Osteoarthritis and Cartilage最新文献

{"title":"The smallest worthwhile effects of strengthening exercise on pain intensity for people with knee osteoarthritis: A benefit-harm trade-off study","authors":"Travis Haber ,&nbsp;Kim Bennell ,&nbsp;Harrison J. Hansford ,&nbsp;James H. McAuley ,&nbsp;Peter Button ,&nbsp;Katrina Hunt ,&nbsp;Peixuan Li ,&nbsp;Anurika De Silva ,&nbsp;Jesse Pardo ,&nbsp;Sarah Stratulate ,&nbsp;Ben Metcalf ,&nbsp;Rana S. Hinman","doi":"10.1016/j.joca.2025.12.004","DOIUrl":"10.1016/j.joca.2025.12.004","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the smallest worthwhile effects (SWEs) of supervised individual, supervised group, or unsupervised digitally-delivered strength exercise on pain intensity, compared to no exercise, for individuals with knee osteoarthritis.</div></div><div><h3>Method</h3><div>Online benefit-harm trade-off study. Participants with knee pain consistent with knee osteoarthritis were allocated information about either supervised individual, supervised group, or unsupervised digitally-delivered strength exercise and a no exercise comparison. Participants selected the pain reduction (percentage) that would make their allocated mode of strength exercise worthwhile, in addition to a 15% improvement with no exercise, considering its cost, harms, and inconveniences. SWEs were estimated as the median (95% confidence interval (CI)) and interquartile range (IQR) of the smallest pain reduction that participants considered worthwhile. SWEs were also estimated across participant subgroups (sex, pain severity, and exercise beliefs and history).</div></div><div><h3>Results</h3><div>We included 1176 participants. Eight to sixteen percent would not consider exercise worthwhile even if it completely resolved their knee pain. The SWE of both supervised individual and group strength exercise was a 20% (95% CI 15–20, IQR 5–30%) knee pain reduction, in addition to the pain reduction expected with no exercise. The SWE of unsupervised digital exercise was a 15% additional pain reduction (95% CI 10–20, IQR 5–25%). SWEs were generally larger among males and those not expecting exercise to be helpful.</div></div><div><h3>Conclusions</h3><div>To consider strength exercise worthwhile, people with knee osteoarthritis require supervised individual or group exercise to provide a 20% reduction in knee pain, and digitally-delivered exercise to provide a 15% reduction, beyond the pain reduction expected without exercising.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 5","pages":"Pages 697-706"},"PeriodicalIF":9.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145730737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of screening period pain inconsistency on placebo response in intra-articular knee osteoarthritis trials","authors":"Jakob Mejdahl Bentin ,&nbsp;Ida Sofie Adrian ,&nbsp;Alejandro Castillo Mondragon ,&nbsp;Andrea Bak Kaaber ,&nbsp;Claire Prener Miller ,&nbsp;Peter Alexandersen ,&nbsp;Lars Arendt-Nielsen ,&nbsp;Asger Reinstrup Bihlet","doi":"10.1016/j.joca.2025.10.018","DOIUrl":"10.1016/j.joca.2025.10.018","url":null,"abstract":"<div><h3>Objective</h3><div>Placebo response (PR) presents a significant challenge in osteoarthritis (OA) trials. Screening Period Pain Inconsistency (SPPI) has been associated with heightened PR in placebo-treated patients. However, existing studies have overlooked whether increasing versus decreasing pain during the screening period affects this relationship differently. This study examines the impact of SPPI magnitude and direction on PR.</div></div><div><h3>Design</h3><div>In a post-hoc analysis of a Phase 2b randomized, double-blind, placebo-controlled knee OA trial, 143 participants receiving intra-articular placebo were categorized into absolute and directional quartiles based on SPPI. The primary endpoint was the change in WOMAC pain from baseline at week 52 in the placebo group, assessed to determine the long-term impact of SPPI on pain changes, using a mixed model for repeated measures.</div></div><div><h3>Results</h3><div>Participants with the highest SPPI had a greater reduction in WOMAC pain scores across the trial period compared to those with more stable pain (group aQ4-aQ1: LSM −11.72, 95%CI: −17.43 to −6.02). The greatest PR was observed in participants whose pain increased during the screening period (group dQ4-dQ1: LSM −6.67, 95%CI: −12.47 to −0.86) and was significant from week 2 (LSM −7.92, 95%CI: −13.65 to −2.19).</div></div><div><h3>Conclusions</h3><div>These findings extend earlier observations by revealing that not only the magnitude, but also the direction of screening pain fluctuation (worsening pain before randomization) predicts PR. These results highlight SPPI as a potential adjustment variable to enhance assay sensitivity and mitigate PR in intra-articular knee OA trials, supporting the development of more effective therapies for chronic pain conditions like OA.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 5","pages":"Pages 691-696"},"PeriodicalIF":9.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145462299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of exercise therapy in patients with thumb carpometacarpal osteoarthritis: A multicenter, randomized controlled trial","authors":"Robbert M. Wouters ,&nbsp;Lisa MJ Esteban Lopez ,&nbsp;Stella CM Heemskerk ,&nbsp;Sita MA Bierma-Zeinstra ,&nbsp;Gerald A. Kraan ,&nbsp;Joost Colaris ,&nbsp;J.Michiel Zuidam ,&nbsp;Guus M. Vermeulen ,&nbsp;Ruud W. Selles ,&nbsp;the THETA Study Group Collaborators","doi":"10.1016/j.joca.2025.10.005","DOIUrl":"10.1016/j.joca.2025.10.005","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the effectiveness and costs of an orthosis + exercise therapy with only an orthosis on pain at 3 months and conversion to surgery &lt;1 year in patients with thumb carpometacarpal (CMC-1) osteoarthritis (OA).</div></div><div><h3>Design</h3><div>Multicenter, single-blinded, randomized controlled trial.</div></div><div><h3>Setting</h3><div>Eighteen outpatient hand surgery and therapy clinics in the Netherlands.</div></div><div><h3>Participants</h3><div>Adult patients with CMC-1 OA.</div></div><div><h3>Interventions</h3><div>Orthosis + exercise therapy versus orthosis-only.</div></div><div><h3>Primary outcome measures</h3><div>Pain at 3 months (Michigan Hand Outcomes Questionnaire pain subscale) and conversion to surgery &lt;1 year.</div></div><div><h3>Results</h3><div>We included 166 patients (81 orthosis + exercise, 85 orthosis-only). There was no difference between the orthosis + exercise group and the orthosis-only group in pain at three months (least mean square difference 3.7 [95% CI −1.0–8.3]). Conversion to surgery was 4.9% (n=4) in the orthosis + exercise group and 9.4% (n=8) in the orthosis-only group, which was not significantly different (risk difference 4.7% [-3.3–12.2%) due to the low conversion to surgery rates. The total societal costs for orthosis + exercise were 37% (-€825 [-2072–421]) lower per patient than orthosis-only. The orthosis + exercise group had favorable outcomes in MHQ subscale activities of daily living scores (6mo), work ability (all time points), satisfaction with hand (3mo), the MHQ total score (3mo, 6mo), satisfaction with treatment results (all except 6mo), grip strength (6w), and illness perceptions (3mo).</div></div><div><h3>Conclusions</h3><div>In patients with CMC-1 OA, an orthosis + exercise therapy is preferred over orthosis-only because of the favorable secondary outcomes.</div></div><div><h3>Trial registration</h3><div>ClinicalTrials.gov: NCT05772715.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 5","pages":"Pages 679-690"},"PeriodicalIF":9.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Single-Cell Biophysical and Biochemical Profiling Reveals Chondrocyte Senescence in Metabolic Osteoarthritis","authors":"Lanlan Zhang ,&nbsp;Hantang Wang ,&nbsp;Lin Zhu ,&nbsp;Thiel Lee ,&nbsp;Minato Kobashi ,&nbsp;Evelyn Hok Yee Cheung ,&nbsp;Xuan Lu ,&nbsp;Xin Diao ,&nbsp;Zuowei Xu ,&nbsp;Kelvin Tsia ,&nbsp;Man Ting Au ,&nbsp;Chunyi Wen","doi":"10.1016/j.joca.2026.01.037","DOIUrl":"10.1016/j.joca.2026.01.037","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 ","pages":"Pages S46-S47"},"PeriodicalIF":9.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147732585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ITGA5+ FIBROBLAST-LIKE SYNOVIOCYTES PROMOTE CARTILAGE DESTRUCTION VIA PARACRINE OXALOACETATE-INDUCED METABOLIC REPROGRAMMING OF CHONDROCYTES","authors":"Ziji Zhang,&nbsp;Yucheng Tu,&nbsp;Baiqi Pan,&nbsp;Xiaoyu Wu,&nbsp;Yunze Kang,&nbsp;Chenying Zeng,&nbsp;Tieling Han","doi":"10.1016/j.joca.2026.01.097","DOIUrl":"10.1016/j.joca.2026.01.097","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 ","pages":"Page S89"},"PeriodicalIF":9.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147732606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATION BETWEEN LOWER LIMB OATEOARTHRITIS, BONE METABOLISM AND LOWER LIMB ALINGMENT IN THE GENERAL POPULATION","authors":"Ryoto Kura ,&nbsp;Kyota Ishibashi ,&nbsp;Eiji Sasaki ,&nbsp;Hikaru K. Ishibashi ,&nbsp;Yuka Kimura ,&nbsp;Eiichi Tsuda ,&nbsp;Yasuyuki Ishibashi","doi":"10.1016/j.joca.2026.01.069","DOIUrl":"10.1016/j.joca.2026.01.069","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 ","pages":"Pages S69-S70"},"PeriodicalIF":9.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147732646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA MODULATES AND ALTERS EXTRACELLULAR MATRIX REMODELLING AND INFLAMMATORY PROCESSES IN OSTEOARTHRITIC SYNOVIAL FIBROBLASTS","authors":"Wesley Tran ,&nbsp;Garth Blackler ,&nbsp;J. Daniel Klapak ,&nbsp;Jan Tuckermann ,&nbsp;Frank Beier ,&nbsp;C. Thomas Appleton ,&nbsp;Matthew W. Grol","doi":"10.1016/j.joca.2026.01.077","DOIUrl":"10.1016/j.joca.2026.01.077","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 ","pages":"Page S75"},"PeriodicalIF":9.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147732739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DOES FAT MASS CONTRIBUTE TO KNEE OSTEOARTHRITIS RISK BEYOND WEIGHT ITSELF? DATA FROM THE MULTICENTER OSTEOARTHRITIS STUDY","authors":"Kristine Godziuk ,&nbsp;Sarah Tilley ,&nbsp;Michael LaValley ,&nbsp;Douglas P. Kiel ,&nbsp;Michael C. Nevitt ,&nbsp;Cora E. Lewis ,&nbsp;James Torner ,&nbsp;Tuhina Neogi","doi":"10.1016/j.joca.2026.01.026","DOIUrl":"10.1016/j.joca.2026.01.026","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 ","pages":"Pages S36-S37"},"PeriodicalIF":9.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147732829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TIBIAL ACCELERATION WHILE WALKING IS NOT ASSOCIATED WITH 2-YEAR CHANGES IN KNEE PAIN: THE MULTICENTER OSTEOARTHRITIS STUDY","authors":"Samantha Price ,&nbsp;Joshua Stefanik ,&nbsp;David Felson ,&nbsp;Nene Ukonu ,&nbsp;Michael LaValley ,&nbsp;Michael C. Nevitt ,&nbsp;Cora E. Lewis ,&nbsp;James Torner ,&nbsp;Patrick Corrigan","doi":"10.1016/j.joca.2026.01.066","DOIUrl":"10.1016/j.joca.2026.01.066","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 ","pages":"Pages S66-S67"},"PeriodicalIF":9.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147732911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Varus Alignment and BMI Jointly Accelerate Medial Femoral Cartilage Thinning: Data from the Osteoarthritis Initiative","authors":"McKenzie S. White ,&nbsp;Feliks Kogan ,&nbsp;Scott L. Delp ,&nbsp;Garry Gold ,&nbsp;Akshay Chaudhari ,&nbsp;Anthony Gatti","doi":"10.1016/j.joca.2026.01.067","DOIUrl":"10.1016/j.joca.2026.01.067","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 ","pages":"Pages S67-S68"},"PeriodicalIF":9.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147732912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}