Open Biology最新文献_第6页

A CDCA2-MYC positive feedback loop controls cancer cells survival. CDCA2-MYC正反馈回路控制着癌细胞的存活。

IF 3.1 3区生物学

Open Biology Pub Date : 2026-03-11 DOI: 10.1098/rsob.250075

Konstantinos Stamatiou, Lorena Ligammari, Malki Bothota, Antonia Tsavou, Ezgi Gokhan, Ylenia Cicirò, Mariano Zacarias, Laura Soucek, Arturo Sala, Paola Vagnarelli

{"title":"A CDCA2-MYC positive feedback loop controls cancer cells survival.","authors":"Konstantinos Stamatiou, Lorena Ligammari, Malki Bothota, Antonia Tsavou, Ezgi Gokhan, Ylenia Cicirò, Mariano Zacarias, Laura Soucek, Arturo Sala, Paola Vagnarelli","doi":"10.1098/rsob.250075","DOIUrl":"10.1098/rsob.250075","url":null,"abstract":"Cellular myelocytomatosis oncogene (MYC) transcription factors are encoded by a family of genes that include the prototype member MYC, MYCN and MYCL, and most human cancers display expression alterations of MYC genes. MYC is regulated at multiple levels, and its stability and activity are modulated by protein phosphorylation. Although there is a reasonable knowledge of the kinases required for MYC modifications, the counteracting phosphatases have been understudied. Here, we have investigated the role of the chromatin-associated protein phosphatase 1 (PP1) regulatory subunit CDCA2, also known as Repo-Man, in the regulation of MYC proteins in cancer cells. Using RNA interference and degron-mediated degradation of CDCA2, we have demonstrated that the PP1 subunit is required for cMYC and MYCN stabilization and viability of triple-negative breast cancer, neuroblastoma and colon cancer cells. Proximity ligation assays indicate that both cMYC and MYCN are in close proximity to CDCA2 in vivo. Furthermore, we have shown that CDC2A is a bona fide MYC target gene in cancer cells, revealing a reciprocal regulatory loop that could be exploited for therapeutic purposes.","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"16 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FRET-based fluorescent sensors for cytosolic and mitochondrial Ca2+ imaging in Drosophila melanogaster. 基于fret的荧光传感器用于黑腹果蝇细胞质和线粒体Ca2+成像。

IF 3.1 3区生物学

Open Biology Pub Date : 2026-03-11 DOI: 10.1098/rsob.250197

Manuela Santalla, Sonia Sonda, Ambra Bertocco, Alejandro Ciocci Pardo, Elisa Greotti, Diana Pendin

引用次数: 0

Using deep learning to predict the sex of human embryos. 利用深度学习来预测人类胚胎的性别。

IF 3.1 3区生物学

Open Biology Pub Date : 2026-03-04 DOI: 10.1098/rsob.250419

Mingshu Liang, Magdalena Zernicka-Goetz, Adiyant Lamba, Dilan Gokyer, Catherine King, Maciej Meglicki, María Luisa Pardiñas, María José de Los Santos, Changhuei Yang

{"title":"Using deep learning to predict the sex of human embryos.","authors":"Mingshu Liang, Magdalena Zernicka-Goetz, Adiyant Lamba, Dilan Gokyer, Catherine King, Maciej Meglicki, María Luisa Pardiñas, María José de Los Santos, Changhuei Yang","doi":"10.1098/rsob.250419","DOIUrl":"10.1098/rsob.250419","url":null,"abstract":"The existence of sex differences in human pre-implantation development remains an open question, with previous attempts based on human observations yielding inconclusive results. In this study, we combined manual annotation and deep learning analysis of a dataset comprising 515 time-lapse embryo movies to investigate whether birth sex influences early developmental dynamics. While manual assessment did not identify any developmental timing parameters that reliably distinguish male from female embryos, a deep learning model trained and tested on these videos achieves a statistically significant sex prediction accuracy of 61%. Importantly, our analyses identified the period after the eight-cell stage as critical for accurate prediction, indicating that subtle sex-related differences may begin to emerge around day 3 of human embryogenesis. Studying sex differences at this early stage may enhance our understanding of why some embryos fail to develop and why sex ratios can be skewed in the context of in vitro fertilization. More broadly, our findings open the possibility for an early, non-invasive detection tool that could assist in identifying and addressing sex-related embryonic developmental abnormalities.","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"16 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147356028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histidine and tyrosine residues are targets for SIRT6 ADP-ribosylation activity. 组氨酸和酪氨酸残基是SIRT6 adp核糖基化活性的靶标。

IF 3.1 3区生物学

Open Biology Pub Date : 2026-03-04 DOI: 10.1098/rsob.250181

Johannes Gregor Matthias Rack, Evgeniia Prokhorova, Raffaella Lauro, Anna Georgina Kopasz, Domagoj Baretić, Roberto Raggiaschi, Jovana Mutabdzija, Dmitri V Filippov, Gyula Timinszky, Orsolya Leidecker, Ivan Ahel, Luca Palazzo

{"title":"Histidine and tyrosine residues are targets for SIRT6 ADP-ribosylation activity.","authors":"Johannes Gregor Matthias Rack, Evgeniia Prokhorova, Raffaella Lauro, Anna Georgina Kopasz, Domagoj Baretić, Roberto Raggiaschi, Jovana Mutabdzija, Dmitri V Filippov, Gyula Timinszky, Orsolya Leidecker, Ivan Ahel, Luca Palazzo","doi":"10.1098/rsob.250181","DOIUrl":"10.1098/rsob.250181","url":null,"abstract":"SIRT6, a highly conserved member of the sirtuin family, plays a critical role in diverse cellular processes, including gene regulation, DNA damage response and maintaining nuclear lamina integrity. These functions are essential in contexts such as differentiation, metabolic regulation, cancer development and ageing. Given the multifaceted influence of SIRT6 on cellular activities, there is an increasing interest in elucidating the regulatory mechanisms governing its enzymatic functions. SIRT6 exhibits two NAD+-dependent activities: deacetylation and ADP-ribosylation, with current research predominantly focusing on the former. However, the latter-its (ADP-ribosyl)transferase activity-remains underexplored, particularly concerning the specific amino acid targets it modifies and the (ADP-ribosyl)hydrolases that can reverse these modifications. In this study, we have utilized biochemical assays and proteomic techniques to investigate these aspects, revealing that SIRT6 transfers ADP-ribosyl moieties onto histidine and tyrosine residues. In addition, we reveal that the (ADP-ribosyl)hydrolase ARH3 has significant activity in erasing SIRT6-derived ADP-ribosylation in cells.","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"16 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147356036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular spike waveform analysis reveals cell type-specific changes in the superior colliculus of fragile X mice. 细胞外尖峰波形分析揭示了脆性X小鼠上丘细胞类型特异性变化。

IF 3.1 3区生物学

Open Biology Pub Date : 2026-02-25 DOI: 10.1098/rsob.250269

Gourav Sharma, Ashley L Russell, Karen G Dixon, Romina Fusha, Jason W Triplett

{"title":"Extracellular spike waveform analysis reveals cell type-specific changes in the superior colliculus of fragile X mice.","authors":"Gourav Sharma, Ashley L Russell, Karen G Dixon, Romina Fusha, Jason W Triplett","doi":"10.1098/rsob.250269","DOIUrl":"10.1098/rsob.250269","url":null,"abstract":"Sensory processing deficits are common in neurodevelopmental disorders (NDDs); however, we lack a full understanding of the circuits impacted. The superior colliculus (SC) is a sensorimotor region that directs complex behaviours, which recent work suggests is adversely impacted in NDDs. However, our understanding of cellular diversity in the SC lags in comparison to other regions, limiting our ability to parse circuit changes in NDDs. A goal of neuroscience has been to elucidate the diversity of neurons in the brain. Analysis of action potential shape in extracellular recordings has revealed subpopulations in several regions, allowing for insights into subtype-specific function in the intact brain. Here, we utilized semi-automated clustering methods to classify neurons in the mouse SC based on features of extracellularly recorded waveforms to identify five putative cell types. Secondary analysis of firing statistics and visual tuning properties supported cluster segregation. Interestingly, the proportions of units assigned to each cluster differed in a mouse model of fragile X syndrome (Fmr1-/y). Furthermore, we observed changes in waveform properties and firing statistics between genotypes in a subtype-specific manner. Taken together, these data add to our understanding of neuronal diversity in the SC and alterations of visual circuit organization and function in NDDs.","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"16 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Looks can be deceiving: discordances in phylogeny and morphology within loricate choanoflagellates. 外表可能是具有欺骗性的：在门状尾鞭毛虫的系统发育和形态上的不一致。

IF 3.1 3区生物学

Open Biology Pub Date : 2026-02-25 DOI: 10.1098/rsob.250261

Alex Gàlvez-Morante, Florentine U Rutaganira, Brian Palenik, Daniel J Richter

{"title":"Looks can be deceiving: discordances in phylogeny and morphology within loricate choanoflagellates.","authors":"Alex Gàlvez-Morante, Florentine U Rutaganira, Brian Palenik, Daniel J Richter","doi":"10.1098/rsob.250261","DOIUrl":"10.1098/rsob.250261","url":null,"abstract":"Choanoflagellates are heterotrophic holozoans that are classified into two groups based on their morphology: loricates, which possess silica-based extracellular structures, and craspedids, which do not. Loricate choanoflagellate taxonomy has historically been based on selected aspects of their lorica morphology and on their division mode, either tectiform or nudiform. Here, we characterize two new loricate strains, BEAP0094 and BEAP0360, that display unexpected morphological features when compared to their closest genetic relatives. The ribosomal gene sequence of BEAP0094 closely matched Pseudostephanoeca paucicostata, but its lorica lacked the characteristic anterior ring found in all Stephanoeca species. Instead, its lorica resembled the Acanthocorbis genus, raising the possibility of the existence of either multiple lorica morphologies in closely related species or multiple species sharing the same ribosomal 18S gene. In contrast, BEAP0360 presented a morphological match to Stephanoeca cauliculata, but its sequence did not, suggesting that different species could share the same lorica architecture. BEAP0360, here described as Cepoeca plumata (n. gen. n. sp.), possesses a key phylogenetic placement, potentially as the earliest-branching nudiform loricate. Our findings are inconsistent with a strict classification based on lorica morphology and support the usage of genetic data as primary criterion for genus-level taxonomic assignment.","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"16 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-apoptotic BCL-2 binds to all three IP3R isoforms, thereby limiting the Ca2+-flux properties of IP3R homo-tetramers. 抗凋亡BCL-2结合所有三种IP3R亚型，从而限制IP3R同源四聚体的Ca2+通量特性。

IF 3.1 3区生物学

Open Biology Pub Date : 2026-02-18 DOI: 10.1098/rsob.250150

Ian de Ridder, Claire Cauwelier, Larry E Wagner Ii, Jens Loncke, Vikas Arige, Irina I Serysheva, David I Yule, Geert Bultynck

{"title":"Anti-apoptotic BCL-2 binds to all three IP3R isoforms, thereby limiting the Ca2+-flux properties of IP3R homo-tetramers.","authors":"Ian de Ridder, Claire Cauwelier, Larry E Wagner Ii, Jens Loncke, Vikas Arige, Irina I Serysheva, David I Yule, Geert Bultynck","doi":"10.1098/rsob.250150","DOIUrl":"10.1098/rsob.250150","url":null,"abstract":"Anti-apoptotic B-cell lymphoma 2 (BCL-2) controls inositol 1,4,5-trisphosphate receptor (IP3R)-mediated Ca²+ signalling. As cells typically express all three IP3R isoforms in variable abundances that assemble in hetero-tetrameric channels, the specific effects of BCL-2 on each isoform remain unclear. Here, we employed a reductionist approach using HEK293 cells triple-IP3R knockout reconstituted with a single IP3R isoform to elucidate the impact of BCL-2 on Ca2+ signalling by homo-tetrameric IP3R channels. Co-immunoprecipitation experiments demonstrated that BCL-2 interacts with each IP3R isoform. Live-cell Ca²+ imaging revealed that BCL-2 overexpression suppresses Ca²+ signals evoked by any of the three IP3R isoforms. Moreover, BCL-2 overexpression impaired mitochondrial Ca²+ uptake following IP3R-mediated Ca²+ release, irrespective of the IP3R isoform present. To investigate the effects on single IP3R-channel activity, we performed Ca²+-puff analysis using TIRF microscopy in response to UV-flash photolysis of caged IP3. BCL-2 overexpression reduced the number of Ca²+ puffs across all IP3R isoforms without affecting the amplitude or duration of individual puffs. Thus, BCL-2 acts as a universal inhibitor of all three IP3R isoforms, highlighting its critical role in fine-tuning intracellular Ca2+ dynamics to promote cell survival and its potential as a therapeutic target in cancer via its role in Ca2+ signalling.","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"16 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

20-hydroxyecdysone regulated exosomal transport of mulberry urease drives nitrogen recycling and silkworm development. 20-羟基蜕皮激素调节桑脲酶外泌体转运驱动氮素循环和家蚕发育。

IF 3.1 3区生物学

Open Biology Pub Date : 2026-02-18 DOI: 10.1098/rsob.250231

Mingbo Li, Jiubo Liang, Hulin Lu, Han Liu, Lin Chen, Kaiying Chen, Shaoyu Zhang, Ningjia He

{"title":"20-hydroxyecdysone regulated exosomal transport of mulberry urease drives nitrogen recycling and silkworm development.","authors":"Mingbo Li, Jiubo Liang, Hulin Lu, Han Liu, Lin Chen, Kaiying Chen, Shaoyu Zhang, Ningjia He","doi":"10.1098/rsob.250231","DOIUrl":"10.1098/rsob.250231","url":null,"abstract":"The recycling of urea nitrogenous by urease presents a valuable approach for optimizing nitrogen utilization in organisms with limited nitrogen resources. In silkworms, haemolymph urea concentration correlates with urease activity, and the urease is derived from their exclusive food source, mulberry leaves. Although mulberry-derived urease has been shown to cross the silkworm midgut barrier, the mechanism of its translocation into the haemolymph remains unknown. In the present study, we investigated the transport mechanism of mulberry urease into the silkworm haemolymph using Western blotting and immunoelectron microscopy. Our results revealed that exosomes and autophagy-related factors, which are regulated by 20-hydroxyecdysone (20E), mediate the stage-specific transport of mulberry urease from the midgut to the haemolymph in silkworm larvae. Urease deficiency impaired silkworm growth and development, significantly reducing cocoon shell weight and egg production. These findings highlight the profound influence of host plants on insect phenotypic traits and reveal a novel cross-kingdom molecular transport mechanism. Our results not only deepen the understanding of plant-insect interactions but also offer practical insights for sericulture improvement, particularly in formulating artificial diets to enhance silk production.","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"16 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heat shock protein 90 as a vital signalling hub in Schistosoma mansoni: a master regulator of stem cell proliferation, development and survival. 热休克蛋白90作为曼氏血吸虫重要信号中枢：干细胞增殖、发育和存活的主要调控因子。

IF 3.1 3区生物学

Open Biology Pub Date : 2026-02-11 DOI: 10.1098/rsob.250131

Nancy Adamma Aguoru, Ruth Suzanne Kirk, Anthony John Walker

{"title":"Heat shock protein 90 as a vital signalling hub in Schistosoma mansoni: a master regulator of stem cell proliferation, development and survival.","authors":"Nancy Adamma Aguoru, Ruth Suzanne Kirk, Anthony John Walker","doi":"10.1098/rsob.250131","DOIUrl":"10.1098/rsob.250131","url":null,"abstract":"Heat shock protein 90s (HSP90s) are molecular chaperones often produced by cells in response to hostile conditions. Here, we characterized the importance of HSP90 to growth/development and survival of the blood fluke Schistosoma mansoni, focusing on life stages that parasitize the human host. Western blotting revealed striking HSP90 upregulation in developing schistosomula in vitro, and pharmacological assays revealed that the HSP90 inhibitors gedunin, 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) and 5-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methylpent-4-yn-2-ol (EC-144) profoundly attenuated the viability/development of skin schistosomula to lung and liver stages. In vitro liver stage, ex vivo adult male/female worms and eggs were also killed. Strikingly, 17-AAG and EC-144 blocked stem cell proliferation in the skin, lung and liver schistosomula, and the testicular lobes and ovaries of adult worms. Small interfering RNA-mediated knockdown of the cytoplasmic HSP90 alpha isoform 2 (Smp_072330) also attenuated stem cell proliferation and restricted schistosomulum growth, supporting the importance of this isoform. 17-AAG and EC-144 attenuated the phosphorylation of schistosomula Akt/protein kinase B, extracellular signal-regulated kinase and p38 mitogen-activated protein kinase, suggesting HSP90 regulates core 'system-based' signalling pathways in the parasite; glucose uptake was also reduced. Collectively, these novel findings highlight the importance of HSP90 to intra-mammalian schistosome life stages and identify HSP90 as a possible drug target to control human schistosomiasis.","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"16 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146157987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transmembrane proteins in cancer: insights from mechanism to clinical impact. 跨膜蛋白在癌症中的作用：从机制到临床影响的见解。

IF 3.1 3区生物学

Open Biology Pub Date : 2026-02-04 DOI: 10.1098/rsob.250259

Chih-Wen Shu, Chia-Hsuan Chang, Hsing-Hsiang Wang, Pei-Feng Liu, Yung-Fu Chang

{"title":"Transmembrane proteins in cancer: insights from mechanism to clinical impact.","authors":"Chih-Wen Shu, Chia-Hsuan Chang, Hsing-Hsiang Wang, Pei-Feng Liu, Yung-Fu Chang","doi":"10.1098/rsob.250259","DOIUrl":"10.1098/rsob.250259","url":null,"abstract":"Transmembrane proteins (TMEMs) constitute a large family of proteins that span biological membranes and are distributed across various cellular organelles, playing key roles in maintaining cellular homeostasis. Increasing evidence has revealed that dysregulation of TMEMs is closely associated with cancer development and progression. Therefore, a deeper understanding of the relationship between TMEMs and cancer is essential. Different TMEMs can function either as oncogenes or tumour suppressors, depending on the context. In this review, we explore the involvement of TMEMs in cancer, categorizing them into three groups based on their roles: oncogenic, tumour-suppressive or dual-function (both oncogenic and tumour-suppressive). We summarize the roles of various TMEMs in different cancer types, highlighting both well-characterized proteins and those identified through database screening, even if their exact molecular mechanisms remain unclear. Where possible, we include known signalling pathways associated with these TMEMs. This review highlights the critical roles of the TMEM protein family and encourages further research into their mechanisms, prognostic value and potential as targets for cancer therapy.","PeriodicalId":19629,"journal":{"name":"Open Biology","volume":"16 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0