Ophthalmology and Therapy最新文献

{"title":"In Vitro Activity of Bacteriophages Against Ocular Methicillin-resistant S. aureus Isolates Collected in the US.","authors":"Camille André, Mathieu Medina, Camille Kolenda, Leslie Blazière, Emilie Helluin, Gregory Resch, Paulo J M Bispo, Frédéric Laurent","doi":"10.1007/s40123-025-01113-2","DOIUrl":"10.1007/s40123-025-01113-2","url":null,"abstract":"<p><strong>Introduction: </strong>Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of sight-threatening infections in the US. These strains pose a significant challenge in managing ocular infections, as they frequently exhibit resistance to first-line empirical antibiotics. To assess the potential of bacteriophages as innovative topical therapies for treatment of recalcitrant ocular infections, we evaluated the in vitro antimicrobial activity of a set of anti-S. aureus phages against a collection of ocular MRSA clinical isolates collected in the US.</p><p><strong>Methods: </strong>The host range of six phages (V4SA2, V1SA9, V1SA12, V1SA19, V1SA20 and V1SA22) was assessed using the spot assay on a panel of 50 multidrug-resistant (MDR) ocular MRSA isolates selected to be representative of clones circulating in the US. Subsequently, liquid culture-based host range assay was performed for the three most active phages using different multiplicity of infection (MOI of 10^-2, 1 or 100 phages/bacteria).</p><p><strong>Results: </strong>In total, 90.0% of bacterial isolates were susceptible to at least one of the six phages. The spot host range assay showed that phages V1SA19, V1SA20 and V1SA22 had the broadest spectrum, being active against 86%, 84% and 82% of the isolates, respectively, including the MDR-MRSA CC5 and the community-associated CC8 lineages. A phage dose effect was observed across the liquid culture-based host range assay.</p><p><strong>Conclusion: </strong>Phages V1SA19, V1SA20 and V1SA22 exhibited high antimicrobial activity against ocular MRSA. Bacteriophages represent a promising anti-infective strategy in ophthalmology that could be explored for improved topical therapy of recalcitrant MRSA infections.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"897-909"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Visual, Refractive, and Functional Outcomes after Implantation of an Extended Depth of Focus Intraocular Lens in Patients with Stable and Mild Glaucoma.","authors":"Aritz Urcola, Gorka Lauzirika, Igor Illarramendi, Andrea Soto-Velasco, Ronald Sánchez-Avila, Carlota Fuente-García, Aitor Fernández-García","doi":"10.1007/s40123-025-01124-z","DOIUrl":"10.1007/s40123-025-01124-z","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study is to describe the visual, refractive, functional, and patients' satisfaction outcomes of the AcrySof™ IQ Vivity™ extended depth-of-focus intraocular lens (EDOF IOL) in patients with mild primary open-angle glaucoma (POAG).</p><p><strong>Methods: </strong>This is an ambispective, multicenter, and descriptive study. Patients with mild and stable POAG for at least 6 months, as well as patients who had the AcrySof™ IQ Vivity™ EDOF IOL implanted were included. Humphrey Field Analyzer III (Carl Zeiss Meditec, Dublin, CA, USA) and Triton optical coherence tomography (Topcon, Japan) were used to evaluate the inclusion criteria. In all cases, the formula used to calculate IOL power was Barrett Universal II. Refractive outcomes and visual acuity at distance, intermediate, and near were evaluated from 3 months postoperatively onward. In addition, monocular and binocular defocus curve and contrast sensitivity (CSV-1000, VectorVision, Greenvile, OH, USA) were assessed. Patient satisfaction was assessed through the Intraocular Lens Satisfaction (IOLSAT) and Questionnaire for Visual Disturbances (QUVID) questionnaires .</p><p><strong>Results: </strong>In total, 72 AcrySof™ IQ Vivity™ lenses from 36 patients were enrolled, of which 28 were women. The mean age was 71.61 ± 7.68 years, the mean thickness of the retinal nerve fiber layer (RNFL) was 79.24 ± 14.96 µm, the mean intraocular pressure (IOP) was 16.88 ± 3.09 mmHg, and the mean number of topical anti-glaucoma medication was 0.89 ± 0.95. Binocular corrected distance visual acuity (CDVA), binocular corrected intermediate visual acuity (CIVA), and binocular corrected near visual acuity (CNVA) were 0.00 ± 0.12, 0.16 ± 0.14, and 0.24 ± 0.11 LogMAR, respectively. Spherical equivalent was -0.27 ± 0.33 diopters (D). In addition, 86.11% of eyes were within ± 0.5 D and 95.83% were within ± 1.0 D. The binocular defocus curve shows a peak of maximum visual acuity (VA) at 0 D (0.00 ± 0.11 LogMAR) and smooth curve at intermediate (66 cm/-1.5 D) 0.11 ± 0.09 LogMAR and near distance (40 cm/-2.5 D) 0.36 ± 0.18 LogMAR. Binocular contrast sensitivity showed a decrease in high spatial frequencies compared with low spatial frequencies. The IOLSAT revealed that in bright light conditions, 88.89%, 91.67%, and 63.89% of patients \"never\" or \"rarely\" need glasses at far, arm's length, and near distances, respectively. In addition, according to the QUVID, 97.06% of patients \"never\" report shadow areas.</p><p><strong>Conclusions: </strong>The new AcrySof™ IQ Vivity™ EDOF IOL seems to provide good visual outcomes at distance, intermediate, and near vision, with an adequate contrast sensitivity, defocus curve, a low rate of visual disturbances and high visual satisfaction in patients with mild and stable POAG.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"1039-1051"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Acute Iris Transillumination Following Systemic Moxifloxacin Intake in the Greek Population.","authors":"Efthymia Kalogera, Evangelos Spanos, Michael Karampelas, Ioannis Halkiadakis, Vasileios Peponis, Kallirroi Konstantopoulou","doi":"10.1007/s40123-025-01135-w","DOIUrl":"10.1007/s40123-025-01135-w","url":null,"abstract":"<p><strong>Introduction: </strong>Bilateral acute iris transillumination (BAIT) is a recently described entity, usually following moxifloxacin intake or respiratory tract infections. Interest in the disease has increased since the COVID-19 pandemic; however, its etiopathogenesis remains unclear. This study presents five cases in Greece with symptoms and signs suggestive of BAIT after systemic moxifloxacin administration. Unusual clinical manifestations and differential diagnosis are highlighted.</p><p><strong>Case presentations: </strong>Five female patients presented to the Uveitis Department complaining of bilateral photophobia and redness following systemic moxifloxacin intake. Past ocular history was unremarkable. The median best corrected visual acuity (BCVA) was 7/10 (range 4/10-9/10) and mean intraocular pressure (IOP) was 17 mmHg, with one eye demonstrating increased IOP of 32 mmHg. Clinical findings included bilateral diffuse mid-peripheral iris transillumination, conjunctival hyperemia, unresponsive pupils, and pigment dispersion into the anterior chamber. Two cases presented blue-colored irides. Gonioscopy showed pigment deposition at the trabecular meshwork. Anterior segment optical coherence tomography (OCT) revealed a normal iris configuration in all cases.</p><p><strong>Discussion: </strong>In Greece, BAIT has been infrequently described, with the highest prevalence being reported in Türkiye. The etiopathogenesis remains unknown, but the typical geographical distribution raises suspicion of a genetic predisposition. BAIT could be considered a drug-related adverse event or an ocular manifestation of viral infections, such as COVID-19. Clinical findings may vary, though differential diagnosis can be quite challenging. In cases with elevated intraocular pressure, topical treatment is usually adequate, although surgical approaches have been reported in the literature. All of our cases fit the clinical features of BAIT. Interestingly, two of the patients had light blue iris color.</p><p><strong>Conclusion: </strong>Understanding the clinical manifestations of the disease and its geographic spread facilitates a prompt clinical diagnosis, preventing unnecessary diagnostic tests. Although BCVA is typically well preserved in BAIT, persistent photophobia may lead to severe visual impairment. Further research is necessary to elucidate the exact etiopathogenesis of BAIT and explore genetic factors that may predispose individuals to this condition.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"1157-1168"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Keratopigmentation: Cosmetic and Functional Outcomes.","authors":"Seyed Javad Hashemian, Sepehr Roozdar, Jorge L Alió","doi":"10.1007/s40123-025-01131-0","DOIUrl":"10.1007/s40123-025-01131-0","url":null,"abstract":"<p><strong>Introduction: </strong>This work aimed to assess the safety and outcomes of femtosecond laser-assisted intrastromal keratopigmentation (FIK) and superficial automated keratopigmentation (SAK) using micronized mineral pigments (MMPs) as a therapeutic cosmetic tool.</p><p><strong>Methods: </strong>Keratopigmentation (KTP) was performed in 85 eyes of 85 patients with moderate-to-severe cosmetic disabilities (20/80 to no light perception) related to various etiologies causing corneal scarring or iris abnormalities. Thirty-six eyes were treated by FIK, 46 eyes by SAK, and three eyes using combined SAK + FIK. The cosmetic outcome, patient satisfaction, and occurrence of any related complications were recorded. The cosmetic or visual outcome was assessed through patient-reported feedback, while an independent observer evaluated the cosmetic appearance at the 6th month postoperatively. The mean follow-up period was 13.06 ± 9.9 months (6-53 months).</p><p><strong>Results: </strong>The study included 48 males and 37 females. The mean age was 37.8 ± 14.25 (14-77 years). An independent observer assessed the cosmetic outcome as excellent or good in 91.8% of cases. Excellent or good cosmetic outcome was reported by the independent observer in 91.4% of the SAK group, 91.5% of the FIK group, and 100% of SAK + FIK combined. Eighty percent of patients reported cosmetic satisfaction 3 weeks postoperative; 73.9% of SAK group, 86% of FIK group, and 100% of the combined SAK + FIK group were satisfied with their cosmetic outcome. Twelve eyes of SAK and five eyes of FIK group required additional KTP procedures because of color fading and cosmetic unsatisfaction. Post-operative symptoms were photophobia (28.2%), tearing (23.5%), and pain (8.2%). Post-operative complications were dry eye (5.8%), delayed epithelial healing (2.3%), and microbial keratitis (1.1%).</p><p><strong>Conclusions: </strong>This study confirms that FIK and SAK using micronized mineral pigments are safe and efficient surgical techniques for managing cosmetic and visual disabilities caused by iris abnormalities and cosmetic issues related to corneal scars.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"1133-1145"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Six-Month Outcomes from a Prospective, Randomized Study of iStent infinite Versus Hydrus in Open-Angle Glaucoma: The INTEGRITY Study.","authors":"Iqbal Ike K Ahmed, John P Berdahl, Arkadiy Yadgarov, George R Reiss, Steven R Sarkisian, Sébastien Gagné, Marco Robles, Lilit A Voskanyan, Omar Sadruddin, Dari Parizadeh, Jane Ellen Giamporcaro, Angela C Kothe, L Jay Katz, Tomas Navratil","doi":"10.1007/s40123-025-01126-x","DOIUrl":"10.1007/s40123-025-01126-x","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;This was a prospective, randomized, double-masked, multicenter, 24-month study to compare effectiveness and safety outcomes following standalone implantation of two types of current generation trabecular stents in adults with open-angle glaucoma (OAG). An interim analysis was performed at month 6.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Eyes with OAG, mean IOP ≤ 24 mmHg on zero to three intraocular pressure (IOP)-lowering medications at screening, and with baseline mean diurnal IOP (MDIOP) 21-36 mmHg after medication washout were randomized to standalone implantation of the current generation of three trabecular micro-bypass stents (iStent infinite) or one trabecular bypass stent (Hydrus). Eyes on medication were to undergo a medication washout prior to the month 6 visit. Analyses included a comparison of the proportion of iStent infinite versus Hydrus eyes achieving MDIOP reduction of 20% or greater from baseline at month 6. Reduction from baseline in MDIOP and number of medications were also assessed. Safety parameters included intraoperative/postoperative complications, corrected visual acuity, slit-lamp biomicroscopy, ophthalmoscopy, gonioscopy, perimetry, and adverse events.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Eyes with primarily mild-to-moderate disease severity were randomized: 91 iStent infinite eyes had screening mean (± standard deviation [SD]) IOP of 17.0 ± 3.2 mmHg on 1.6 ± 0.9 medications and baseline unmedicated MDIOP of 23.7 ± 2.9 mmHg; 89 Hydrus eyes had screening mean (± SD) IOP of 17.1 ± 3.3 mmHg on 1.5 ± 0.9 medications and baseline unmedicated MDIOP of 23.5 ± 2.7 mmHg. At month 6, a similar proportion of iStent infinite eyes (82.7%) versus Hydrus eyes (78.9%) achieved MDIOP reduction ≥ 20% from baseline regardless of IOP medication use or surgical complications. The difference was statistically significantly different (78.2% iStent infinite versus 65.0% Hydrus) for unmedicated MDIOP reduction ≥ 20% from baseline in eyes with no surgical complications (difference 13.2%; 95% confidence interval (CI) 3.0%, 23.3%). Mean MDIOP change from baseline, regardless of IOP medication use or surgical complications, was similar between groups (- 7.4 ± 2.9 mmHg iStent infinite and - 7.2 ± 2.9 mmHg Hydrus), whereas unmedicated MDIOP change from baseline without surgical complications was statistically significantly superior in iStent infinite eyes (- 6.8 ± 4.1 mmHg) versus Hydrus eyes (- 5.7 ± 4.1 mmHg) (difference - 1.1 mmHg; 95% CI - 2.0 mmHg, - 0.2 mmHg). Improper stent placement was reported in one iStent infinite and seven Hydrus eyes (1.1% versus 7.9%). One iStent infinite versus four Hydrus eyes experienced peripheral anterior synechiae &gt; 1 mm (1.1% versus 4.5%). Overall, there were significantly fewer surgical complications in the iStent infinite eyes (3.3%) compared to Hydrus eyes (16.9%; difference of - 13.6%, 95% CI - 23.8%, - 3.4%).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;In this study of standalone implantation ","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"1005-1024"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis of Perceptual Learning and Video Game Training for Adults with Monocular Amblyopia.","authors":"Xiaolu Ming, Gantian Huang, Xiaohang Chen, Meng Liao, Longqian Liu","doi":"10.1007/s40123-025-01128-9","DOIUrl":"10.1007/s40123-025-01128-9","url":null,"abstract":"<p><strong>Introduction: </strong>Amblyopia is a neurodevelopmental disorder characterized by a reduction in best-corrected visual acuity (BCVA). This meta-analysis aimed to analyze the effectiveness of perceptual learning and video game training for adults with amblyopia.</p><p><strong>Methods: </strong>Following Cochrane guidelines (PROSPERO CRD42024504502), we conducted a systematic search across multiple databases. Randomized controlled trials (RCTs) on adults with amblyopia receiving behavioral therapies were included. Data on interventions, sample size, and logMAR visual acuity were extracted and analyzed using Review Manager 5.4 and Stata 17.0.</p><p><strong>Results: </strong>A total of 6439 studies were identified, with 22 meeting the inclusion criteria after screening. The meta-analysis included 422 adult patients with amblyopia across these studies. Quality assessment revealed that 78% of studies had a low risk of bias. The analysis showed a statistically significant standardized mean difference (SMD) of -0.68 in the experimental group compared with controls, indicating an improvement in visual acuity (P < 0.05). Subgroup analyses indicated that perceptual learning and video game training also resulted in visual improvement (P < 0.05). In addition, the results indicated a significant improvement in visual acuity with dichoptic training or monocular training, reaching visual acuity improvement (P < 0.05).</p><p><strong>Conclusions: </strong>These findings indicate that targeted visual training facilitates neural plasticity, reduces interocular suppression, and reinforces neural pathways associated with visual processing. While video game-based interventions represent a viable and engaging rehabilitation strategy, a combined approach may be most effective in enhancing monocular and binocular functions. Future research should focus on refining training protocols to enhance both monocular and binocular visual function more effectively.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"857-881"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: A Preservative-Free Combination of Sodium Hyaluronate and Trehalose Improves Dry Eye Signs and Symptoms and Increases Patient Satisfaction in Real-Life Settings: The TEARS Study.","authors":"Antonio J Mateo-Orobia, Sarah Farrant, Eduardo Del-Prado-Sanz, Alejandro Blasco-Martínez, Miriam Idoipe-Corta, Noelia Lafuente-Ojeda, Luis E Pablo-Júlvez","doi":"10.1007/s40123-025-01110-5","DOIUrl":"10.1007/s40123-025-01110-5","url":null,"abstract":"","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"1169-1171"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a New Fully Automatic OLCR Biometer: Repeatability, Reproducibility, and Agreement with an SS-OCT Biometer.","authors":"Chak Seng Lei, Xinning Yang, Rui Ning, Jinxuan Xiahou, Xinyu Jiang, Giacomo Savini, Domenico Schiano-Lomoriello, Xingtao Zhou, Kexin Li, Jinhai Huang","doi":"10.1007/s40123-025-01120-3","DOIUrl":"10.1007/s40123-025-01120-3","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the intraobserver repeatability and interobserver reproducibility of the LUS-1000 Plus, a new fully automatic optical low coherence reflectometry (OLCR)-based biometer, and its agreement with the IOLMaster 700, a swept-source optical coherence tomography (SS-OCT)-based biometer, for biometric measurement.</p><p><strong>Methods: </strong>This prospective study included 77 right eyes from 77 healthy participants. The axial length (AL), central corneal thickness (CCT), aqueous depth (AQD), anterior chamber depth (ACD), flattest, steepest, mean keratometry (Kf, Ks, Km), astigmatism magnitude (AST), J₀, J₄₅ vectors, and corneal diameter (CD) were measured. Repeatability and reproducibility were evaluated using the within-subject standard deviation (S_w), test-retest (TRT) repeatability, coefficient of variation (CoV), and intraclass correlation coefficient (ICC). To compare differences and establish agreement between the devices, paired t test and Bland-Altman plots were utilized. Double-angle plots were employed to analyze corneal astigmatism.</p><p><strong>Results: </strong>Repeatability and reproducibility analysis revealed low S_w, TRT, and CoV, accompanied by high ICC values for all evaluated parameters. The interdevice agreement was excellent, Bland-Altman plots showed narrow 95% limits of agreement (LoA) (AL - 0.05 to 0.04 mm, CCT - 22.03 to - 7.50 μm, AQD 0.01 to 0.14 mm, ACD 0.00 to 0.13 mm, LT - 0.16 to 0.02 mm, Kf - 0.24 to 0.23 D, Ks - 0.36 to 0.21 D, Km - 0.24 to 0.16 D, AST - 0.41 to 0.27 D, J₀ - 0.15 to 0.17 D, J₄₅ - 0.14 to 0.22 D, CD - 0.38 to 0.18 mm).</p><p><strong>Conclusion: </strong>The LUS-1000 Plus demonstrated high repeatability and reproducibility, and excellent agreement with the IOLMaster 700, confirming its reliability and interchangeable use with the IOLMaster 700 in clinical practice.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"1097-1109"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Deep Learning Segmentation Model for Detection of Active Proliferative Diabetic Retinopathy.","authors":"Sebastian Dinesen, Marianne G Schou, Christoffer V Hedegaard, Yousif Subhi, Thiusius R Savarimuthu, Tunde Peto, Jakob K H Andersen, Jakob Grauslund","doi":"10.1007/s40123-025-01127-w","DOIUrl":"10.1007/s40123-025-01127-w","url":null,"abstract":"<p><strong>Introduction: </strong>Existing deep learning (DL) algorithms lack the capability to accurately identify patients in immediate need of treatment for proliferative diabetic retinopathy (PDR). We aimed to develop a DL segmentation model to detect active PDR in six-field retinal images by the annotation of new retinal vessels and preretinal hemorrhages.</p><p><strong>Methods: </strong>We identified six-field retinal images classified at level 4 of the International Clinical Diabetic Retinopathy Disease Severity Scale collected at the Island of Funen from 2009 to 2019 as part of the Danish screening program for diabetic retinopathy (DR). A certified grader (grader 1) manually dichotomized the images into active or inactive PDR, and the images were then reassessed by two independent certified graders. In cases of disagreement, the final classification decision was made in collaboration between grader 1 and one of the secondary graders. Overall, 637 images were classified as active PDR. We then applied our pre-established DL segmentation model to annotate nine lesion types before training the algorithm. The segmentations of new vessels and preretinal hemorrhages were corrected for any inaccuracies before training the DL algorithm. After the classification and pre-segmentation phases the images were divided into training (70%), validation (10%), and testing (20%) datasets. We added 301 images with inactive PDR to the testing dataset.</p><p><strong>Results: </strong>We included 637 images of active PDR and 301 images of inactive PDR from 199 individuals. The training dataset had 1381 new vessel and preretinal hemorrhage lesions, while the validation dataset had 123 lesions and the testing dataset 374 lesions. The DL system demonstrated a sensitivity of 90% and a specificity of 70% for annotation-assisted classification of active PDR. The negative predictive value was 94%, while the positive predictive value was 57%.</p><p><strong>Conclusions: </strong>Our DL segmentation model achieved excellent sensitivity and acceptable specificity in distinguishing active from inactive PDR.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"1053-1063"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep-Learning-Assisted Analysis of Early Biomarker Changes in Treatment-Naïve Patients with Neovascular AMD Under Intravitreal Faricimab.","authors":"Michael Hafner, Ben Asani, Franziska Eckardt, Jakob Siedlecki, Benedikt Schworm, Siegfried G Priglinger, Johannes Schiefelbein","doi":"10.1007/s40123-025-01125-y","DOIUrl":"10.1007/s40123-025-01125-y","url":null,"abstract":"<p><strong>Introduction: </strong>Artificial intelligence (AI)-driven biomarker segmentation offers an objective approach to assessing neovascular age-related macular degeneration (nAMD). In addition, faricimab, a bispecific VEGF and Ang-2 inhibitor, presents new potential in disease management. This study applies an AI-based segmentation algorithm to quantify key optical coherence tomography (OCT) biomarkers and assess the short-term efficacy of intravitreal faricimab in treatment-naïve patients.</p><p><strong>Methods: </strong>This retrospective analysis includes 40 eyes from 38 treatment-naïve patients with nAMD treated with faricimab at LMU University Hospital Munich between January 2023 and September 2024. Patients received 4-monthly intravitreal injections. Biomarkers of disease activity, including central retinal thickness (CRT), intraretinal fluid (IRF), subretinal fluid (SRF), subretinal hyperreflective material (SHRM) and fibrovascular pigment epithelium detachment (fvPED), were quantified using a deep learning-based semantic segmentation algorithm. Best-corrected visual acuity (BCVA) and OCT imaging data were analyzed at baseline (mo0) and after 1 (mo1), 2 (mo2) and 3 months (mo3).</p><p><strong>Results: </strong>AI-driven analysis revealed significant reductions in key biomarkers. CRT decreased from 433.6 (IQR: 306.6) µm at mo0 to 241.5 (IQR: 130.8) µm at mo3 (p < 0.0001). IRF and SRF volumes were reduced by > 99% from mo0 to mo3 (both p < 0.0001). BCVA improved from 0.60 (IQR: 0.30) logMAR at mo0 to 0.40 (IQR: 0.33) logMAR at mo3 (p < 0.0001). Correlation analysis identified IRF and SHRM reductions as the strongest predictors of visual improvement.</p><p><strong>Conclusion: </strong>This study demonstrates the potential of AI-assisted biomarker analysis for precise disease monitoring in nAMD. Faricimab significantly reduced disease activity biomarkers and improved visual acuity in treatment-naïve patients, reinforcing its efficacy in early disease control. Future studies should explore long-term outcomes and further integrate AI-driven biomarker evaluation in clinical practice.</p>","PeriodicalId":19623,"journal":{"name":"Ophthalmology and Therapy","volume":" ","pages":"1025-1037"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}