Ophthalmology and Therapy最新文献

{"title":"Early Posterior Corneal Changes and Belin/Ambrósio Scores Following Photorefractive Keratectomy: A Pentacam Study.","authors":"Konuralp Yakar, Göksu Alaçamlı, Gökhan Özgür","doi":"10.1007/s40123-025-01199-8","DOIUrl":"https://doi.org/10.1007/s40123-025-01199-8","url":null,"abstract":"<p><strong>Introduction: </strong>To evaluate early postoperative changes in the posterior corneal surface, anterior chamber parameters, and Belin/Ambrósio Enhanced Ectasia Display (BAD) scores following photorefractive keratectomy (PRK) using Pentacam tomography.</p><p><strong>Methods: </strong>This observational study included 102 eyes of 51 patients (mean age 28.43 ± 6.27 years) undergoing alcohol-assisted PRK for myopia and/or astigmatism. Preoperative and 1-month postoperative assessments were performed using the Pentacam system, measuring, anterior chamber depth (ACD), anterior chamber volume (ACV), central corneal thickness, posterior keratometry, posterior elevation, and BAD scores. PRK was conducted with a WaveLight^® EX 500 excimer laser, followed by mitomycin-C application. Statistical analysis utilized paired t-tests and Pearson's correlation.</p><p><strong>Results: </strong>At 1 month post-PRK, ACV significantly decreased (p < 0.01), while ACD reduction was not significant (p = 0.40). Posterior keratometry (K1, K2, Kmean) and astigmatism decreased (p < 0.01), with a mean posterior elevation increase of -2.50 ± 2.94 µm (p < 0.01). A weak negative correlation was observed between maximum posterior elevation difference and ablation depth (p = 0.03, r = -0.20) and ablation depth/preoperative pachymetry ratio (p = 0.03, r = -0.20). BAD-D scores (Dp, Dt, Da, total D) significantly increased (p < 0.01), except for Df (p = 0.41). No correlation was found with preoperative pachymetry or residual stroma.</p><p><strong>Conclusions: </strong>PRK induces minimal posterior corneal protrusion and BAD score changes at 1 month, potentially mimicking early ectasia. Multimodal testing is advised for accurate ectasia detection. Larger, longer-term studies are needed to validate these findings.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in Peripheral Refraction are Most Significant Just Before the Onset of Myopia: Evidence from Multispectral Refraction Topography.","authors":"Feijia Xie, Xukai Mao, Mingming Jiang, Jun Li, Jing Zhang","doi":"10.1007/s40123-025-01198-9","DOIUrl":"https://doi.org/10.1007/s40123-025-01198-9","url":null,"abstract":"<p><strong>Introduction: </strong>This study aims to explore the characteristics of retinal defocus values (RDVs) during refractive development of Chinese children.</p><p><strong>Methods: </strong>In this cross-sectional study, 2125 children (2125 right eyes) aged 4-15 years were included and divided into several groups according to spherical equivalent (SE) or axial length (AL). Ocular biological parameters including AL, central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT) and corneal curvature were detected, and multispectral refractive tomography (MRT) was used to measure total retinal defocus values (TRDV), RDVs of 0°-15°/15°-30°/30°-45° concentric annulus area (RDV-15/30/45), RDVs of the superior, nasal, inferior and temporal fan-shaped region (RDV-S/N/I/T).</p><p><strong>Results: </strong>CCT and ACD increased while LT decreased with myopia progression. As diopter descended, almost all RDVs gradually inclined to hyperopic defocus; however, the superior retina demonstrated consistent myopic defocus across different dioptric states. RDV-45 and RDV-T changed most obviously among RDV-15/30/45 and RDV-S/N/I/T, respectively. Importantly, hyperopic shift of RDVs was most pronounced between the emmetropia and low myopia group, and also when AL was approximately 23 mm. Additionally, difference between superior and inferior RDVs also peaks in early myopia.</p><p><strong>Conclusions: </strong>The rapid changes and longitudinal inequality of RDVs are most significant just before 23 mm of AL, this condition may have important predictive value for the occurrence of myopia. Additionally, defocus of the temporal retina showed the greatest variation in dioptric development, suggesting that nasal visual information may affect refractive outcomes.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal Findings in Patients Treated with Belantamab Mafodotin: A Prospective Case Series Focusing on Corneal Nerves.","authors":"Jakob Schweighofer, Hermine Agis, Maria Krauth, Ruth Donner, Marion Funk, Jan Lammer, Michal Klimek, Gerald Schmidinger, Julia Aschauer","doi":"10.1007/s40123-025-01147-6","DOIUrl":"10.1007/s40123-025-01147-6","url":null,"abstract":"<p><strong>Introduction: </strong>This prospective case series investigated corneal epithelial and subbasal nerve plexus changes associated with belantamab mafodotin (Belamaf) therapy in patients with refractory/relapsed multiple myeloma using a multimodal imaging approach.</p><p><strong>Methods: </strong>We included eight patients (mean age 66 ± 10) scheduled for Belamaf who were monitored for at least three treatment cycles. Standard clinical eye exams with Snellen best corrected visual acuity (BCVA) measurements were complemented by epithelial thickness mapping, slit lamp photography, corneal sensitivity testing, and corneal confocal microscopy.</p><p><strong>Results: </strong>The mean drop in BCVA was limited to 1 line (20/25 to 20/32) with mean loss in sensitivity from 5.2 ± 0.4 to 8.7 ± 3.4 mg/S. Corneal epithelial thickness increased (from a mean of 62 ± 4.7 to 74 ± 6.2 μm) presenting an irregular pattern from the apex to the mid-periphery. All patients developed microcystic epithelial changes and ocular surface disease. Confocal microscopy revealed a decrease in mean nerve fiber length and density from 12.46 ± 4.94 mm/mm² and 21.87 ± 10.27/mm² at baseline to 3.27 ± 3.9 mm/mm² and 1.78 ± 3.22/mm² at last follow-up, respectively, with preserved limbal architecture.</p><p><strong>Conclusion: </strong>This prospective study confirms and further characterizes the pathognomonic epithelial changes caused by Belamaf, which are accompanied by severe impairment in subbasal nerve fiber architecture, indicating a neurotoxic effect of the medication that requires further investigation.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"1453-1464"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathologic Genetic Mutations May Correlate with Poor Visual Outcome in Patients with Hydroxychloroquine Retinopathy.","authors":"Hsun-I Chiu, Hui-Chen Cheng, Chih-Chiau Wu, Shih-Jen Chen, De-Kuang Hwang, Yi-Ming Huang, Yu-Bai Chou, Po-Kang Lin, Tai-Chi Lin, Ko-Hua Chen, Pei-Yu Lin, Yu-Fan Chang, An-Guor Wang","doi":"10.1007/s40123-025-01151-w","DOIUrl":"10.1007/s40123-025-01151-w","url":null,"abstract":"<p><strong>Introduction: </strong>To evaluate the progression rate and identify potential genetic risk factors for poor visual outcome in chloroquine/hydroxychloroquine (CQ/HCQ) retinopathy.</p><p><strong>Methods: </strong>Ocular variables, including best-corrected visual acuity (BCVA), hypoautofluorescent area in fundus autofluorescence (FAF) and others were analyzed in patients with a diagnosis of CQ/HCQ retinopathy based on comprehensive ocular and demographic examinations. Whole exome sequencing (WES) was used to investigate the candidate genes associated with inherited retinal diseases. Multivariate analysis was used to analyze the correlation between pathogenic genetic mutation and visual outcome, with poor vision defined as BCVA < 6/12.</p><p><strong>Results: </strong>Forty-one patients with an average age of 61.1 ± 13.6 years, daily dose of 8.2 ± 3.6 mg/kg, and treatment period of 12.4 ± 5.6 years were recruited with a mean follow-up of 3.3 ± 2.8 years. Longitudinal observation revealed that eyes continued to have visual acuity decline with a mean progression rate of 0.065 ± 0.164 (ΔLogMAR/year) and structural change with a mean progression rate of 2.16 ± 4.32 (Δhypoautofluorescent area-to-disc-area ratio per year) despite drug cessation. Pathogenic genetic mutations were found in nine of 29 patients (31%) and were associated with poor visual acuity (odds ratio, OR = 17.402, p = 0.024). Elevated HCQ dose and renal disease were related to increased hypoautofluorescent area in FAF (OR = 17.659, p < 0.001, and OR = 7.285, p = 0.007, respectively).</p><p><strong>Conclusions: </strong>The study highlights the importance of identifying genetic mutations and monitoring hypoautofluorescent areas in FAF for predicting and managing visual outcomes in patients with CQ/HCQ retinopathy.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"1465-1480"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Natural History of Acanthamoeba Keratitis: A Systematic Literature Review.","authors":"Vincenzo Papa, Danielle H Bodicoat, Angela Arteaga Duarte, John K G Dart, Maria De Francesco","doi":"10.1007/s40123-025-01152-9","DOIUrl":"10.1007/s40123-025-01152-9","url":null,"abstract":"<p><strong>Introduction: </strong>Acanthamoeba keratitis (AK) was first identified in 1972 and the first patient cured with propamidine was reported in 1985. Treatment outcomes, before the advent of the first effective anti-amoebic treatment, were known to be poor and often required therapeutic keratoplasty (TK) but have not been evaluated in detail. Analysis of these outcomes has value for several reasons: it gives an historical perspective, describes the natural history of AK when the disease was minimally modified by the early treatments and provides a benchmark against which current treatments can be compared and how these have changed the therapeutic results.</p><p><strong>Methods: </strong>We conducted a systematic literature review for the period 1970-1995 using PRISMA guidelines. The population of interest comprised patients with AK treated without products having established anti-amoebic activity against both trophozoites and cysts (biguanides or diamidines). The outcomes of interest were medical cure, TK and enucleation. Proportions and 95% confidence intervals were estimated.</p><p><strong>Results: </strong>Fifty-six case reports were eligible. Risk factors for AK were reported in 44/56 patients: contact lens wear in 30/44 (68.2%) and trauma in 14/44 (31.8%). The mean time from presentation to diagnosis was 7.3 weeks (standard deviation 9.3 weeks); 13/56 (23.2%) were diagnosed within 4 weeks. Topical treatments given to patients included corticosteroids (85.2%), antibiotics (85.2%), antivirals (72.2%) and antifungals (51.8%). Final visual acuity was ≥ 20/40 in 17/33 (51.5%) patients with no missing data. Medical cures were reported in 11/56 patients (19.6%), TK in 38/56 (67.9%), other surgery in 4/56 (7.1%) and enucleation in 3/56 (5.4%).</p><p><strong>Conclusion: </strong>This study suggests that, before the availability of propamidine as the first effective treatment for AK, the clinical outcome of these patients was poor with only a few patients cured without surgery. These findings should be interpreted with caution because they rely on case reports and series that are subject to inherent bias.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"1369-1383"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Data on Morphological and Functional Responses After Switching to Faricimab in Recalcitrant, Chronic Diabetic Macular Edema.","authors":"Viktoria Deiters, Anna Lorger, Franziska Eckardt, Jakob Siedlecki, Benedikt Schworm, Siegfried G Priglinger, Tina R Herold","doi":"10.1007/s40123-025-01162-7","DOIUrl":"10.1007/s40123-025-01162-7","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to assess the morphological and functional effects of faricimab in patients with chronic diabetic macular edema (DME) who had an insufficient response to previous treatments.</p><p><strong>Methods: </strong>We conducted a single-center, retrospective study including eyes with pretreated chronic DME that were switched to faricimab and received at least three injections. The main outcome measures were central subfield thickness (CST) and best-corrected visual acuity (BCVA) changes before and after switching to faricimab.</p><p><strong>Results: </strong>Twenty-two eyes from 18 patients were analyzed, with a mean pretreatment period of 5.7 years. Most eyes had been treated with two or more intravitreal agents. Before switching to faricimab, the mean CST was 468.5 ± 163.6 µm, which decreased to 383.1 ± 125.3 µm, 362.8 ± 93.4 µm (p = 0.207), and 339.5 ± 94.3 µm (p < 0.001) after the first, second, and third injections, respectively. BCVA showed improvement from 0.48 to 0.37 logMAR after the third injection, though the change was only statistically significant after the first injection (p = 0.022).</p><p><strong>Conclusions: </strong>The study demonstrated significant CST reduction in patients with chronic DME in a real-world setting, even after prolonged treatment, suggesting that faricimab can lead to morphological and functional benefits in these cases. Further data are needed to explore the real-world, long-term effects and durability of faricimab in chronic DME.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"1481-1489"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Narrative Review of Amniotic Membrane Transplantation in Ocular Surface Repair: Unveiling the Immunoregulatory Pathways for Timely Intervention.","authors":"Andrew Hopkinson, Francisco C Figueiredo","doi":"10.1007/s40123-025-01143-w","DOIUrl":"10.1007/s40123-025-01143-w","url":null,"abstract":"<p><p>This narrative review explores the pathophysiology of ocular surface inflammation and highlights the therapeutic potential of patch amniotic membrane transplantation (patch-AMT) in ocular surface repair. Disruptions in ocular surface homeostasis caused by trauma, disease, or immune dysregulation trigger an inflammatory cascade that, if unresolved, can impair epithelial healing, lead to fibrosis, corneal haze, and vision loss. Patch-AMT provides a biological intervention with epitheliotropic, anti-inflammatory, anti-fibrotic, anti-angiogenic, and neuroprotective effects that support wound healing, regulate inflammation, and reduce pain. The review examines patch-AMT's role in acute conditions (chemical burns, Stevens-Johnson Syndrome) and chronic disease (persistent epithelial defects, dry eye disease), focusing on its ability to entrap immune cells, regulate cytokine signaling, and prevent fibrotic remodeling while releasing trophic proteins. Additionally, this review explores how preservation methods, application orientation, and intervention timing influences patch-AMT's efficacy. Recent advancements in non-surgical application methods have expanded accessibility, enabling earlier intervention and outpatient use. However, variability in clinical protocols emphasize the need for standardized guidelines. The review concludes by highlighting the need for further research to refine treatment timing, optimize repeat application strategies, and evaluate cost-effectiveness. While patch-AMT remains underutilized, growing evidence underscores its potential to improve clinical outcomes, particularly when applied early in disease progression.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"1385-1409"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptomology and Impact of Dry Eye Disease: A Patient and Physician Perspective.","authors":"Noel Cheong, Juliana Hiok-Lian Ang, Cansu Kaya, Ashish Kumar, Sean Shao Wei Lam, Louis Tong","doi":"10.1007/s40123-025-01166-3","DOIUrl":"10.1007/s40123-025-01166-3","url":null,"abstract":"<p><p>Dry eye disease (DED) is a common ocular surface disease that results from tear instability, leading to visual disturbance, decreased work productivity, and reduced quality of life. Contributing factors to DED are multifactorial, ranging from air quality to Sjögren's syndrome (primary or secondary), and the associated comorbidities make management particularly challenging. Additionally, knowledge on the natural history of dry eye is lacking, and there is no consensus on the optimal treatment for various DED subtypes and their comorbidities. It is critical that information remains accurate and accessible to patients, caregivers, and physicians. Here, the experiences of a patient with DED are contextualized by an ophthalmologist with a review of the current available literature on DED to establish a groundwork for future research into DED. The patient experience suggests that a clear and accessible information source for patients and caregivers remains an overlooked aspect of holistic care in DED. Symptoms such as watery eyes and refractive changes are often not well understood by patients, and a systems-based approach suggests that patient care would benefit from multidisciplinary collaborations between ophthalmologists, general physicians, and other health professionals in managing this chronic condition. Further advancements in DED research and delivery of care will depend on increasing community engagement on DED diagnosis, comorbidities, and current evidence-based treatment protocols.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"1357-1368"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging of Geographic Atrophy: A Practical Approach.","authors":"Gregor S Reiter, Enrico Borrelli, Rosa Dolz-Marco, Raymond Iezzi, Sophie J Bakri","doi":"10.1007/s40123-025-01158-3","DOIUrl":"10.1007/s40123-025-01158-3","url":null,"abstract":"<p><p>Geographic atrophy (GA) secondary to age-related macular degeneration is a chronic degenerative disease involving the retinal pigment epithelium, photoreceptors, and choriocapillaris leading to irreversible loss of visual function. Identification of imaging markers associated with GA development and progression has progressed over the past decades, moving from two-dimensional to three-dimensional imaging, as well as image interpretation using artificial intelligence. However, there is an open discussion about the \"must-haves\" for GA detection and follow-up as well as complementary imaging. This practical approach provides an overview of the advantages of key imaging modalities for GA and their applicability in clinical and experimental settings.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"1621-1632"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Mixed Reality Headset: First Exploratory Use in Intraocular Surgery and Telementoring.","authors":"Rodolfo Mastropasqua, Maria Ludovica Ruggeri, Alberto Quarta, Ruggero Tartaro, Luca Vecchiarino, Luca Virgilio Corboli, Lorenza Brescia, Matteo Orione, Andrea Russo, Teresio Avitabile, Leonardo Mastropasqua","doi":"10.1007/s40123-025-01117-y","DOIUrl":"10.1007/s40123-025-01117-y","url":null,"abstract":"<p><strong>Introduction: </strong>In this work, we aimed to explore the applicability of a mixed reality headset (MRH) in intraocular surgery and its potential benefits as an innovative telementoring model of surgical teaching.</p><p><strong>Methods: </strong>A total of nine surgeries were performed. All surgeries were planned and performed with the aid of the Apple Vision Pro (Apple Inc., Cupertino, CA, USA) MRH integrated with multimodal imaging technology to provide a dynamic, detailed, real-time, all-in-one three-dimensional (3D) live visualization of surgical cases. A live connection between surgeons enabled real-time sharing of the surgical field. Feedback from surgeons and fellows, along with their satisfaction levels, was recorded to assess the applicability of this approach in intraocular surgery and surgical education.</p><p><strong>Results: </strong>The integrated system proved to be an efficient all-in-one solution, demonstrating efficacy in surgical planning and keeping the surgeon informed throughout the procedure (> 8). No signal delay nor additional complications were detected in the real-time video feed, which allowed for uninterrupted guidance throughout the procedure. Both surgeons and fellows showed overall satisfaction and interest in the new model (> 8), appreciating the advantages in terms of knowledge gap filling, future perspective in surgical telementoring, and the possibility of application in surgical training.</p><p><strong>Conclusions: </strong>Introducing an MRH in intraocular surgery provides an innovative and immersive visualization, leading to significant benefits in telementoring. This advancement opens new educational opportunities and could be a game-changer in the training of future ophthalmic surgeons.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"1597-1609"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}