Alterations in Peripheral Refraction are Most Significant Just Before the Onset of Myopia: Evidence from Multispectral Refraction Topography.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2025-07-10 DOI:10.1007/s40123-025-01198-9

Feijia Xie, Xukai Mao, Mingming Jiang, Jun Li, Jing Zhang

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Abstract

Introduction: This study aims to explore the characteristics of retinal defocus values (RDVs) during refractive development of Chinese children.

Methods: In this cross-sectional study, 2125 children (2125 right eyes) aged 4-15 years were included and divided into several groups according to spherical equivalent (SE) or axial length (AL). Ocular biological parameters including AL, central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT) and corneal curvature were detected, and multispectral refractive tomography (MRT) was used to measure total retinal defocus values (TRDV), RDVs of 0°-15°/15°-30°/30°-45° concentric annulus area (RDV-15/30/45), RDVs of the superior, nasal, inferior and temporal fan-shaped region (RDV-S/N/I/T).

Results: CCT and ACD increased while LT decreased with myopia progression. As diopter descended, almost all RDVs gradually inclined to hyperopic defocus; however, the superior retina demonstrated consistent myopic defocus across different dioptric states. RDV-45 and RDV-T changed most obviously among RDV-15/30/45 and RDV-S/N/I/T, respectively. Importantly, hyperopic shift of RDVs was most pronounced between the emmetropia and low myopia group, and also when AL was approximately 23 mm. Additionally, difference between superior and inferior RDVs also peaks in early myopia.

Conclusions: The rapid changes and longitudinal inequality of RDVs are most significant just before 23 mm of AL, this condition may have important predictive value for the occurrence of myopia. Additionally, defocus of the temporal retina showed the greatest variation in dioptric development, suggesting that nasal visual information may affect refractive outcomes.

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周边屈光的改变在近视发生前最为显著：来自多光谱屈光地形的证据。

前言：本研究旨在探讨中国儿童屈光发育过程中视网膜离焦值（RDVs）的特征。方法：采用横断面研究方法，选取4 ~ 15岁儿童2125例（右眼2125例），根据球体当量（SE）或眼轴长度（AL）分为几组。检测AL、角膜中央厚度（CCT）、前房深度（ACD）、晶状体厚度（LT）、角膜曲率等眼部生物学参数，并采用多光谱屈光体层析成像（MRT）测量视网膜总离焦值（TRDV）、0°-15°/15°-30°/30°-45°同心圆区rdv （RDV-15/30/45）、上、鼻、下、颞扇形区rdv （RDV-S/N/I/T）。结果：随近视进展，CCT和ACD升高，LT降低。随着屈光度的降低，几乎所有的rdv都逐渐倾向于远视离焦；然而，上视网膜在不同屈光状态下表现出一致的近视离焦。RDV-45和RDV-T分别在RDV-15/30/45和RDV-S/N/I/T中变化最明显。重要的是，在远视组和低近视眼组之间，以及AL约为23 mm时，RDVs的远视移位最为明显。此外，优、劣rdv差异在早期近视也达到峰值。结论：在距近视23 mm前，rdv的快速变化和纵向不均匀性最为显著，这一情况可能对近视的发生具有重要的预测价值。此外，颞视网膜离焦在屈光发育中表现出最大的变化，表明鼻腔视觉信息可能影响屈光结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. Rapid Publication The journal’s publication timelines aim for a rapid peer review of 2 weeks. If an article is accepted it will be published 3–4 weeks from acceptance. The rapid timelines are achieved through the combination of a dedicated in-house editorial team, who manage article workflow, and an extensive Editorial and Advisory Board who assist with peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. Combined with the journal’s open access model this allows for the rapid, efficient communication of the latest research and reviews, fostering the advancement of ophthalmic therapies. Open Access All articles published by Ophthalmology and Therapy are open access. 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