoarthritis","authors":"Feliks Kogan,&nbsp;Lauren E. Watkins,&nbsp;Ananya Goyal","doi":"10.1016/j.joca.2024.10.011","DOIUrl":"10.1016/j.joca.2024.10.011","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 1","pages":"Pages 5-8"},"PeriodicalIF":7.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the comment on ‘The coexistence of diabetes, hypertension and obesity is associated with worse pain outcomes following exercise for osteoarthritis: A cohort study on 80 893 patients’","authors":"Andrea Dell’Isola ,&nbsp;Stefan L. Lohmander,&nbsp;Ali Kiadaliri","doi":"10.1016/j.joca.2024.11.003","DOIUrl":"10.1016/j.joca.2024.11.003","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 1","pages":"Pages 186-187"},"PeriodicalIF":7.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zoledronate alleviates subchondral bone collapse and articular cartilage degeneration in a rat model of rotator cuff tear arthropathy","authors":"Hiroki Tawaratsumida ,&nbsp;Tomohiro Iuchi ,&nbsp;Yusuke Masuda ,&nbsp;Takayuki Ide ,&nbsp;Shingo Maesako ,&nbsp;Takasuke Miyazaki ,&nbsp;Toshiro Ijuin ,&nbsp;Shingo Maeda ,&nbsp;Noboru Taniguchi","doi":"10.1016/j.joca.2024.08.005","DOIUrl":"10.1016/j.joca.2024.08.005","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the humeral head bone volume of patients with cuff tear arthropathy (CTA) and examine the therapeutic effect of zoledronate in a rat modified model of CTA (mCTA).</div></div><div><h3>Design</h3><div>The bone mass in patients with CTA was measured using Hounsfield units from CT images. The mCTA was induced by transecting the rotator cuff, biceps brachii tendon, and superior half of the joint capsule in adult rat shoulders. A single subcutaneous injection of zoledronate was followed by bone histomorphometry and immunohistochemistry of the humeral head, as well as the Murine Shoulder Arthritis Score (MSAS) assessment.</div></div><div><h3>Results</h3><div>The humeral head bone volume was decreased in patients with CTA. In the mCTA model, M1 macrophages were increased in the synovium and were decreased by zoledronate treatment. The increased expressions of TNF-α, IL-1β and IL-6 in mCTA synovium and articular cartilage were suppressed in the zoledronate-treated mCTA group. The expression of catabolic enzymes in the articular cartilage and MSAS showed similar results. The zoledronate-treated mCTA group showed a decreased subchondral bone collapse with a decreased RANKL/OPG expression ratio and a suppressed number of osteoclasts compared with the control mCTA group. The enhanced expressions of HMGB1 and S100A9 in the mCTA shoulders were eliminated in the zoledronate-treated mCTA group.</div></div><div><h3>Conclusions</h3><div>The humeral head subchondral bone was decreased in patients with CTA. In the mCTA model, the collapse and osteoarthritic changes were prevented by zoledronate administration. Zoledronate seemed to suppress the number of M1 macrophages in the synovium and osteoclasts in the subchondral bone.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 1","pages":"Pages 101-115"},"PeriodicalIF":7.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding “Association between synovial tissue damage and pain in late-stage knee osteoarthritis: A cross-sectional study”","authors":"Tzu Han Feng ,&nbsp;Chen Dong ,&nbsp;Brian Shiian Chen ,&nbsp;James Cheng Chung Wei","doi":"10.1016/j.joca.2024.10.006","DOIUrl":"10.1016/j.joca.2024.10.006","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 1","pages":"Pages 180-181"},"PeriodicalIF":7.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoarthritis year in review 2024: Imaging","authors":"Daichi Hayashi ,&nbsp;Frank W. Roemer ,&nbsp;Ali Guermazi","doi":"10.1016/j.joca.2024.10.009","DOIUrl":"10.1016/j.joca.2024.10.009","url":null,"abstract":"<div><h3>Objective</h3><div>To review recent literature evidence describing imaging of osteoarthritis (OA) and to identify the current trends in research on OA imaging.</div></div><div><h3>Method</h3><div>This is a narrative review of publications in English, published between April, 2023, and March, 2024. A Pubmed search was conducted using the following search terms: osteoarthritis/OA, radiography, ultrasound/US, computed tomography/CT, magnetic resonance imaging/MRI, DXA/DEXA, and artificial intelligence/AI/deep learning. Most publications focus on OA imaging in the knee and hip. Imaging of OA in other joints and OA imaging with artificial intelligence (AI) are also reviewed.</div></div><div><h3>Results</h3><div>Compared to the same period last year (April 2022 – March 2023), there has been no significant change in the number of publications utilizing CT, MRI, and AI. A notable reduction in the number of OA research papers using radiography and ultrasound is noted. There were several observational studies focusing on imaging of knee OA, such as the Multicenter Osteoarthritis Study, Rotterdam Study, Strontium ranelate efficacy in knee OA (SEKOIA) study, and the Osteoarthritis Initiative FNIH Biomarker study. Hip OA observational studies included, but not limited to, Cohort Hip and Cohort Knee study and UK Biobank study. Studies on emerging applications of AI in OA imaging were also covered. A small number of OA clinical trials were published with a focus on imaging-based outcomes.</div></div><div><h3>Conclusion</h3><div>MRI-based OA imaging research continues to play an important role compared to other modalities. Usage of various AI tools as an adjunct to human assessment is increasingly applied in OA imaging research.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 1","pages":"Pages 88-93"},"PeriodicalIF":7.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A major functional role of synovial fluid is to reduce the rate of cartilage fatigue failure under cyclical compressive loading","authors":"C.V. Sise ,&nbsp;C.A. Petersen ,&nbsp;A.K. Ashford ,&nbsp;J. Yun ,&nbsp;B.K. Zimmerman ,&nbsp;S. Vukelic ,&nbsp;C.T. Hung ,&nbsp;G.A. Ateshian","doi":"10.1016/j.joca.2024.08.008","DOIUrl":"10.1016/j.joca.2024.08.008","url":null,"abstract":"<div><h3>Objective</h3><div>Based on our recent study, which showed that cartilage fatigue failure in reciprocating sliding contact results from cyclical compressive forces, not from cyclical frictional forces, we hypothesize that a major functional role for synovial fluid (SF) is to reduce the rate of articular cartilage fatigue failure from cyclical compressive loading.</div></div><div><h3>Design</h3><div>The rate of cartilage fatigue failure due to repetitive compressive loading was measured by sliding a glass lens against an immature bovine cartilage tibial plateau strip immersed in mature bovine SF, phosphate-buffered saline (PBS), or SF/PBS dilutions (50% SF and 25% SF; n = 8 for all four bath conditions). After 24 h of reciprocating sliding (5400 cycles), samples were visually assessed, and if damage was observed, the test was terminated; otherwise, testing was continued for 72 h (16,200 cycles), with solution refreshed daily.</div></div><div><h3>Results</h3><div>All eight samples in the PBS group exhibited physical damage after 24 h, with an average final surface roughness of <em>R</em>_<em>q</em>= 0.210 ± 0.067 mm. The SF group showed no damage after 24 h; however, two of eight samples became damaged after 72 h, producing a significantly lower average surface roughness than the PBS group (<em>R</em>_<em>q</em>=0.059 ± 0.030 mm; p &lt; <span><math><msup><mrow><mn>10</mn></mrow><mrow><mo>−</mo><mn>4</mn></mrow></msup></math></span>). For the remaining groups, at 72 h, one of eight samples was damaged in the 50% SF group, and five of eight samples were damaged in the 25% SF group.</div></div><div><h3>Conclusions</h3><div>The results strongly support our hypothesis, showing that decreased amounts of SF in the testing bath produce increased rates of fatigue failure in cartilage that was subjected to reciprocating sliding contact.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 1","pages":"Pages 94-100"},"PeriodicalIF":7.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoarthritis year in review 2024: Biology","authors":"Zsuzsa Jenei-Lanzl,&nbsp;Frank Zaucke","doi":"10.1016/j.joca.2024.10.008","DOIUrl":"10.1016/j.joca.2024.10.008","url":null,"abstract":"<div><div>Osteoarthritis (OA) research is a fast-growing and extremely wide field, in which a substantial increase in knowledge has been achieved over the last year. It covers many different topics, however, a PubMed search using the terms ‘osteoarthritis’ and ‘biology’ resulted in only a limited number of studies that were published between April 2023 and April 2024. In order to identify OA-relevant studies that focus on mechanistic studies of biological processes at the tissue, cellular, and molecular level, the following keywords were included as search terms: tissue interactions, single cell sequencing, transcriptomics, extracellular matrix, signaling, ion channels, and pain. The final selection of publications presented in this ‘year in review’ was influenced by the personal preferences of the authors, and eventually three larger key themes emerged: 1) Joint tissue interactions covering meniscus, subchondral bone, fat tissue, synovium, and synovial fluid. 2) Degeneration of the cartilage extracellular matrix and generation of bioactive fragments. 3) Receptors, ion channels, signaling pathways, and cellular metabolism. Many of the studies summarized here identified novel potential targets for OA treatment, and promising results were already obtained addressing these targets in different animal models. It will be exciting to see which findings can be translated into future clinical studies and eventually lead to novel treatment approaches for human OA.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 1","pages":"Pages 58-66"},"PeriodicalIF":7.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring a novel outcome measure of symptom progression in knee osteoarthritis utilizing a large randomized trial","authors":"Philip G. Conaghan ,&nbsp;Nathaniel Katz ,&nbsp;David J. Hunter ,&nbsp;Ali Guermazi ,&nbsp;Marc C. Hochberg ,&nbsp;Kenneth Somberg ,&nbsp;Julia Clive ,&nbsp;Chris Knight ,&nbsp;Mary Johnson ,&nbsp;Luping Zhao ,&nbsp;Niti Goel","doi":"10.1016/j.joca.2024.12.003","DOIUrl":"10.1016/j.joca.2024.12.003","url":null,"abstract":"<div><h3>Objectives</h3><div>Explore a newly defined composite measure of symptom progression for knee osteoarthritis (KOA) in a large, randomized study of a potential disease-modifying osteoarthritis drug (DMOAD).</div></div><div><h3>Design</h3><div>Using longitudinal KOA studies, a potential composite endpoint of time to symptom progression was defined as the first occurrence of worsening of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain of ≥10 points with no improvement (≤9 point decrease) in WOMAC Function (0–100 scale). A post hoc analysis explored discrimination and association with structural outcomes in the sprifermin FORWARD trial through Years 3 and 5. All treatment arms of the intent-to-treat population were analyzed.</div></div><div><h3>Results</h3><div>Among the 549 FORWARD participants, 442 (80.5%) completed Year 3, and 378 (68.9%) completed Year 5. Sprifermin showed dose-dependent benefits in the time to symptom progression at Year 3 with hazard ratio (95% CI) for each sprifermin treatment arm vs placebo as follows: 100 μg every 6 months (Q6M), 0.51 (0.28, 0.93); 100 μg Q12M, 0.69 (0.40, 1.20); 30 μg Q6M, 0.89 (0.53, 1.50); and 30 μg Q12M, 0.80 (0.47, 1.35). Similar findings were seen through Year 5 and for a subgroup based on modern clinical trial inclusion criteria. There were increased numbers of knee replacements in symptom progressors (n=8, 5.6%) vs non-progressors (n=7, 1.7%).</div></div><div><h3>Conclusions</h3><div>The symptom progression endpoint discriminated between placebo and treatment responses in a post hoc analysis of a Phase 2 investigational DMOAD KOA trial. The endpoint requires validation and further exploration in DMOAD clinical trials.</div></div><div><h3>Trial number</h3><div>NCT01919164</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 3","pages":"Pages 383-390"},"PeriodicalIF":7.2,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proliferative behaviours of CD90-expressing chondrocytes under the control of the TSC1-mTOR/PTHrP-nuclear localisation segment pathway","authors":"Lingfeng Xu ,&nbsp;Yuejiao Zhang ,&nbsp;Hongxu Yang ,&nbsp;Qian Liu ,&nbsp;Peinan Fan ,&nbsp;Jia Yu ,&nbsp;Mian Zhang ,&nbsp;Shibin Yu ,&nbsp;Yaoping Wu ,&nbsp;Meiqing Wang","doi":"10.1016/j.joca.2024.11.011","DOIUrl":"10.1016/j.joca.2024.11.011","url":null,"abstract":"<div><h3>Objective</h3><div>Some cells in temporomandibular joint (TMJ) cartilage undergo proliferation in response to negative pressure, which can be induced in vivo by creating bilateral anterior elevation (BAE). TMJ cartilage harbours CD90-expressing cells, and CD90 expression increases under certain controlled conditions. The parathyroid hormone-related peptide (PTHrP) nuclear localisation segment (NLS) promotes chondrocyte proliferation, and mammalian target of rapamycin (mTOR) signalling plays a regulatory role in promoting PTHrP transcription. The purpose of this study was to determine the role of the mTOR/PTHrP-NLS axis in the proliferative responses of CD90⁺ chondrocytes in TMJ cartilage to BAE.</div></div><div><h3>Methods</h3><div>CD90⁺ cells were isolated from TMJ cartilage and subjected to negative pressure followed by RNA sequencing (RNA-seq). A PTHrP-NLS conditional mutation (<em>CD90</em>-CreER;<em>Pthlh</em>^84STOP-fl/fl) mouse model was developed to obtain CD90⁺ cell-specific PTHrP-NLS conditional mutation (<em>Pthlh</em>^84STOP) littermate. <em>CD90</em>-Cre;<em>Tsc1</em>^fl/fl mice and <em>CD90</em>-Cre;<em>mTOR</em>^fl/fl mice were generated to obtain <em>Mtor</em> conditional knockout (<em>Mtor</em>-CKO) and <em>Tsc1</em>-CKO littermates.</div></div><div><h3>Results</h3><div>Using RNA-seq, the mTOR signalling pathway was identified as the most significant biological process occurring in superficial zone cells of the TMJ condylar cartilage under negative pressure. Proliferation of CD90⁺ cells was stimulated in <em>Tsc1</em>-CKO littermates but inhibited in both <em>Mtor</em>-CKO and <em>Pthlh</em>^84STOP littermates. BAE did not promote chondrocyte proliferation in either <em>Mtor</em>-CKO or <em>Pthlh</em>^84STOP littermates. Administration of the PTHrP_87–139 peptide to <em>Mtor</em>-CKO mice restored chondrocyte proliferation and rescued the promoting effect of BAE in TMJ cartilage.</div></div><div><h3>Conclusions</h3><div>CD90⁺ chondrocytes in TMJ cartilage proliferate in response to negative pressure under the control of the TSC1-mTOR/PTHrP-NLS pathway.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 4","pages":"Pages 437-446"},"PeriodicalIF":7.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}